{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:54:07Z","timestamp":1790402047017,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0006963","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,11,30]],"date-time":"2018-11-30T00:00:00Z","timestamp":1543536000000}}],"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2018,11,16]],"date-time":"2018-11-16T00:00:00Z","timestamp":1542326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["8P41GM103422"],"award-info":[{"award-number":["8P41GM103422"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["K08AI121422"],"award-info":[{"award-number":["K08AI121422"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPPGH 5242"],"award-info":[{"award-number":["OPPGH 5242"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Coalition for Operational Research on Neglected Tropical Diseases (COR-NTD)"},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["NIH Loan Repayment Program"],"award-info":[{"award-number":["NIH Loan Repayment Program"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0006963","type":"journal-article","created":{"date-parts":[[2018,11,16]],"date-time":"2018-11-16T18:32:17Z","timestamp":1542393137000},"page":"e0006963","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":32,"title":["Identification and characterization of Loa loa antigens responsible for cross-reactivity with rapid diagnostic tests for lymphatic filariasis"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7929-7756","authenticated-orcid":true,"given":"Marla I.","family":"Hertz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugues","family":"Nana-Djeunga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Kamgno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdel","family":"Jelil Njouendou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerine","family":"Chawa Chunda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Wanji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Rush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter U.","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary J.","family":"Weil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0069-2372","authenticated-orcid":true,"given":"Philip J.","family":"Budge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,11,16]]},"reference":[{"issue":"11","key":"ref1","doi-asserted-by":"crossref","first-page":"e3333","DOI":"10.1371\/journal.pntd.0003333","article-title":"Assessing progress in reducing the at-risk population after 13 years of the global programme to eliminate lymphatic filariasis","volume":"8","author":"PJ Hooper","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"issue":"9070","key":"ref2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0140-6736(96)11094-1","article-title":"Serious reactions after mass treatment of onchocerciasis with ivermectin in an area endemic for Loa loa infection","volume":"350","author":"J Gardon","year":"1997","journal-title":"Lancet"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4269\/ajtmh.13-0089","article-title":"Laboratory and field evaluation of a new rapid test for detecting Wuchereria bancrofti antigen in human blood","volume":"89","author":"GJ Weil","year":"2013","journal-title":"Am J Trop Med Hyg"},{"issue":"10","key":"ref4","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0169-4758(97)01130-7","article-title":"The ICT Filariasis Test: A rapid-format antigen test for diagnosis of bancroftian filariasis","volume":"13","author":"GJ Weil","year":"1997","journal-title":"Parasitol Today"},{"issue":"9","key":"ref5","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.4049\/jimmunol.138.9.3035","article-title":"Identification and partial characterization of a parasite antigen in sera from humans infected with Wuchereria bancrofti","volume":"138","author":"GJ Weil","year":"1987","journal-title":"J Immunol"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1093\/infdis\/156.2.350","article-title":"A monoclonal antibody-based enzyme immunoassay for detecting parasite antigenemia in bancroftian filariasis","volume":"156","author":"GJ Weil","year":"1987","journal-title":"J Infect Dis"},{"issue":"6","key":"ref7","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.4269\/ajtmh.14-0358","article-title":"Filarial antigenemia and Loa loa night blood microfilaremia in an area without bancroftian filariasis in the Democratic Republic of Congo","volume":"91","author":"DK Bakajika","year":"2014","journal-title":"Am J Trop Med Hyg"},{"issue":"11","key":"ref8","doi-asserted-by":"crossref","first-page":"e0004184","DOI":"10.1371\/journal.pntd.0004184","article-title":"Cross-Reactivity of Filariais ICT Cards in Areas of Contrasting Endemicity of Loa loa and Mansonella perstans in Cameroon: Implications for Shrinking of the Lymphatic Filariasis Map in the Central African Region","volume":"9","author":"S Wanji","year":"2015","journal-title":"PLoS neglected tropical diseases"},{"issue":"6","key":"ref9","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.4269\/ajtmh.16-0547","article-title":"Positivity of Antigen Tests Used for Diagnosis of Lymphatic Filariasis in Individuals Without Wuchereria bancrofti Infection But with High Loa loa Microfilaremia","volume":"95","author":"SD Pion","year":"2016","journal-title":"Am J Trop Med Hyg"},{"issue":"5","key":"ref10","doi-asserted-by":"crossref","first-page":"826","DOI":"10.4269\/ajtmh.2006.74.826","article-title":"A real-time PCR-based assay for detection of Wuchereria bancrofti DNA in blood and mosquitoes","volume":"74","author":"RU Rao","year":"2006","journal-title":"Am J Trop Med Hyg"},{"issue":"6","key":"ref11","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/S0035-9203(96)90437-X","article-title":"Prolonged clearance of microfilaraemia in patients with bancroftian filariasis after multiple high doses of ivermectin or diethylcarbamazine","volume":"90","author":"MM Ismail","year":"1996","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1093\/cid\/civ882","article-title":"Efficacy, Safety, and Pharmacokinetics of Coadministered Diethylcarbamazine, Albendazole, and Ivermectin for Treatment of Bancroftian Filariasis","volume":"62","author":"EK Thomsen","year":"2016","journal-title":"Clinical infectious diseases: an official publication of the Infectious Diseases Society of America"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"e1479","DOI":"10.1371\/journal.pntd.0001479","article-title":"A multicenter evaluation of diagnostic tools to define endpoints for programs to eliminate bancroftian filariasis","volume":"6","author":"K Gass","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"issue":"8","key":"ref14","doi-asserted-by":"crossref","first-page":"e1299","DOI":"10.1371\/journal.pntd.0001299","article-title":"Rapid molecular assays for specific detection and quantitation of Loa loa microfilaremia","volume":"5","author":"DL Fink","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1186\/s13071-016-1556-8","article-title":"Further evidence of the cross-reactivity of the Binax NOW(R) Filariasis ICT cards to non-Wuchereria bancrofti filariae: experimental studies with Loa loa and Onchocerca ochengi","volume":"9","author":"S Wanji","year":"2016","journal-title":"Parasit Vectors"},{"issue":"5","key":"ref16","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nmeth.1322","article-title":"Universal sample preparation method for proteome analysis","volume":"6","author":"JR Wisniewski","year":"2009","journal-title":"Nature methods"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1186\/1471-2164-15-788","article-title":"Single molecule sequencing and genome assembly of a clinical specimen of Loa loa, the causative agent of loiasis","volume":"15","author":"LJ Tallon","year":"2014","journal-title":"BMC Genomics"},{"issue":"5","key":"ref18","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/ng.2585","article-title":"Genomics of Loa loa, a Wolbachia-free filarial parasite of humans","volume":"45","author":"CA Desjardins","year":"2013","journal-title":"Nat Genet"},{"issue":"10","key":"ref19","doi-asserted-by":"crossref","first-page":"3420","DOI":"10.1093\/nar\/gkn176","article-title":"High-throughput functional annotation and data mining with the Blast2GO suite","volume":"36","author":"S Gotz","year":"2008","journal-title":"Nucleic Acids Res"},{"issue":"10","key":"ref20","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1038\/emboj.2013.79","article-title":"Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology","volume":"32","author":"C Steentoft","year":"2013","journal-title":"EMBO J"},{"key":"ref21","unstructured":"Gupta R, Jung E, Brunak S. Prediction of N-glycosylation sites in human proteins. 2004."},{"issue":"10","key":"ref22","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/nmeth.1701","article-title":"SignalP 4.0: discriminating signal peptides from transmembrane regions","volume":"8","author":"TN Petersen","year":"2011","journal-title":"Nature methods"},{"issue":"4","key":"ref23","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1093\/protein\/gzh037","article-title":"Feature-based prediction of non-classical and leaderless protein secretion","volume":"17","author":"JD Bendtsen","year":"2004","journal-title":"Protein Eng Des Sel"},{"issue":"9","key":"ref24","doi-asserted-by":"crossref","first-page":"e0004001","DOI":"10.1371\/journal.pntd.0004001","article-title":"Mapping of Bancroftian Filariasis in Cameroon: Prospects for Elimination","volume":"9","author":"HC Nana-Djeunga","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"issue":"18","key":"ref25","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1093\/bioinformatics\/bti610","article-title":"Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research","volume":"21","author":"A Conesa","year":"2005","journal-title":"Bioinformatics"},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.molbiopara.2008.02.007","article-title":"The secretome of the filarial parasite, Brugia malayi: proteomic profile of adult excretory-secretory products","volume":"160","author":"JP Hewitson","year":"2008","journal-title":"Mol Biochem Parasitol"},{"issue":"10","key":"ref27","doi-asserted-by":"crossref","first-page":"e326","DOI":"10.1371\/journal.pntd.0000326","article-title":"Stage- and gender-specific proteomic analysis of Brugia malayi excretory-secretory products","volume":"2","author":"Y Moreno","year":"2008","journal-title":"PLoS Negl Trop Dis"},{"issue":"4","key":"ref28","doi-asserted-by":"crossref","first-page":"e410","DOI":"10.1371\/journal.pntd.0000410","article-title":"Brugia malayi excreted\/secreted proteins at the host\/parasite interface: stage- and gender-specific proteomic profiling","volume":"3","author":"S Bennuru","year":"2009","journal-title":"PLoS Negl Trop Dis"},{"issue":"23","key":"ref29","doi-asserted-by":"crossref","first-page":"9649","DOI":"10.1073\/pnas.1011481108","article-title":"Stage-specific proteomic expression patterns of the human filarial parasite Brugia malayi and its endosymbiont Wolbachia","volume":"108","author":"S Bennuru","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref30","article-title":"Preventive chemotherapy in human helminthiasis: coordinated use of anthelminthic drugs in control interventions: a manual for health professionals and programme managers","year":"2006"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1093\/infdis\/170.1.247","article-title":"Og4C3 circulating antigen: a marker of infection and adult worm burden in Wuchereria bancrofti filariasis","volume":"170","author":"S Chanteau","year":"1994","journal-title":"J Infect Dis"},{"issue":"3","key":"ref32","first-page":"176","article-title":"Loa loa antigen detection by ELISA: a new approach to diagnosis","volume":"72","author":"WG Jaoko","year":"1995","journal-title":"East Afr Med J"},{"issue":"6","key":"ref33","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1111\/j.1365-3156.1996.tb00109.x","article-title":"Detection of circulating antigens in Gabonese patients with Loa loa filariasis","volume":"1","author":"A Walker-Deemin","year":"1996","journal-title":"Trop Med Int Health"},{"issue":"2","key":"ref34","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1007\/s00436-003-1024-1","article-title":"Identification and specificity of a 38 kDa Loa loa antigenic fraction in sera from high-microfilaraemic Gabonese patients","volume":"92","author":"A Walker-Deemin","year":"2004","journal-title":"Parasitol Res"},{"issue":"1","key":"ref35","doi-asserted-by":"crossref","first-page":"e02132","DOI":"10.1128\/mBio.02132-15","article-title":"Identification and Validation of Loa loa Microfilaria-Specific Biomarkers: a Rational Design Approach Using Proteomics and Novel Immunoassays","volume":"7","author":"PM Drame","year":"2016","journal-title":"MBio"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0006963","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,11,30]],"date-time":"2018-11-30T00:00:00Z","timestamp":1543536000000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0006963","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T05:52:08Z","timestamp":1694065928000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0006963"}},"subtitle":[],"editor":[{"given":"Sabine","family":"Specht","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,11,16]]},"references-count":35,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2018,11,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0006963","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pntd.0006963","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,16]]}}}