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Onchocerciasis Elimination Program for the Americas 2015 [May 7, 2015]. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.cartercenter.org\/health\/river_blindness\/oepa.html\" xlink:type=\"simple\">http:\/\/www.cartercenter.org\/health\/river_blindness\/oepa.html<\/ext-link>."},{"issue":"9","key":"ref8","doi-asserted-by":"crossref","first-page":"e1825","DOI":"10.1371\/journal.pntd.0001825","article-title":"Proof-of-principle of onchocerciasis elimination with ivermectin treatment in endemic foci in Africa: Final results of a study in Mali and Senegal","volume":"6","author":"MO Traore","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1756-3305-5-28","article-title":"Impact of long-term treatment of onchocerciasis with ivermectin in Kaduna State, Nigeria: First evidence of the potential for elimination in the operational area of the African Programme for Onchocerciasis Control","volume":"5","author":"AH Tekle","year":"2012","journal-title":"Parasit Vect"},{"issue":"5","key":"ref10","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.ijpara.2010.12.009","article-title":"Control of onchocerciasis in Africa: threshold shifts, breakpoints and rules for elimination","volume":"41","author":"HP Duerr","year":"2011","journal-title":"Int J Parasitol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1186\/s13071-015-1159-9","article-title":"Required duration of mass ivermectin treatment for onchocerciasis elimination in Africa: A comparative modelling analysis","volume":"8","author":"WA Stolk","year":"2015","journal-title":"Parasit Vect"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"420928","DOI":"10.1155\/2013\/420928","article-title":"Fifteen years of annual mass treatment of onchocerciasis with ivermectin have not interrupted transmission in the West Region of Cameroon","volume":"2013","author":"MN Katabarwa","year":"2013","journal-title":"J Parasitol Res"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"293","DOI":"10.4269\/ajtmh.13-0037","article-title":"Transmission of <italic>Onchocerca volvulus<\/italic> Continues in Nyagak-Bondo Focus of Northwestern Uganda after 18 Years of a Single Dose of Annual Treatment with Ivermectin","volume":"89","author":"MN Katabarwa","year":"2013","journal-title":"Am J Trop Med Hyg"},{"issue":"Suppl 1","key":"ref14","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1186\/1475-2883-2-S1-S7","article-title":"<italic>Loa loa<\/italic> encephalopathy temporally related to ivermectin administration reported from onchocerciasis mass treatment programs from 1989 to 2001: Implications for the future","volume":"2","author":"NA Twum-Danso","year":"2003","journal-title":"Filaria J"},{"key":"ref15","first-page":"75","article-title":"The eradication of <italic>Simulium neavei<\/italic> from Kenya","volume":"19","author":"JP McMahon","year":"1958","journal-title":"Bull WHO"},{"issue":"2","key":"ref16","first-page":"195","article-title":"Onchocerciasis in Kenya 9, 11 and 18 years after elimination of the vector","volume":"37","author":"JM Roberts","year":"1967","journal-title":"Bull WHO"},{"issue":"1","key":"ref17","first-page":"12","article-title":"River blindness. Protection for 54 cents a year","author":"F Vieta","year":"1998","journal-title":"United Nations Chronicle"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"748540","DOI":"10.1155\/2012\/748540","article-title":"Transmission of onchocerciasis in Wadelai focus of Northwestern Uganda has been interrupted and the disease eliminated","volume":"2012","author":"M Katabarwa","year":"2012","journal-title":"J Parasitol Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.actatropica.2013.02.016","article-title":"The disappearance of onchocerciasis from the Itwara focus, Western Uganda after elimination of the vector <italic>Simulium neavei<\/italic> and 19 years of annual ivermectin treatments","volume":"126","author":"TL Lakwo","year":"2013","journal-title":"Acta Trop"},{"issue":"6","key":"ref20","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.4269\/ajtmh.13-0501","article-title":"Transmission of <italic>Onchocerca volvulus<\/italic> by <italic>Simulium neavei<\/italic> in Mount Elgon focus of Eastern Uganda has been interrupted","volume":"90","author":"M Katabarwa","year":"2014","journal-title":"Am J Trop Med Hyg"},{"issue":"5","key":"ref21","doi-asserted-by":"crossref","first-page":"e0006471","DOI":"10.1371\/journal.pntd.0006471","article-title":"Interruption of onchocerciasis transmission in Bioko Island: Accelerating the movement from control to elimination in Equatorial Guinea","volume":"12","author":"Z Herrador","year":"2018","journal-title":"PLoS Negl Trop Dis"},{"key":"ref22","unstructured":"Anonomous. Uganda Launches Bold Policy to Eliminate River Blindness <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.cartercenter.org\/resources\/pdfs\/news\/health_publications\/eye_of_eagle\/uganda-launches-rb-policy-eoe_072007_eng.pdf:\" xlink:type=\"simple\">https:\/\/www.cartercenter.org\/resources\/pdfs\/news\/health_publications\/eye_of_eagle\/uganda-launches-rb-policy-eoe_072007_eng.pdf:<\/ext-link> The Carter Center; 2007 [cited 2017 May 9, 2017]."},{"issue":"4","key":"ref23","first-page":"505","article-title":"The distribution, bionomics and control of onchocerciasis vectors (Diptera: Simuliidae) in Eastern Africa and the Yemen","volume":"30","author":"JN Raybould","year":"1979","journal-title":"Tropenmed Parasitol"},{"issue":"7","key":"ref24","doi-asserted-by":"crossref","first-page":"e2342","DOI":"10.1371\/journal.pntd.0002342","article-title":"Validation of a remote sensing model to identify <italic>Simulium damnosum<\/italic> s.l. breeding sites in sub-Saharan Africa","volume":"7","author":"BG Jacob","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"ref25","unstructured":"Yu Media Group. Weather Atlas 2018 [cited 2018 May 21]. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.weather-atlas.com\/en\/uganda\/gulu-climate\" xlink:type=\"simple\">https:\/\/www.weather-atlas.com\/en\/uganda\/gulu-climate<\/ext-link>."},{"issue":"2","key":"ref26","first-page":"135","article-title":"Localized onchocerciasis vector control in the Bahr el Ghazal Region of South-Western Sudan. II. Control","volume":"37","author":"RH Baker","year":"1986","journal-title":"Trop Med Parasitol"},{"issue":"1","key":"ref27","first-page":"17","article-title":"Studies on biting <italic>Simulium damnosum<\/italic> s.l. at a breeding site in the Onchocerciasis Control Programme area during and after an interruption of insecticidal treatments","volume":"32","author":"JB Davies","year":"1981","journal-title":"Trop Med Parasitol"},{"issue":"5","key":"ref28","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1080\/00034983.1993.11812793","article-title":"Criteria for the selection of larvicides by the Onchocerciasis Control Programme in West Africa","volume":"87","author":"JM Hougard","year":"1993","journal-title":"Ann Trop Med Parasitol"},{"issue":"6390","key":"ref29","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1126\/science.aar3780","article-title":"Wicked evolution: Can we address the sociobiological dilemma of pesticide resistance?","volume":"360","author":"F Gould","year":"2018","journal-title":"Science (New York, NY)"},{"key":"ref30","first-page":"721","article-title":"Progress in controlling the reinvasion of Windborne Vectors into the Western Area of Onchocerciasis Control Programme in West Africa","volume":"B328","author":"RHA Baker","year":"1990","journal-title":"Phil Trans Roy Soc, London"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/bs.apar.2016.08.003","article-title":"River Blindness: Mathematical Models for Control and Elimination","volume":"94","author":"MG Basanez","year":"2016","journal-title":"Adv Parasitol"},{"key":"ref32","unstructured":"Christensen O. 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