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Proceedings of an international symposium on yaws and other endemic treponematoses. Washington DC, 16\u201318 April 1984. Rev Infect Dis. 1985; 7: S217\u2013S351."},{"key":"ref6","unstructured":"Expert Committee on venereal infections and treponematoses (fifth report). Geneva: World Health Organization (WHO Technical Report Series, No. 190; <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/whqlibdoc.who.int\/trs\/WHO_TRS_190.pdf\" xlink:type=\"simple\">http:\/\/whqlibdoc.who.int\/trs\/WHO_TRS_190.pdf<\/ext-link>)."},{"key":"ref7","article-title":"Four decades of achievements: highlights of work of WHO","year":"1988"},{"key":"ref8","first-page":"911","article-title":"Yaws eradication campaign in Nsukka Division, Eastern Nigeria","volume":"15","author":"A Zahra","year":"1956","journal-title":"Bull World Health Organ"},{"key":"ref9","first-page":"897","article-title":"Treponematosis eradication, with special reference to yaws eradication in Haiti","volume":"15","author":"GE Samame","year":"1956","journal-title":"Bull World Health Organ"},{"key":"ref10","unstructured":"Resolution WHA31.58. Control of endemic treponematoses. 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