{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T06:12:29Z","timestamp":1776147149923,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pntd.0007371","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,6,24]],"date-time":"2019-06-24T00:00:00Z","timestamp":1561334400000}}],"reference-count":55,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T00:00:00Z","timestamp":1560297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["U01AI066050"],"award-info":[{"award-number":["U01AI066050"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R21AI107520"],"award-info":[{"award-number":["R21AI107520"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0007371","type":"journal-article","created":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T17:25:35Z","timestamp":1560360335000},"page":"e0007371","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":21,"title":["Maternal, placental and cord blood cytokines and the risk of adverse birth outcomes among pregnant women infected with Schistosoma japonicum in the Philippines"],"prefix":"10.1371","volume":"13","author":[{"given":"Ajibola I.","family":"Abioye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily A.","family":"McDonald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2407-0962","authenticated-orcid":true,"given":"Sangshin","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayush","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan D.","family":"Kurtis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunthorn","family":"Pond-Tor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surendra","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9456-2044","authenticated-orcid":true,"given":"Jan","family":"Ernerudh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Palmera","family":"Baltazar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luz P.","family":"Acosta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Remigio M.","family":"Olveda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica","family":"Tallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer F.","family":"Friedman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2019,6,12]]},"reference":[{"issue":"9859","key":"ref1","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/S0140-6736(12)61728-0","article-title":"Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"R Lozano","year":"2013","journal-title":"Lancet"},{"issue":"7","key":"ref2","doi-asserted-by":"crossref","first-page":"e0159461","DOI":"10.1371\/journal.pone.0159461","article-title":"LBW and SGA impact longitudinal growth and nutritional status of Filipino infants","volume":"11","author":"RA Blake","year":"2016","journal-title":"PloS One"},{"issue":"8","key":"ref3","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1111\/jcpp.12358","article-title":"Neuro\u2010cognitive performance of very preterm or very low birth weight adults at 26 years","volume":"56","author":"S Eryigit Madzwamuse","year":"2015","journal-title":"J Child Psychol Psychiatry"},{"issue":"9890","key":"ref4","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0140-6736(13)60993-9","article-title":"Mortality risk in preterm and small-for-gestational-age infants in low-income and middle-income countries: a pooled country analysis","volume":"382","author":"J Katz","year":"2013","journal-title":"Lancet"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"222","DOI":"10.3109\/14767058.2012.715006","article-title":"Short-term and long-term sequelae in intrauterine growth retardation (IUGR)","volume":"26","author":"S Longo","year":"2013","journal-title":"J Matern Fetal Med"},{"issue":"9938","key":"ref6","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0140-6736(14)60496-7","article-title":"Every Newborn: progress, priorities, and potential beyond survival","volume":"384","author":"JE Lawn","year":"2014","journal-title":"Lancet"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.pt.2007.02.006","article-title":"Schistosomiasis and pregnancy","volume":"23","author":"Friedman","year":"2007","journal-title":"Trends in parasitology"},{"issue":"12","key":"ref8","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/S1473-3099(12)70222-0","article-title":"Malaria prevention in pregnancy, birthweight, and neonatal mortality: a meta-analysis of 32 national cross-sectional datasets in Africa","volume":"12","author":"TP Eisele","year":"2012","journal-title":"Lancet Infect Dis"},{"issue":"6","key":"ref9","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1001\/jama.2012.216231","article-title":"Intermittent preventive therapy for malaria during pregnancy using 2 vs 3 or more doses of sulfadoxine-pyrimethamine and risk of low birth weight in Africa: systematic review and meta-analysis","volume":"309","author":"K Kayentao","year":"2013","journal-title":"JAMA"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1128\/IAI.01072-10","article-title":"Maternal Schistosomiasis japonica is associated with maternal, placental, and fetal inflammation","volume":"79","author":"JD Kurtis","year":"2011","journal-title":"Infect Immun"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S1473-3099(15)00345-X","article-title":"Efficacy and safety of praziquantel for the treatment of human schistosomiasis during pregnancy: a phase 2, randomised, double-blind, placebo-controlled trial","volume":"16","author":"RM Olveda","year":"2016","journal-title":"Lancet Infect Dis"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1034\/j.1600-0897.2002.1o057.x","article-title":"Spontaneous Secretion of Interleukin\u20104, Interleukin\u201010 and Interferon\u2010\u03b30 and Interferontr\u00f6m C, Matthiesen L, Berg G, Sharma S, Ernerudh J. Spontaneous Secretion of Interleukin\u20104, Interleukin\u201010 and Interferon\u2010\u03b3 by First Trimester Decidual Mononuclear Cells","volume":"47","author":"C Ekerfelt","year":"2002","journal-title":"Am J Reprod Immunol"},{"issue":"11","key":"ref13","doi-asserted-by":"crossref","first-page":"5721","DOI":"10.4049\/jimmunol.164.11.5721","article-title":"Gestational age-dependent expression of IL-10 and its receptor in human placental tissues and isolated cytotrophoblasts","volume":"164","author":"N Hanna","year":"2000","journal-title":"J Immunol"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.toxlet.2005.09.009","article-title":"Tumor necrosis factor alpha partially contributes to lipopolysaccharide-induced intra-uterine fetal growth restriction and skeletal development retardation in mice","volume":"163","author":"D-X Xu","year":"2006","journal-title":"Toxicol Lett"},{"issue":"8","key":"ref15","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.placenta.2014.05.002","article-title":"Inflammation-induced fetal growth restriction in rats is associated with altered placental morphometrics","volume":"35","author":"T Cotechini","year":"2014","journal-title":"Placenta"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0301-2115(00)00321-3","article-title":"Increased production of tumor necrosis factor-\u03b1 TNF-\u03b1 by IUGR human placentae","volume":"94","author":"G Holcberg","year":"2001","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"6","key":"ref17","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.4049\/jimmunol.163.6.3491","article-title":"A deficiency of placental IL-10 in preeclampsia","volume":"163","author":"A Hennessy","year":"1999","journal-title":"J Immunol"},{"issue":"6","key":"ref18","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1086\/315135","article-title":"Malaria and pregnancy: placental cytokine expression and its relationship to intrauterine growth retardation","volume":"180","author":"AM Moormann","year":"1999","journal-title":"J Infect Dis"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"115","DOI":"10.4269\/ajtmh.2003.68.1.0680115","article-title":"Placental monocyte infiltrates in response to Plasmodium falciparum malaria infection and their association with adverse pregnancy outcomes","volume":"68","author":"SJ Rogerson","year":"2003","journal-title":"Am J Trop Med Hyg"},{"issue":"6","key":"ref20","first-page":"2505","article-title":"Expression of Inflammatory Cytokines in Placentas from Women with Preeclampsia 1","volume":"86","author":"DF Benyo","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1203\/00006450-200202000-00013","article-title":"Aberrations in placental cytokine mRNA related to intrauterine growth retardation","volume":"51","author":"M Hahn-Zoric","year":"2002","journal-title":"Pediatr Res"},{"issue":"5","key":"ref22","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1093\/infdis\/jiq099","article-title":"Tissue inhibitor of matrix-metalloprotease-1 predicts risk of hepatic fibrosis in human Schistosoma japonicum infection","volume":"203","author":"V Fabre","year":"2011","journal-title":"J Infect Dis"},{"key":"ref23","unstructured":"Prevention and control of intestinal parasitic infections. Report of a WHO Expert Committee. World Health Organization technical report series. 1987;749:1\u201386. Epub 1987\/01\/01. 3111104."},{"key":"ref24","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1017\/S0031182000006867","article-title":"The public health significance of Trichuris trichiura","volume":"121","author":"LS Stephenson","year":"2000","journal-title":"Parasitology"},{"key":"ref25","first-page":"1","article-title":"A WHO Collaborative Study","volume":"73","year":"1995"},{"issue":"5","key":"ref26","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/S0002-9378(11)91714-1","article-title":"Effect of fat and fat-free mass deposition during pregnancy on birth weight","volume":"167","author":"J Villar","year":"1992","journal-title":"Am J Obstet Gynecol"},{"issue":"9946","key":"ref27","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0140-6736(14)60932-6","article-title":"International standards for newborn weight, length, and head circumference by gestational age and sex: the Newborn Cross-Sectional Study of the INTERGROWTH-21st Project","volume":"384","author":"J Villar","year":"2014","journal-title":"Lancet"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1093\/jn\/136.1.183","article-title":"Nutritional status improves after treatment of schistosoma japonicum-infected children and adolescents","volume":"136","author":"HM Coutinho","year":"2006","journal-title":"J Nutr"},{"issue":"7","key":"ref29","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1093\/aje\/kwh090","article-title":"A modified poisson regression approach to prospective studies with binary data","volume":"159","author":"G. Zou","year":"2004","journal-title":"Am J Epidemiol"},{"issue":"4","key":"ref30","doi-asserted-by":"crossref","first-page":"721","DOI":"10.3945\/ajcn.115.113548","article-title":"Best (but oft-forgotten) practices: the multiple problems of multiplicity-whether and how to correct for many statistical tests","volume":"102","author":"DL Streiner","year":"2015","journal-title":"Am J Clin Nutr"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0920-9964(00)00032-3","article-title":"Prenatal exposure to maternal infection alters cytokine expression in the placenta, amniotic fluid, and fetal brain","volume":"47","author":"A Urakubo","year":"2001","journal-title":"Schizophr Res"},{"issue":"40","key":"ref32","doi-asserted-by":"crossref","first-page":"10695","DOI":"10.1523\/JNEUROSCI.2178-07.2007","article-title":"Maternal immune activation alters fetal brain development through interleukin-6","volume":"27","author":"SE Smith","year":"2007","journal-title":"J Neurosci"},{"issue":"5","key":"ref33","doi-asserted-by":"crossref","first-page":"1039s","DOI":"10.3945\/jn.114.194571","article-title":"Inflammation and Nutritional Science for Programs\/Policies and Interpretation of Research Evidence (INSPIRE)","volume":"145","author":"DJ Raiten","year":"2015","journal-title":"J Nutr"},{"issue":"3","key":"ref34","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1128\/IAI.01149-12","article-title":"Schistosome egg antigens elicit a proinflammatory response by trophoblast cells of the human placenta","volume":"81","author":"EA McDonald","year":"2013","journal-title":"Infect Immun"},{"issue":"3","key":"ref35","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1093\/infdis\/jit446","article-title":"Schistosomiasis japonica during pregnancy is associated with elevated endotoxin levels in maternal and placental compartments","volume":"209","author":"EA McDonald","year":"2014","journal-title":"J Infect Dis"},{"issue":"4","key":"ref36","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/ni.3131","article-title":"Immune mechanisms at the maternal-fetal interface: perspectives and challenges","volume":"16","author":"M PrabhuDas","year":"2015","journal-title":"Nat Immunol"},{"issue":"4","key":"ref37","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1177\/1099800409344620","article-title":"Integrated review of cytokines in maternal, cord, and newborn blood: part I\u2014associations with preterm birth","volume":"11","author":"D Lyon","year":"2010","journal-title":"Biol Res Nurs"},{"issue":"2","key":"ref38","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/jcmm.12012","article-title":"Infiltration of myeloid cells into decidua is a critical early event in the labour cascade and post\u2010partum uterine remodelling","volume":"17","author":"O Shynlova","year":"2013","journal-title":"J Cell Mol Med"},{"issue":"2","key":"ref39","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jsgi.2005.12.002","article-title":"Leukocyte Density and Proinflammatory Mediator Expression in Regional Human Fetal Membranes and Decidua Before and During Labot at Term","volume":"13","author":"I Osman","year":"2006","journal-title":"J Soc Gynecol Investig"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"967629","DOI":"10.1155\/2012\/967629","article-title":"The Th1:th2 dichotomy of pregnancy and preterm labour","volume":"2012","author":"L Sykes","year":"2012","journal-title":"Mediators Inflamm"},{"issue":"2","key":"ref41","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1023\/A:1021740108284","article-title":"TNF-alpha in pregnancy loss and embryo maldevelopment: a mediator of detrimental stimuli or a protector of the fetoplacental unit?","volume":"20","author":"V Toder","year":"2003","journal-title":"J Assist Reprod Genet"},{"issue":"02","key":"ref42","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1055\/s-0033-1334879","article-title":"Levels of cytokines in umbilical cord blood in small for gestational age preterm infants","volume":"225","author":"U Lindner","year":"2013","journal-title":"Klin Padiatr"},{"key":"ref43","first-page":"2014","article-title":"Adiponectin levels are reduced while markers of systemic inflammation and aortic remodelling are increased in intrauterine growth restricted mother-child couple","author":"S Visentin","year":"2014","journal-title":"Biomed Res Int"},{"issue":"1","key":"ref44","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.cyto.2014.09.011","article-title":"T cell subsets and their signature cytokines in autoimmune and inflammatory diseases","volume":"74","author":"I Raphael","year":"2015","journal-title":"Cytokine"},{"issue":"2","key":"ref45","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1095\/biolreprod47.2.220","article-title":"Human placenta constitutively produces interleukin-8 during pregnancy and enhances its production in intrauterine infection","volume":"47","author":"K Shimoya","year":"1992","journal-title":"Biol Reprod"},{"issue":"4","key":"ref46","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.4049\/jimmunol.143.4.1366","article-title":"Genomic structure of the human monocyte-derived neutrophil chemotactic factor IL-8","volume":"143","author":"N Mukaida","year":"1989","journal-title":"J Immunol"},{"issue":"2","key":"ref47","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1084\/jem.181.2.537","article-title":"Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha production","volume":"181","author":"A D'Andrea","year":"1995","journal-title":"J Exp Med"},{"issue":"9","key":"ref48","doi-asserted-by":"crossref","first-page":"3034","DOI":"10.1128\/IAI.00220-12","article-title":"CXC ligand 9 response to malaria during pregnancy is associated with low-birth-weight deliveries","volume":"80","author":"S Dong","year":"2012","journal-title":"Infect Immun"},{"issue":"8","key":"ref49","doi-asserted-by":"crossref","first-page":"e0003995","DOI":"10.1371\/journal.pntd.0003995","article-title":"CD4+CD25hiFOXP3+ Regulatory T Cells and Cytokine Responses in Human Schistosomiasis before and after Treatment with Praziquantel","volume":"9","author":"Y Schmiedel","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"issue":"4","key":"ref50","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1086\/422604","article-title":"Increases in human T helper 2 cytokine responses to Schistosoma mansoni worm and worm-tegument antigens are induced by treatment with praziquantel","volume":"190","author":"S Joseph","year":"2004","journal-title":"J Infect Dis"},{"issue":"8","key":"ref51","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.1128\/AAC.00173-08","article-title":"Effect of chemotherapy with praziquantel on the production of cytokines and morbidity associated with schistosomiasis mansoni","volume":"52","author":"P Martins-Leite","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"issue":"5","key":"ref52","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1128\/CVI.13.5.584-593.2006","article-title":"Eosinophil activity in Schistosoma mansoni infections in vivo and in vitro in relation to plasma cytokine profile pre-and posttreatment with praziquantel","volume":"13","author":"CM Reimert","year":"2006","journal-title":"Clin Vaccine Immunol"},{"issue":"1","key":"ref53","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2471\/BLT.17.198879","article-title":"Praziquantel for the treatment of schistosomiasis during human pregnancy. World Health Organization","volume":"96","author":"JF Friedman","year":"2018","journal-title":"Bull World Health Organ"},{"issue":"5","key":"ref54","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1128\/CVI.13.5.568-574.2006","article-title":"Evaluation of Various Methods of Maternal Placental Blood Collection for Immunology Studies","volume":"13","author":"C Othoro","year":"2006","journal-title":"Clin Vaccine Immunol"},{"issue":"4","key":"ref55","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/j.1471-0528.2011.03266.x","article-title":"Dysregulated biomarkers induce distinct pathways in preterm birth","volume":"119","author":"L Brou","year":"2012","journal-title":"BJOG"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0007371","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,6,24]],"date-time":"2019-06-24T00:00:00Z","timestamp":1561334400000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0007371","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T11:29:43Z","timestamp":1694950183000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0007371"}},"subtitle":[],"editor":[{"given":"Cinzia","family":"Cantacessi","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,6,12]]},"references-count":55,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,6,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0007371","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pntd.0007371","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,12]]}}}