{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:43:31Z","timestamp":1791333811020,"version":"4.3.1"},"update-to":[{"DOI":"10.1371\/journal.pntd.0006417","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,4,30]],"date-time":"2018-04-30T00:00:00Z","timestamp":1525046400000}}],"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T00:00:00Z","timestamp":1524009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","award":["IV-105-SP-03"],"award-info":[{"award-number":["IV-105-SP-03"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["105-TDU-M-212-000006"],"award-info":[{"award-number":["105-TDU-M-212-000006"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["MR-106-PP-01"],"award-info":[{"award-number":["MR-106-PP-01"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["105-2321-B-400-006"],"award-info":[{"award-number":["105-2321-B-400-006"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0006417","type":"journal-article","created":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T15:50:04Z","timestamp":1524066604000},"page":"e0006417","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":21,"title":["Establishment of a mouse model for the complete mosquito-mediated transmission cycle of Zika virus"],"prefix":"10.1371","volume":"12","author":[{"given":"Yi-Ping","family":"Kuo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuen-Nan","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin-Chiu","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Jung","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Wen","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Sian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Feng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Yang","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung-Hsien","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Syong","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan-Chen","family":"Tseng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Han","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De-Jiun","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Ting","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Hong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0790-8727","authenticated-orcid":true,"given":"Guann-Yi","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,4,18]]},"reference":[{"issue":"9","key":"ref1","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1093\/infdis\/jiw302","article-title":"Outbreak of Zika Virus Infection, Chiapas State, Mexico, 2015, and First Confirmed Transmission by Aedes aegypti Mosquitoes in the Americas","volume":"214","author":"M Guerbois","year":"2016","journal-title":"J Infect Dis"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"625","DOI":"10.3201\/eid2304.161484","article-title":"Variation in Aedes aegypti Mosquito Competence for Zika Virus Transmission","volume":"23","author":"CM Roundy","year":"2017","journal-title":"Emerg Infect Dis"},{"issue":"10","key":"ref3","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.3201\/eid2110.150847","article-title":"Zika Virus Outbreak, Bahia, Brazil","volume":"21","author":"GS Campos","year":"2015","journal-title":"Emerg Infect Dis"},{"issue":"10","key":"ref4","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1056\/NEJMoa1600651","article-title":"Zika Virus Associated with Microcephaly","volume":"374","author":"J Mlakar","year":"2016","journal-title":"The New England journal of medicine"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"59","DOI":"10.15585\/mmwr.mm6503e2","article-title":"Possible Association Between Zika Virus Infection and Microcephaly\u2014Brazil, 2015","volume":"65","author":"L Schuler-Faccini","year":"2016","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"6","key":"ref6","doi-asserted-by":"crossref","first-page":"159","DOI":"10.15585\/mmwr.mm6506e1","article-title":"Notes from the Field: Evidence of Zika Virus Infection in Brain and Placental Tissues from Two Congenitally Infected Newborns and Two Fetal Losses\u2014Brazil, 2015","volume":"65","author":"RB Martines","year":"2016","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"9","key":"ref7","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES2014.19.9.20720","article-title":"Zika virus infection complicated by Guillain-Barre syndrome\u2014case report, French Polynesia, December 2013","volume":"19","author":"E Oehler","year":"2014","journal-title":"Euro Surveill"},{"issue":"10027","key":"ref8","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1016\/S0140-6736(16)00562-6","article-title":"Guillain-Barre Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study","volume":"387","author":"VM Cao-Lormeau","year":"2016","journal-title":"Lancet"},{"issue":"8","key":"ref9","doi-asserted-by":"crossref","first-page":"215","DOI":"10.15585\/mmwr.mm6508e2","article-title":"Transmission of Zika Virus Through Sexual Contact with Travelers to Areas of Ongoing Transmission\u2014Continental United States, 2016","volume":"65","author":"SL Hills","year":"2016","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"22","key":"ref10","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1056\/NEJMc1604449","article-title":"Evidence of Sexual Transmission of Zika Virus","volume":"374","author":"E D'Ortenzio","year":"2016","journal-title":"The New England journal of medicine"},{"issue":"5","key":"ref11","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.chom.2016.03.010","article-title":"A Mouse Model of Zika Virus Pathogenesis","volume":"19","author":"HM Lazear","year":"2016","journal-title":"Cell host & microbe"},{"issue":"6","key":"ref12","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.4269\/ajtmh.16-0111","article-title":"Characterization of a Novel Murine Model to Study Zika Virus","volume":"94","author":"SL Rossi","year":"2016","journal-title":"Am J Trop Med Hyg"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"e1006258","DOI":"10.1371\/journal.ppat.1006258","article-title":"A novel Zika virus mouse model reveals strain specific differences in virus pathogenesis and host inflammatory immune responses","volume":"13","author":"S Tripathi","year":"2017","journal-title":"PLoS Pathog"},{"key":"ref14","article-title":"Animal Models of Zika Virus Infection, Pathogenesis, and Immunity","author":"TE Morrison","year":"2017","journal-title":"Journal of virology"},{"issue":"6","key":"ref15","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/j.immuni.2016.06.002","article-title":"Host Inflammatory Response to Mosquito Bites Enhances the Severity of Arbovirus Infection","volume":"44","author":"M Pingen","year":"2016","journal-title":"Immunity"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"330","DOI":"10.4269\/ajtmh.16-0969","article-title":"Differential Vector Competency of Aedes albopictus Populations from the Americas for Zika Virus","volume":"97","author":"SR Azar","year":"2017","journal-title":"Am J Trop Med Hyg"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1186\/s13071-017-2286-2","article-title":"Zika virus transmission to mouse ear by mosquito bite: a laboratory model that replicates the natural transmission process","volume":"10","author":"NFC Secundino","year":"2017","journal-title":"Parasit Vectors"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0092-8674(00)81289-1","article-title":"Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease","volume":"84","author":"JE Durbin","year":"1996","journal-title":"Cell"},{"issue":"6","key":"ref19","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.chom.2016.05.009","article-title":"Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling","volume":"19","author":"A Grant","year":"2016","journal-title":"Cell host & microbe"},{"issue":"2","key":"ref20","doi-asserted-by":"crossref","first-page":"e1006164","DOI":"10.1371\/journal.ppat.1006164","article-title":"Zika Virus Antagonizes Type I Interferon Responses during Infection of Human Dendritic Cells","volume":"13","author":"JR Bowen","year":"2017","journal-title":"PLoS Pathog"},{"issue":"12","key":"ref21","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.15252\/embr.201642627","article-title":"Zika virus inhibits type-I interferon production and downstream signaling","volume":"17","author":"A Kumar","year":"2016","journal-title":"EMBO Rep"},{"issue":"50","key":"ref22","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2016.21.50.30426","article-title":"Serodiagnosis of Zika virus (ZIKV) infections by a novel NS1-based ELISA devoid of cross-reactivity with dengue virus antibodies: a multicohort study of assay performance, 2015 to 2016","volume":"21","author":"K Steinhagen","year":"2016","journal-title":"Euro Surveill"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","first-page":"324","DOI":"10.4269\/ajtmh.1993.48.324","article-title":"Serum levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1 beta (IL-1 beta) in dengue-infected patients","volume":"48","author":"D Hober","year":"1993","journal-title":"Am J Trop Med Hyg"},{"issue":"5421","key":"ref24","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1126\/science.284.5421.1835","article-title":"The nature of the principal type 1 interferon-producing cells in human blood","volume":"284","author":"FP Siegal","year":"1999","journal-title":"Science"},{"issue":"12","key":"ref25","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1038\/ni736","article-title":"Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology","volume":"2","author":"C Asselin-Paturel","year":"2001","journal-title":"Nat Immunol"},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.chom.2016.05.015","article-title":"Zika Virus Infects Human Placental Macrophages","volume":"20","author":"KM Quicke","year":"2016","journal-title":"Cell host & microbe"},{"issue":"7","key":"ref27","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1093\/cid\/ciw878","article-title":"Zika Virus Infects Human Fetal Brain Microglia and Induces Inflammation","volume":"64","author":"FM Lum","year":"2017","journal-title":"Clin Infect Dis"},{"issue":"7","key":"ref28","doi-asserted-by":"crossref","first-page":"3741","DOI":"10.3390\/v7072795","article-title":"Tissue Barriers to Arbovirus Infection in Mosquitoes","volume":"7","author":"AW Franz","year":"2015","journal-title":"Viruses"},{"issue":"7","key":"ref29","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/j.cell.2009.11.042","article-title":"A Wolbachia symbiont in Aedes aegypti limits infection with dengue, Chikungunya, and Plasmodium","volume":"139","author":"LA Moreira","year":"2009","journal-title":"Cell"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1038\/s41467-017-01244-6","article-title":"Blood meal acquisition enhances arbovirus replication in mosquitoes through activation of the GABAergic system","volume":"8","author":"Y Zhu","year":"2017","journal-title":"Nat Commun"},{"key":"ref31","article-title":"Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoes","author":"Y Liu","year":"2017","journal-title":"Nature"},{"issue":"10","key":"ref32","doi-asserted-by":"crossref","first-page":"5508","DOI":"10.1128\/JVI.07081-11","article-title":"The magnitude of dengue virus NS1 protein secretion is strain dependent and does not correlate with severe pathologies in the mouse infection model","volume":"86","author":"S Watanabe","year":"2012","journal-title":"J Virol"},{"issue":"11","key":"ref33","doi-asserted-by":"crossref","first-page":"5518","DOI":"10.1128\/JVI.02575-06","article-title":"Both virus and tumor necrosis factor alpha are critical for endothelium damage in a mouse model of dengue virus-induced hemorrhage","volume":"81","author":"HC Chen","year":"2007","journal-title":"J Virol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.antiviral.2017.08.007","article-title":"Ribavirin inhibits Zika virus (ZIKV) replication in vitro and suppresses viremia in ZIKV-infected STAT1-deficient mice","volume":"146","author":"N Kamiyama","year":"2017","journal-title":"Antiviral Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"17990","DOI":"10.1038\/srep17990","article-title":"Infectious dengue vesicles derived from CD61+ cells in acute patient plasma exhibited a diaphanous appearance","volume":"5","author":"AY Hsu","year":"2015","journal-title":"Sci Rep"},{"issue":"4","key":"ref36","doi-asserted-by":"crossref","first-page":"e672","DOI":"10.1371\/journal.pntd.0000672","article-title":"A non mouse-adapted dengue virus strain as a new model of severe dengue infection in AG129 mice","volume":"4","author":"GK Tan","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"issue":"8","key":"ref37","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.3201\/eid1408.080287","article-title":"Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007","volume":"14","author":"RS Lanciotti","year":"2008","journal-title":"Emerg Infect Dis"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0006417","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,4,30]],"date-time":"2018-04-30T00:00:00Z","timestamp":1525046400000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0006417","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T18:00:12Z","timestamp":1540317612000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0006417"}},"subtitle":[],"editor":[{"given":"Rhoel Ramos","family":"Dinglasan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,4,18]]},"references-count":37,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,4,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0006417","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pntd.0006417","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,18]]}}}