{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T16:28:43Z","timestamp":1778603323930,"version":"3.51.4"},"reference-count":57,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T00:00:00Z","timestamp":1578614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007375","name":"Pr\u00f3-Reitoria de Pesquisa, Universidade Federal de Minas Gerais","doi-asserted-by":"publisher","award":["2014"],"award-info":[{"award-number":["2014"]}],"id":[{"id":"10.13039\/501100007375","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["Schoolarship"],"award-info":[{"award-number":["Schoolarship"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0006596","type":"journal-article","created":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T13:28:52Z","timestamp":1578662932000},"page":"e0006596","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["Obesity impairs resistance to Leishmania major infection in C57BL\/6 mice"],"prefix":"10.1371","volume":"14","author":[{"given":"Vinicius Dantas","family":"Martins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franciele Carolina","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6351-3327","authenticated-orcid":true,"given":"Felipe","family":"Caixeta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1494-4603","authenticated-orcid":true,"given":"Matheus Batista","family":"Carneiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graziele Ribeiro","family":"Goes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00edcia","family":"Torres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara C\u00e2ndida","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Vaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nivea Carolina","family":"Paiva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e1udia Martins","family":"Carneiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leda Quercia","family":"Vieira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Maria Caetano","family":"Faria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7538-3208","authenticated-orcid":true,"given":"Tatiani Uceli","family":"Maioli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2020,1,10]]},"reference":[{"key":"pntd.0006596.ref001","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature05485","article-title":"Inflammation and metabolic disorders","volume":"444","author":"GS Hotamisligil","year":"2006","journal-title":"Nature"},{"key":"pntd.0006596.ref002","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.molmed.2013.05.001","article-title":"Chronic adipose tissue inflammation: all immune cells on the stage","volume":"19","author":"G Cildir","year":"2013","journal-title":"Trends Mol Med"},{"key":"pntd.0006596.ref003","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/nri2449","article-title":"Nutrient sensing and inflammation in metabolic diseases","volume":"8","author":"GS Hotamisligil","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"pntd.0006596.ref004","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1126\/science.7678183","article-title":"Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance","volume":"259","author":"GS Hotamisligil","year":"1993","journal-title":"Science (80-)"},{"key":"pntd.0006596.ref005","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1172\/JCI29881","article-title":"Obesity induces a phenotypic switch in adipose tissue macrophage polarization","volume":"117","author":"CN Lumeng","year":"2007","journal-title":"J Clin Invest"},{"key":"pntd.0006596.ref006","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/nm.1964","article-title":"CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity","volume":"15","author":"S Nishimura","year":"2009","journal-title":"Nat Med"},{"key":"pntd.0006596.ref007","doi-asserted-by":"crossref","first-page":"e8660","DOI":"10.1371\/journal.pone.0008660","article-title":"Natural Killer Cells in Obesity: Impaired Function and Increased Susceptibility to the Effects of Cigarette Smoke","volume":"5","author":"D O\u2019Shea","year":"2010","journal-title":"PLoS One"},{"key":"pntd.0006596.ref008","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1038\/ijo.2013.16","article-title":"Changes in human dendritic cell number and function in severe obesity may contribute to increased susceptibility to viral infection","volume":"37","author":"D O\u2019Shea","year":"2013","journal-title":"Int J Obes (Lond)"},{"key":"pntd.0006596.ref009","doi-asserted-by":"crossref","first-page":"379","DOI":"10.3389\/fimmu.2014.00379","article-title":"Role of T cells in malnutrition and obesity","volume":"5","author":"VA Gerriets","year":"2014","journal-title":"Front Immunol"},{"key":"pntd.0006596.ref010","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1038\/nm.2002","article-title":"Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters","volume":"15","author":"M Feuerer","year":"2009","journal-title":"Nat Med"},{"key":"pntd.0006596.ref011","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s00011-015-0902-1","article-title":"High sugar and butter (HSB) diet induces obesity and metabolic syndrome with decrease in regulatory T cells in adipose tissue of mice","volume":"65","author":"TU Maioli","year":"2016","journal-title":"Inflamm Res"},{"key":"pntd.0006596.ref012","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S1473-3099(10)70304-2","article-title":"Obesity-related immunodeficiency in patients with pandemic influenza H1N1","volume":"11","author":"H Nave","year":"2011","journal-title":"Lancet Infect Dis"},{"key":"pntd.0006596.ref013","article-title":"Interaction of obesity and infections","author":"NV Dhurandhar","year":"2015","journal-title":"Obes Rev"},{"key":"pntd.0006596.ref014","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1128\/IAI.00976-08","article-title":"Defects in innate immunity predispose C57BL\/6J-Leprdb\/Leprdb mice to infection by Staphylococcus aureus","volume":"77","author":"S Park","year":"2009","journal-title":"Infect Immun"},{"key":"pntd.0006596.ref015","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.3945\/jn.110.123653","article-title":"Diet-induced obesity in mice reduces the maintenance of influenza-specific CD8+ memory T cells","volume":"140","author":"EA Karlsson","year":"2010","journal-title":"J Nutr"},{"key":"pntd.0006596.ref016","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1002\/oby.20383","article-title":"Overweight and obese adult humans have a defective cellular immune response to pandemic H1N1 influenza A virus","volume":"21","author":"HA Paich","year":"2013","journal-title":"Obesity (Silver Spring)"},{"key":"pntd.0006596.ref017","first-page":"73","article-title":"A Positive Association between T. gondii Seropositivity and Obesity","volume":"1","author":"GM Reeves","year":"2013","journal-title":"Front Public Heal"},{"key":"pntd.0006596.ref018","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/1475-2875-7-81","article-title":"Malaria and obesity: obese mice are resistant to cerebral malaria","volume":"7","author":"V Robert","year":"2008","journal-title":"Malar J"},{"key":"pntd.0006596.ref019","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.cyto.2015.01.025","article-title":"Plasmodium berghei ANKA infection results in exacerbated immune responses from C57BL\/6 mice displaying hypothalamic obesity","volume":"76","author":"RVH de Carvalho","year":"2015","journal-title":"Cytokine"},{"key":"pntd.0006596.ref020","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1093\/infdis\/jir840","article-title":"Response of adipose tissue to early infection with Trypanosoma cruzi (Brazil strain)","volume":"205","author":"F Nagajyothi","year":"2012","journal-title":"J Infect Dis"},{"key":"pntd.0006596.ref021","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1086\/656189","article-title":"Crucial role of the central leptin receptor in murine Trypanosoma cruzi infection","volume":"202","author":"F Nagajyothi","year":"2010","journal-title":"J Infect Dis"},{"key":"pntd.0006596.ref022","doi-asserted-by":"crossref","DOI":"10.1017\/S003118201600127X","article-title":"Diet-induced obesity promotes systemic inflammation and increased susceptibility to murine visceral leishmaniasis","volume":"143","author":"GD Sarn\u00e1glia","year":"2016","journal-title":"Parasitology"},{"key":"pntd.0006596.ref023","doi-asserted-by":"crossref","first-page":"3994","DOI":"10.1128\/IAI.70.8.3994-4001.2002","article-title":"Leishmania priming of human dendritic cells for CD40 ligand-induced interleukin-12p70 secretion is strain and species dependent","volume":"70","author":"MA McDowell","year":"2002","journal-title":"Infect Immun"},{"key":"pntd.0006596.ref024","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.4049\/jimmunol.147.9.3149","article-title":"IFN-gamma modulates the early development of Th1 and Th2 responses in a murine model of cutaneous leishmaniasis","volume":"147","author":"P Scott","year":"1991","journal-title":"J Immunol"},{"key":"pntd.0006596.ref025","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nri933","article-title":"The immunology of susceptibility and resistance to Leishmania major in mice","volume":"2","author":"D Sacks","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"pntd.0006596.ref026","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1093\/jn\/123.11.1939","article-title":"AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet","volume":"123","author":"Reeves","year":"1993","journal-title":"J Nutr"},{"key":"pntd.0006596.ref027","doi-asserted-by":"crossref","first-page":"2952","DOI":"10.1128\/IAI.61.7.2952-2959.1993","article-title":"Immune responses associated with susceptibility of C57BL\/10 mice to Leishmania amazonensis","volume":"61","author":"LC Afonso","year":"1993","journal-title":"Infect Immun"},{"key":"pntd.0006596.ref028","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"OH Lowry","year":"1951","journal-title":"J Biol Chem"},{"key":"pntd.0006596.ref029","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-X","article-title":"Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids","volume":"126","author":"LC Green","year":"1982","journal-title":"Anal Biochem"},{"key":"pntd.0006596.ref030","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0022-1759(94)90027-2","article-title":"Determination of arginase activity in macrophages: a micromethod","volume":"174","author":"IM Corraliza","year":"1994","journal-title":"J Immunol Methods"},{"key":"pntd.0006596.ref031","doi-asserted-by":"crossref","first-page":"617","DOI":"10.4049\/jimmunol.143.2.617","article-title":"CR1, the C3b receptor, mediates binding of infective Leishmania major metacyclic promastigotes to human macrophages","volume":"143","author":"RP Da Silva","year":"1989","journal-title":"J Immunol"},{"key":"pntd.0006596.ref032","doi-asserted-by":"crossref","first-page":"e3118","DOI":"10.1371\/journal.pntd.0003118","article-title":"High fat diet modulates Trypanosoma cruzi infection associated myocarditis","volume":"8","author":"F Nagajyothi","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"pntd.0006596.ref033","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.pt.2016.11.008","article-title":"Adipose Tissue: A Safe Haven for Parasites?","volume":"33","author":"HB Tanowitz","year":"2017","journal-title":"Trends Parasitol"},{"key":"pntd.0006596.ref034","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1007\/s00125-016-3904-9","article-title":"Adipose tissue macrophages: going off track during obesity","volume":"59","author":"L Boutens","year":"2016","journal-title":"Diabetologia"},{"key":"pntd.0006596.ref035","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1590\/S1517-86922009000600012","article-title":"Obesidade e adipocinas inflamat\u00f3rias: implica\u00e7\u00f5es pr\u00e1ticas para a prescri\u00e7\u00e3o de exerc\u00edcio","volume":"15","author":"WL do Prado","year":"2009","journal-title":"Rev Bras Med do Esporte"},{"key":"pntd.0006596.ref036","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.4049\/jimmunol.1000021","article-title":"Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic inflammation and insulin resistance","volume":"185","author":"H Yang","year":"2010","journal-title":"J Immunol"},{"key":"pntd.0006596.ref037","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1126\/science.271.5251.987","article-title":"Susceptibility to Leishmania major infection in interleukin-4-deficient mice","volume":"271","author":"N Noben-Trauth","year":"1996","journal-title":"Science (80-)"},{"key":"pntd.0006596.ref038","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.4049\/jimmunol.178.2.1077","article-title":"Activation of the MAPK, ERK, following Leishmania amazonensis infection of macrophages","volume":"178","author":"Z Yang","year":"2007","journal-title":"J Immunol"},{"key":"pntd.0006596.ref039","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1084\/jem.188.1.217","article-title":"Reversal of Proinflammatory Responses by Ligating the Macrophage Fc\u03b3 Receptor Type I","volume":"188","author":"FS Sutterwala","year":"1998","journal-title":"J Exp Med"},{"key":"pntd.0006596.ref040","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1084\/jem.20041470","article-title":"A role for IgG immune complexes during infection with the intracellular pathogen Leishmania","volume":"201","author":"SA Miles","year":"2005","journal-title":"J Exp Med"},{"key":"pntd.0006596.ref041","first-page":"15403","article-title":"Obesity enhances Th2 inflammatory response via natural killer T cells in a murine model of allergic asthma","volume":"8","author":"YP Chen","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"pntd.0006596.ref042","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.iac.2014.07.001","article-title":"Childhood obesity and risk of allergy or asthma","volume":"34","author":"D Raj","year":"2014","journal-title":"Immunol Allergy Clin North Am"},{"key":"pntd.0006596.ref043","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/ni1497","article-title":"Development, cytokine profile and function of human interleukin 17-producing helper T cells","volume":"8","author":"NJ Wilson","year":"2007","journal-title":"Nat Immunol"},{"key":"pntd.0006596.ref044","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1126\/science.1200439","article-title":"Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity","volume":"332","author":"A Puel","year":"2011","journal-title":"Science (80)"},{"key":"pntd.0006596.ref045","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1111\/j.1348-0421.2007.tb04008.x","article-title":"Interleukin-17 as an effector molecule of innate and acquired immunity against infections","volume":"51","author":"G Matsuzaki","year":"2007","journal-title":"Microbiol Immunol"},{"key":"pntd.0006596.ref046","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3389\/fimmu.2012.00129","article-title":"TH17 Cells in Autoimmunity and Immunodeficiency: Protective or Pathogenic?","volume":"3","author":"AK Marwaha","year":"2012","journal-title":"Frontiers in Immunology"},{"key":"pntd.0006596.ref047","doi-asserted-by":"crossref","first-page":"595","DOI":"10.3109\/00365513.2015.1066845","article-title":"Elevated levels of Th17 cells in children with central obesity","volume":"75","author":"W Luczynski","year":"2015","journal-title":"Scand J Clin Lab Invest"},{"key":"pntd.0006596.ref048","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.celrep.2015.07.014","article-title":"Obesity Drives Th17 Cell Differentiation by Inducing the Lipid Metabolic Kinase, ACC1","volume":"12","author":"Y Endo","year":"2015","journal-title":"Cell Rep"},{"key":"pntd.0006596.ref049","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.4049\/jimmunol.0713598","article-title":"IL-17 promotes progression of cutaneous leishmaniasis in susceptible mice","volume":"182","author":"S Lopez Kostka","year":"2009","journal-title":"J Immunol"},{"key":"pntd.0006596.ref050","doi-asserted-by":"crossref","first-page":"e1003243","DOI":"10.1371\/journal.ppat.1003243","article-title":"IL-17 Mediates Immunopathology in the Absence of IL-10 Following Leishmania major Infection","volume":"9","author":"C Gonzalez-Lombana","year":"2013","journal-title":"PLoS Pathog"},{"key":"pntd.0006596.ref051","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/pim.12078","article-title":"Neutrophils have a protective role during early stages of Leishmania amazonensis infection in BALB\/c mice","volume":"36","author":"LM Sousa","year":"2014","journal-title":"Parasite Immunol"},{"key":"pntd.0006596.ref052","doi-asserted-by":"crossref","first-page":"23668","DOI":"10.1074\/jbc.M402042200","article-title":"Arginase plays a pivotal role in polyamine precursor metabolism in Leishmania. Characterization of gene deletion mutants","volume":"279","author":"SC Roberts","year":"2004","journal-title":"J Biol Chem"},{"key":"pntd.0006596.ref053","doi-asserted-by":"crossref","first-page":"e108494","DOI":"10.1371\/journal.pone.0108494","article-title":"Interleukin-17 Induces an Atypical M2-Like Macrophage Subpopulation That Regulates Intestinal Inflammation","volume":"9","author":"K Nishikawa","year":"2014","journal-title":"PLoS One"},{"key":"pntd.0006596.ref054","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1159\/000374115","article-title":"Interleukin-17A Promotes Arginase-1 Production and 2,4-Dinitrochlorobenzene-Induced Acute Hyperinflammation in Human Papillomavirus E7 Oncoprotein-Expressing Skin","volume":"7","author":"LS Tran","year":"2015","journal-title":"J Innate Immun"},{"key":"pntd.0006596.ref055","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/imm.13028","article-title":"Interleukin-17\/interleukin-17 receptor axis elicits intestinal neutrophil migration, restrains gut dysbiosis and lipopolysaccharide translocation in high-fat diet-induced metabolic syndrome model","volume":"156","author":"MM P\u00e9rez","year":"2019","journal-title":"Immunology"},{"key":"pntd.0006596.ref056","doi-asserted-by":"crossref","first-page":"969","DOI":"10.4049\/jimmunol.165.2.969","article-title":"A natural model of Leishmania major infection reveals a prolonged \u201csilent\u201d phase of parasite amplification in the skin before the onset of lesion formation and immunity","volume":"165","author":"Y Belkaid","year":"2000","journal-title":"J Immunol"},{"key":"pntd.0006596.ref057","doi-asserted-by":"crossref","first-page":"827","DOI":"10.4049\/jimmunol.157.2.827","article-title":"Mice lacking the TNF receptor p55 fail to resolve lesions caused by infection with Leishmania major, but control parasite replication","volume":"157","author":"LQ Vieira","year":"1996","journal-title":"J Immunol"}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0006596","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T19:47:42Z","timestamp":1695584862000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0006596"}},"subtitle":[],"editor":[{"given":"Armando","family":"Jardim","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,1,10]]},"references-count":57,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,1,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0006596","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/342642","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,10]]}}}