{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T15:05:51Z","timestamp":1787929551815,"version":"build-2784847793"},"update-to":[{"DOI":"10.1371\/journal.pntd.0006834","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T00:00:00Z","timestamp":1544054400000}}],"reference-count":21,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T00:00:00Z","timestamp":1543190400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI082577"],"award-info":[{"award-number":["R01AI082577"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R21AI127594"],"award-info":[{"award-number":["R21AI127594"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R56AI099476"],"award-info":[{"award-number":["R56AI099476"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI124046"],"award-info":[{"award-number":["R01AI124046"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0006834","type":"journal-article","created":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T19:34:51Z","timestamp":1543260891000},"page":"e0006834","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["Anilinoquinoline based inhibitors of trypanosomatid proliferation"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8992-0919","authenticated-orcid":true,"given":"Lori","family":"Ferrins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amrita","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah M.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naimee","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessey","family":"Erath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Tanghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan E.","family":"Leed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kojo","family":"Mensa-Wilmot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Sciotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Gillingwater","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9943-7197","authenticated-orcid":true,"given":"Michael P.","family":"Pollastri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,11,26]]},"reference":[{"key":"ref1","article-title":"Neglected Tropical Diseases","year":"2009"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e0006052","DOI":"10.1371\/journal.pntd.0006052","article-title":"Drug resistance and treatment failure in leishmaniasis: A 21st century challenge","volume":"11","author":"A Ponte-Sucre","year":"2017","journal-title":"PLOS Neglected Tropical Diseases"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"16092","DOI":"10.1038\/nmicrobiol.2016.92","article-title":"Drug resistance in eukaryotic microorganisms","volume":"1","author":"AH Fairlamb","year":"2016","journal-title":"Nature Microbiology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1016\/S0140-6736(12)61689-4","article-title":"Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990\u20132010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"CJL Murray","year":"2012","journal-title":"The Lancet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e1828","DOI":"10.1371\/journal.pntd.0001828","article-title":"Trypanosome Diversity in Wildlife Species from the Serengeti and Luangwa Valley Ecosystems","volume":"6","author":"H Auty","year":"2012","journal-title":"PLOS Neglected Tropical Diseases"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1017\/S0031182016001268","article-title":"The animal trypanosomiases and their chemotherapy: a review","volume":"143","author":"F Giordani","year":"2016","journal-title":"Parasitology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S1471-4922(00)01827-4","article-title":"African bovine trypanosomiasis: the problem of drug resistance","volume":"17","author":"S Geerts","year":"2001","journal-title":"Trends in Parasitology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.drup.2007.02.004","article-title":"Drugs and drug resistance in African trypanosomiasis","volume":"10","author":"V Delespaux","year":"2007","journal-title":"Drug Resistance Updates"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1016\/j.bmcl.2016.03.103","article-title":"Repurposing strategies for tropical disease drug discovery","volume":"26","author":"DM Klug","year":"2016","journal-title":"Bioorganic & Medicinal Chemistry Letters"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"5522","DOI":"10.1021\/acs.jmedchem.5b00515","article-title":"Protozoan Parasite Growth Inhibitors Discovered by Cross-Screening Yield Potent Scaffolds for Lead Discovery","volume":"58","author":"W Devine","year":"2015","journal-title":"Journal of Medicinal Chemistry"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1021\/acsinfecdis.7b00212","article-title":"Optimization of Physicochemical Properties for 4-Anilinoquinoline Inhibitors of <italic>Plasmodium falciparum<\/italic> Proliferation","volume":"4","author":"N Mehta","year":"2018","journal-title":"ACS Infectious Diseases"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.ejmech.2013.09.032","article-title":"Discovery of a potent dual EGFR\/HER-2 inhibitor L-2 (selatinib) for the treatment of cancer","volume":"69","author":"L Zhang","year":"2013","journal-title":"European Journal of Medicinal Chemistry"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nrd4163","article-title":"The role of ligand efficiency metrics in drug discovery","volume":"13","author":"AL Hopkins","year":"2014","journal-title":"Nature Reviews Drug Discovery"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(00)00129-0","article-title":"Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3\u201325.1","volume":"46","author":"CA Lipinski","year":"2001","journal-title":"Advanced Drug Delivery Reviews"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/nrd4683","article-title":"Hit and lead criteria in drug discovery for infectious diseases of the developing world","volume":"14","author":"K Katsuno","year":"2015","journal-title":"Nature Reviews Drug Discovery"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.4155\/fmc.13.162","article-title":"Drug discovery and human African trypanosomiasis: a disease less neglected?","volume":"5","author":"L Ferrins","year":"2013","journal-title":"Future Medicinal Chemistry"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"32083","DOI":"10.1038\/srep32083","article-title":"Discovery of a Carbazole-Derived Lead Drug for Human African Trypanosomiasis","volume":"6","author":"SM Thomas","year":"2016","journal-title":"Scientific Reports"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/0169-4758(94)90402-2","article-title":"Axenic culture of African trypanosome bloodstream forms","volume":"10","author":"H Hirumi","year":"1994","journal-title":"Parasitology Today"},{"key":"ref19","article-title":"<italic>In vitro<\/italic>, <italic>Ex vivo<\/italic> and <italic>In vivo<\/italic> Activity of Diamidines against <italic>Trypanosoma congolense<\/italic> and <italic>Trypanosoma vivax<\/italic>","author":"K Gillingwater","year":"2017","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.1371\/journal.pntd.0000034","article-title":"Optimization of Topical Therapy for Leishmania major Localized Cutaneous Leishmaniasis Using a Reliable C57BL\/6 Model","volume":"1","author":"H Lecoeur","year":"2007","journal-title":"PLOS Neglected Tropical Diseases"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0022-1759(90)90187-Z","article-title":"MTT colorimetric assay for testing macrophage cytotoxic activity <italic>in vitro<\/italic>","volume":"131","author":"M Ferrari","year":"1990","journal-title":"Journal of Immunological Methods"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0006834","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T00:00:00Z","timestamp":1544054400000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0006834","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T12:23:11Z","timestamp":1589026991000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0006834"}},"subtitle":[],"editor":[{"given":"Timothy G.","family":"Geary","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,11,26]]},"references-count":21,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2018,11,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0006834","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pntd.0006834","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,26]]}}}