{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:59:40Z","timestamp":1793332780662,"version":"4.5.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0006120","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T00:00:00Z","timestamp":1513814400000}}],"reference-count":119,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T00:00:00Z","timestamp":1512950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2012-03364"],"award-info":[{"award-number":["2012-03364"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0006120","type":"journal-article","created":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T18:37:45Z","timestamp":1513017465000},"page":"e0006120","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":101,"title":["Characterization of the Giardia intestinalis secretome during interaction with human intestinal epithelial cells: The impact on host cells"],"prefix":"10.1371","volume":"11","author":[{"given":"Showgy Y.","family":"Ma\u2019ayeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitra","family":"Peirasmaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"H\u00f6rnaeus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Bergstr\u00f6m Lind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Grabherr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Bergquist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7392-1746","authenticated-orcid":true,"given":"Staffan G.","family":"Sv\u00e4rd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,12,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.mib.2016.07.019","article-title":"An up-date on <italic>Giardia<\/italic> and giardiasis","volume":"34","author":"E Einarsson","year":"2016","journal-title":"Curr Opin Microbiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/nrmicro2317","article-title":"Behind the smile: cell biology and disease mechanisms of <italic>Giardia<\/italic> species","volume":"8","author":"J Ankarklev","year":"2010","journal-title":"Nat Rev Microbiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.ijpara.2011.05.002","article-title":"Host parasite interactions and pathophysiology in <italic>Giardia<\/italic> infections","volume":"41","author":"JA Cotton","year":"2011","journal-title":"Int J Parasitol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1093\/jpids\/piw082","article-title":"Determinants and Impact of Giardia Infection in the First 2 Years of Life in the MAL-ED Birth Cohort","volume":"6","author":"ET Rogawski","year":"2017","journal-title":"J Pediatric Infect Dis Soc"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"8974","DOI":"10.3748\/wjg.v19.i47.8974","article-title":"Extra-intestinal and long term consequences of <italic>Giardia duodenalis<\/italic> infections","author":"MCM Halliez","year":"2013","journal-title":"World Journal of Gastroenterology"},{"key":"ref6","first-page":"801","article-title":"Effect of excretory-secretory products of <italic>Giardia lamblia<\/italic> on glucose and phenylalanine transport in the small intestine of Swiss albino mice","volume":"17","author":"HK Samra","year":"1988","journal-title":"Biochem Int"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1128\/CDLI.11.1.152-160.2004","article-title":"Systemic and mucosal responses to oral administration of excretory and secretory antigens from <italic>Giardia intestinalis<\/italic>","volume":"11","author":"JC Jim\u00e9nez","year":"2004","journal-title":"Clin Diagn Lab Immunol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s00436-006-0339-0","article-title":"Excreted\/secreted glycoproteins of G. intestinalis play an essential role in the antibody response","volume":"100","author":"JC Jim\u00e9nez","year":"2007","journal-title":"Parasitol Res. Springer-Verlag"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/S0014-4894(03)00054-7","article-title":"A potentially important excretory-secretory product of <italic>Giardia lamblia<\/italic>","volume":"102","author":"J Shant","year":"2002","journal-title":"Exp Parasitol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1017\/S0031182001008629","article-title":"Identification and characterization of an excretory-secretory product from <italic>Giardia lamblia<\/italic>","volume":"123","author":"H Kaur","year":"2001","journal-title":"Parasitology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1590\/S0074-02762006000600020","article-title":"<italic>Giardia duodenalis<\/italic>: Analysis of secreted proteases upon trophozoite-epithelial cell interaction in vitro","volume":"101","author":"GB Rodr\u00edguez-Fuentes","year":"2006","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/748206","article-title":"Host-Parasite Interaction: Parasite-Derived and -Induced Proteases That Degrade Human Extracellular Matrix","volume":"2012","author":"C Pi\u00f1a-V\u00e1zquez","year":"2012","journal-title":"J Parasitol Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1093\/infdis\/160.6.1076","article-title":"Characterization of a thiol proteinase in <italic>Giardia lamblia<\/italic>","volume":"160","author":"DM Parenti","year":"1989","journal-title":"J Infect Dis"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e109087","DOI":"10.1371\/journal.pone.0109087","article-title":"<italic>Giardia duodenalis<\/italic> infection reduces granulocyte infiltration in an in vivo model of bacterial toxin-induced colitis and attenuates inflammation in human intestinal tissue","volume":"9","author":"JA Cotton","year":"2014","journal-title":"PLoS One"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.1128\/IAI.01771-14","article-title":"<italic>Giardia duodenalis<\/italic> cathepsin B proteases degrade intestinal epithelial interleukin-8 and attenuate interleukin-8-induced neutrophil chemotaxis","volume":"82","author":"JA Cotton","year":"2014","journal-title":"Infect Immun"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1186\/1471-2180-13-256","article-title":"The role of arginine and arginine-metabolizing enzymes during <italic>Giardia<\/italic>\u2014host cell interactions in vitro","volume":"13","author":"B Stadelmann","year":"2013","journal-title":"BMC Microbiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.molbiopara.2008.02.005","article-title":"Release of metabolic enzymes by <italic>Giardia<\/italic> in response to interaction with intestinal epithelial cells","volume":"159","author":"E Ringqvist","year":"2008","journal-title":"Mol Biochem Parasitol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1128\/IAI.00004-13","article-title":"<italic>Giardia duodenalis<\/italic> arginine deiminase modulates the phenotype and cytokine secretion of human dendritic cells by depletion of arginine and formation of ammonia","volume":"81","author":"S Banik","year":"2013","journal-title":"Infect Immun"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.exppara.2011.01.006","article-title":"Elongation factor 1-alpha is released into the culture medium during growth of <italic>Giardia intestinalis<\/italic> trophozoites","volume":"127","author":"H Skarin","year":"2011","journal-title":"Exp Parasitol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"10143","DOI":"10.1021\/bi960473b","article-title":"The release of the variant surface protein of <italic>Giardia<\/italic> to its soluble isoform is mediated by the selective cleavage of the conserved carboxy-terminal domain","volume":"35","author":"P Papanastasiou","year":"1996","journal-title":"Biochemistry"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1086\/375356","article-title":"Identification of immunoreactive proteins during acute human giardiasis","volume":"187","author":"JED Palm","year":"2003","journal-title":"J Infect Dis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/nature07585","article-title":"Antigenic variation in <italic>Giardia lamblia<\/italic> is regulated by RNA interference","volume":"456","author":"CG Prucca","year":"2008","journal-title":"Nature"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.ijpara.2010.12.014","article-title":"Membrane trafficking and organelle biogenesis in <italic>Giardia lamblia<\/italic>: use it or lose it","volume":"41","author":"C Faso","year":"2011","journal-title":"Int J Parasitol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"3567","DOI":"10.1007\/s00436-015-4659-9","article-title":"Ingrid Evans-Osses1,2 &amp; Luis H. Reichembach2 &amp; Marcel I. Ramirez1 2. Exosomes or microvesicles? Two kinds of extracellular vesicles with different routes to modify protozoan-host cell interaction","volume":"114","author":"I Evans-Osses","year":"2015","journal-title":"Parasitol Res. Springer Berlin Heidelberg"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"24","DOI":"10.15252\/embr.201439363","article-title":"Exosomes and other extracellular vesicles in host-pathogen interactions","volume":"16","author":"JS Schorey","year":"2015","journal-title":"EMBO Rep"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ejcb.2017.01.005","article-title":"Microvesicles released from <italic>Giardia intestinalis<\/italic> disturb host-pathogen response in vitro","volume":"96","author":"I Evans-Osses","year":"2017","journal-title":"Eur J Cell Biol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"e45325","DOI":"10.1371\/journal.pone.0045325","article-title":"Arginine Consumption by the Intestinal Parasite <italic>Giardia intestinalis<\/italic> Reduces Proliferation of Intestinal Epithelial Cells","volume":"7","author":"B Stadelmann","year":"2012","journal-title":"PLoS One"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"7806","DOI":"10.1128\/MCB.24.17.7806-7819.2004","article-title":"NF-kappaB and AP-1 connection: mechanism of NF-kappaB-dependent regulation of AP-1 activity","volume":"24","author":"S Fujioka","year":"2004","journal-title":"Mol Cell Biol. American Society for Microbiology (ASM)"},{"key":"ref29","first-page":"16483","article-title":"The regulation of AP-1 activity by mitogen-activated protein kinases","volume":"270","author":"M Karin","year":"1995","journal-title":"J Biol Chem. American Society for Biochemistry and Molecular Biology"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.bbamcr.2006.11.011","article-title":"Regulation of gene transcription by mitogen-activated protein kinase signaling pathways","volume":"1773","author":"AJ Whitmarsh","year":"2007","journal-title":"Biochim Biophys Acta\u2014Mol Cell Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1146\/annurev.immunol.021908.132641","article-title":"Regulation and Function of NF-\u03baB Transcription Factors in the Immune System","volume":"27","author":"S Vallabhapurapu","year":"2009","journal-title":"Annu Rev Immunol. Annual Reviews"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1017\/S0031182010001277","article-title":"Lipid metabolism in <italic>Giardia<\/italic>: a post-genomic perspective","volume":"138","author":"M Yichoy","year":"2011","journal-title":"Parasitology. NIH Public Access"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.ijpara.2012.04.004","article-title":"Representational difference analysis identifies specific genes in the interaction of <italic>Giardia duodenalis<\/italic> with the murine intestinal epithelial cell line, IEC-6","volume":"42","author":"SY Ma\u2019ayeh","year":"2012","journal-title":"Int J Parasitol"},{"key":"ref34","first-page":"410","article-title":"The many faces of epidermal growth factor repeats","volume":"2","author":"CG Davis","year":"1990","journal-title":"New Biol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1128\/EC.00268-08","article-title":"Changes in the N-glycome, glycoproteins with Asn-linked glycans, of <italic>Giardia lamblia<\/italic> with differentiation from trophozoites to cysts","volume":"7","author":"DM Ratner","year":"2008","journal-title":"Eukaryot Cell. American Society for Microbiology"},{"key":"ref36","article-title":"Exocytosis and protein secretion in <italic>Trypanosoma<\/italic>","author":"A Geiger","journal-title":"Exocytosis and protein secretion in"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"R35","DOI":"10.1186\/gb-2008-9-2-r35","article-title":"Proteomic analysis of the secretome of <italic>Leishmania donovani<\/italic>","volume":"9","author":"JM Silverman","year":"2008","journal-title":"Genome Biol"},{"key":"ref38","article-title":"Extracellular vesicles in parasitic diseases","author":"A Marcilla","year":"2014","journal-title":"Int Heal Res"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.7150\/ijbs.7.1239","article-title":"Macrophage migration inhibitory factor (MIF): a key player in protozoan infections","volume":"7","author":"J de D Rosado","year":"2011","journal-title":"Int J Biol Sci"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"8204","DOI":"10.1128\/IAI.73.12.8204-8208.2005","article-title":"<italic>Giardia lamblia<\/italic>-induced changes in gene expression in differentiated caco-2 human intestinal epithelial cells","volume":"73","author":"K Roxstr\u00f6m-Lindquist","year":"2005","journal-title":"Infect Immun"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jbior.2016.05.001","article-title":"Gene regulation in the immediate-early response process","volume":"62","author":"S Bahrami","year":"2016","journal-title":"Adv Biol Regul"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.lfs.2011.11.017","article-title":"Mitogen-activated protein kinase phosphatase (MKP)-1 in immunology, physiology, and disease","volume":"90","author":"LM Wancket","year":"2012","journal-title":"Life Sci"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1016\/j.molimm.2011.06.439","article-title":"Attenuation of the acute inflammatory response by dual specificity phosphatase 1 by inhibition of p38 MAP kinase","volume":"48","author":"R Korhonen","year":"2011","journal-title":"Mol Immunol"},{"key":"ref44","first-page":"42703","article-title":"Human tribbles, a protein family controlling mitogen-activated protein kinase cascades","volume":"279","author":"E Kiss-Toth","year":"2004","journal-title":"J Biol Chem. American Society for Biochemistry and Molecular Biology"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1016\/j.peptides.2010.07.020","article-title":"Insulin-induced gene: A new regulator in lipid metabolism","volume":"31","author":"X-Y Dong","year":"2010","journal-title":"Peptides"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s00125-006-0479-x","article-title":"Human evidence for the involvement of insulin-induced gene 1 in the regulation of plasma glucose concentration","volume":"50","author":"S Krapivner","year":"2007","journal-title":"Diabetologia"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0092-8674(02)00872-3","article-title":"Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER","volume":"110","author":"T Yang","year":"2002","journal-title":"Cell. Elsevier"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"e0133598","DOI":"10.1371\/journal.pone.0133598","article-title":"Deficiency of Nuclear Receptor Nur77 Aggravates Mouse Experimental Colitis by Increased NF\u03baB Activity in Macrophages","volume":"10","author":"AAJ Hamers","year":"2015","journal-title":"PLoS One. Public Library of Science"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1210\/me.2005-0331","article-title":"Regulation of Macrophage Inflammatory Gene Expression by the Orphan Nuclear Receptor Nur77","volume":"20","author":"L Pei","year":"2006","journal-title":"Mol Endocrinol"},{"key":"ref50","article-title":"Cytochrome c Release and Apoptosis Induced by Mitochondrial Targeting of Nuclear Orphan Receptor TR3","volume":"289","author":"H Li","year":"2000","journal-title":"Science (80-)"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/ng1296-482","article-title":"Identification of BTG2, an antiproliferative p53\u2013dependent component of the DNA damage cellular response pathway","volume":"14","author":"J-P Rouault","year":"1996","journal-title":"Nat Genet. Nature Publishing Group"},{"key":"ref52","first-page":"266","article-title":"Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen","author":"M Smith","year":"1994","journal-title":"Science (80-)"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"e24978","DOI":"10.4161\/tisb.24978","article-title":"Claudins in intestines: Distribution and functional significance in health and diseases","volume":"1","author":"Z Lu","year":"2013","journal-title":"Tissue barriers. Taylor & Francis"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"11458","DOI":"10.1073\/pnas.96.20.11458","article-title":"Novel neurotrophin-1\/B cell-stimulating factor-3: a cytokine of the IL-6 family","volume":"96","author":"G Senaldi","year":"1999","journal-title":"Proc Natl Acad Sci U S A. National Academy of Sciences"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.bbagrm.2013.02.003","article-title":"Tristetraprolin (TTP): Interactions with mRNA and proteins, and current thoughts on mechanisms of action","volume":"1829","author":"SA Brooks","year":"2013","journal-title":"Biochim Biophys Acta\u2014Gene Regul Mech"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1038\/nature07924","article-title":"Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay","volume":"458","author":"K Matsushita","year":"2009","journal-title":"Nature"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1128\/CVI.05356-11","article-title":"Analysis of <italic>Entamoeba histolytica<\/italic> excretory-secretory antigen and identification of a new potential diagnostic marker","volume":"18","author":"WK Wong","year":"2011","journal-title":"Clin Vaccine Immunol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"103","DOI":"10.5483\/BMBRep.2015.48.2.116","article-title":"Modulation of dendritic cell function by <italic>Trichomonas vaginalis<\/italic>-derived secretory products","volume":"48","author":"M-J Song","year":"2015","journal-title":"BMB Rep"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.ijpara.2009.02.018","article-title":"Identification of total and differentially expressed excreted-secreted proteins from <italic>Trypanosoma congolense<\/italic> strains exhibiting different virulence and pathogenicity","volume":"39","author":"P Gr\u00e9baut","year":"2009","journal-title":"Int J Parasitol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.molbiopara.2014.02.005","article-title":"Extracellular functions of glycolytic enzymes of parasites: unpredicted use of ancient proteins","volume":"193","author":"A G\u00f3mez-Arreaza","year":"2014","journal-title":"Mol Biochem Parasitol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.1111\/j.1462-5822.2007.00979.x","article-title":"The proteins secreted by <italic>Trichomonas vaginalis<\/italic> and vaginal epithelial cell response to secreted and episomally expressed AP65","volume":"9","author":"AS Kucknoor","year":"2007","journal-title":"Cell Microbiol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"e0136102","DOI":"10.1371\/journal.pone.0136102","article-title":"<italic>Giardia duodenalis<\/italic> Surface Cysteine Proteases Induce Cleavage of the Intestinal Epithelial Cytoskeletal Protein Villin via Myosin Light Chain Kinase","volume":"10","author":"A Bhargava","year":"2015","journal-title":"PLoS One. Public Library of Science"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s00436-008-1185-z","article-title":"Protease activity in extracellular products secreted in vitro by trophozoites of <italic>Giardia duodenalis<\/italic>","volume":"104","author":"TB de Carvalho","year":"2008","journal-title":"Parasitol Res"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1007\/s00436-009-1478-x","article-title":"Involvement of serine proteases in the excystation and metacystic development of <italic>Entamoeba invadens<\/italic>","volume":"105","author":"A Makioka","year":"2009","journal-title":"Parasitol Res"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1006\/mpat.2000.0403","article-title":"Characterization and pathogenetic role of proteinase from <italic>Acanthamoeba castellanii<\/italic>","volume":"30","author":"B-K Na","year":"2001","journal-title":"Microb Pathog"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3347\/kjp.2003.41.4.189","article-title":"Purification and characterization of a 33 kDa serine protease from <italic>Acanthamoeba lugdunensis<\/italic> KA\/E2 isolated from a Korean keratitis patient","volume":"41","author":"H-K Kim","year":"2003","journal-title":"Korean J Parasitol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0925-4439(92)90040-T","article-title":"Characterization of different proteolytic activities in <italic>Trypanosoma brucei<\/italic> brucei","volume":"1138","author":"G Huet","year":"1992","journal-title":"Biochim Biophys Acta"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0166-6851(01)00244-4","article-title":"In vitro cytocidal effects on <italic>Trypanosoma brucei<\/italic> and inhibition of Leishmania major GP63 by peptidomimetic metalloprotease inhibitors","volume":"114","author":"JD Bangs","year":"2001","journal-title":"Mol Biochem Parasitol"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1365-3156.2010.02642.x","article-title":"Matrix metalloproteinase-9 and intercellular adhesion molecule 1 are powerful staging markers for human African trypanosomiasis","volume":"16","author":"A Hainard","year":"2011","journal-title":"Trop Med Int Health"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1128\/CMR.14.3.447-475.2001","article-title":"Biology of Giardia lamblia","volume":"14","author":"RD Adam","year":"2001","journal-title":"Clin Microbiol Rev"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.molbiopara.2014.09.007","article-title":"Gene expression changes during <italic>Giardia<\/italic>-host cell interactions in serum-freeh medium","volume":"197","author":"M Ferella","year":"2014","journal-title":"Mol Biochem Parasitol"},{"key":"ref72","first-page":"3687","article-title":"Differences in activities and substrate specificity of human and murine pyrimidine nucleoside phosphorylases: implications for chemotherapy with 5-fluoropyrimidines","volume":"53","author":"MH el Kouni","year":"1993","journal-title":"Cancer Res"},{"key":"ref73","first-page":"31789","article-title":"Identification and biochemical characterization of unique secretory nucleases of the human enteric pathogen, <italic>Entamoeba histolytica<\/italic>","volume":"282","author":"GC McGugan","year":"2007","journal-title":"J Biol Chem. American Society for Biochemistry and Molecular Biology"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1074\/jbc.273.4.2214","article-title":"Purification and characterization of a catalytic domain of rat intestinal phospholipase B\/lipase associated with brush border membranes","volume":"273","author":"H Tojo","year":"1998","journal-title":"J Biol Chem"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1128\/CMR.13.1.122-143.2000","article-title":"Potential role of phospholipases in virulence and fungal pathogenesis","volume":"13","author":"MA Ghannoum","year":"2000","journal-title":"Clin Microbiol Rev"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0005-2760(97)00122-7","article-title":"1l-myo-Inositol-1-phosphate synthase","volume":"1348","author":"AL Majumder","year":"1997","journal-title":"Biochim Biophys Acta\u2014Lipids Lipid Metab"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0166-6851(01)00435-2","article-title":"Generation of myo-inositol-auxotrophic <italic>Leishmania mexicana<\/italic> mutants by targeted replacement of the myo-inositol-1-phosphate synthase gene","volume":"120","author":"T Ilg","year":"2002","journal-title":"Mol Biochem Parasitol"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0020-7519(97)00172-0","article-title":"Anaerobic bacterial metabolism in the ancient eukaryote <italic>Giardia duodenalis<\/italic>","volume":"28","author":"DM Brown","year":"1998","journal-title":"Int J Parasitol"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1128\/EC.00308-06","article-title":"The 29-kilodalton thiol-dependent peroxidase of <italic>Entamoeba histolytica<\/italic> is a factor involved in pathogenesis and survival of the parasite during oxidative stress","volume":"6","author":"A Sen","year":"2007","journal-title":"Eukaryot Cell. American Society for Microbiology (ASM)"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.molbiopara.2004.08.009","article-title":"Molecular characterization of peroxiredoxin from <italic>Entamoeba moshkovskii<\/italic> and a comparison with <italic>Entamoeba histolytica<\/italic>","volume":"138","author":"X-J Cheng","year":"2004","journal-title":"Mol Biochem Parasitol"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.molbiopara.2005.04.014","article-title":"An unusual surface peroxiredoxin protects invasive <italic>Entamoeba histolytica<\/italic> from oxidant attack","volume":"143","author":"M-H Choi","year":"2005","journal-title":"Mol Biochem Parasitol"},{"key":"ref82","article-title":"Transcriptional profiling of <italic>Giardia intestinalis<\/italic> in response to oxidative stress","author":"SY Ma\u2019ayeh","year":"2015","journal-title":"Int J Parasitol"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"227","DOI":"10.3389\/fcimb.2017.00227","article-title":"Transcriptomic Profiling of High-Density Giardia Foci Encysting in the Murine Proximal Intestine","volume":"7","author":"JK Pham","year":"2017","journal-title":"Front Cell Infect Microbiol. Frontiers Media SA"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1128\/IAI.56.3.705-707.1988","article-title":"Small-intestinal factors promote encystation of <italic>Giardia lamblia in vitro<\/italic>","volume":"56","author":"FD Gillin","year":"1988","journal-title":"Infect Immun"},{"key":"ref85","first-page":"20765","article-title":"Induction of virulence factors in <italic>Giardia duodenalis<\/italic> independent of host attachment","volume":"6","author":"SJ Emery","year":"2016","journal-title":"Sci Rep. Nature Publishing Group"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1128\/MCB.21.7.2570-2580.2001","article-title":"Epidermal growth factor-like repeats mediate lateral and reciprocal interactions of Ep-CAM molecules in homophilic adhesions","volume":"21","author":"M Balzar","year":"2001","journal-title":"Mol Cell Biol"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S1084-9521(02)00179-9","article-title":"An overview of the Notch signalling pathway","volume":"14","author":"M Baron","year":"2003","journal-title":"Semin Cell Dev Biol"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"10116","DOI":"10.1073\/pnas.94.19.10116","article-title":"The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein-protein interactions independent of carbohydrate moiety","volume":"94","author":"A Aspberg","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"10590","DOI":"10.1073\/pnas.92.23.10590","article-title":"The versican C-type lectin domain recognizes the adhesion protein tenascin-R","volume":"92","author":"A Aspberg","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref90","first-page":"383","article-title":"Post-translational modifications of exosomal proteins","volume":"5","author":"O Moreno-Gonzalo","year":"2014","journal-title":"Front Immunol. Frontiers Media SA"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1111\/j.1462-5822.2011.01647.x","article-title":"Lipid raft-dependent adhesion of Giardia intestinalis trophozoites to a cultured human enterocyte-like Caco-2\/TC7 cell monolayer leads to cytoskeleton-dependent functional injuries","volume":"13","author":"MA Humen","year":"2011","journal-title":"Cell Microbiol"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.parint.2011.11.002","article-title":"<italic>Giardia<\/italic> disrupts the arrangement of tight, adherens and desmosomal junction proteins of intestinal cells","volume":"61","author":"C Maia-Brigag\u00e3o","year":"2012","journal-title":"Parasitol Int"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"3673","DOI":"10.1128\/IAI.70.7.3673-3680.2002","article-title":"Strain-dependent induction of enterocyte apoptosis by <italic>Giardia lamblia<\/italic> disrupts epithelial barrier function in a caspase-3-dependent manner","volume":"70","author":"AC Chin","year":"2002","journal-title":"Infect Immun"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1016\/j.febslet.2008.02.040","article-title":"Regulation of cell structure and function by actin-binding proteins: Villin\u2019s perspective","author":"S Khurana","year":"2008","journal-title":"FEBS Letters"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/j.1460-2075.1995.tb07017.x","article-title":"Suppression of villin expression by antisense RNA impairs brush border assembly in polarized epithelial intestinal cells","volume":"14","author":"M a Costa de Beauregard","year":"1995","journal-title":"EMBO J"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"3096","DOI":"10.1074\/jbc.M308878200","article-title":"Association of Villin with Phosphatidylinositol 4,5-Bisphosphate Regulates the Actin Cytoskeleton","volume":"279","author":"N Kumar","year":"2004","journal-title":"J Biol Chem"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"35278","DOI":"10.1074\/jbc.C109.060830","article-title":"Differential effects of lysophosphatidic acid and phosphatidylinositol 4,5-bisphosphate on actin dynamics by direct association with the actin-binding protein villin","volume":"284","author":"A Tomar","year":"2009","journal-title":"J Biol Chem"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1128\/IAI.01648-05","article-title":"Macrophage migration inhibitory factor contributes to host defense against acute <italic>Trypanosoma cruzi<\/italic> infection","volume":"74","author":"JL Reyes","year":"2006","journal-title":"Infect Immun. American Society for Microbiology (ASM)"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"3661","DOI":"10.1096\/fj.08-111666","article-title":"Macrophage migration inhibitory factor (MIF) is critical for the host resistance against <italic>Toxoplasma gondii<\/italic>","volume":"22","author":"M Flores","year":"2008","journal-title":"FASEB J. The Federation of American Societies for Experimental Biology"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1128\/IAI.69.2.906-911.2001","article-title":"Migration-Inhibitory Factor Gene-Deficient Mice Are Susceptible to Cutaneous <italic>Leishmania major<\/italic> Infection","volume":"69","author":"AR Satoskar","year":"2001","journal-title":"Infect Immun"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"e1004414","DOI":"10.1371\/journal.ppat.1004414","article-title":"MIF contributes to <italic>Trypanosoma brucei<\/italic> associated immunopathogenicity development","volume":"10","author":"B Stijlemans","year":"2014","journal-title":"PLoS Pathog"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"e25259","DOI":"10.1371\/journal.pone.0025259","article-title":"MIF participates in <italic>Toxoplasma gondii<\/italic>-induced pathology following oral infection","volume":"6","author":"MG Cavalcanti","year":"2011","journal-title":"PLoS One"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"e1198","DOI":"10.1371\/journal.pntd.0001198","article-title":"Evidence That Lipopolisaccharide May Contribute to the Cytokine Storm and Cellular Activation in Patients with Visceral Leishmaniasis","volume":"5","author":"JR Santos-Oliveira","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1128\/IAI.00074-16","article-title":"Complement Activation by <italic>Giardia duodenalis<\/italic> Parasites through the Lectin Pathway Contributes to Mast Cell Responses and Parasite Control","volume":"84","author":"E Li","year":"2016","journal-title":"Infect Immun. American Society for Microbiology (ASM)"},{"key":"ref105","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1172\/JCI112952","article-title":"Mechanism of killing of <italic>Giardia lamblia<\/italic> trophozoites by complement","volume":"79","author":"M Deguchi","year":"1987","journal-title":"J Clin Invest"},{"key":"ref106","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.4049\/jimmunol.132.4.2046","article-title":"Susceptibility of <italic>Giardia lamblia<\/italic> trophozoites to the lethal effect of human serum","volume":"132","author":"DR Hill","year":"1984","journal-title":"J Immunol"},{"key":"ref107","first-page":"34","article-title":"Complement and its role in innate and adaptive immune responses","volume":"20","author":"JR Dunkelberger","year":"2010","journal-title":"Cell Res. Nature Publishing Group"},{"key":"ref108","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.ijpara.2007.12.004","article-title":"SGLT-1-mediated glucose uptake protects human intestinal epithelial cells against Giardia duodenalis-induced apoptosis","volume":"38","author":"LCH Yu","year":"2008","journal-title":"Int J Parasitol"},{"key":"ref109","first-page":"185","article-title":"Expression of sodium-glucose co-transporter and brush border disaccharidases in <italic>Giardia lamblia<\/italic> infected rat intestine","volume":"39","author":"S Mahmood","year":"2002","journal-title":"Indian J Biochem Biophys"},{"key":"ref110","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1645\/GE-3021.1","article-title":"<italic>Giardia duodenalis<\/italic> assemblage-specific induction of apoptosis and tight junction disruption in human intestinal epithelial cells: effects of mixed infections","volume":"99","author":"WH Koh","year":"2013","journal-title":"J Parasitol"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/j.1574-695X.2007.00304.x","article-title":"Caspase-dependent apoptosis of the HCT-8 epithelial cell line induced by the parasite <italic>Giardia intestinalis<\/italic>","volume":"51","author":"MA Panaro","year":"2007","journal-title":"FEMS Immunol Med Microbiol"},{"key":"ref112","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1067\/mai.2003.1594","article-title":"Chemokines: roles in leukocyte development, trafficking, and effector function","volume":"111","author":"SJ Ono","year":"2003","journal-title":"J Allergy Clin Immunol. Garland, New York"},{"key":"ref113","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1365-3024.2012.01354.x","article-title":"Excretory-secretory products of <italic>Giardia lamblia<\/italic> induce interleukin-8 production in human colonic cells via activation of p38, ERK1\/2, NF-\u03baB and AP-1","volume":"34","author":"H-YH-Y Lee","year":"2012","journal-title":"Parasite Immunol"},{"key":"ref114","first-page":"418","article-title":"Dual-specificity phosphatases: critical regulators with diverse cellular targets","author":"KI Patterson","year":"2009","journal-title":"Biochem J"},{"key":"ref115","first-page":"7197","article-title":"Isolation and characterization of a novel dual specific phosphatase, HVH2, which selectively dephosphorylates the mitogen-activated protein kinase","volume":"270","author":"KL Guan","year":"1995","journal-title":"J Biol Chem. American Society for Biochemistry and Molecular Biology"},{"key":"ref116","doi-asserted-by":"crossref","first-page":"29897","DOI":"10.1016\/S0021-9258(18)43965-8","article-title":"A novel dual specificity phosphatase induced by serum stimulation and heat shock","volume":"269","author":"T Ishibashi","year":"1994","journal-title":"J Biol Chem"},{"key":"ref117","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1042\/BST20160166","article-title":"The control of inflammation via the phosphorylation and dephosphorylation of tristetraprolin: a tale of two phosphatases","volume":"44","author":"AR Clark","year":"2016","journal-title":"Biochem Soc Trans"},{"key":"ref118","first-page":"7418","article-title":"The RNA-binding protein TTP is a global post-transcriptional regulator of feedback control in inflammation","volume":"44","author":"C Tiedje","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"ref119","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/nrgastro.2016.142","article-title":"Human mini-guts: new insights into intestinal physiology and host\u2014pathogen interactions","volume":"13","author":"JG In","year":"2016","journal-title":"Nat Rev Gastroenterol Hepatol. Nature Research"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0006120","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T00:00:00Z","timestamp":1513814400000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0006120","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T20:53:40Z","timestamp":1693342420000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0006120"}},"subtitle":[],"editor":[{"given":"Armando","family":"Jardim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,12,11]]},"references-count":119,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2017,12,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0006120","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pntd.0006120","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,11]]}}}