{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:47:22Z","timestamp":1792788442283,"version":"4.5.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0006628","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T00:00:00Z","timestamp":1532563200000}}],"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T00:00:00Z","timestamp":1531699200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"name":"Intramural Research Program, NIAID, NIH"},{"name":"European Union\u2019s Horizon 2020 research and innovation program","award":["732732"],"award-info":[{"award-number":["732732"]}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0006628","type":"journal-article","created":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T13:28:58Z","timestamp":1531747738000},"page":"e0006628","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":78,"title":["Nucleocapsid protein-based vaccine provides protection in mice against lethal Crimean-Congo hemorrhagic fever virus challenge"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4337-8487","authenticated-orcid":true,"given":"Marko","family":"Zivcec","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Safronetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana P.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelly","family":"Robertson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9448-8227","authenticated-orcid":true,"given":"Heinz","family":"Feldmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,7,16]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S1473-3099(06)70435-2","article-title":"Crimean-Congo haemorrhagic fever","volume":"6","author":"O Ergonul","year":"2006","journal-title":"Lancet Infect Dis"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.antiviral.2013.07.006","article-title":"Crimean-Congo hemorrhagic fever: history, epidemiology, pathogenesis, clinical syndrome and genetic diversity","volume":"100","author":"DA Bente","year":"2013","journal-title":"Antiviral Res"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3390\/v8040106","article-title":"Molecular Insights into Crimean-Congo Hemorrhagic Fever Virus","volume":"8","author":"M Zivcec","year":"2016","journal-title":"Viruses"},{"issue":"5","key":"ref4","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1097\/QCO.0b013e3282a56a0a","article-title":"Crimean-Congo hemorrhagic fever","volume":"20","author":"R Vorou","year":"2007","journal-title":"Curr Opin Infect Dis"},{"issue":"5","key":"ref5","doi-asserted-by":"crossref","first-page":"541","DOI":"10.4269\/ajtmh.1989.40.541","article-title":"Viremia and antibody response of small African and laboratory animals to Crimean-Congo hemorrhagic fever virus infection","volume":"40","author":"AJ Shepherd","year":"1989","journal-title":"Am J Trop Med Hyg"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.jcv.2014.08.029","article-title":"Recent advances in research on Crimean-Congo hemorrhagic fever","volume":"64","author":"A Papa","year":"2015","journal-title":"J Clin Virol"},{"issue":"8","key":"ref7","doi-asserted-by":"crossref","first-page":"4323","DOI":"10.1128\/JVI.78.8.4323-4329.2004","article-title":"Human MxA protein inhibits the replication of Crimean-Congo hemorrhagic fever virus","volume":"78","author":"I Andersson","year":"2004","journal-title":"J Virol"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/jmv.20530","article-title":"Type I interferon inhibits Crimean-Congo hemorrhagic fever virus in human target cells","volume":"78","author":"I Andersson","year":"2006","journal-title":"J Med Virol"},{"issue":"1\u20132","key":"ref9","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.virusres.2006.03.005","article-title":"Exogenous nitric oxide inhibits Crimean Congo hemorrhagic fever virus","volume":"120","author":"M Simon","year":"2006","journal-title":"Virus Res"},{"issue":"21","key":"ref10","doi-asserted-by":"crossref","first-page":"11089","DOI":"10.1128\/JVI.01383-10","article-title":"Pathogenesis and immune response of Crimean-Congo hemorrhagic fever virus in a STAT-1 knockout mouse model","volume":"84","author":"DA Bente","year":"2010","journal-title":"J Virol"},{"issue":"Pt 6","key":"ref11","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1099\/vir.0.019034-0","article-title":"Crimean-Congo hemorrhagic fever virus infection is lethal for adult type I interferon receptor-knockout mice","volume":"91","author":"S Bereczky","year":"2010","journal-title":"J Gen Virol"},{"issue":"12","key":"ref12","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1093\/infdis\/jit061","article-title":"Lethal Crimean-Congo hemorrhagic fever virus infection in interferon alpha\/beta receptor knockout mice is associated with high viral loads, proinflammatory responses, and coagulopathy","volume":"207","author":"M Zivcec","year":"2013","journal-title":"J Infect Dis"},{"issue":"48","key":"ref13","doi-asserted-by":"crossref","DOI":"10.2807\/ese.17.48.20327-en","article-title":"Sequencing and phylogenetic characterisation of a fatal Crimean\u2014Congo haemorrhagic fever case imported into the United Kingdom, October 2012","volume":"17","author":"B Atkinson","year":"2012","journal-title":"Euro Surveill"},{"issue":"30","key":"ref14","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES2014.19.30.20864","article-title":"Non-fatal case of Crimean-Congo haemorrhagic fever imported into the United Kingdom (ex Bulgaria), June 2014","volume":"19","author":"S Lumley","year":"2014","journal-title":"Euro Surveill"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3201\/eid2101.141413","article-title":"Health care response to CCHF in US soldier and nosocomial transmission to health care providers, Germany, 2009","volume":"21","author":"NG Conger","year":"2015","journal-title":"Emerg Infect Dis"},{"issue":"6","key":"ref16","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.3201\/eid2306.161950","article-title":"Crimean-Congo Hemorrhagic Fever in Migrant Worker Returning from Oman to India, 2016","volume":"23","author":"PD Yadav","year":"2017","journal-title":"Emerg Infect Dis"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1471-2334-7-54","article-title":"Imported Crimean-Congo hemorrhagic fever cases in Istanbul","volume":"7","author":"K Midilli","year":"2007","journal-title":"BMC Infect Dis"},{"issue":"9","key":"ref18","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1089\/vbz.2011.0767","article-title":"Unraveling the ecological complexities of tick-associated Crimean-Congo hemorrhagic fever virus transmission: a gap analysis for the western Palearctic","volume":"12","author":"A Estrada-Pena","year":"2012","journal-title":"Vector Borne Zoonotic Dis"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/jam.12039","article-title":"Factors driving the circulation and possible expansion of Crimean-Congo haemorrhagic fever virus in the western Palearctic","volume":"114","author":"A Estrada-Pena","year":"2013","journal-title":"J Appl Microbiol"},{"issue":"2","key":"ref20","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1080\/21645515.2015.1078045","article-title":"A Crimean-Congo hemorrhagic fever (CCHF) viral vaccine expressing nucleoprotein is immunogenic but fails to confer protection against lethal disease","volume":"12","author":"SD Dowall","year":"2016","journal-title":"Hum Vaccin Immunother"},{"issue":"3","key":"ref21","doi-asserted-by":"crossref","first-page":"e91516","DOI":"10.1371\/journal.pone.0091516","article-title":"A novel vaccine against Crimean-Congo Haemorrhagic Fever protects 100% of animals against lethal challenge in a mouse model","volume":"9","author":"KR Buttigieg","year":"2014","journal-title":"PLoS One"},{"issue":"12","key":"ref22","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1089\/vbz.2015.1855","article-title":"Crimean-Congo Hemorrhagic Fever Virus Subunit Vaccines Induce High Levels of Neutralizing Antibodies But No Protection in STAT1 Knockout Mice","volume":"15","author":"J Kortekaas","year":"2015","journal-title":"Vector Borne Zoonotic Dis"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","first-page":"e0003579","DOI":"10.1371\/journal.pntd.0003579","article-title":"Immunization of knock-out alpha\/beta interferon receptor mice against high lethal dose of Crimean-Congo hemorrhagic fever virus with a cell culture based vaccine","volume":"9","author":"N Canakoglu","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"ref24","first-page":"91","article-title":"Immunization with DNA Plasmids Coding for Crimean-Congo Hemorrhagic Fever Virus Capsid and Envelope Proteins and\/or Virus-Like Particles Induces Protection and Survival in Challenged Mice","author":"J Hinkula","year":"2017","journal-title":"J Virol"},{"issue":"9","key":"ref25","doi-asserted-by":"crossref","first-page":"e0005908","DOI":"10.1371\/journal.pntd.0005908","article-title":"A DNA vaccine for Crimean-Congo hemorrhagic fever protects against disease and death in two lethal mouse models","volume":"11","author":"AR Garrison","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"issue":"9","key":"ref26","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1017\/S0950268814000818","article-title":"Next-generation sequencing of southern African Crimean-Congo haemorrhagic fever virus isolates reveals a high frequency of M segment reassortment","volume":"142","author":"D Goedhals","year":"2014","journal-title":"Epidemiol Infect"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.virusres.2009.11.009","article-title":"The complete genome analysis of Crimean-Congo hemorrhagic fever virus isolated in Turkey","volume":"147","author":"A Ozdarendeli","year":"2010","journal-title":"Virus Res"},{"issue":"10","key":"ref28","doi-asserted-by":"crossref","first-page":"e3548","DOI":"10.1371\/journal.pone.0003548","article-title":"Nasal delivery of an adenovirus-based vaccine bypasses pre-existing immunity to the vaccine carrier and improves the immune response in mice","volume":"3","author":"MA Croyle","year":"2008","journal-title":"PLoS One"},{"key":"ref29","article-title":"Crimean-Congo Hemorrhagic Fever in Humanized Mice Reveals Glial Cells as Primary Targets of Neurological Infection","author":"JR Spengler","year":"2017","journal-title":"J Infect Dis"},{"issue":"7","key":"ref30","doi-asserted-by":"crossref","first-page":"e40380","DOI":"10.1371\/journal.pone.0040380","article-title":"Schmallenberg virus infection of adult type I interferon receptor knock-out mice","volume":"7","author":"K Wernike","year":"2012","journal-title":"PLoS One"},{"issue":"4","key":"ref31","doi-asserted-by":"crossref","first-page":"e5171","DOI":"10.1371\/journal.pone.0005171","article-title":"Establishment of a bluetongue virus infection model in mice that are deficient in the alpha\/beta interferon receptor","volume":"4","author":"E Calvo-Pinilla","year":"2009","journal-title":"PLoS One"},{"issue":"10","key":"ref32","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1002\/eji.201040453","article-title":"Concomitant type I IFN receptor-triggering of T cells and of DC is required to promote maximal modified vaccinia virus Ankara-induced T-cell expansion","volume":"40","author":"T Frenz","year":"2010","journal-title":"European journal of immunology"},{"issue":"8","key":"ref33","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/j.vaccine.2011.12.103","article-title":"Intrinsic adjuvanting of a novel single-cycle flavivirus vaccine in the absence of type I interferon receptor signaling","volume":"30","author":"ER Winkelmann","year":"2012","journal-title":"Vaccine"},{"issue":"12","key":"ref34","doi-asserted-by":"crossref","first-page":"e1002407","DOI":"10.1371\/journal.ppat.1002407","article-title":"A temporal role of type I interferon signaling in CD8+ T cell maturation during acute West Nile virus infection","volume":"7","author":"AK Pinto","year":"2011","journal-title":"PLoS pathogens"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1186\/1471-2164-10-350","article-title":"Type I interferon receptor-independent and -dependent host transcriptional responses to mouse hepatitis coronavirus infection in vivo","volume":"10","author":"M Raaben","year":"2009","journal-title":"BMC genomics"},{"issue":"6","key":"ref36","doi-asserted-by":"crossref","first-page":"e0156637","DOI":"10.1371\/journal.pone.0156637","article-title":"Protective effects of a Modified Vaccinia Ankara-based vaccine candidate against Crimean-Congo Haemorrhagic Fever virus require both cellular and humoral responses","volume":"11","author":"SD Dowall","year":"2016","journal-title":"PLoS One"},{"issue":"2","key":"ref37","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/sj.mt.6300024","article-title":"Type I interferon inhibits antibody responses induced by a chimpanzee adenovirus vector","volume":"15","author":"SE Hensley","year":"2007","journal-title":"Molecular therapy: the journal of the American Society of Gene Therapy"},{"issue":"11","key":"ref38","doi-asserted-by":"crossref","first-page":"e0143273","DOI":"10.1371\/journal.pone.0143273","article-title":"Protective Efficacy in Sheep of Adenovirus-Vectored Vaccines against Bluetongue Virus Is Associated with Specific T Cell Responses","volume":"10","author":"V Martin","year":"2015","journal-title":"PLoS One"},{"issue":"9996","key":"ref39","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0140-6736(15)61117-5","article-title":"Efficacy and effectiveness of an rVSV-vectored vaccine expressing Ebola surface glycoprotein: interim results from the Guinea ring vaccination cluster-randomised trial","volume":"386","author":"AM Henao-Restrepo","year":"2015","journal-title":"Lancet"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0006628","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T00:00:00Z","timestamp":1532563200000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0006628","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T14:17:43Z","timestamp":1661609863000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0006628"}},"subtitle":[],"editor":[{"given":"Dennis A.","family":"Bente","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,7,16]]},"references-count":39,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2018,7,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0006628","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,16]]}}}