{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:53:00Z","timestamp":1791377580628,"version":"4.3.2"},"update-to":[{"DOI":"10.1371\/journal.pntd.0006871","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T00:00:00Z","timestamp":1541980800000}}],"reference-count":25,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T00:00:00Z","timestamp":1540512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006675","name":"Instituto Nacional de Ci\u00eancia e Tecnologia de Doen\u00e7as Tropicais","doi-asserted-by":"publisher","award":["576269\/2008"],"award-info":[{"award-number":["576269\/2008"]}],"id":[{"id":"10.13039\/501100006675","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006181","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado da Bahia","doi-asserted-by":"publisher","award":["JCB0010\/2013"],"award-info":[{"award-number":["JCB0010\/2013"]}],"id":[{"id":"10.13039\/501100006181","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0006871","type":"journal-article","created":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T13:27:26Z","timestamp":1540560446000},"page":"e0006871","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["High accuracy of an ELISA test based in a flagella antigen of Leishmania in serodiagnosis of canine visceral leishmaniasis with potential to improve the control measures in Brazil \u2013 A Phase II study"],"prefix":"10.1371","volume":"12","author":[{"given":"Lairton Souza","family":"Borja","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00edvia Brito","family":"Coelho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matheus Silva de","family":"Jesus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur Trancoso Lopo","family":"de Queiroz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola Alejandra Fiorani","family":"Celedon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilson Ivo Tonin","family":"Zachin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edimilson Domingos","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f4nio Gomes Pinto","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Aur\u00e9lio","family":"Krieger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia Sampaio Tavares","family":"Veras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4788-0319","authenticated-orcid":true,"given":"Deborah Bittencourt Moth\u00e9","family":"Fraga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,10,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S1471-4922(02)02347-4","article-title":"Canine leishmaniasis: epidemiological risk and the experimental model","volume":"18","author":"J Moreno","year":"2002","journal-title":"Trends Parasitol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/S0102-09352001000100001","article-title":"Urbanization of visceral leishmaniose in Belo Horizonte, Brazil","volume":"53","author":"PD Bevilacqua","year":"2001","journal-title":"Arq Bras Med Vet E Zootec"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1017\/S0031182009991156","article-title":"Transmission, reservoir hosts and control of zoonotic visceral leishmaniasis","volume":"136","author":"RJ Quinnell","year":"2009","journal-title":"Parasitology"},{"key":"ref4","unstructured":"Minist\u00e9rio da Sa\u00fade, Secretaria de Vigil\u00e2ncia em Sa\u00fade, Departamento de Vigil\u00e2ncia Epidemiol\u00f3gica. Manual de vigil\u00e2ncia e controle da leishmaniose visceral [Internet]. 2nd ed. A, editor. Brasil: Minist\u00e9rio da Sa\u00fade; 2006. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/portal.saude.gov.br\/portal\/arquivos\/pdf\/manual\" xlink:type=\"simple\">http:\/\/portal.saude.gov.br\/portal\/arquivos\/pdf\/manual<\/ext-link>"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"53","DOI":"10.4269\/ajtmh.1998.59.53","article-title":"Studies on control of visceral leishmaniasis: Impact of dog control on canine and human visceral leishmaniasis in Jacobina, bahia, Brazil","volume":"59","author":"DA Ashford","year":"1998","journal-title":"Am J Trop Med Hyg"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.vetpar.2004.05.019","article-title":"Assessment of an optimized dog-culling program in the dynamics of canine Leishmania transmission","volume":"122","author":"ED Moreira","year":"2004","journal-title":"Vet Parasitol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.vetpar.2005.12.020","article-title":"Canine visceral leishmaniosis: a comparative analysis of the EIE-leishmaniose-visceral-canina-Bio-Manguinhos and the IFI-leishmaniose-visceral-canina-Bio-Manguinhos kits","volume":"137","author":"RA Lira","year":"2006","journal-title":"Vet Parasitol"},{"key":"ref8","article-title":"The Rapid Test Based on Leishmania infantum Chimeric rK28 Protein Improves the Diagnosis of Canine Visceral Leishmaniasis by Reducing the Detection of False-Positive Dogs","volume":"10","author":"DBM Fraga","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"ref9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003429","article-title":"Novel Recombinant Multiepitope Proteins for the Diagnosis of Asymptomatic Leishmania infantum-Infected Dogs","volume":"9","author":"AR Faria","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e1310","DOI":"10.1371\/journal.pntd.0001310","article-title":"High-throughput analysis of synthetic peptides for the immunodiagnosis of canine visceral leishmaniasis","volume":"5","author":"AR Faria","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.4269\/ajtmh.2011.11-0102","article-title":"Characterization of novel Leishmania infantum recombinant proteins encoded by genes from five families with distinct capacities for serodiagnosis of canine and human visceral leishmaniasis","volume":"85","author":"GG Oliveira","year":"2011","journal-title":"Am J Trop Med Hyg"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.biologicals.2006.01.005","article-title":"A strategy for identifying serodiagnostically relevant antigens of Leishmania or other pathogens in genetic libraries","volume":"35","author":"MC Teixeira","year":"2007","journal-title":"Biologicals."},{"key":"ref13","article-title":"Evaluation of a new set of recombinant antigens for the serological diagnosis of human and canine visceral leishmaniasis","author":"FB Magalh\u00e3es","year":"2017","journal-title":"PLoS One"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13071-015-0651-6","article-title":"Multi-antigen print immunoassay (MAPIA)-based evaluation of novel recombinant Leishmania infantum antigens for the serodiagnosis of canine visceral leishmaniasis","volume":"8","author":"IQ de Oliveira","year":"2015","journal-title":"Parasit Vectors"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-3024.2011.01334.x","article-title":"Evaluation of an ELISA for canine leishmaniasis immunodiagnostic using recombinant proteins","volume":"34","author":"CM de Souza","year":"2012","journal-title":"Parasite Immunol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/1756-3305-7-136","article-title":"A multicentric evaluation of the recombinant Leishmania infantum antigen-based immunochromatographic assay for the serodiagnosis of canine visceral leishmaniasis","volume":"7","author":"DB Fraga","year":"2014","journal-title":"Parasit Vectors"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e103635","DOI":"10.1371\/journal.pone.0103635","article-title":"Evaluating the accuracy of molecular diagnostic testing for canine visceral leishmaniasis using latent class analysis","volume":"9","author":"S Solca Mda","year":"2014","journal-title":"PLoS One"},{"key":"ref18","unstructured":"Dean A, Sullivan K, Soe M. OpenEpi: Open Source Epidemiologic Statistics for Public Health. Updat 2011\/23\/06. 2011; Version 2.3.1. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.OpenEpi.com\" xlink:type=\"simple\">www.OpenEpi.com<\/ext-link>"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/tmi.12429","article-title":"Serological diagnosis of canine visceral leishmaniasis in Brazil: systematic review and meta-analysis","volume":"20","author":"HM Peixoto","year":"2015","journal-title":"Trop Med Int Heal"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"529","DOI":"10.7326\/0003-4819-155-8-201110180-00009","article-title":"Quadas-2: A revised tool for the quality assessment of diagnostic accuracy studies","author":"PF Whiting","year":"2011","journal-title":"Annals of Internal Medicine"},{"key":"ref21","first-page":"2014","article-title":"Relationship between Leishmania IFAT titer and clinicopathological manifestations (clinical score) in dogs","author":"D Proverbio","year":"2014","journal-title":"Biomed Res Int"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0304-4017(00)00446-5","article-title":"Leishmania infantum-specific IgG, IgG1 and IgG2 antibody responses in healthy and ill dogs from endemic areas: Evolution in the course of infection and after treatment","volume":"96","author":"L Solano-Gallego","year":"2001","journal-title":"Vet Parasitol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.trstmh.2011.10.001","article-title":"Evaluation of a novel chromatographic immunoassay based on Dual-Path Platform technology (DPP(R) CVL rapid test) for the serodiagnosis of canine visceral leishmaniasis","volume":"106","author":"Grimaldi G Jr.","year":"2012","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1128\/CVI.00420-06","article-title":"Comparative evaluation of enzyme-linked immunosorbent assays based on crude and recombinant leishmanial antigens for serodiagnosis of symptomatic and asymptomatic Leishmania infantum visceral infections in dogs","volume":"14","author":"R Porrozzi","year":"2007","journal-title":"Clin Vaccine Immunol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1096\/fj.07-9254com","article-title":"Retooling Leishmania metabolism: from sand fly gut to human macrophage","volume":"22","author":"D Rosenzweig","year":"2008","journal-title":"FASEB J"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0008346","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T00:00:00Z","timestamp":1589932800000}},{"DOI":"10.1371\/journal.pntd.0006871","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T00:00:00Z","timestamp":1541980800000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0006871","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T20:45:04Z","timestamp":1588970704000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0006871"}},"subtitle":[],"editor":[{"given":"Waleed Saleh","family":"Al-Salem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,10,26]]},"references-count":25,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2018,10,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0006871","relation":{"correction":[{"id-type":"doi","id":"10.1371\/journal.pntd.0008346","asserted-by":"object"}],"new_version":[{"id-type":"doi","id":"10.1371\/journal.pntd.0006871","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,26]]}}}