{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T22:39:50Z","timestamp":1790548790195,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0007089","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T00:00:00Z","timestamp":1549497600000}}],"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T00:00:00Z","timestamp":1548633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Brazil National Institute of Science and Technology - Tropical Diseases","award":["CNPq:465229\/2014-0"],"award-info":[{"award-number":["CNPq:465229\/2014-0"]}]},{"name":"Heiser Foundation for Leprosy Research"},{"name":"Burroughs Wellcome Fund \/ American Society of Tropical Medicine and Hygiene","award":["Postdoctoral fellowship"],"award-info":[{"award-number":["Postdoctoral fellowship"]}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0007089","type":"journal-article","created":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T18:43:00Z","timestamp":1548700980000},"page":"e0007089","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Differential immunoglobulin and complement levels in leprosy prior to development of reversal reaction and erythema nodosum leprosum"],"prefix":"10.1371","volume":"13","author":[{"given":"Francianne M.","family":"Amorim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maur\u00edcio L.","family":"Nobre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa S.","family":"Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alesson M.","family":"Miranda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gl\u00f3ria R. G.","family":"Monteiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco P.","family":"Freire-Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria do Carmo Palmeira","family":"Queiroz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 W.","family":"Queiroz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm S.","family":"Duthie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos R.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven G.","family":"Reed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren D.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7100-2917","authenticated-orcid":true,"given":"Kathryn M.","family":"Dupnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selma M. B.","family":"Jeronimo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,1,28]]},"reference":[{"key":"ref1","article-title":"Chemotherapy of Leprosy for Control Programmes","year":"1982"},{"issue":"11","key":"ref2","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1002\/eji.201142198","article-title":"CD163 favors Mycobacterium leprae survival and persistence by promoting anti-inflammatory pathways in lepromatous macrophages","volume":"42","author":"DF Moura","year":"2012","journal-title":"Eur J Immunol"},{"issue":"12","key":"ref3","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1038\/ng.477","article-title":"Comparative genomic and phylogeographic analysis of Mycobacterium leprae","volume":"41","author":"M Monot","year":"2009","journal-title":"Nat Genet"},{"issue":"5639","key":"ref4","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1126\/science.1087785","article-title":"Use of genetic profiling in leprosy to discriminate clinical forms of the disease","volume":"301","author":"JR Bleharski","year":"2003","journal-title":"Science"},{"issue":"5029","key":"ref5","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1126\/science.1925582","article-title":"Defining protective responses to pathogens: cytokine profiles in leprosy lesions","volume":"254","author":"M Yamamura","year":"1991","journal-title":"Science"},{"issue":"3","key":"ref6","first-page":"255","article-title":"Classification of leprosy according to immunity. A five-group system","volume":"34","author":"DS Ridley","year":"1966","journal-title":"Int J Lepr Other Mycobact Dis"},{"issue":"3","key":"ref7","first-page":"254","article-title":"Leprosy control policies set by WHO","volume":"43","author":"K. Saigawa","year":"1974","journal-title":"Repura"},{"issue":"3","key":"ref8","first-page":"328","article-title":"Progress of impairment scores following commencement of chemotherapy in multibacillary leprosy patients","volume":"65","author":"NK Reed","year":"1997","journal-title":"Int J Lepr Other Mycobact Dis"},{"issue":"4","key":"ref9","doi-asserted-by":"crossref","first-page":"304","DOI":"10.47276\/lr.86.4.304","article-title":"Erythema nodosum leprosum research: ENLISTing support","volume":"86","author":"SL Walker","year":"2015","journal-title":"Lepr Rev"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"372","DOI":"10.47276\/lr.79.4.372","article-title":"Leprosy type 1 (reversal) reactions and their management","volume":"79","author":"SL Walker","year":"2008","journal-title":"Lepr Rev"},{"issue":"12","key":"ref11","doi-asserted-by":"crossref","first-page":"e351","DOI":"10.1371\/journal.pntd.0000351","article-title":"Development and validation of a severity scale for leprosy type 1 reactions","volume":"2","author":"SL Walker","year":"2008","journal-title":"PLoS Negl Trop Dis"},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.trstmh.2008.01.004","article-title":"Towards understanding the pathology of erythema nodosum leprosum","volume":"102","author":"IP Kahawita","year":"2008","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3389\/fimmu.2017.00233","article-title":"A Systematic Review of Immunological Studies of Erythema Nodosum Leprosum","volume":"8","author":"A Polycarpou","year":"2017","journal-title":"Front Immunol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"499","DOI":"10.47276\/lr.88.4.499","article-title":"The impact of Erythema Nodosum Leprosum on health related quality of life in Rio de Janeiro","volume":"88","author":"X Sales AMI","year":"2017","journal-title":"Lepr Rev"},{"issue":"10","key":"ref15","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1093\/infdis\/jiu612","article-title":"Transcriptional changes that characterize the immune reactions of leprosy","volume":"211","author":"KM Dupnik","year":"2015","journal-title":"J Infect Dis"},{"issue":"7","key":"ref16","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.humpath.2006.12.017","article-title":"Leprosy-specific B-cells within cellular infiltrates in active leprosy lesions","volume":"38","author":"AM Iyer","year":"2007","journal-title":"Hum Pathol"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1365-2567.2010.03314.x","article-title":"A role for interleukin-5 in promoting increased immunoglobulin M at the site of disease in leprosy","volume":"131","author":"MT Ochoa","year":"2010","journal-title":"Immunology"},{"issue":"12","key":"ref18","doi-asserted-by":"crossref","first-page":"e0006121","DOI":"10.1371\/journal.pntd.0006121","article-title":"Increased activated memory B-cells in the peripheral blood of patients with erythema nodosum leprosum reactions","volume":"11","author":"E Negera","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nrmicro3415","article-title":"Pathogen manipulation of B cells: the best defence is a good offence","volume":"13","author":"K Nothelfer","year":"2015","journal-title":"Nat Rev Microbiol"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/cr.2009.139","article-title":"Complement and its role in innate and adaptive immune responses","volume":"20","author":"JR Dunkelberger","year":"2010","journal-title":"Cell Res"},{"issue":"6466","key":"ref21","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/368070a0","article-title":"A 13-amino-acid motif in the cytoplasmic domain of Fc gamma RIIB modulates B-cell receptor signalling","volume":"368","author":"T Muta","year":"1994","journal-title":"Nature"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.clim.2010.08.006","article-title":"Down regulation of Fc and complement receptors on B cells in rheumatoid arthritis","volume":"137","author":"KE Prokopec","year":"2010","journal-title":"Clin Immunol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1196\/annals.1422.020","article-title":"Altered expression of Fcgamma and complement receptors on B cells in systemic lupus erythematosus","volume":"1108","author":"P Gergely Jr.","year":"2007","journal-title":"Ann N Y Acad Sci"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/intimm\/dxm132","article-title":"Physiological up-regulation of inhibitory receptors Fc gamma RII and CR1 on memory B cells is lacking in SLE patients","volume":"20","author":"A Isaak","year":"2008","journal-title":"Int Immunol"},{"key":"ref25","unstructured":"Leprosy elimination: Diagnosis of Leprosy [November 1, 2018]. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/lep\/diagnosis\/en\/\" xlink:type=\"simple\">http:\/\/www.who.int\/lep\/diagnosis\/en\/<\/ext-link>."},{"key":"ref26","year":"2010","unstructured":"Br\u00e1sil. <chapter-title>Guia de procedimentos t\u00e9cnicos: Baciloscopia em Hansen\u00edase [Guide to technical procedures: Bacilloscopy in Hansen\u2019s Disease]<\/chapter-title>. <publisher-loc>Bras\u00edlia<\/publisher-loc>: <publisher-name>Minist\u00e9rio da Sa\u00fade<\/publisher-name>; <year>2010<\/year>."},{"key":"ref27","unstructured":"How to recognize and manage leprosy reactions: Learning Guide 2. In: (ILEP) TIFoA-LA, editor. 2002."},{"issue":"3","key":"ref28","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nri3158","article-title":"Standardizing immunophenotyping for the Human Immunology Project","volume":"12","author":"HT Maecker","year":"2012","journal-title":"Nat Rev Immunol"},{"issue":"9","key":"ref29","doi-asserted-by":"crossref","first-page":"e0004934","DOI":"10.1371\/journal.pntd.0004934","article-title":"Identifying Leprosy and Those at Risk of Developing Leprosy by Detection of Antibodies against LID-1 and LID-NDO","volume":"10","author":"FM Amorim","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.diagmicrobio.2014.02.006","article-title":"A rapid ELISA for the diagnosis of MB leprosy based on complementary detection of antibodies against a novel protein-glycolipid conjugate","volume":"79","author":"MS Duthie","year":"2014","journal-title":"Diagn Microbiol Infect Dis"},{"issue":"4","key":"ref31","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.4049\/jimmunol.1301361","article-title":"CD19 and CD32b differentially regulate human B cell responsiveness","volume":"192","author":"JL Karnell","year":"2014","journal-title":"J Immunol"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s40249-016-0203-0","article-title":"Can baseline ML Flow test results predict leprosy reactions? An investigation in a cohort of patients enrolled in the uniform multidrug therapy clinical trial for leprosy patients in Brazil","volume":"5","author":"EM Hungria","year":"2016","journal-title":"Infect Dis Poverty"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"520","DOI":"10.3389\/fimmu.2014.00520","article-title":"IgG subclasses and allotypes: from structure to effector functions","volume":"5","author":"G Vidarsson","year":"2014","journal-title":"Front Immunol"},{"issue":"1","key":"ref34","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nri2206","article-title":"Fcgamma receptors as regulators of immune responses","volume":"8","author":"F Nimmerjahn","year":"2008","journal-title":"Nat Rev Immunol"},{"issue":"5","key":"ref35","doi-asserted-by":"crossref","first-page":"e0004703","DOI":"10.1371\/journal.pntd.0004703","article-title":"Anti-PGL-1 Positivity as a Risk Marker for the Development of Leprosy among Contacts of Leprosy Cases: Systematic Review and Meta-analysis","volume":"10","author":"ML Penna","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"issue":"2","key":"ref36","doi-asserted-by":"crossref","first-page":"e0005396","DOI":"10.1371\/journal.pntd.0005396","article-title":"Leprosy reactions: The predictive value of Mycobacterium leprae-specific serology evaluated in a Brazilian cohort of leprosy patients (U-MDT\/CT-BR)","volume":"11","author":"EM Hungria","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"issue":"Suppl 2","key":"ref37","first-page":"67","article-title":"Association between leprosy reactions after treatment and bacterial load evaluated using anti PGL-I serology and bacilloscopy","volume":"41","author":"F Brito Mde","year":"2008","journal-title":"Rev Soc Bras Med Trop"},{"issue":"3","key":"ref38","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1093\/trstmh\/trx026","article-title":"Anti-natural octyl disaccharide-leprosy IDRI diagnostic (NDO-LID) antibodies as indicators of leprosy reactions and neuritis","volume":"111","author":"H Serrano-Coll","year":"2017","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"2","key":"ref39","first-page":"105","article-title":"Selective decrease of M. leprae-specific IgG1 and IgG3 antibodies in leprosy patients associated with ENL","volume":"64","author":"A Kifayet","year":"1996","journal-title":"Int J Lepr Other Mycobact Dis"},{"issue":"2","key":"ref40","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.molimm.2015.03.255","article-title":"Molecular properties of human IgG subclasses and their implications for designing therapeutic monoclonal antibodies against infectious diseases","volume":"67","author":"V Irani","year":"2015","journal-title":"Mol Immunol"},{"issue":"11","key":"ref41","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/0019-2791(71)90489-7","article-title":"The reaction of monomeric and aggregated immunoglobulins with C1","volume":"8","author":"W Augener","year":"1971","journal-title":"Immunochemistry"},{"issue":"3","key":"ref42","doi-asserted-by":"crossref","first-page":"e0006321","DOI":"10.1371\/journal.pntd.0006321","article-title":"Complement C1q expression in Erythema nodosum leprosum","volume":"12","author":"E Negera","year":"2018","journal-title":"PLoS Negl Trop Dis"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0007089","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T00:00:00Z","timestamp":1549497600000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0007089","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T23:20:04Z","timestamp":1606260004000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0007089"}},"subtitle":[],"editor":[{"given":"Diana N. J.","family":"Lockwood","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,1,28]]},"references-count":42,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,1,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0007089","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pntd.0007089","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,28]]}}}