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A. 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In: ACTwatch Group, editor, Washington DC. Proceedings of the 65th Annual American Society of Tropical Medicine and Hygiene Meeting; 2016 Nov 13\u201317; Atlanta."},{"issue":"1","key":"ref38","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1186\/s12936-017-1800-5","article-title":"Private sector opportunities and threats to achieving malaria elimination in the Greater Mekong Subregion: results from malaria outlet surveys in Cambodia, the Lao PDR, Myanmar, and Thailand","volume":"16","author":"S Phok","year":"2017","journal-title":"Malar J"},{"key":"ref39","unstructured":"World Health Organization. (2018) Overview of malaria elimination. Available from (<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/malaria\/areas\/elimination\/overview\/en\/\" xlink:type=\"simple\">http:\/\/www.who.int\/malaria\/areas\/elimination\/overview\/en\/<\/ext-link>)"},{"issue":"3","key":"ref40","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.actatropica.2011.06.008","article-title":"Malaria in selected non-Amazonian countries of Latin America","volume":"121","author":"M Arevalo-Herrera","year":"2012","journal-title":"Acta Trop"},{"issue":"5","key":"ref41","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1590\/0074-0276140123","article-title":"G6PD deficiency in Latin America: systematic review on prevalence and variants","volume":"109","author":"WM Monteiro","year":"2014","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"3","key":"ref42","doi-asserted-by":"crossref","first-page":"e0151898","DOI":"10.1371\/journal.pone.0151898","article-title":"Single Low Dose Primaquine (0.25 mg\/kg) Does Not Cause Clinically Significant Haemolysis in G6PD Deficient Subjects","volume":"11","author":"G Bancone","year":"2016","journal-title":"PLoS ONE"},{"issue":"1","key":"ref43","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1186\/s12916-016-0701-8","article-title":"An optimised age-based dosing regimen for single low-dose primaquine for blocking malaria transmission in Cambodia","volume":"14","author":"R Leang","year":"2016","journal-title":"BMC Med"},{"issue":"1","key":"ref44","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1186\/s12879-017-2378-9","article-title":"Modelling the therapeutic dose range of single low dose primaquine to reduce malaria transmission through age-based dosing","volume":"17","author":"DJ Hayes","year":"2017","journal-title":"BMC Infect Dis"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/s12936-015-0714-3","article-title":"An assessment of the supply, programmatic use, and regulatory issues of single low-dose primaquine as a <italic>Plasmodium falciparum<\/italic> gametocytocide for sub-Saharan Africa","volume":"14","author":"I Chen","year":"2015","journal-title":"Malar J"},{"key":"ref46","unstructured":"Department for International Development (DFID) (2014) Myanmar Artemisinin Monotherapy Replacement Malaria Project (AMTR) Independent Evaluation. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.montroseint.com\/wp-content\/uploads\/2015\/05\/Myanmar-AMTR-Independent-Evaluation-Working-Paper-4-Corporate-Role-\u2026.pdf\" xlink:type=\"simple\">http:\/\/www.montroseint.com\/wp-content\/uploads\/2015\/05\/Myanmar-AMTR-Independent-Evaluation-Working-Paper-4-Corporate-Role-\u2026.pdf<\/ext-link>"},{"key":"ref47","unstructured":"PATH (2014) A guide to fluorescent spot testing for G6PD deficiency. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/sites.path.org\/dx\/files\/2012\/04\/FST-Guidebook.pdf\" xlink:type=\"simple\">http:\/\/sites.path.org\/dx\/files\/2012\/04\/FST-Guidebook.pdf<\/ext-link>"},{"issue":"8","key":"ref48","doi-asserted-by":"crossref","first-page":"e1002379","DOI":"10.1371\/journal.pmed.1002379","article-title":"Unsupervised primaquine for the treatment of <italic>Plasmodium vivax<\/italic> malaria relapses in southern Papua: A hospital-based cohort study","volume":"14","author":"NM Douglas","year":"2017","journal-title":"PLoS Med"},{"issue":"1","key":"ref49","first-page":"9","article-title":"Directly observed therapy with primaquine to reduce the recurrence rate of <italic>plasmodium vivax<\/italic> infection along the Thai-Myanmar border","volume":"42","author":"W Maneeboonyang","year":"2011","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1186\/1475-2875-9-308","article-title":"Directly-observed therapy (DOT) for the radical 14-day primaquine treatment of <italic>Plasmodium vivax<\/italic> malaria on the Thai-Myanmar border","volume":"9","author":"R Takeuchi","year":"2010","journal-title":"Malar J"},{"issue":"3","key":"ref51","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/S0035-9203(03)00041-5","article-title":"Compliance with 14-day primaquine therapy for radical cure of vivax malaria\u2014a randomized placebo-controlled trial comparing unsupervised with supervised treatment","volume":"98","author":"T Leslie","year":"2004","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1186\/1475-2875-10-355","article-title":"Adherence to <italic>Plasmodium vivax<\/italic> malaria treatment in the Brazilian Amazon Region","volume":"10","author":"EA 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Noori-Daloii","year":"2004","journal-title":"J Physiol Biochem"},{"issue":"3","key":"ref73","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1046\/j.1365-2141.2002.03483.x","article-title":"Three major glucose-6-phosphate dehydrogenase-deficient polymorphic variants identified in Mazandaran state of Iran","volume":"117","author":"SA Mesbah-Namin","year":"2002","journal-title":"Br J Haematol"},{"issue":"11","key":"ref74","first-page":"15013","article-title":"Molecular epidemiological investigation of G6PD deficiency by a gene chip among Chinese Hakka of southern Jiangxi province","volume":"8","author":"R Hu","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"issue":"1","key":"ref75","first-page":"26","article-title":"Molecular epidemiology of G6PD deficiency in Chaozhou area of eastern Guangdong Province","volume":"33","author":"F Lin","year":"2016","journal-title":"Zhonghua Yi Xue Yi Chuan Xue Za 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Peru. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"ftp:\/\/ftp2.minsa.gob.pe\/normaslegales\/2015\/RM-116-2015-MINSA-25-02-PARTE01.pdf\" xlink:type=\"simple\">ftp:\/\/ftp2.minsa.gob.pe\/normaslegales\/2015\/RM-116-2015-MINSA-25-02-PARTE01.pdf<\/ext-link>"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12936-015-1069-5","article-title":"Prevalence and molecular characterization of G6PD deficiency in two Plasmodium vivax endemic areas in Venezuela: predominance of the African A-(202A\/376G) variant","volume":"15","author":"E Vizzi","year":"2016","journal-title":"Malar J"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1186\/s12936-015-0823-z","article-title":"Glucose-6-phosphate dehydrogenase deficiency among malaria patients of Honduras: a descriptive study of archival blood samples","volume":"14","author":"MA Zuniga","year":"2015","journal-title":"Malar J"},{"key":"ref87","unstructured":"Belize Ministry of Health (2016) National Malaria Guidelines revised edition 2016. Belize."}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0006230","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T15:52:26Z","timestamp":1751557946000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0006230"}},"subtitle":[],"editor":[{"given":"Photini","family":"Sinnis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,4,19]]},"references-count":87,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,4,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0006230","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,19]]}}}