{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:25:28Z","timestamp":1790724328693,"version":"4.1.0"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T00:00:00Z","timestamp":1547596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008777","name":"Fundaci\u00f3n Bunge y Born","doi-asserted-by":"publisher","award":["Chagas-2012"],"award-info":[{"award-number":["Chagas-2012"]}],"id":[{"id":"10.13039\/501100008777","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","award":["PIP \/0974-2011"],"award-info":[{"award-number":["PIP \/0974-2011"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","award":["PIP \/0547-2015"],"award-info":[{"award-number":["PIP \/0547-2015"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007637","name":"Departamento Administrativo de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["CT 657-2015"],"award-info":[{"award-number":["CT 657-2015"]}],"id":[{"id":"10.13039\/100007637","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0007033","type":"journal-article","created":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T18:38:09Z","timestamp":1547663889000},"page":"e0007033","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Association study between CCR2-CCR5 genes polymorphisms and chronic Chagas heart disease in Wichi and in admixed populations from Argentina"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3330-4425","authenticated-orcid":true,"given":"Natalia Anah\u00ed","family":"Juiz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elkyn","family":"Estupi\u00f1\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Garcilazo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal","family":"Chadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisela","family":"Morales Sanfurgo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro Gabriel","family":"Schijman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5036-8717","authenticated-orcid":true,"given":"Silvia Andrea","family":"Longhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara Isabel","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,1,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ijcha.2015.10.001","article-title":"Clinical predictors of inducible sustained ventricular tachycardia during electrophysiologic study in patients with chronic Chagas\u2019 heart disease. International Journal of Cardiology Heart &amp;","volume":"9","author":"A Cardinalli-Neto","year":"2015","journal-title":"Vasculature"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ijcard.2009.04.034","article-title":"Predicting prognosis in patients with Chagas disease: why are the results of various studies so different?","volume":"145","author":"A Rassi Jr","year":"2010","journal-title":"Int J Cardiol"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.meegid.2011.12.009","article-title":"The revised Trypanosoma cruzi subspecific nomenclature: rationale, epidemiological relevance and research applications","volume":"12","author":"B Zingales","year":"2012","journal-title":"Infect Genet Evol"},{"issue":"5","key":"ref4","doi-asserted-by":"crossref","first-page":"e687","DOI":"10.1371\/journal.pntd.0000687","article-title":"Lineage Analysis of Circulating Trypanosoma cruzi Parasites and Their Association with Clinical Forms of Chagas Disease in Bolivia","volume":"4","author":"R Del Puerto","year":"2010","journal-title":"PLoS Neglected Tropical Diseases"},{"issue":"8","key":"ref5","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1007\/s00436-015-4503-2","article-title":"Trypanosoma cruzi burden, genotypes, and clinical evaluation of Chilean patients with chronic Chagas cardiopathy","volume":"114","author":"W Apt","year":"2015","journal-title":"Parasitology Research"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.cyto.2012.04.035","article-title":"Genetic susceptibility to chronic Chagas disease: an overview of single nucleotide polymorphisms of cytokine genes","volume":"59","author":"RHT Vasconcelos","year":"2012","journal-title":"Cytokine"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1399-0039.1998.tb03028.x","article-title":"Polymorphisms at tumor necrosis factor (TNF) loci are not associated with Chagas\u2019 disease\u2019","volume":"52","author":"Y Bera\u00fan","year":"1998","journal-title":"Tissue Antigens"},{"issue":"1","key":"ref8","first-page":"97","article-title":"Tumor necrosis factor-alpha promoter polymorphism in Mexican patients with Chagas\u2019 disease. Immunol","volume":"98","author":"JM Rodr\u00edguez-P\u00e9rez","year":"2005","journal-title":"Lett"},{"issue":"3\u20134","key":"ref9","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1080\/08820130902729637","article-title":"Association between IL-1B and IL-1RN gene polymorphisms and Chagas&apos; disease development susceptibility","volume":"38","author":"D Cruz-Robles","year":"2009","journal-title":"Immunol Invest"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.cyto.2011.12.007","article-title":"Genetic polymorphisms in TNFA\/TNFR2 genes and Chagas disease in a Colombian endemic population","volume":"57","author":"L Criado","year":"2012","journal-title":"Cytokine"},{"issue":"9","key":"ref11","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/j.1365-3024.2011.01314.x","article-title":"Interleukin 4, interleukin 4 receptor-\u03b1 and interleukin 10 gene polymorphisms in Chagas disease","volume":"33","author":"O Fl\u00f3rez","year":"2011","journal-title":"Parasite Immunol"},{"issue":"9","key":"ref12","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.humimm.2006.06.004","article-title":"Interleukin-1 gene cluster polymorphism in chagas disease in a Colombian case-control study","volume":"67","author":"O Fl\u00f3rez","year":"2006","journal-title":"Hum. Immunol"},{"issue":"2","key":"ref13","first-page":"131","article-title":"Lack of association between IL-6-174G\/C gene polymorphism and Chagas disease","volume":"76","author":"OA Torres","year":"2010","journal-title":"Tissue Antigens"},{"issue":"5","key":"ref14","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.meegid.2010.03.009","article-title":"Role of the IFNG +874T\/A polymorphism in Chagas disease in a Colombian population","volume":"10","author":"OA Torres","year":"2010","journal-title":"Infect Genet Evol"},{"issue":"12","key":"ref15","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1016\/j.humimm.2014.09.023","article-title":"SNP\/haplotype associations of CCR2 and CCR5 genes with severity of chagasic cardiomyopathy","volume":"75","author":"MA Machuca","year":"2014","journal-title":"Hum Immunol"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1086\/596061","article-title":"Functional IL-10 gene polymorphism is associated with Chagas disease cardiomyopathy","volume":"199","author":"GC Costa","year":"2009","journal-title":"J Infect Dis"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"e976","DOI":"10.1371\/journal.pntd.0000976","article-title":"Genetic and Functional Role of TNF-alpha in the Development Trypanosoma cruzi Infection","volume":"5","author":"CW Pissetti","year":"2011","journal-title":"PLoS Neglected Tropical Diseases"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.micinf.2005.08.009","article-title":"TNF gene polymorphisms are associated with reduced survival in severe Chagas&apos; disease cardiomyopathy patients","volume":"8","author":"SA Drigo","year":"2006","journal-title":"Microbes Infect"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"615","DOI":"10.3389\/fimmu.2018.00615","article-title":"Genetic Polymorphism at CCL5 Is Associated With Protection in Chagas&apos; Heart Disease: Antagonistic Participation of CCR1(+) and CCR5(+) Cells in Chronic Chagasic Cardiomyopathy","volume":"9","author":"AM Batista","year":"2018","journal-title":"Front Immunol"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.jaci.2010.10.026","article-title":"Sequence variation in the IL4 gene and resistance to Trypanosoma cruzi infection in Bolivians","volume":"127","author":"LE Alvarado Arnez","year":"2011","journal-title":"The Journal of Allergy and Clinical Immunology"},{"issue":"6","key":"ref21","first-page":"33","article-title":"Chagas disease in Latin America: an epidemiological update based on 2010 estimates. World Health Organization, 2015","volume":"90","year":"2015","journal-title":"Wkly Epidemiol Rec"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1258\/000456306776865205","article-title":"HLA class II DRB1 polymorphism in Argentinians undergoing chronic Trypanosoma cruzi infection","volume":"43","author":"S Garc\u00eda Borr\u00e1s","year":"2006","journal-title":"Ann Clin Biochem"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1080\/08820130902766589","article-title":"Distribution of HLA-DRB1 alleles in Argentinean patients with Chagas\u2019 disease cardiomyopathy","volume":"38","author":"S Garc\u00eda Borr\u00e1s","year":"2009","journal-title":"Immunological Investigations"},{"issue":"8","key":"ref24","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.humimm.2012.04.005","article-title":"Genetic variants in the chemokines and chemokine receptors in Chagas disease","volume":"73","author":"O Fl\u00f3rez","year":"2012","journal-title":"Hum Immunol"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1189\/jlb.1009671","article-title":"Dual targeting of CCR2 and CCR5: therapeutic potential for immunologic and cardiovascular diseases","volume":"88","author":"Q. Zhao","year":"2010","journal-title":"J Leukoc Biol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/447655a","article-title":"Replicating genotype-phenotype associations","volume":"447","author":"SJ Chanock","year":"2007","journal-title":"Nature"},{"issue":"6","key":"ref27","first-page":"544","article-title":"Consenso de Enfermedad de Chagas-Mazza","volume":"79","year":"2011","journal-title":"Rev. argent. cardiol., Ciudad Aut\u00f3noma de Buenos Aires"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"S Purcell","year":"2007","journal-title":"Am J Hum Genet"},{"key":"ref29","first-page":"47","article-title":"Arlequin (version 3.0): an integrated software package for population genetics data analysis","volume":"1","author":"L Excoffier","year":"2007","journal-title":"Evol Bioinform Online"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"Haploview: analysis and visualization of LD and haplotype maps","volume":"21","author":"JC Barrett","year":"2005","journal-title":"Bioinformatics"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/bioinformatics\/19.1.149","article-title":"Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits","volume":"19","author":"S Purcell","year":"2003","journal-title":"Bioinformatics"},{"issue":"25","key":"ref32","doi-asserted-by":"crossref","first-page":"18946","DOI":"10.1074\/jbc.M000169200","article-title":"Evolution of human and non-human primate CC chemokine receptor 5 gene and mRNA. Potential roles for haplotype and mRNA diversity, differential haplotype-specific transcriptional activity, and altered transcription factor binding to polymorphic nucleotides in the pathogenesis of HIV-1 and simian immunodeficiency virus","volume":"275","author":"S Mummidi","year":"2000","journal-title":"J Biol Chem"},{"issue":"2","key":"ref33","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1093\/genetics\/155.2.945","article-title":"Inference of population structure using multilocus genotype data","volume":"155","author":"JK Pritchard","year":"2000","journal-title":"Genetics"},{"issue":"5602","key":"ref34","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1126\/science.1078311","article-title":"Genetic structure of human populations","volume":"298","author":"NA Rosenberg","year":"2002","journal-title":"Science"},{"issue":"2","key":"ref35","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/nrg2734","article-title":"How culture shaped the human genome: bringing genetics and the human sciences together","volume":"11","author":"KN Laland","year":"2010","journal-title":"Nat Rev Genet"},{"issue":"7","key":"ref36","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1073\/pnas.0307312101","article-title":"A 9,000-year record of Chagas&apos; disease","volume":"101","author":"AC Aufderheide","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"ref37","doi-asserted-by":"crossref","first-page":"e64054","DOI":"10.1371\/journal.pone.0064054","article-title":"Analysis of population substructure in two sympatric populations of Gran Chaco, Argentina","volume":"8","author":"F Sevini","year":"2013","journal-title":"PLoS One"},{"issue":"5","key":"ref38","doi-asserted-by":"crossref","first-page":"687","DOI":"10.3378\/027.085.0503","article-title":"Genetic Variation of X-STRs in the Wich\u00ed Population from Chaco Province, Argentina","volume":"85","author":"LA Glesmann","year":"2013","journal-title":"Hum Biol"},{"issue":"5","key":"ref39","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1590\/S0074-02762010000500004","article-title":"Chagas disease: serological and electrocardiographic studies in Wichi and Creole communities of Misi\u00f3n Nueva Pompeya, Chaco, Argentina","volume":"105","author":"E Moretti","year":"2010","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.meegid.2016.08.012","article-title":"The role of CCR5 in Chagas disease\u2014a systematic review","volume":"45","author":"AP de Oliveira","year":"2016","journal-title":"Infection, Genetics and Evolution"},{"issue":"7","key":"ref41","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.humimm.2004.05.002","article-title":"Is the CCR5-59029-G\/G genotype a protective factor for cardiomyopathy in Chagas disease?","volume":"65","author":"MT Fern\u00e1ndez-Mestre","year":"2004","journal-title":"Hum Immunol"},{"issue":"3","key":"ref42","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1034\/j.1399-0039.2001.580302.x","article-title":"Chemokine receptor CCR5 polymorphisms and Chagas&apos; disease cardiomyopathy","volume":"58","author":"JE Calzada","year":"2001","journal-title":"Tissue Antigens"}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0007033","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T11:48:44Z","timestamp":1662810524000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0007033"}},"subtitle":[],"editor":[{"given":"Walderez O.","family":"Dutra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,1,16]]},"references-count":42,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,1,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0007033","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,16]]}}}