{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:48:34Z","timestamp":1791308914800,"version":"4.3.1"},"update-to":[{"DOI":"10.1371\/journal.pntd.0006415","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T00:00:00Z","timestamp":1524009600000}}],"reference-count":60,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T00:00:00Z","timestamp":1522972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI052473"],"award-info":[{"award-number":["R01 AI052473"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 AI088752"],"award-info":[{"award-number":["U01 AI088752"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R25 TW009338"],"award-info":[{"award-number":["R25 TW009338"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 TW009504"],"award-info":[{"award-number":["R01 TW009504"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI121207"],"award-info":[{"award-number":["R01 AI121207"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wilbur G. Downs International Student Health Travel Fellowship"},{"DOI":"10.13039\/100006038","name":"Tinker Foundation","doi-asserted-by":"publisher","award":["Field Research Grant"],"award-info":[{"award-number":["Field Research Grant"]}],"id":[{"id":"10.13039\/100006038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0006415","type":"journal-article","created":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T17:26:27Z","timestamp":1523035587000},"page":"e0006415","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":73,"title":["Quantification of pathogenic Leptospira in the soils of a Brazilian urban slum"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1454-9059","authenticated-orcid":true,"given":"Andrew G.","family":"Schneider","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3301-6143","authenticated-orcid":true,"given":"Arnau","family":"Casanovas-Massana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn P.","family":"Hacker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsio A.","family":"Wunder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Begon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitermayer G.","family":"Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Childs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet C.","family":"Lindow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert I.","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,4,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"e0003898","DOI":"10.1371\/journal.pntd.0003898","article-title":"Global Morbidity and Mortality of Leptospirosis: A Systematic Review","volume":"9","author":"F Costa","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"ref2","article-title":"Deciphering the unexplored Leptospira diversity from soils uncovers genomic evolution to virulence","author":"R Thibeaux","year":"2018","journal-title":"Microb Genomics"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1099\/ijsem.0.002528","article-title":"Leptospira venezuelensis sp. nov., a new member of the intermediate group isolated from rodents, cattle and humans","volume":"68","author":"R Puche","year":"2018","journal-title":"Int J Syst Evol Microbiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3201\/eid1801.101892","article-title":"Outbreak of leptospirosis after flood, the Philippines, 2009","volume":"18","author":"AST Amilasan","year":"2012","journal-title":"Emerg Infect Dis"},{"key":"ref5","first-page":"281","article-title":"Leptospirosis: an emerging health problem in Thailand","volume":"36","author":"W Tangkanakul","year":"2005","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/S0140-6736(99)80012-9","article-title":"Urban epidemic of severe leptospirosis in Brazil","volume":"354","author":"AI Ko","year":"1999","journal-title":"Lancet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/nrmicro2208","article-title":"Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen","volume":"7","author":"AI Ko","year":"2009","journal-title":"Nat Rev Microbiol"},{"key":"ref8","author":"S Faine","year":"1994"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1097\/01.qco.0000178824.05715.2c","article-title":"Leptospirosis","volume":"18","author":"AJA McBride","year":"2005","journal-title":"Curr Opin Infect Dis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3201\/eid1403.071064","article-title":"Leptospirosis- associated Severe Pulmonary Hemorrhagic Syndrome, Salvador, Brazil","volume":"14","author":"EL Gouveia","year":"2008","journal-title":"Emerg Infect Dis"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1089\/vbz.2012.1195","article-title":"Rats, cities, people, and pathogens: A systematic review and narrative synthesis of literature regarding the ecology of rat-associated zoonoses in urban centers","volume":"13","author":"CG. b Himsworth","year":"2013","journal-title":"Vector-Borne Zoonotic Dis"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1017\/S0950268806007746","article-title":"A survey of zoonotic pathogens carried by Norway rats in Baltimore, Maryland, USA","volume":"135","author":"JD Easterbrook","year":"2007","journal-title":"Epidemiol Infect"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1089\/vbz.2013.1378","article-title":"Infections by Leptospira interrogans, Seoul virus, and Bartonella spp. among Norway rats (Rattus norvegicus) from the urban slum environment in Brazil","volume":"14","author":"F Costa","year":"2014","journal-title":"Vector Borne Zoonotic Dis"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e0003819","DOI":"10.1371\/journal.pntd.0003819","article-title":"Patterns in Leptospira Shedding in Norway Rats (Rattus norvegicus) from Brazilian Slum Communities at High Risk of Disease Transmission","volume":"9","author":"F Costa","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actatropica.2008.07.005","article-title":"Carriage of Leptospira interrogans among domestic rats from an urban setting highly endemic for leptospirosis in Brazil","volume":"108","author":"MT Faria","year":"2008","journal-title":"Acta Trop"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"889","DOI":"10.4269\/ajtmh.2010.09-0711","article-title":"Serologic and molecular studies of Leptospira and leptospirosis among rats in the Philippines","volume":"82","author":"SYAM Villanueva","year":"2010","journal-title":"Am J Trop Med Hyg"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"605","DOI":"10.4269\/ajtmh.2002.66.605","article-title":"Population-based case-control investigation of risk factors for leptospirosis during an urban epidemic","volume":"66","author":"U Sarkar","year":"2002","journal-title":"Am J Trop Med Hyg"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e0004275","DOI":"10.1371\/journal.pntd.0004275","article-title":"Spatiotemporal determinants of urban leptospirosis transmission: Four-year prospective cohort study of slum residents in Brazil","volume":"10","author":"JE Hagan","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e228","DOI":"10.1371\/journal.pntd.0000228","article-title":"Impact of environment and social gradient on Leptospira infection in urban slums","volume":"2","author":"RB Reis","year":"2008","journal-title":"PLoS Negl Trop Dis"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1371\/journal.pmed.0030308","article-title":"Determining risk for severe leptospirosis by molecular analysis of environmental surface waters for pathogenic Leptospira","volume":"3","author":"CA Ganoza","year":"2006","journal-title":"PLoS Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"6666","DOI":"10.3390\/ijerph110706666","article-title":"Leptospira contamination in household and environmental water in rural communities in southern Chile","volume":"11","author":"C Mu\u00f1oz-Zanzi","year":"2014","journal-title":"Int J Environ Res Public Health"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1128\/AEM.29.1.30-33.1975","article-title":"Pathogenic leptospiras isolated from Malaysian surface waters","volume":"29","author":"AD Alexander","year":"1975","journal-title":"Appl Microbiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1128\/AEM.02728-12","article-title":"Comparative analysis of Leptospira strains isolated from environmental soil and water in the Philippines and Japan","volume":"79","author":"M Saito","year":"2013","journal-title":"Appl Environ Microbiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"6926","DOI":"10.1128\/AEM.02568-14","article-title":"PCR and culture identification of pathogenic Leptospira from coastal soil in Leyte, Philippines after a storm surge during Super Typhoon Haiyan (Yolanda)","volume":"80","author":"M Saito","year":"2014","journal-title":"Appl Environ Microbiol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e0005414","DOI":"10.1371\/journal.pntd.0005414","article-title":"Seeking the environmental source of Leptospirosis reveals durable bacterial viability in river soils","volume":"11","author":"R Thibeaux","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"key":"ref26","first-page":"289","article-title":"An investigation on the distribution of leptospirae interrogans in water and soil in southwest of Yunnan Province","volume":"15","author":"W Yang","year":"1994","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"key":"ref27","first-page":"2060241","article-title":"Molecular Characterization of Leptospira spp. in Environmental Samples from North-Eastern Malaysia Revealed a Pathogenic Strain, Leptospira alstonii","volume":"2016","author":"MA Azali","journal-title":"J Trop Med"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1099\/ijs.0.002766-0","article-title":"Leptospira kmetyi sp. nov., isolated from an environmental source in Malaysia","volume":"59","author":"AT. T Slack","year":"2009","journal-title":"Int J Syst Evol Microbiol"},{"key":"ref29","article-title":"Human Leptospirosis in Malaysia: Reviewing the Challenges After 8 Decades (1925\u20132012)","author":"D Benacer","year":"2016","journal-title":"Asia-Pacific J Public Heal"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e2927","DOI":"10.1371\/journal.pntd.0002927","article-title":"Prospective study of leptospirosis transmission in an urban slum community: role of poor environment in repeated exposures to the leptospira agent","volume":"8","author":"RDM Felzemburgh","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.watres.2017.11.068","article-title":"Spatial and temporal dynamics of pathogenic Leptospira in surface waters from the urban slum environment","volume":"130","author":"A Casanovas-Massana","year":"2018","journal-title":"Water Res"},{"key":"ref32","article-title":"The Challenge of Slums\u2014Global report on human settlements","year":"2003","journal-title":"The Challenge of Slums\u2014Global report on human settlements"},{"key":"ref33","article-title":"Slum health: diseases of neglected populations","author":"LW Riley","year":"2007","journal-title":"BMC Int Health Hum Rights 7"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s11252-015-0519-8","article-title":"A comparative assessment of track plates to quantify fine scale variations in the relative abundance of Norway rats in urban slums","volume":"19","author":"KP Hacker","year":"2016","journal-title":"Urban Ecosyst"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"e0160523","DOI":"10.1371\/journal.pone.0160523","article-title":"An Optimized Method for Quantification of Pathogenic Leptospira in Environmental Water Samples","volume":"11","author":"IN Riediger","year":"2016","journal-title":"PLoS One"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.diagmicrobio.2009.03.014","article-title":"Detection of pathogenic Leptospira spp. through TaqMan polymerase chain reaction targeting the LipL32 gene","volume":"64","author":"RA Stoddard","journal-title":"Diagn Microbiol Infect Dis"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1471-2334-2-13","article-title":"A quantitative PCR (TaqMan) assay for pathogenic Leptospira spp","volume":"2","author":"L Smythe","year":"2002","journal-title":"BMC Infect Dis"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1128\/JB.186.7.2164-2172.2004","article-title":"Comparative Genomics of Two Leptospira interrogans Serovars Reveals Novel Insights into Physiology and Pathogenesis","volume":"186","author":"ALTO Nascimento","year":"2004","journal-title":"J Bacteriol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1373\/clinchem.2008.112797","article-title":"The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments","volume":"55","author":"SA Bustin","year":"2009","journal-title":"Clin Chem"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"e0004403","DOI":"10.1371\/journal.pntd.0004403","article-title":"What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira","volume":"10","author":"DE Fouts","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"W465","DOI":"10.1093\/nar\/gkn180","article-title":"Phylogeny.fr: robust phylogenetic analysis for the non-specialist","volume":"36","author":"A Dereeper","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/sysbio\/syq010","article-title":"New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0","volume":"59","author":"S Guindon","year":"2010","journal-title":"Syst Biol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.1111\/j.1462-2920.2008.01682.x","article-title":"Quantitative microbial faecal source tracking with sampling guided by hydrological catchment dynamics","volume":"10","author":"GH Reischer","year":"2008","journal-title":"Environ Microbiol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"7531","DOI":"10.1128\/AEM.01121-06","article-title":"Rainfall-induced release of fecal coliforms and other manure constituents: comparison and modeling","volume":"72","author":"AK Guber","year":"2006","journal-title":"Appl Environ Microbiol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.1128\/AEM.01791-08","article-title":"Percolation and survival of Escherichia coli O157:H7 and Salmonella enterica serovar Typhimurium in soil amended with contaminated dairy manure or slurry","volume":"75","author":"V Semenov A","year":"2009","journal-title":"Appl Environ Microbiol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/j.1475-2743.2003.tb00322.x","article-title":"Simulation of transport through soil of E. coli derived from livestock slurry using the macro model","volume":"19","author":"MB McGechan","year":"2006","journal-title":"Soil Use Manag"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.2134\/jeq2008.0432","article-title":"Effect of tillage and rainfall on transport of manure-applied Cryptosporidium parvum oocysts through soil","volume":"38","author":"NE Ramirez","year":"2009","journal-title":"J Environ Qual"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.watres.2017.02.003","article-title":"Mobilisation of microbial indicators, microbial source tracking markers and pathogens after rainfall events","volume":"112","author":"C Garc\u00eda-Aljaro","year":"2017","journal-title":"Water Res"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"637","DOI":"10.2166\/wh.2011.064","article-title":"Quantitative PCR-based detection of pathogenic Leptospira in Hawai\u2019ian coastal streams","volume":"9","author":"EJ Viau","year":"2011","journal-title":"J Water Health"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1128\/AEM.35.3.492-499.1978","article-title":"Distribution of the genus Leptospira in soil and water","volume":"35","author":"RA Henry","year":"1978","journal-title":"Appl Environ Microbiol"},{"key":"ref51","first-page":"123","article-title":"The survival of leptospira interrogans in the Malasyan environment","volume":"3","author":"S Khairani-Bejo","year":"2004","journal-title":"J Anim Vet Adv"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0034-5288(18)33003-0","article-title":"Survival of Leptospira interrogans serovar pomona in an acidic soil under simulated New Zealand field conditions","volume":"25","author":"JS Hellstrom","year":"1978","journal-title":"Res Vet Sci"},{"key":"ref53","first-page":"385","article-title":"Survival of Leptospira outside their hosts","volume":"56","author":"L Kirschner","year":"1957","journal-title":"N Z Med J"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"865","DOI":"10.3201\/eid0808.010445","article-title":"Human Infection Caused by Leptospira fainei","volume":"8","author":"J-P Arzouni","year":"2002","journal-title":"Emerg Infect Dis"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"e213","DOI":"10.1371\/journal.pntd.0000213","article-title":"Human leptospirosis caused by a new, antigenically unique Leptospira associated with a Rattus species reservoir in the Peruvian Amazon","volume":"2","author":"MA Matthias","year":"2008","journal-title":"PLoS Negl Trop Dis"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1099\/0022-1317-50-1-96","article-title":"First isolation of Leptospira fainei serovar Hurstbridge from two human patients with Weil\u2019s syndrome","volume":"50","author":"KA Krogfelt","year":"2001","journal-title":"J Med Microbiol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1099\/ijs.0.63783-0","article-title":"Leptospira broomii sp. nov., isolated from humans with leptospirosis","volume":"56","author":"PN Levett","year":"2006","journal-title":"Int J Syst Evol Microbiol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.3201\/eid2112.140659","article-title":"High Prevalence of Intermediate Leptospira spp. DNA in Febrile Humans from Urban and Rural Ecuador","volume":"21","author":"J Chiriboga","year":"2015","journal-title":"Emerg Infect Dis"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"e0004122","DOI":"10.1371\/journal.pntd.0004122","article-title":"Global Burden of Leptospirosis: Estimated in Terms of Disability Adjusted Life Years","volume":"9","author":"PR Torgerson","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"22","DOI":"10.4236\/ojepi.2015.51004","article-title":"Spatial Analysis of Leptospira in Rats, Water and Soil in Bantul District Yogyakarta Indonesia","volume":"5","author":"H Sumanta","year":"2015","journal-title":"Open J Epidemiol"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0006415","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T00:00:00Z","timestamp":1524009600000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0006415","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T06:15:57Z","timestamp":1604124957000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0006415"}},"subtitle":[],"editor":[{"given":"Melissa J.","family":"Caimano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,4,6]]},"references-count":60,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,4,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0006415","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pntd.0006415","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,6]]}}}