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Weng","year":"2018","journal-title":"Infectious diseases of poverty"},{"issue":"7","key":"ref15","doi-asserted-by":"crossref","first-page":"e2865","DOI":"10.1371\/journal.pntd.0002865","article-title":"The global burden of disease study 2010: interpretation and implications for the neglected tropical diseases.","volume":"8","author":"PJ Hotez","year":"2014","journal-title":"PLoS neglected tropical diseases"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"281","DOI":"10.4269\/ajtmh.1994.50.281","article-title":"Kinetics of egg production and egg excretion by <italic>Schistosoma mansoni<\/italic> and <italic>S<\/italic>. <italic>japonicum<\/italic> in mice infected with a single pair of worms","volume":"50","author":"AW Cheever","year":"1994","journal-title":"The American journal of tropical medicine and hygiene"},{"issue":"6","key":"ref17","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1097\/QCO.0b013e328318978f","article-title":"Praziquantel: 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<italic>Schistosoma mansoni<\/italic> isolates and the generation of a laboratory strain with reduced susceptibility to the drug","volume":"4","author":"IN Mwangi","year":"2014","journal-title":"International journal for parasitology Drugs and drug resistance"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.molbiopara.2014.06.002","article-title":"Schistosomiasis control: praziquantel forever?","volume":"195","author":"D Cioli","year":"2014","journal-title":"Molecular and biochemical parasitology"},{"issue":"1","key":"ref22","first-page":"33","article-title":"Schistosomiasis-Studien. II. \u00dcber die Eibildung bei <italic>Schistosoma mansoni<\/italic> und das Schicksal der Eier im Wirtsorganismus","volume":"6","author":"R G\u00f6nnert","year":"1955","journal-title":"Zeitschrift fur Tropenmedizin und Parasitologie"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0166-6851(94)00058-U","article-title":"The female-specific W1 sequence of the Puerto Rican strain of <italic>Schistosoma mansoni<\/italic> occurs in both genders of a Liberian strain","volume":"71","author":"CG Grevelding","year":"1995","journal-title":"Molecular and biochemical parasitology"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/BF00930846","article-title":"Enhanced efficacy of the paddling method for schistosome infection of rodents by a four-step pre-soaking procedure","volume":"76","author":"CD Dettman","year":"1989","journal-title":"Parasitology research"},{"issue":"s1","key":"ref25","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1517\/17460441.2.S1.S53","article-title":"Schistosomes: challenges in compound screening.","volume":"2","author":"B Ramirez","year":"2007","journal-title":"Expert opinion on drug discovery"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1472-6750-3-18","article-title":"Real-time PCR based on SYBR-Green I fluorescence: an alternative to the TaqMan assay for a relative quantification of gene rearrangements, gene amplifications and micro gene deletions","volume":"3","author":"F Ponchel","year":"2003","journal-title":"BMC biotechnology"},{"issue":"4","key":"ref27","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods (San Diego, Calif)."},{"issue":"7","key":"ref28","doi-asserted-by":"crossref","first-page":"e2336","DOI":"10.1371\/journal.pntd.0002336","article-title":"Whole-organ isolation approach as a basis for tissue-specific analyses in <italic>Schistosoma mansoni<\/italic>","volume":"7","author":"S Hahnel","year":"2013","journal-title":"PLoS neglected tropical diseases"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A new and rapid colorimetric determination of acetylcholinesterase activity","volume":"7","author":"GL Ellman","year":"1961","journal-title":"Biochemical pharmacology"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00436-004-1241-2","article-title":"A new description of the reproductive system of <italic>Schistosoma mansoni<\/italic> (Trematoda: Schistosomatidae) analyzed by confocal laser scanning microscopy","volume":"95","author":"RH Neves","year":"2005","journal-title":"Parasitology research"},{"issue":"5","key":"ref31","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.ijpara.2010.01.007","article-title":"Imatinib has a fatal impact on morphology, pairing stability and survival of adult <italic>Schistosoma mansoni in vitro<\/italic>","volume":"40","author":"S Beckmann","year":"2010","journal-title":"International journal for parasitology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"170","DOI":"10.3389\/fgene.2014.00170","article-title":"Gonad RNA-specific qRT-PCR analyses identify genes with potential functions in schistosome reproduction such as SmFz1 and SmFGFRs","volume":"5","author":"S Hahnel","year":"2014","journal-title":"Frontiers in genetics"},{"key":"ref33","unstructured":"Schmidt U. Harmonia axyridis (Pallas, 177). 2008. p. Online Image. Retrieved from <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.flickr.com\/photos\/coleoptera-us\/2918252388\/\" xlink:type=\"simple\">https:\/\/www.flickr.com\/photos\/coleoptera-us\/2918252388\/<\/ext-link>."},{"key":"ref34","unstructured":"Nagel NC. Synthesis and bioactivity studies of harmonine\u2013the defense alkaloid of the Asian lady beetle Harmonia axyridis (doctoral dissertation), retrieved from <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.db-thueringen.de\/servlets\/MCRFileNodeServlet\/dbt_derivate_00035920\/NagelDis.pdf\" xlink:type=\"simple\">https:\/\/www.db-thueringen.de\/servlets\/MCRFileNodeServlet\/dbt_derivate_00035920\/NagelDis.pdf<\/ext-link>. Jena: University Jena; 2015."},{"issue":"3","key":"ref35","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/j.1476-5381.1972.tb08145.x","article-title":"Inhibition by metrifonate and dichlorvos of cholinesterases in schistosomes","volume":"46","author":"E Bueding","year":"1972","journal-title":"British journal of pharmacology"},{"issue":"12","key":"ref36","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1110\/ps.8.12.2553","article-title":"Acetylcholinesterase of <italic>Schistosoma mansoni<\/italic>\u2014functional correlates. Contributed in honor of Professor Hans Neurath&apos;s 90th birthday","volume":"8","author":"R Arnon","year":"1999","journal-title":"Protein science: a publication of the Protein Society"},{"issue":"9","key":"ref37","article-title":"Acetylcholinesterase and nicotinic acetylcholine receptors in schistosomes and other parasitic helminths","volume":"22","author":"H You","year":"2017","journal-title":"Molecules (Basel, Switzerland)."},{"issue":"1","key":"ref38","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.molbiopara.2005.01.019","article-title":"Expression and comparative functional characterisation of recombinant acetylcholinesterase from three species of <italic>Schistosoma<\/italic>","volume":"141","author":"GN Bentley","year":"2005","journal-title":"Molecular and biochemical parasitology"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"31150","DOI":"10.1038\/srep31150","article-title":"Schistosome sex matters: a deep view into gonad-specific and pairing-dependent transcriptomes reveals a complex gender interplay","volume":"6","author":"Z Lu","year":"2016","journal-title":"Scientific reports"},{"issue":"3","key":"ref40","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1021\/ci900491t","article-title":"Virtual screening discovery of new acetylcholinesterase inhibitors issued from CERMN chemical library","volume":"50","author":"J Sopkova-de Oliveira Santos","year":"2010","journal-title":"Journal of chemical information and modeling"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.cbi.2017.01.020","article-title":"Effects of organophosphates on the regulation of mesenchymal stem cell proliferation and differentiation","volume":"266","author":"AM Prugh","year":"2017","journal-title":"Chemico-biological interactions"},{"key":"ref42","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.35449","article-title":"Stem cell heterogeneity drives the parasitic life cycle of <italic>Schistosoma mansoni<\/italic>","volume":"7","author":"B Wang","year":"2018","journal-title":"eLife"},{"issue":"14","key":"ref43","doi-asserted-by":"crossref","first-page":"5901","DOI":"10.1073\/pnas.0609708104","article-title":"Nanos function is essential for development and regeneration of planarian germ cells","volume":"104","author":"Y Wang","year":"2007","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"7438","key":"ref44","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/nature11924","article-title":"Adult somatic stem cells in the human parasite <italic>Schistosoma mansoni<\/italic>","volume":"494","author":"JJ Collins 3rd","year":"2013","journal-title":"Nature"},{"issue":"1","key":"ref45","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/2041-9139-5-10","article-title":"The unique stem cell system of the immortal larva of the human parasite <italic>Echinococcus multilocularis<\/italic>","volume":"5","author":"U Koziol","year":"2014","journal-title":"EvoDevo"},{"issue":"9","key":"ref46","doi-asserted-by":"crossref","first-page":"e0004994","DOI":"10.1371\/journal.pntd.0004994","article-title":"Stimulating neoblast-like cell proliferation in juvenile <italic>Fasciola hepatica<\/italic> supports growth and progression towards the adult phenotype <italic>in vitro<\/italic>","volume":"10","author":"P McCusker","year":"2016","journal-title":"PLoS neglected tropical diseases"},{"issue":"2","key":"ref47","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1017\/S0031182000046394","article-title":"A comparative study of the reproductive system of mature, immature and &quot;unisexual&quot; female <italic>Schistosoma mansoni<\/italic>","volume":"67","author":"DA Erasmus","year":"1973","journal-title":"Parasitology"},{"issue":"Pt 2","key":"ref48","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1017\/S0031182099006174","article-title":"A confocal microscopical study of the musculature of adult <italic>Schistosoma mansoni<\/italic>","volume":"121","author":"GR Mair","year":"2000","journal-title":"Parasitology"},{"issue":"6","key":"ref49","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.ijpara.2006.01.007","article-title":"Functions of the tegument of schistosomes: clues from the proteome and lipidome","volume":"36","author":"JJ Van Hellemond","year":"2006","journal-title":"International journal for parasitology"},{"issue":"3","key":"ref50","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/0014-4894(84)90042-0","article-title":"<italic>Schistosoma mansoni<\/italic>: ultrastructure of adults from mice treated with oxamniquine","volume":"58","author":"I Popiel","year":"1984","journal-title":"Experimental parasitology"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1242\/jcs.34.1.173","article-title":"The mechansim of antibody-dependent, eosinophil-mediated damage to 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