{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T23:11:42Z","timestamp":1771629102020,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pntd.0006824","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T00:00:00Z","timestamp":1538697600000}}],"reference-count":26,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T00:00:00Z","timestamp":1537833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0006824","type":"journal-article","created":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T13:26:21Z","timestamp":1537881981000},"page":"e0006824","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Filarial infection during pregnancy has profound consequences on immune response and disease outcome in children: A birth cohort study"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0473-6686","authenticated-orcid":true,"given":"Madhusmita","family":"Bal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoranjan","family":"Ranjit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashok K.","family":"Satapathy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hemant K.","family":"Khuntia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanghamitra","family":"Pati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,9,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/s00281-017-0653-x","article-title":"Transfer of maternal immunity and programming of the newborn immune system","volume":"39","author":"MF Jennewein","year":"2017","journal-title":"Semin Immunopathol"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"e0003466","DOI":"10.1371\/journal.pntd.0003466","article-title":"Effect of Antenatal Parasitic Infections on Anti-vaccine IgG Levels in Children: A Prospective Birth Cohort Study in Kenya","volume":"9","author":"I Malhotra","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"issue":"7","key":"ref3","doi-asserted-by":"crossref","first-page":"e0003955","DOI":"10.1371\/journal.pntd.0003955","article-title":"Maternal Infection is a Risk Factor fo -rEarly Childhood Infection in Filariasis","volume":"9","author":"M Bal","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"5231","DOI":"10.1128\/IAI.71.9.5231-5237.2003","article-title":"Influence of maternal filariasis on childhood infection and immunity to <italic>Wuchereria bancrofti<\/italic>in Kenya","volume":"71","author":"I Malhotra","year":"2003","journal-title":"Infect Immun"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1086\/500472","article-title":"Prenatal T cell immunity to <italic>Wuchereria bancroft<\/italic>i and its effect on filarial immunity and infection susceptibility during childhood","volume":"193","author":"I Malhotra","year":"2006","journal-title":"J Infect Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1017\/S0031182009991478","article-title":"Transplacental transfer of filarial antigens from <italic>Wuchereria bancrofti<\/italic> infected mothers to their offspring","volume":"137","author":"MS Bal","year":"2010","journal-title":"Parasitol"},{"issue":"11","key":"ref7","doi-asserted-by":"crossref","first-page":"e0005144","DOI":"10.1371\/journal.pntd.0005144","article-title":"Maternal Filarial Infection Influences the Development of Regulatory T Cells in Children from Infancy to Early Childhood","volume":"10","author":"M Bal","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/pim.12121","article-title":"In-utero sensitization modulates IgG isotype, IFN-\u03b3 and IL-10 responses of neonates in bancroftian filariasis","author":"KG Achary","year":"2014","journal-title":"Parasite Immunol"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/S0035-9203(02)90117-3","article-title":"Anti-filarial and total IgG4 and IgE antibody levels are correlated in mothers and their offspring","volume":"96","author":"AJ Terhell","year":"2002","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.trstmh.2008.08.006","article-title":"Antigenemia in young children living in <italic>Wuchereria bancrofti<\/italic> endemic areas of Orissa, India","volume":"103","author":"MS Bal","year":"2009","journal-title":"Trans Roy Socf Trop Med Hyg"},{"issue":"10","key":"ref11","doi-asserted-by":"crossref","first-page":"e0005631","DOI":"10.1371\/journal.pntd.0005631","article-title":"Lymphatic pathology in asymptomatic and symptomatic children with <italic>Wuchereria bancrofti<\/italic> infection in children from Odisha, India and its reversal with DEC and albendazole treatment","volume":"11","author":"SK Kar","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"issue":"6","key":"ref12","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1179\/136485910X12786389891407","article-title":"Induction of immunoglobulin G4 in human filariasis: an indicator of immunoregulation","volume":"104","author":"T Adjobimey","year":"2010","journal-title":"Ann Trop Med Parasitol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1002\/eji.200838193","article-title":"Tr1 and naturally occurring regulatory T cells induce IgG4 in B cells through GITR\/GITR-L interaction, IL-10 and TGF-b","volume":"38","author":"JS Satoguina","year":"2008","journal-title":"Euro J of Immunol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"97","DOI":"10.4269\/ajtmh.2006.75.97","article-title":"Filarial-specific antibody response in East African bancroftian filariasis: effects of host infection, clinical disease, and filarial endemicity","volume":"75","author":"WG Jaoko","year":"2006","journal-title":"Am J Trop Med Hyg"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/S1471-4922(03)00139-9","article-title":"Class and subclass selection in parasite-specific antibody responses","volume":"l19","author":"O Garraud","year":"2003","journal-title":"Trends Parasitol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2013.00305","article-title":"Regulatory T cell subsets in filarial infection and their function","volume":"4","author":"S Metenou","year":"2013","journal-title":"Front Immunol"},{"key":"ref17","first-page":"1","article-title":"Maternal and child cytokine relationship in early life is not altered by cytokine gene polymorphisms","author":"Y Djuardi","year":"2016","journal-title":"Genes Immun"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1710-1492-9-13","article-title":"The development of TH2 responses from infancy to 4 years of age and atopic sensitization in areas endemic for helminth infections","volume":"9","author":"Y Djuardi","year":"2013","journal-title":"Allergy Asthma Clin Immunol"},{"issue":"5","key":"ref19","doi-asserted-by":"crossref","first-page":"e1655","DOI":"10.1371\/journal.pntd.0001655","article-title":"Regulatory T Cells in Human Lymphatic Filariasis: Stronger Functional Activity in Microfilaremics","volume":"6","author":"LJ Wammes","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"ref20","first-page":"97","article-title":"The Filaria","author":"PJ Lammie","year":"2002"},{"issue":"5","key":"ref21","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1002\/eji.201646836","article-title":"Chronic schistosomiasis during pregnancy epigenetically reprograms T cell differentiation in offspring of infected mothers","volume":"47","author":"K Klar","year":"2017","journal-title":"Eur J Immunol"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/QCO.0b013e32835fb8bf","article-title":"Early life response to infection","volume":"26","author":"P Ghazal","year":"2013","journal-title":"Curr Opin Infect Dis"},{"issue":"8","key":"ref23","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/pim.12101","article-title":"Pregnancy and helminth infections","volume":"36","author":"H Mpairwe","year":"2014","journal-title":"Parasite Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S0035-9203(97)90521-6","article-title":"<italic>Wuchereriabancrofti<\/italic> microfilaraemia in children in relation to parental infection status","volume":"91","author":"PK Das","year":"1997","journal-title":"Trans Roy Soc Trop Med Hyg"},{"issue":"2","key":"ref25","first-page":"3","article-title":"Parental infection confounded with local infection intensity as risk factors for childhood microfilaraemia in bancroftian filariasis","volume":"92","author":"N D Alexander","year":"1998","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s11908-002-0069-0","article-title":"Update on lymphatic filarial infections","volume":"4","author":"TB Nutman","year":"2002","journal-title":"Curr Infect Dis Rep"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0006824","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T00:00:00Z","timestamp":1538697600000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0006824","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T21:25:01Z","timestamp":1540243501000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0006824"}},"subtitle":[],"editor":[{"given":"Sabine","family":"Specht","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,9,25]]},"references-count":26,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2018,9,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0006824","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pntd.0006824","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,25]]}}}