{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:10:34Z","timestamp":1790187034270,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0006267","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T00:00:00Z","timestamp":1519257600000}}],"reference-count":84,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T00:00:00Z","timestamp":1518134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0006267","type":"journal-article","created":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T18:42:15Z","timestamp":1518201735000},"page":"e0006267","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":28,"title":["Unique pharmacological properties of serotoninergic G-protein coupled receptors from cestodes"],"prefix":"10.1371","volume":"12","author":[{"given":"Federico","family":"Camicia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7564-0908","authenticated-orcid":true,"given":"Ana M.","family":"Celentano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm E.","family":"Johns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6965-1336","authenticated-orcid":true,"given":"Lucas","family":"Maldonado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5395-8402","authenticated-orcid":true,"given":"Hugo","family":"Vaca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9035-8174","authenticated-orcid":true,"given":"Nicol\u00e1s","family":"Di Siervi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Kamentezky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7171-9878","authenticated-orcid":true,"given":"Ana M.","family":"Gamo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Ortega-Gutierrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4848-0109","authenticated-orcid":true,"given":"Mar","family":"Martin-Fontecha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Davio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6592-0877","authenticated-orcid":true,"given":"Jonathan S.","family":"Marchant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5271-6321","authenticated-orcid":true,"given":"Mara C.","family":"Rosenzvit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,2,9]]},"reference":[{"key":"ref1","first-page":"21","article-title":"Neglected tropical diseases","volume":"26","author":"D Molyneux","year":"2013","journal-title":"Community Eye Health"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"453","DOI":"10.2307\/3282690","article-title":"The Rarity of Asexual Reproduction among Mesocestoides Tetrathyridia (Cestoda)","volume":"76","author":"DB Conn","year":"1990","journal-title":"J Parasitol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1017\/S0031182001001329","article-title":"<italic>Mesocestoides corti<\/italic> (syn. <italic>M<\/italic>. <italic>vogae<\/italic>): modulation of larval motility by neuropeptides, serotonin and acetylcholine","volume":"124","author":"G Hrckova","year":"2002","journal-title":"Parasitology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S1054-3589(08)61112-6","article-title":"The Pharmacology and Biochemistry of Parasitic Helminths","volume":"3","author":"TE Mansour","year":"1964","journal-title":"Adv Pharmacol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1017\/S0031182000077891","article-title":"Functional morphology of the platyhelminth nervous system","volume":"113","author":"DW Halton","year":"1996","journal-title":"Parasitology"},{"key":"ref6","first-page":"156","article-title":"Chemotherapeutic Targets in Parasites: Contemporary Strategies","author":"TE Mansour","year":"2002"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"S83","DOI":"10.1017\/S003118200007791X","article-title":"Neuromuscular physiology and pharmacology of parasitic flatworms","volume":"113","author":"RA Pax","year":"1996","journal-title":"Parasitology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"619","DOI":"10.55782\/ane-1996-1167","article-title":"Evolutionary ancient roles of serotonin: long-lasting regulation of activity and development","volume":"56","author":"K Turlejski","year":"1996","journal-title":"Acta Neurobiol Exp"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"101","DOI":"10.5607\/en.2012.21.3.101","article-title":"Serotonin and synaptic transmission at invertebrate neuromuscular junctions","volume":"21","author":"WH Wu","year":"2012","journal-title":"Exp Neurobiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/j.1460-9568.2007.05655.x","article-title":"Influence of PCPA and MDMA (ecstasy) on physiology, development and behavior in <italic>Drosophila melanogaster<\/italic>","volume":"26","author":"S Dasari","year":"2007","journal-title":"Eur J Neurosci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1242\/jeb.102.1.187","article-title":"Modulation of synaptic transmission and excitation-contraction coupling in the opener muscle of the crayfish, <italic>Astacus leptodactylus<\/italic>, by 5-hydroxytryptamine and octopamine","volume":"102","author":"L Fischer","year":"1983","journal-title":"J Exp Biol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.1476-5381.1961.tb01085.x","article-title":"Effects of 5-hydroxytryptamine on the dorsal muscle of the leech (<italic>Hirudo medicinalis<\/italic>)","volume":"16","author":"RJ Schain","year":"1961","journal-title":"Br J Pharmacol Chemother"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.2108\/zsj.19.1217","article-title":"Innervation of holothurian body wall muscle: inhibitory effects and localization of 5-HT","volume":"19","author":"M Inoue","year":"2002","journal-title":"Zoolog Sci"},{"key":"ref14","first-page":"406","article-title":"The effect of lysergic acid diethylamide, 5-hydroxytryptamine, and related compounds on the liver fluke, <italic>Fasciola hepatica<\/italic>","volume":"12","author":"TE Mansour","year":"1957","journal-title":"Br J Pharmacol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"e0004063","DOI":"10.1371\/journal.pntd.0004063","article-title":"Ergot Alkaloids (Re)generate New Leads as Antiparasitics","volume":"9","author":"JD Chan","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.ijpara.2013.03.006","article-title":"The nervous and prenervous roles of serotonin in <italic>Echinococcus spp<\/italic>","volume":"43","author":"F Camicia","year":"2013","journal-title":"Int J Parasitol"},{"key":"ref17","first-page":"1","article-title":"Serotonin receptors in parasitic worms","volume":"23","author":"TE Mansour","year":"1984","journal-title":"Adv Parasitol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e1003878","DOI":"10.1371\/journal.ppat.1003878","article-title":"Serotonin Signaling in <italic>Schistosoma mansoni<\/italic>: A Serotonin\u2013Activated G Protein-Coupled Receptor Controls Parasite Movement","volume":"10","author":"N Patocka","year":"2014","journal-title":"PLoS Pathog"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0006-2952(62)90022-9","article-title":"Activation of phosphofructokinase from the liver fluke <italic>Fasciola hepatica<\/italic> by serotonin and cyclic 3\u00b45\u00b4-AMP","volume":"9","author":"TE Mansour","year":"1962","journal-title":"Biochem Pharmacol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1017\/S0031182005008565","article-title":"Classical transmitters and their receptors in flatworms","volume":"131","author":"P Ribeiro","year":"2005","journal-title":"Parasitology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1017\/S0031182000073273","article-title":"Neurobiology of parasitic plathelminths: possible solutions to the problems of correlating structure with function","volume":"102","author":"RA Pax","year":"1991","journal-title":"Parasitology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.ijpara.2015.12.001","article-title":"Protein kinase A signalling in <italic>Schistosoma mansoni<\/italic> cercariae and schistosomules","volume":"46","author":"NL Hirst","year":"2016","journal-title":"Int J Parasitol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.ijpddr.2016.06.002","article-title":"Kinetic profiling an abundantly expressed planarian serotonergic GPCR identifies bromocriptine as a perdurant antagonist","volume":"6","author":"JD Chan","year":"2016","journal-title":"Int J Parasitol Drugs Drug Resist"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.ijpddr.2016.06.001","article-title":"Pharmacological profiling an abundantly expressed schistosome serotonergic GPCR identifies nuciferine as a potent antagonist","volume":"6","author":"JD Chan","year":"2016","journal-title":"Int J Parasitol Drugs Drug Resist"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e1005651","DOI":"10.1371\/journal.ppat.1005651","article-title":"A Miniaturized Screen of a <italic>Schistosoma mansoni<\/italic> Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective Inhibitors","volume":"12","author":"JD Chan","year":"2016","journal-title":"PLoS Pathog"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"6380","DOI":"10.1002\/anie.201302116","article-title":"The structural basis of G-protein-coupled receptor signaling (Nobel Lecture)","volume":"52","author":"B Kobilka","year":"2013","journal-title":"Angew Chem Int Ed Engl"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0091-3057(01)00746-8","article-title":"Molecular, pharmacological and functional diversity of 5-HT receptors","volume":"71","author":"D Hoyer","year":"2002","journal-title":"Pharmacol Biochem Behav"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0091-3057(01)00745-6","article-title":"The medical benefit of 5-HT research","volume":"71","author":"BJ Jones","year":"2002","journal-title":"Pharmacol Biochem Behav"},{"key":"ref29","first-page":"CD008615","article-title":"Sumatriptan (oral route of administration) for acute migraine attacks in adults","volume":"2","author":"CJ Derry","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1038\/s41467-017-02084-0","article-title":"The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand","volume":"8","author":"JD Chan","year":"2017","journal-title":"Nat Commun"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature12031","article-title":"The genomes of four tapeworm species reveal adaptations to Parasitism","volume":"496","author":"IJ Tsai","year":"2013","journal-title":"Nature"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1038\/ng.2757","article-title":"The genome of the hydatid tapeworm Echinococcus granulosus","volume":"45","author":"H Zheng","year":"2013","journal-title":"Nat Genet"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/s12864-017-3574-0","article-title":"The <italic>Echinoccus canadensis<\/italic> (G7) genome: a key knowledge of parasitic platyhelminth human diseases","volume":"18","author":"LL Maldonado","year":"2017","journal-title":"BMC Genomics"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"e524","DOI":"10.1371\/journal.pntd.0000524","article-title":"Treatment Response of Cystic Echinococcosis to Benzimidazoles: A Systematic Review","volume":"3","author":"M Stojkovic","year":"2009","journal-title":"PLoS Negl Trop Dis"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3947\/ic.2013.45.1.32","article-title":"Praziquantel Treatment in Trematode and Cestode Infections: An Update","volume":"45","author":"J-Y Chai","year":"2015","journal-title":"Infect Chemother"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.vetpar.2010.04.022","article-title":"Phenotypic and genotypic characterisation of benzimidazole susceptible and resistant isolates of <italic>Haemonchus contortus<\/italic>","volume":"172","author":"P Cudekov\u00e1","year":"2010","journal-title":"Vet Parasitol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.pt.2015.06.001","article-title":"Threat of alveolar echinococcosis to public health\u2014a challenge for Europe","volume":"31","author":"B Gottstein","year":"2015","journal-title":"Trends Parasitol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1021\/ml100053y","article-title":"Development of Fluorescent Ligands for the Human 5-HT<sub>1A<\/sub> Receptor","volume":"1","author":"D Alonso","year":"2010","journal-title":"ACS Med Chem Lett"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"10881","DOI":"10.1093\/nar\/16.22.10881","article-title":"Multiple sequence alignment with hierarchical clustering","volume":"16","author":"F Corpet","year":"1988","journal-title":"Nucleic Acids Res"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/msb.2011.75","article-title":"Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega","volume":"7","author":"F Sievers","year":"2011","journal-title":"Mol Syst Biol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1089\/aid.2013.0134","article-title":"Near Full-Length Genome Identification of a Novel HIV Type 1 B\u2032\/C Recombinant Isolate JL100091 in Jilin, China","volume":"29","author":"C Ning","year":"2013","journal-title":"AIDS Res Hum Retroviruses"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/sysbio\/syq010","article-title":"New Algorithms and Methods to Estimate Maximum-Likelihood Phylogenies: Assessing the Performance of PhyML 3.0","volume":"59","author":"S Guindon","year":"2010","journal-title":"Syst Biol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs","volume":"25","author":"SF Altschul","year":"1997","journal-title":"Nucleic Acids Res"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"D247","DOI":"10.1093\/nar\/gkj149","article-title":"Pfam: clans, web tools and services","volume":"34","author":"RD Finn","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nprot.2015.053","article-title":"The Phyre2 web portal for protein modeling, prediction and analysis","volume":"10","author":"LA Kelley","year":"2015","journal-title":"Nat Protoc"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"W252","DOI":"10.1093\/nar\/gku340","article-title":"SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information","volume":"42","author":"M Biasini","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/bioinformatics\/bti770","article-title":"The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling","volume":"22","author":"K Arnold","year":"2006","journal-title":"Bioinformatics"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"D387","DOI":"10.1093\/nar\/gkn750","article-title":"The SWISS-MODEL Repository and associated resources","volume":"37","author":"F Kiefer","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"S162","DOI":"10.1002\/elps.200900140","article-title":"Automated comparative protein structure modeling with SWISS-MODEL and Swiss-PdbViewer: a historical perspective","volume":"30","author":"N Guex","year":"2009","journal-title":"Electrophoresis"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.cell.2012.05.017","article-title":"The structure of human argonaute-2 in complex with miR-20a","volume":"150","author":"E Elkayam","year":"2012","journal-title":"Cell"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1021\/jm048999e","article-title":"Synthesis and structure-activity relationships of a new model of arylpiperazines. 8. <sup>1<\/sup> Computational simulation of ligand-receptor interaction of 5-HT<sub>1A<\/sub>R agonists with selectivity over \u03b1<sub>1<\/sub>-adrenoceptors","volume":"48","author":"ML L\u00f3pez-Rodr\u00edguez","year":"2005","journal-title":"J Med Chem"},{"key":"ref52","first-page":"350","article-title":"Idiotypic modulation of the antibody response of mice to <italic>Echinococcus granulosus<\/italic> antigens","volume":"84","author":"A Baz","year":"1995","journal-title":"Immunology"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.ijpara.2010.11.010","article-title":"Identification of <italic>Echinococcus granulosus<\/italic> microRNAs and their expression in different life cycle stages and parasite genotypes","volume":"41","author":"M Cucher","year":"2011","journal-title":"Int J Parasitol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.molbiopara.2016.08.004","article-title":"Identification and profiling of microRNAs in two developmental stages of the model cestode parasite <italic>Mesocestoides corti<\/italic>","volume":"210","author":"T Basika","year":"2016","journal-title":"Mol Biochem Parasitol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S1095-6433(00)00320-2","article-title":"Structure and function of invertebrate 5-HT receptors: a review","volume":"128","author":"A Tierney","year":"2001","journal-title":"Comp Biochem Physiol A Mol Integr Physiol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.jneumeth.2006.11.015","article-title":"An automated tracking system for <italic>Caenorhabditis elegans<\/italic> locomotor behavior and circadian studies application","volume":"161","author":"S Simonetta","year":"2007","journal-title":"J Neurosci Methods"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/chem.201503101","article-title":"Chemoproteomic approach to explore the target profile of GPCR ligands: application to 5-HT1A and 5-HT6 receptors","volume":"22","author":"AM Gamo","year":"2016","journal-title":"Chemistry"},{"key":"ref58","first-page":"60","article-title":"Heterotrimeric G protein activation by G-protein-coupled receptors","volume":"9","author":"W Oldham","year":"2008","journal-title":"Nature"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.pharmthera.2015.01.009","article-title":"Structure and function of serotonin G protein-coupled receptors","volume":"150","author":"JD McCorvy","year":"2015","journal-title":"Pharmacol Ther"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1021\/cr078224o","article-title":"Serotonin receptors","volume":"108","author":"DE Nichols","year":"2008","journal-title":"Chem Rev"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"S379","DOI":"10.1038\/sj.bjp.0707604","article-title":"Agonist-selective mechanisms of GPCR desensitization","volume":"153","author":"E Kelly","year":"2008","journal-title":"Br J Pharmacol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1126\/science.1232807","article-title":"Structural basis for molecular recognition at serotonin receptors","volume":"340","author":"W Wang","year":"2013","journal-title":"Science"},{"key":"ref63","first-page":"366","article-title":"Methods in Neurosciences","volume":"25","author":"JA Ballesteros","year":"1995"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1146\/annurev.pharmtox.42.091101.144224","article-title":"The binding site of aminergic G protein-coupled receptors: The transmembrane segments and second extracellular loop","volume":"42","author":"L Shi","year":"2002","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nature19107","article-title":"Diverse activation patways in class A GPCRs converge near the G-protein-coupling region","volume":"536","author":"AJ Venkatakrishnan","year":"2016","journal-title":"Nature"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/nature10361","article-title":"Crystal structure of the \u03b22 adrenergic receptor-Gs protein complex","volume":"477","author":"SGF Rasmussen","year":"2012","journal-title":"Nature"},{"key":"ref67","first-page":"143","article-title":"The Serotonin Receptors. The Receptors","author":"JH Turner","year":"2006"},{"key":"ref68","first-page":"39","article-title":"The Serotonin Receptors. The Receptors","author":"RB Westkaemper","year":"2006"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"8547","DOI":"10.1073\/pnas.90.18.8547","article-title":"Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation","volume":"90","author":"M Ruat","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1111\/j.1471-4159.2006.04012.x","article-title":"Am5-HT7: molecular and pharmacological characterization of the first serotonin receptor of the honeybee (<italic>Apis mellifera<\/italic>)","volume":"98","author":"J Schlenstedt","year":"2006","journal-title":"J Neurochem"},{"key":"ref71","first-page":"e314","article-title":"Serotonin, serotonin receptors and their actions in insects","volume":"2","author":"R Vleugels","year":"2015","journal-title":"Neurotransmitter"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1038\/sj.bjp.0701946","article-title":"Functional characterisation of the human cloned 5-HT7 receptor (long form); antagonist profile of SB-258719","volume":"124","author":"DR Thomas","year":"1998","journal-title":"Br J Pharmacol"},{"key":"ref73","first-page":"406","article-title":"The effect of Lysergic acid diethylamide, 5-hydroxytryptamine, and related compound on the liver fluke <italic>Fasciola hepatica<\/italic>","volume":"12","author":"TE Mansour","year":"1957","journal-title":"Brit. J. Pharmacol"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"8940","DOI":"10.1073\/pnas.87.22.8940","article-title":"Cloning and characterization of a <italic>Drosophila<\/italic> serotonin receptor that activates adenylate cyclase","volume":"87","author":"P Witz","year":"1990","journal-title":"PNAS USA"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1476-5381.1974.tb09657.x","article-title":"The Nature of the binding between LSD and 5-HT receptor: A posible explanation for hallucinogenic activity","volume":"51","author":"MJ Berridge","year":"1974","journal-title":"Br J Pharmacol"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0006-8993(80)90595-8","article-title":"Distribution of serotonin and dopamine receptors in <italic>Aplysia<\/italic> tissues: analysis by [3H] LSD binding and adenylate cyclase stimulation","volume":"184","author":"AH Drummond","year":"1980","journal-title":"Brain Research"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s00210-002-0588-0","article-title":"Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors","volume":"366","author":"R Seifert","year":"2002","journal-title":"Naunyn-Schmiedeberg\u00b4s Arch Pharmacol"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1038\/sj.bjp.0701946","article-title":"Functional characterization of the human cloned 5-HT7 receptor (long form); antagonist profile of SB-258719","volume":"124","author":"DR Thomas","year":"1998","journal-title":"Br J Pharmacol"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1046\/j.1471-4159.2003.01967.x","article-title":"SER-7b, a constitutively active Galphas coupled 5-HT7-like receptor expressed in the <italic>Caenorhabditis elegans<\/italic> M4 pharyngeal motorneuron","volume":"87","author":"RJ Hobson","year":"2003","journal-title":"J Neurochem"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/BF02152059","article-title":"Neuronal signal substances in asexual multiplication and development in flatworms","volume":"16","author":"M Reuter","year":"1996","journal-title":"Cell Mol Neurobiol"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"178","DOI":"10.2307\/1542921","article-title":"Serotonin injections induce metamorphosis in larvae of the gastropod mollusc <italic>Ilyanassa obsoleta<\/italic>","volume":"191","author":"JM Couper","year":"1996","journal-title":"Biological Bulletin"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0896-6273(00)80523-1","article-title":"Regulation of synaptic vesicle recycling by calcium and serotonin","volume":"21","author":"C Wang","year":"1998","journal-title":"Neuron"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"5160","DOI":"10.1523\/JNEUROSCI.18-14-05160.1998","article-title":"Neuromodulators enhance transmitter release by two separate mechanisms at the inhibitor of crayfish opener muscle","volume":"16","author":"A Vyshedskiy","year":"1998","journal-title":"J Neurosci"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1017\/S0031182000076356","article-title":"Immunocytochemical localization of serotonin (5-HT) in the nervous system of the hydatid organism, <italic>Echinococcus granulosus<\/italic> (Cestoda, Cyclophyllidea)","volume":"109","author":"DJA Brownlee","year":"1994","journal-title":"Parasitology"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0006267","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T00:00:00Z","timestamp":1519257600000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0006267","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T03:13:00Z","timestamp":1719803580000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0006267"}},"subtitle":[],"editor":[{"given":"John Pius","family":"Dalton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,2,9]]},"references-count":84,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,2,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0006267","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pntd.0006267","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,9]]}}}