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Guia pr\u00e1tico de tratamento da mal\u00e1ria no Brasil. Secretaria de Vigil\u00e2ncia em Sa\u00fade, Departamento de Vigil\u00e2ncia Epidemiol\u00f3gica. S\u00e9rie A Normas e Manuais T\u00e9cnicos. 2010."},{"key":"ref54","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1186\/s12936-015-0733-0","article-title":"Establishment of a free-mating, long-standing and highly productive laboratory colony of <italic>Anopheles darlingi<\/italic> from the Peruvian Amazon","volume":"14","author":"C Villarreal-Trevino","year":"2015","journal-title":"Malaria journal"},{"issue":"5","key":"ref55","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s002280050131","article-title":"Ivermectin distribution in the plasma and tissues of patients infected with <italic>Onchocerca volvulus<\/italic>","volume":"50","author":"OZ Baraka","year":"1996","journal-title":"Eur J Clin Pharmacol"},{"key":"ref56","article-title":"Guidance for industry: bioanalytical method validation","year":"2001"},{"issue":"1","key":"ref57","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1128\/AAC.47.1.170-173.2003","article-title":"Simple in vitro assay for determining the sensitivity of <italic>Plasmodium vivax<\/italic> isolates from fresh human blood to antimalarials in areas where <italic>P<\/italic>. <italic>vivax<\/italic> is endemic","volume":"47","author":"BM Russell","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"issue":"10","key":"ref58","doi-asserted-by":"crossref","first-page":"6638","DOI":"10.1128\/AAC.01136-15","article-title":"Purification Methodology for Viable and Infective <italic>Plasmodium vivax<\/italic> Gametocytes That Is Compatible with Transmission-Blocking Assays","volume":"59","author":"O Vera","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"ref59","unstructured":"Laboratories MR. Stromectol new drug application. In: FDA Center for drug evaluation and research. 1996. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/wwwaccessdatafdagov\/drugsatfda_docs\/label\/2009\/050742s026lblpdf\" xlink:type=\"simple\">http:\/\/wwwaccessdatafdagov\/drugsatfda_docs\/label\/2009\/050742s026lblpdf<\/ext-link>"},{"issue":"1","key":"ref60","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.actatropica.2011.10.007","article-title":"Comparative evaluation of systemic drugs for their effects against <italic>Anopheles gambiae<\/italic>","volume":"121","author":"MP Butters","year":"2012","journal-title":"Acta Trop"},{"issue":"2","key":"ref61","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.actatropica.2010.06.001","article-title":"The effect of oral anthelmintics on the survivorship and re-feeding frequency of anthropophilic mosquito disease vectors","volume":"116","author":"KC Kobylinski","year":"2010","journal-title":"Acta Trop"},{"issue":"7","key":"ref62","doi-asserted-by":"crossref","first-page":"e2587","DOI":"10.1371\/journal.pone.0002587","article-title":"Chloroquine mediated modulation of <italic>Anopheles gambiae<\/italic> gene expression","volume":"3","author":"P Abrantes","year":"2008","journal-title":"PLoS One"},{"issue":"1\u20132","key":"ref63","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.imlet.2013.07.004","article-title":"Chloroquine: modes of action of an undervalued drug","volume":"153","author":"R Thome","year":"2013","journal-title":"Immunol Lett"},{"issue":"6","key":"ref64","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.1128\/AAC.02794-13","article-title":"Pharmacokinetic interactions between primaquine and chloroquine","volume":"58","author":"S Pukrittayakamee","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"issue":"3","key":"ref65","first-page":"552","article-title":"Lack of in vitro effect of ivermectin on <italic>Plasmodium falciparum<\/italic>","volume":"34","author":"P Nasveld","year":"2003","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1186\/s12936-015-0940-8","article-title":"Quantification of Plasmodium ex vivo drug susceptibility by flow cytometry","volume":"14","author":"G Wirjanata","year":"2015","journal-title":"Malaria journal"},{"issue":"1","key":"ref67","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3347\/kjp.2015.53.1.43","article-title":"Plasmodium vivax drug resistance genes; Pvmdr1 and Pvcrt-o polymorphisms in relation to chloroquine sensitivity from a malaria endemic area of Thailand","volume":"53","author":"K Rungsihirunrat","year":"2015","journal-title":"Korean J Parasitol"},{"issue":"11","key":"ref68","doi-asserted-by":"crossref","first-page":"6354","DOI":"10.1128\/AAC.03191-14","article-title":"In vitro susceptibility of <italic>Plasmodium vivax<\/italic> to antimalarials in Colombia","volume":"58","author":"D Fernandez","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/1475-2875-13-73","article-title":"<italic>Plasmodium vivax<\/italic> and <italic>Plasmodium falciparum<\/italic> ex vivo susceptibility to anti-malarials and gene characterization in Rondonia, West Amazon, Brazil","volume":"13","author":"AC Aguiar","year":"2014","journal-title":"Malaria journal"},{"issue":"4","key":"ref70","doi-asserted-by":"crossref","first-page":"e1002588","DOI":"10.1371\/journal.ppat.1002588","article-title":"Ross, macdonald, and a theory for the dynamics and control of mosquito-transmitted pathogens","volume":"8","author":"DL Smith","year":"2012","journal-title":"PLoS Pathog"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0006221","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T00:00:00Z","timestamp":1519689600000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0006221","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T04:48:46Z","timestamp":1603860526000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0006221"}},"subtitle":[],"editor":[{"given":"Genevieve","family":"Milon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,2,14]]},"references-count":70,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,2,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0006221","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pntd.0006221","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,14]]}}}