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Rapport synth\u00e9tique d&apos;activit\u00e9s et de resultats TMM-PAUSENS 2013 Maladies Tropicales Neglig\u00e9es. Madagascar. 2013."},{"key":"ref22","unstructured":"Minist\u00e8re de la Sant\u00e9 Publique, Gouvernement de Madagascar. Direction des Urgences et de Lutte contre les Maladies End\u00e9miques et N\u00e9glig\u00e9es: Plan Directeur de Lutte contre les Maladies Tropicales N\u00e9glig\u00e9es 2016\u20132020. Madagascar. 2016."},{"key":"ref23","unstructured":"World Bank Report No. 17507 MAG, Project appraisal document on a proposed credit in the amount of SDR 20.4 millions equivalents to the Republic of Madagascar for a community nutrition II project, March 1998. Washington DC: World Bank, 1998."},{"key":"ref24","unstructured":"Minist\u00e8re de la Sant\u00e9 Publique, Gouvernement de Madagascar. Rapport synth\u00e9tique d&apos;activit\u00e9s et de resultats TMM-PAUSENS 2014 Maladies Tropicales Neglig\u00e9es. Madagascar. 2014."},{"key":"ref25","first-page":"1","article-title":"Direction des Urgences et de Lutte contre les Maladies End\u00e9miques et N\u00e9glig\u00e9es: Plan Directeur de Lutte contre les Maladies Tropicales N\u00e9glig\u00e9es 2014\u20132018","year":"2014","journal-title":"Madagascar"},{"key":"ref26","unstructured":"World Bank. World Bank Indicator: Out-of-pocket health expenditure 2017. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/data.worldbank.org\/indicator\/SH.XPD.OOPC.TO.ZS?locations=MG\" xlink:type=\"simple\">http:\/\/data.worldbank.org\/indicator\/SH.XPD.OOPC.TO.ZS?locations=MG<\/ext-link>."},{"issue":"8","key":"ref27","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1179\/2047773211Y.0000000010","article-title":"Cost-effectiveness of triple drug administration (TDA) with praziquantel, ivermectin and albendazole for the prevention of neglected tropical diseases in Nigeria","volume":"105","author":"D Evans","year":"2013","journal-title":"Annals of Tropical Medicine & Parasitology"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1093\/inthealth\/ihs010","article-title":"Neglected tropical diseases: comparison of the costs of integrated and vertical preventive chemotherapy treatment in Niger","volume":"5","author":"J Leslie","year":"2013","journal-title":"International Health"},{"key":"ref29","unstructured":"Institute for Health Metrics and Evaluation. 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Calverton, MD, USA: 2016."},{"issue":"9541","key":"ref32","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/S0140-6736(06)69440-3","article-title":"Human schistosomiasis","volume":"368","author":"B Gryseels","year":"2006","journal-title":"The Lancet"},{"key":"ref33","unstructured":"World Health Organization. Estimates of Unit Costs for Patient Services for Madagascar 2017. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/choice\/country\/mdg\/cost\/en\/\" xlink:type=\"simple\">http:\/\/www.who.int\/choice\/country\/mdg\/cost\/en\/<\/ext-link>."},{"issue":"2","key":"ref34","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2471\/BLT.06.030353","article-title":"Impact of a national helminth control programme on infection and morbidity in Ugandan schoolchildren","volume":"85","author":"NB Kabatereine","year":"2007","journal-title":"Bull World Health Organ"},{"issue":"5","key":"ref35","doi-asserted-by":"crossref","first-page":"959","DOI":"10.4269\/ajtmh.14-0661","article-title":"The impact of Two Semiannual Treatments with Albendazole Alone on Lymphatic Filariasis and Soil-Transmitted Helminth Infections: A Community-Based Study in the Republic of Congo","volume":"92","author":"SDS Pion","year":"2015","journal-title":"The American Journal of Tropical Medicine and Hygiene"},{"key":"ref36","unstructured":"Minist\u00e8re de la Sant\u00e9 Publique, Gouvernement de Madagascar. Annuaire des Statistiques du Secteur Sante de Madagascar. Madagascar. 2015."},{"key":"ref37","unstructured":"World Bank Madagascar. Cost of treatment for lymphedema and hydrocele in Madagascar (personal communication). 2017."},{"issue":"10","key":"ref38","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.trstmh.2008.04.039","article-title":"Impact of two rounds of mass treatment with diethylcarbamazine plus albendazole on Wuchereria bancrofti infection and the sensitivity of immunochromatographic test in Malindi, Kenya","volume":"102","author":"SM Njenga","year":"2008","journal-title":"Transactions of the Royal Society of Tropical Medicine and Hygiene"},{"key":"ref39","author":"DT Jamison","year":"2012"},{"issue":"8","key":"ref40","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.jval.2016.02.017","article-title":"Country-Level Cost-Effectiveness Thresholds: Initial Estimates and the Need for Further Research","volume":"19","author":"B Woods","year":"2016","journal-title":"Value Health"},{"key":"ref41","unstructured":"Montenegro CE, Patrinos HA. Comparable estimates of returns to schooling around the world. World Bank Policy Research Working Paper. 2014;WPS7020. <comment>doi: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/doi.org\/10.1596\/1813-9450-7020\" xlink:type=\"simple\">10.1596\/1813-9450-7020<\/ext-link><\/comment>"},{"key":"ref42","author":"M. Drummond","year":"2015"},{"key":"ref43","unstructured":"Institut National de la Statistique, Gouvernement de Madagascar. Enqu\u00eate nationale sur l\u2019emploi et secteur informel (ENEMPSI). Madagascar. 2012."},{"key":"ref44","unstructured":"Gouvernement de Madagascar. D\u00e9cret N\u00ba 2017\u2013143. Fixant les Salaires Minima d&apos;Embauche et d&apos;Anciennet\u00e9 par Cat\u00e9gorie Professionnelle. Madagascar. 2017."},{"issue":"5","key":"ref45","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1093\/ije\/dyv128","article-title":"Re-analysis of health and educational impacts of a school-based deworming programme in western Kenya: a statistical replication of a cluster quasi-randomized stepped-wedge trial","volume":"44","author":"C Davey","year":"2015","journal-title":"International Journal of Epidemiology"},{"key":"ref46","unstructured":"GiveWell. Errors in DCP2 cost-effectiveness estimate for deworming 2011. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/blog.givewell.org\/2011\/09\/29\/errors-in-dcp2-cost-effectiveness-estimate-for-deworming\/\" xlink:type=\"simple\">http:\/\/blog.givewell.org\/2011\/09\/29\/errors-in-dcp2-cost-effectiveness-estimate-for-deworming\/<\/ext-link>."},{"issue":"3","key":"ref47","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/0010-4809(86)90020-0","article-title":"Probabilistic sensitivity analysis methods for general decision models","volume":"19","author":"GC Critchfield","year":"1986","journal-title":"Comput Biomed Res"},{"issue":"2","key":"ref48","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1177\/0272989X8500500205","article-title":"Probabilistic Sensitivity Analysis Using Monte Carlo Simulation","volume":"5","author":"P Doubilet","year":"2016","journal-title":"Medical Decision Making"},{"issue":"1","key":"ref49","doi-asserted-by":"crossref","DOI":"10.1186\/s40249-017-0280-8","article-title":"Building a global schistosomiasis alliance: an opportunity to join forces to fight inequality and rural poverty","volume":"6","author":"L Savioli","year":"2017","journal-title":"Infectious Diseases of Poverty"},{"key":"ref50","unstructured":"World Bank Madagascar. Estimated unit cost of drugs for neglected tropical diseases in Madagascar (personal communication). 2017."},{"issue":"7","key":"ref51","doi-asserted-by":"crossref","first-page":"e2865","DOI":"10.1371\/journal.pntd.0002865","article-title":"The Global Burden of Disease Study 2010: Interpretation and Implications for the Neglected Tropical Diseases","volume":"8","author":"N de Silva","year":"2014","journal-title":"PLoS Neglected Tropical Diseases."},{"issue":"10","key":"ref52","doi-asserted-by":"crossref","first-page":"e629","DOI":"10.1016\/S2214-109X(15)00047-9","article-title":"Comparison of community-wide, integrated mass drug administration strategies for schistosomiasis and soil-transmitted helminthiasis: a cost-effectiveness modelling study","volume":"3","author":"NC Lo","year":"2015","journal-title":"The Lancet Global Health"},{"issue":"16","key":"ref53","doi-asserted-by":"crossref","DOI":"10.1001\/jama.299.16.1937","article-title":"Efficacy of Current Drugs Against Soil-Transmitted Helminth Infections","volume":"299","author":"J Keiser","year":"2008","journal-title":"Jama"},{"issue":"1","key":"ref54","doi-asserted-by":"crossref","first-page":"86","DOI":"10.4314\/thrb.v12i1.56366","article-title":"Soil transmitted helminth infections and schistosomiasis in school age children in sub-Saharan Africa: Efficacy of chemotherapeutic intervention since World Health Assembly Resolution 2001","volume":"12","author":"C. 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Economics Working Paper Series 1711 Oklahoma State University, Department of Economics and Legal Studies in Business. 2017."},{"issue":"1","key":"ref59","doi-asserted-by":"crossref","first-page":"e40","DOI":"10.1016\/S2214-109X(16)30242-X","article-title":"Mass deworming to improve developmental health and wellbeing of children in low-income and middle-income countries: a systematic review and network meta-analysis","volume":"5","author":"VA Welch","year":"2017","journal-title":"The Lancet Global Health"},{"issue":"6","key":"ref60","doi-asserted-by":"crossref","first-page":"e0005481","DOI":"10.1371\/journal.pntd.0005481","article-title":"Should the WHO withdraw support for mass deworming?","volume":"11","author":"K Croke","year":"2017","journal-title":"PLOS Neglected Tropical Diseases"},{"key":"ref61","article-title":"Deworming drugs for soil-transmitted intestinal worms in children: effects on nutritional indicators, haemoglobin and school performance","author":"DC Taylor-Robinson","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"issue":"suppl 1","key":"ref62","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1093\/wber\/lhv008","article-title":"When Should Governments Subsidize Health? 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