{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T18:24:43Z","timestamp":1778869483470,"version":"3.51.4"},"reference-count":101,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T00:00:00Z","timestamp":1547769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/07467-1"],"award-info":[{"award-number":["2013\/07467-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["301358\/2017-6"],"award-info":[{"award-number":["301358\/2017-6"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0007017","type":"journal-article","created":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T18:23:07Z","timestamp":1547835787000},"page":"e0007017","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":25,"title":["Naja annulifera Snake: New insights into the venom components and pathogenesis of envenomation"],"prefix":"10.1371","volume":"13","author":[{"given":"Felipe","family":"Silva-de-Fran\u00e7a","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isadora Maria","family":"Villas-Boas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solange Maria de Toledo","family":"Serrano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Cogliati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia Aparecida de Andrade","family":"Chudzinski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscila Hess","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo Shigueo","family":"Kitano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinthya Kimori","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1896-9074","authenticated-orcid":true,"given":"Denise V.","family":"Tambourgi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2019,1,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1371\/journal.pmed.0030150","article-title":"Confronting the neglected problem of snake bite envenoming: the need for a global partnership","volume":"3","author":"JM Guti\u00e9rrez","year":"2006","journal-title":"PloS Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1371\/journal.pmed.0050218","article-title":"The global burden of snakebite: a literature analysis and modeling based on regional estimates of envenoming and deaths","volume":"5","author":"A Kasturiratne","year":"2008","journal-title":"PloS Med"},{"key":"ref3","first-page":"1","article-title":"Priority actions and progress to substantially and sustainably reduce the mortality, morbidity and socioeconomic burden of tropical snakebite","volume":"24","author":"RA Harrison","year":"2016","journal-title":"Toxins"},{"key":"ref4","unstructured":"The Reptile Database. Species number. 2018 [accessed Oct 18, 2018]. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.reptile-database.org\/db-info\/SpeciesStat.html\" xlink:type=\"simple\">http:\/\/www.reptile-database.org\/db-info\/SpeciesStat.html<\/ext-link>"},{"key":"ref5","article-title":"Bites of venomous snakes","author":"KS Gold","year":"2002","journal-title":"N Engl J Med"},{"key":"ref6","article-title":"A vida dos vertebrados","author":"FH Pough","year":"2008"},{"key":"ref7","unstructured":"The Reptile Database. Higher taxa in extant reptiles. 2018 [accessed Oct 18, 2018]. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.reptile-database.org\/db-info\/taxa.html\" xlink:type=\"simple\">http:\/\/www.reptile-database.org\/db-info\/taxa.html<\/ext-link>"},{"key":"ref8","unstructured":"The Reptile Database. Higher taxa: Elapidae. 2018 [accessed Oct 18, 2018]. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/reptile-database.reptarium.cz\/advanced_search?taxon=Elapidae&submit=Search\" xlink:type=\"simple\">http:\/\/reptile-database.reptarium.cz\/advanced_search?taxon=Elapidae&amp;submit=Search<\/ext-link>"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1006\/mpev.1997.0434","article-title":"Inferring species trees from trees: a phylogenetic analysis of the Elapidae (Serpentes) based on the amino acid sequences of venom proteins","volume":"8","author":"JB Slowinski","year":"1997","journal-title":"Mol Phylogenet Evol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.biochi.2003.11.012","article-title":"Snake postsynaptic neurotoxins: gene structure, phylogeny and applications in research and therapy","volume":"86","author":"JS Phui Yee","year":"2003","journal-title":"Biochimie"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/S0014-5793(01)02201-3","article-title":"New polypeptide components purified from mamba venom","volume":"491","author":"J Tytgat","year":"2001","journal-title":"FEBS Lett"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1007\/s00239-003-2573-8","article-title":"Cobra (<italic>Naja spp<\/italic>) nicotinic acetylcholine receptor exhibits resistance to erabu sea snake (Laticauda semifasciata) short-chain \u03b1- neurotoxin","volume":"58","author":"Z Takacs","year":"2004","journal-title":"J Mol Evol"},{"key":"ref13","first-page":"745","article-title":"A comparative study of cobra (<italic>Naja<\/italic>) venom enzymes","volume":"90","author":"NH Tan","year":"1988","journal-title":"Comp Biochem Physiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1021\/pr101040f","article-title":"Snake venomics of African spitting cobras: toxin composition and assessment of congeneric cross-reactivity of the pan- african echitab-plus-ICP antivenom by antivenomics and neutralization approaches","volume":"10","author":"D Petras","year":"2010","journal-title":"J Proteome Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pntd.0000622","article-title":"Diversity of <italic>Micrurus<\/italic> snake species related to their venom toxic effects and the prospective of antivenom neutralization","volume":"4","author":"GD Tanaka","year":"2010","journal-title":"Plos Negl Trop Dis"},{"key":"ref16","first-page":"1","article-title":"<italic>Micrurus<\/italic> snake venoms activate human complement system and generate anaphylatoxins","volume":"13","author":"GD Tanaka","year":"2012","journal-title":"BCM Immunol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.jprot.2013.11.012","article-title":"Proteomic analysis of Moroccan cobra <italic>Naja haje legionis<\/italic> venom using tandem mass spectrometry","volume":"16","author":"I Malih","year":"2014","journal-title":"J Proteomics"},{"key":"ref18","first-page":"1","article-title":"Comparative analysis of the venom proteome of four Malaysian snake species","volume":"20","author":"J Vejayan","journal-title":"J Venom Anim Toxins Incl Trop Dis"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.toxicon.2006.09.027","article-title":"Distribuition of low molecular weight platelet aggregation inhibitors from snake venoms","volume":"49","author":"E Oyama","year":"2006","journal-title":"Toxicon"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"13928","DOI":"10.1016\/S0021-9258(19)49658-0","article-title":"A new member of the natriuretic peptide family is present in the venom of the green mamba (<italic>Dendroaspis angusticeps<\/italic>)","volume":"267","author":"H Shweitz","year":"1992","journal-title":"J Biol Chem"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/0005-2736(83)90213-4","article-title":"The binding of snake venom cardiotoxins to heart cell membranes","volume":"732","author":"L Tonsing","year":"1983","journal-title":"Biochimt Biophysa Acta"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0019064","article-title":"Snake cytotoxins bind to membranes via interactions with phosphatidylserine head groups of lipids","volume":"6","author":"AG Konshina","year":"2011","journal-title":"Plos One"},{"key":"ref23","article-title":"Guidelines for the prevention and clinical management of snakebite in \u00c1frica","year":"2010"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.toxicon.2011.08.018","article-title":"Comparative study of the cytolytic activity of snake venoms African spitting cobras (<italic>Naja<\/italic> spp., Elapidae) and its neutralization by a polyspecific antivenom","volume":"58","author":"I Mendez","year":"2011","journal-title":"Toxicon"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.toxicon.2015.05.012","article-title":"Intracranial haemorrhages associated with Venom induced consumption coagulophaty in Australian snakebites","volume":"102","author":"I Berling","year":"2015","journal-title":"Toxicon"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1111\/j.1476-5381.1994.tb13137.x","article-title":"Pro-inflammatory activities in elapid snake venoms","volume":"112","author":"DV Tambourgi","year":"1994","journal-title":"Br J Pharmacol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"31352","DOI":"10.1074\/jbc.M302446200","article-title":"Pulmonary inflammation and edema induced by Phospolipase A2: Global gene analysis on aquaporins and Na+\/K+-ATPase","volume":"278","author":"CDN Cher","year":"2003","journal-title":"J Biol Chem"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0022-1759(03)00277-1","article-title":"Immunogenicity of venoms from four common snakes in the South of Vietnam and development of ELISA kit for venom detection","volume":"282","author":"VL Dong","year":"2003","journal-title":"J Immunol Methods"},{"key":"ref29","first-page":"75","article-title":"Snake antivenoms in southern Africa","volume":"29","author":"TL Koen","year":"2011","journal-title":"C M E"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/21564574.2004.9635504","article-title":"A review of the southern African \u201c<italic>non spitting<\/italic>\u201d cobras (Serpentes: Elapidae: <italic>Naja<\/italic>)","volume":"53","author":"DG Broadley","year":"2004","journal-title":"African J Herpet"},{"key":"ref31","unstructured":"Clinical Toxinology Resource. Snakes Search Page; 2018 [accessed Oct 18 2018]. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.toxinology.com\/fusebox.cfm?fuseaction=main.snakes.display&id=SN0231\" xlink:type=\"simple\">http:\/\/www.toxinology.com\/fusebox.cfm?fuseaction=main.snakes.display&amp;id=SN0231<\/ext-link>"},{"key":"ref32","first-page":"401","article-title":"Management of common animal bites in the emergency centre: The most common animal bites to present in emergencies are dog and snake bites","volume":"30","author":"A Eangelbrecht","year":"2012","journal-title":"Continuing Medical Education"},{"key":"ref33","first-page":"1","article-title":"The Snouted Cobra, <italic>Naja annulifera<\/italic>, Peters 1854","volume":"6","author":"L Westrin","year":"2011","journal-title":"Berus"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"169","DOI":"10.4102\/jsava.v75i4.477","article-title":"Retrospective study of snake envenomation in 155 dogs from the onderstepoort area of South Africa","volume":"75","author":"RG Lobetti","year":"2004","journal-title":"J S Afr Vet Assoc"},{"key":"ref35","first-page":"1006","article-title":"Myocardial injury in dogs with snake envenomation and its relation to systemic inflammation","volume":"24","author":"R Langhorn","year":"2014","journal-title":"J Vet Emerg Crit Care (San Antonio)"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1111\/vec.12236","article-title":"Hemostatic analysis of dogs naturally envenomed by the African Puffader (<italic>Bitis arietans<\/italic>) and Snouted Cobra (<italic>Naja annulifera<\/italic>)","volume":"24","author":"SS Nagel","year":"2014","journal-title":"J Vet Emerg Crit Care (San Antonio)"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1515\/bchm2.1973.354.2.1317","article-title":"The purification of toxins V<sup>II<\/sup>1 and V<sup>II<\/sup>2, two cytotoxin homologues from banded egyptian cobra (<italic>Naja haje annulifera<\/italic>) venom, and the complete amino acid sequence of toxin V<sup>II<\/sup>1","volume":"354","author":"KHK Weise","year":"1973","journal-title":"Hoppe Seylers Z Physiol Chem"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1515\/bchm2.1975.356.1.53","article-title":"The amino acid sequences of three toxins (CM-10, CM-12 and CM-14) from <italic>Naja haje annulifera<\/italic> (Egyptian Cobra) venom","volume":"356","author":"FJ Joubert","year":"1975","journal-title":"Hoppe Seylers Z Physiol Chem"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1515\/bchm2.1975.356.2.1893","article-title":"The amino acid sequences of toxin V<sup>II<\/sup>2, a cytotoxin homologue from banded egyptian cobra (<italic>Naja haje annulifera<\/italic>) venom","volume":"356","author":"FJ Joubert","year":"1975","journal-title":"Hoppe Seylers Z Physiol Chem"},{"key":"ref40","first-page":"1901","article-title":"The purification and amino acid sequence of toxin CM-13b from <italic>Naja haje annulifera<\/italic> (Egyptian Cobra) venom","volume":"356","author":"FJ Joubert","year":"1975","journal-title":"Hoppe Seylers Z Physiol Chem"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1432-1033.1976.tb10291.x","article-title":"The amino acid sequences of three toxins (CM-8, CM-11 and CM-13a) from <italic>Naja haje annulifera<\/italic> (Egyptian Cobra) venom","volume":"64","author":"FJ Joubert","year":"1976","journal-title":"Eur J Biochem"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.toxicon.2012.11.002","article-title":"An efficient analytical platform for on-line microfluidic profiling of neuroactive snake venoms towards nicotinic receptor affinity","volume":"61","author":"F Heus","year":"2013","journal-title":"Toxicon"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"15","author":"UK Laemmli","year":"1970","journal-title":"Nature"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0003-2697(81)90783-1","article-title":"Silver stain for proteins in polyacrilamide gels: a modified procedure with enhanced uniform sensitivity","volume":"117","author":"JH Morrissey","year":"1980","journal-title":"Anal Bioch"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"4350","DOI":"10.1073\/pnas.76.9.4350","article-title":"Eletrophoretic transfer of proteins from polyacrilamide gels to nitrocellulose sheets: procedure and some applications","volume":"76","author":"H Towbin","year":"1979","journal-title":"PNAS"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pntd.0003419","article-title":"African adders: partial characterization of snake venoms from three <italic>Bitis<\/italic> species of medical importance and their neutralization by experimental equine antivenoms","volume":"9","author":"D Paix\u00e3o-Cavalcante","year":"2015","journal-title":"Plos Negl Trop Dis"},{"key":"ref47","first-page":"161","article-title":"Protein sequencing and identification using tandem mass spectrometry","author":"M Kinter","year":"2000"},{"issue":"8","key":"ref48","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1038\/nprot.2007.261","article-title":"Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips","volume":"2","author":"J Rappsilber","year":"2007","journal-title":"Nat Protoc"},{"issue":"12","key":"ref49","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nbt.1511","article-title":"MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification","volume":"26","author":"J Cox","year":"2008","journal-title":"Nature Biotechnology"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nbt.2839","article-title":"ProteomeXchange provides globally coordinated proteomics data submission and dissemination","volume":"32","author":"J. Vizca\u00edno","year":"2014","journal-title":"Nat. Biotechnol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/0003-2697(80)90338-3","article-title":"Electrophoretic analysis of plasminogen activators in polyacrylamide gels containing sodium dodecyl sulfate and copolymerized substrates","volume":"102","author":"C Heussen","year":"1980","journal-title":"Anal Biochem"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/0041-0101(88)90245-0","article-title":"The hyaluronidase activities of some southeast asian snake venoms","volume":"26","author":"S Pukrittayakamee","year":"1988","journal-title":"Toxicon"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"T Mosmann","year":"1980","journal-title":"J Immunol Methods"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"490","DOI":"10.5858\/2009-0474-OA.1","article-title":"International normalized ratio versus plasma levels of coagulation factors in patients on vitamin L antagonist therapy","volume":"135","author":"G Gulati","journal-title":"Arch Pathol Lab Med"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.toxicon.2008.09.002","article-title":"Characterization of a new polyvalent antivenom (Antivipmyn Africa) against African vipers e elapids","volume":"52","author":"B Ramos-Cerrillo","year":"2008","journal-title":"Toxicon"},{"key":"ref56","article-title":"Probit Analysis","author":"PJ Finney","year":"1971"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/978-1-4684-0886-7_10","article-title":"Fractionation of sakishima habu (<italic>Trimeresurus elegans<\/italic>) venom and lethal hemorrhagic, and edema forming activities of fractions","volume":"48","author":"M Yamakawa","year":"1976","journal-title":"In Animal plant and microbial toxins"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.toxicon.2009.08.009","article-title":"Contribution of mast cells to the oedema induced by <italic>Bothrops moojeni<\/italic> snake venom and pharmacological assessment of the inflammatory mediator involved","volume":"55","author":"N Galv\u00e3o Nascimento","year":"2010","journal-title":"Toxicon"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.toxicon.2006.11.006","article-title":"Role of cyclooxigenases in oedema-forming activity of bothropic venoms","volume":"49","author":"R Olivo","year":"2007","journal-title":"Toxicon"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.toxicon.2014.08.001","article-title":"<italic>Bothrops jararacussu<\/italic> snake venom-induces a local inflammatory response in a prostanoid- and neutrophil-dependent manner","volume":"90","author":"CW Wanderley","year":"2014","journal-title":"Toxicon"},{"key":"ref61","first-page":"1","article-title":"Opposing roles of LTB4 and PGE2 in regulating the inflammasome-dependent scorpion venom-induced mortality","volume":"23","author":"KF Zoccal","year":"2016","journal-title":"Nat Commun"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/0014-2999(89)90364-6","article-title":"A study of phospholipase A<sub>2<\/sub>-induced oedema in rat paw","volume":"166","author":"G Cirino","year":"1989","journal-title":"Eur J Pharmacol"},{"key":"ref63","first-page":"1","article-title":"Boosting adaptive immunity: A new role for PAFR antagonists","volume":"14","author":"MM Koga","year":"2016","journal-title":"Sci Rep"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/978-1-4684-0949-9_3","article-title":"Studies on the combining sites of concanavalin A","volume":"55","author":"IJ Goldstein","year":"1975","journal-title":"Adv Exp Med Biol"},{"key":"ref65","first-page":"1","article-title":"WGA-based lectin affinity gel electrophoresis: A novel method for the detection of O-GlcNAc-modified proteins","volume":"7","author":"Y Kubota","year":"2017","journal-title":"PLoS One"},{"key":"ref66","first-page":"1","article-title":"How the cobra got its flesh-eating venom: Cytotoxicity as a defensive innovation and its co-evolutaion with hooding, aposematic marking, and spitting","volume":"13","author":"N Panagides","year":"2017","journal-title":"Toxins (Basel)"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.toxicon.2015.09.017","article-title":"Cobra venom cytotoxins: apoptotic or necrotic agents","volume":"108","author":"K Ebrahim","year":"2015","journal-title":"Toxicon"},{"issue":"8","key":"ref68","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1021\/acs.jproteome.6b00217","article-title":"Proteomic and glycoproteomic profilings reveal that post-translational modifications of toxins contribute to venom phenotype in snakes","volume":"15","author":"D Andrade-Silva","year":"2016","journal-title":"J Proteome Res"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.jprot.2011.09.017","article-title":"N-glycome profiling of <italic>Bothrops jararaca<\/italic> newborn and adults venoms","volume":"75","author":"A Zelanis","year":"2012","journal-title":"J Proteome Res"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1021\/pr901027r","article-title":"Analysis of the ontogenetic variation in the venom proteome\/peptidome of <italic>Bothrops jararaca<\/italic> reveals different strategies to deal with prey","volume":"9","author":"A Zelanis","year":"2010","journal-title":"J Proteome Res"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/nri800","article-title":"Evolution of the lectin-complement pathway and its role in innate immunity","volume":"2","author":"T Fujita","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nrneph.2016.70","article-title":"Complement in disease: a defence system turning offensive","volume":"12","author":"D Ricklin","year":"2016","journal-title":"Nat Rev Nephrol"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"4544","DOI":"10.1111\/j.1742-4658.2011.08115.x","article-title":"Enzymatic toxins from snake venom: structural characterization and mechanisms of catalysis","volume":"278","author":"TS Kang","year":"2011","journal-title":"FEBS J"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/0305-0491(88)90329-X","article-title":"A comparative study of cobra (<italic>Naja<\/italic>) venom enzymes","volume":"90","author":"NH Tan","year":"1988","journal-title":"Comp Biochem Physiol B"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/0305-0491(92)90029-Q","article-title":"The biological properties of venoms of some American coral snakes (Genus <italic>Micrurus<\/italic>)","volume":"101","author":"NH Tan","year":"1992","journal-title":"Comp Biochem Physiol B"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.toxicon.2012.06.004","article-title":"No evidence for proteolytic venom resistance in southern African ground squirrels","volume":"60","author":"MA Phillips","year":"2012","journal-title":"Toxicon"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/cbf.1261","article-title":"Snake venom hyaluronidase: a therapeutic target","volume":"24","author":"K Kemparaju","year":"2006","journal-title":"Cell Biochem Funct"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1089\/ten.tea.2013.0403","article-title":"Hyaluronidase-Loaded PLGA Microparticles as a new strategy for the treatment of pulmonary fibrosis","volume":"21","author":"CD Bitencourt","year":"2015","journal-title":"Tissue Eng Part A"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1038\/nm1315","article-title":"Regulation of lung injury and repair by Toll-like receptors and hyaluronan","volume":"11","author":"D Jiang","year":"2005","journal-title":"Nat Med"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1194\/jlr.R800033-JLR200","article-title":"Phospholipase A<sub>2<\/sub> structure\/function, mechanisms, and signaling","volume":"50","author":"JE Burke","year":"2009","journal-title":"J Lipid Res"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1590\/S0103-50532011000200016","article-title":"Evaluation of snake Venom Phospholipase A<sub>2<\/sub>: hydrolysis of non-natural esters","volume":"22","author":"RAS Pirolla","year":"2011","journal-title":"J Braz Chem Soc"},{"issue":"1","key":"ref82","doi-asserted-by":"crossref","first-page":"15514","DOI":"10.1038\/s41598-017-15614-z","article-title":"PLA2-like proteins myotoxic mechanism: a dynamic model description","volume":"7","author":"RJ Borges","year":"2017","journal-title":"Sci Rep. Nov 14"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0093741","article-title":"Critical role of TLR2 and MyD88 for functional response of macrophages to a group IIA-secreted phospholipase A2 from snake venom","volume":"9","author":"E Leiguez","year":"2014","journal-title":"PLoS One"},{"key":"ref84","first-page":"153","article-title":"Elucidating the biogeographical variation of the venom of <italic>Naja naja<\/italic> (spectacled cobra) from Pakistan through a venom-decomplexing proteomic study","volume":"175","author":"KY Wong","year":"2018","journal-title":"J Proteomics"},{"key":"ref85","article-title":"Venomics, lethality and neutralization of <italic>Naja kaouthia<\/italic> (monocloned cobra) venoms from three different geographical regions of Southeast Asia","author":"KY Tan","year":"2015"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jprot.2016.08.024","article-title":"Exploring the venom of the forest cobra: Toxicovenomics and antivenom profiling of <italic>Naja melanoleuca<\/italic>","volume":"150","author":"LP Lauridsen","year":"2016","journal-title":"J Proteomics"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1016\/j.jprot.2013.11.012","article-title":"Proteomic analysis of Moroccan cobra <italic>Naja haje legionis<\/italic> venom using tandem mass spectrometry","volume":"96","author":"I Malih","year":"2014","journal-title":"J Proteomics"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.toxicon.2018.04.013","article-title":"Snake venoms from Angola: Intra-specific variations and immunogenicity","volume":"148","author":"PR Sim\u00f5es de Oliveira","year":"2018","journal-title":"Toxicon"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/0049-3848(89)90056-X","article-title":"The inhibition of clotting complexes of the extrinsic cascade by the phospholipase A<sub>2<\/sub> isoenzymes from <italic>Naja nigricollis<\/italic> venom","volume":"15","author":"S Stefansson","year":"1989","journal-title":"Thromb Res"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"7742","DOI":"10.1021\/bi00485a024","article-title":"The basic phospholipase A<sub>2<\/sub> from <italic>Naja nigricollis<\/italic> venom inhibits the prothrombinase complex by a novel nonenzymatic mechanism","volume":"21","author":"S Stefansson","year":"1990","journal-title":"Biochemistry"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1016\/0041-0101(95)00103-4","article-title":"The role of enzymatic activity in inhibition of the extrinsic tenase complex by phospholipase A<sub>2<\/sub> isoenzymes from <italic>Naja nigricollis<\/italic> venom","volume":"33","author":"RM Kini","year":"1995","journal-title":"Toxicon"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1006\/abbi.1999.1345","article-title":"Targeting of venom phospholipase: the strongly anticoagulant Phospholipase A<sub>2<\/sub> from <italic>Naja nigricollis<\/italic> venom binds to coagulation factor Xa to inhibit the protrombinase complex","volume":"369","author":"RT Kerns","year":"1999","journal-title":"Arch Biochem Biophys"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1136\/jcp.22.3.304","article-title":"Effects three cobra venoms on blood coagulation, platelet aggregation, and fibrinolysis","volume":"22","author":"N MacKay","year":"1969","journal-title":"J clin Path"},{"key":"ref94","article-title":"International symposium on coral snakes: Elapidae snakebite in Africa and Asia","author":"J White","year":"2016"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S0041-0101(99)00184-1","article-title":"Sea snake <italic>Hydrophis cyanocinctus<\/italic> venom. II. Histopathological changes, induced by a myotoxic phospholipase A<sub>2<\/sub> (PLA<sub>2<\/sub>-H1)","volume":"38","author":"SA Ali","year":"2000","journal-title":"Toxicon"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/0041-0101(93)90376-T","article-title":"Cardiotoxin 1 from cobra (<italic>Naja naja atra<\/italic>) venom causes necrosis of skeletal muscle in vivo","volume":"31","author":"CL Ownby","year":"1993","journal-title":"Toxicon"},{"key":"ref97","first-page":"611","article-title":"Interleukin-6 production in hemorrhagic shock is accompanied by neutrophil recruitment and lung injury","volume":"275","author":"C Hierholzer","year":"1998","journal-title":"Am J Physiol"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1152\/ajpregu.00650.2006","article-title":"Monocyte chemoattractant protein-1 influences trauma-hemorrhage-induced distal organ damage via regulation of keratinocyte-derived chemokine production","volume":"292","author":"M Frink","year":"2006","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.cyto.2010.09.005","article-title":"Productive capacity of alveolar macrophages and pulmonar organ damage after femoral fracture and hemorrhage in IL-6 knockout mice","volume":"53","author":"P Mommsen","year":"2011","journal-title":"Cytokine"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pntd.0004325","article-title":"Development of equine IgG antivenoms against major snake groups in Mozambique","volume":"10","author":"FR Guidolin","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.toxicon.2016.11.259","article-title":"Expanding the neutralization scope of the EchiTAb-plus-ICP antivenom to include venoms of elapids from Southern Africa","volume":"125","author":"A S\u00e1nchez","year":"2017","journal-title":"Toxicon"}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0007017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T17:17:35Z","timestamp":1662830255000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0007017"}},"subtitle":[],"editor":[{"given":"Nicholas R.","family":"Casewell","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,1,18]]},"references-count":101,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,1,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0007017","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,18]]}}}