{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:20:26Z","timestamp":1790713226049,"version":"4.1.0"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T00:00:00Z","timestamp":1559606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","award":["481446\/2013-3"],"award-info":[{"award-number":["481446\/2013-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0007441","type":"journal-article","created":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T17:24:52Z","timestamp":1559669092000},"page":"e0007441","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":24,"title":["Antifungal activity of two oxadiazole compounds for the paracoccidioidomycosis treatment"],"prefix":"10.1371","volume":"13","author":[{"given":"Franciele Abigail Vilugron","family":"Rodrigues-Vendramini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniella Renata","family":"Faria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glaucia Sayuri","family":"Arita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isis Regina Grenier","family":"Capoci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina Mayumi","family":"Sakita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana Martins","family":"Caparroz-Assef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania Cristina Alexandrino","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia","family":"de Souza Bonfim-Mendon\u00e7a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Sueli","family":"Felipe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terezinha Inez Estivalet","family":"Svidzinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Maigret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3290-8577","authenticated-orcid":true,"given":"\u00c9rika Seki","family":"Kioshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,6,4]]},"reference":[{"issue":"27","key":"ref1","first-page":"e0500001","article-title":"Brazilian guidelines for the clinical management of paracoccidioidomycosis","volume":"16","author":"MA Shikanai-Yasuda","year":"2018","journal-title":"Epidemiol Serv Saude"},{"key":"ref2","article-title":"Acute form of paracoccidioidomycosis: analysis of thirteen autopsies with emphasis on the pulmonary involvement","volume":"111","author":"J Defaveri","year":"2002","journal-title":"Annu Rev Biomed Sci"},{"key":"ref3","article-title":"Chronic form of paracoccidioidomycosis: analysis of forty autopsies with emphasis on the pulmonary pathogeny","volume":"111","author":"J Defaveri","year":"2002","journal-title":"Annu Rev Biomed Sci"},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3109\/13693786.2012.714529","article-title":"Endemic paracoccidioidomycosis: relationship between clinical presentation and patients&apos; demographic features","volume":"51","author":"F Bellissimo-Rodrigues","year":"2013","journal-title":"Med Mycol"},{"key":"ref5","first-page":"185","article-title":"Paracoccidioidomycosis.","volume":"4","author":"M Franco","year":"1989","journal-title":"Bailli\u00e8re\u2019s Clin Trop Med Communic Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1086\/377538","article-title":"Residual pulmonary abnormalities in adult patients with chronic paracoccidioidomycosis: prolonged follow-up after itraconazole therapy","volume":"37","author":"AM Tobon","year":"2003","journal-title":"Clin Infect Dis"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.pupt.2010.09.005","article-title":"Combined itraconazole-pentoxifylline treatment promptly reduces lung fibrosis induced by chronic pulmonary paracoccidioidomycosis in mice","volume":"24","author":"TW Naranjo","year":"2011","journal-title":"Pulm Pharmacol Ther"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.ccm.2017.04.003","article-title":"Overview of treatment approaches for fungal infections","volume":"38","author":"EM Carmona","year":"2017","journal-title":"Clin Chest Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1080\/mmy.40.4.411.417","article-title":"Randomized trial with itraconazole, ketoconazole and sulfadiazine in paracoccidioidomycosis","volume":"40","author":"MA Shikanai-Yasuda","year":"2002","journal-title":"Med Mycol"},{"issue":"5","key":"ref10","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1590\/0037-8682-0230-2017","article-title":"Brazilian guidelines for the clinical management of paracoccidioidomycosis","volume":"50","author":"MA Shikanai-Yasuda","year":"2017","journal-title":"Rev Soc Bras Med Trop"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1124\/pr.112.007336","article-title":"Computational methods in drug discovery","volume":"66","author":"G Sliwoski","year":"2014","journal-title":"Pharmacol Rev"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.2174\/1568026617666161116143440","article-title":"Bioinformatics and drug discovery","volume":"17","author":"X Xia","year":"2017","journal-title":"Curr Top Med Chem"},{"key":"ref13","first-page":"12","article-title":"Comparative genomics allowed the identification of drug targets against human fungal pathogens","volume":"27","author":"AK Abadio","year":"2011","journal-title":"BMC Genomics"},{"issue":"11","key":"ref14","doi-asserted-by":"crossref","first-page":"5854","DOI":"10.1073\/pnas.100114897","article-title":"Structure and mechanism of mammalian thioredoxin reductase: the active site is a redox-active selenolthiol\/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence","volume":"97","author":"L Zhong","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"17045","DOI":"10.1074\/jbc.272.27.17045","article-title":"Thioredoxin reductase-dependent inhibition of MCB cell cycle box activity in <italic>Saccharomyces cerevisiae<\/italic>","volume":"272","author":"AK Machado","year":"1997","journal-title":"J Biol Chem"},{"issue":"11","key":"ref16","doi-asserted-by":"crossref","first-page":"e0142926","DOI":"10.1371\/journal.pone.0142926","article-title":"Identification of new antifungal compounds targeting thioredoxin reductase of <italic>Paracoccidioides<\/italic> Genus.","volume":"10","author":"AKR Abadio","year":"2015","journal-title":"PLoS ONE"},{"key":"ref17","article-title":"Composi\u00e7\u00e3o farmac\u00eautica baseada em compostos 1,3,4-oxadiaz\u00f3licos e seu uso na prepara\u00e7\u00e3o de medicamentos para tratamento de infec\u00e7\u00f5es sist\u00eamicas","author":"ES Kioshima","year":"2018"},{"key":"ref18","doi-asserted-by":"crossref","DOI":"10.1002\/0471142735.ima03bs21","article-title":"Trypan blue exclusion test of cell viability","author":"W Strober","year":"2001","journal-title":"Curr Protoc Immunol"},{"key":"ref19","article-title":"Reference method for broth dilution antifungal susceptibility testing of yeast","year":"2008"},{"key":"ref20","first-page":"e01097","article-title":"Promising new antifungal treatment targeting chorismate synthase from <italic>Paracoccidioides brasiliensis<\/italic>","author":"FAV Rodrigues-Vendramini","year":"2018","journal-title":"Antimicrob Agents Chemother"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1128\/JCM.02231-12","article-title":"Influence of different media, incubation times, and temperatures for determining the MICs of seven antifungal agents against <italic>Paracoccidioides brasiliensis<\/italic> by microdilution","volume":"51","author":"RC Cruz","year":"2013","journal-title":"J Clin Microbiol"},{"issue":"2","key":"ref22","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1128\/JCM.12.2.279-281.1980","article-title":"Growth of <italic>Paracoccidioides brasiliensis<\/italic> yeast phase in a chemically defined culture medium","volume":"12","author":"A Restrepo","year":"1980","journal-title":"J Clin Microbiol"},{"issue":"4","key":"ref23","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.ijantimicag.2016.12.020","article-title":"Miltefosine is fungicidal to <italic>Paracoccidioides<\/italic> spp. yeast cells but subinhibitory concentrations induce melanisation","volume":"49","author":"DCP Rossi","year":"2017","journal-title":"Int J Antimicrob Agents"},{"issue":"7","key":"ref24","first-page":"1068","article-title":"Comparison of methods used for assessing the viability and vitality of yeast cells","volume":"14","author":"M Kwolek-Mirek","year":"2014","journal-title":"FEMS Yeast Res"},{"issue":"9","key":"ref25","doi-asserted-by":"crossref","first-page":"e00165","DOI":"10.1128\/AAC.00165-17","article-title":"Targeting homoserine dehydrogenase from <italic>Paracoccidioides<\/italic> genus against systemic fungal infections","volume":"61","author":"MC Bagatin","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"issue":"3","key":"ref26","first-page":"e00647","article-title":"Identification of a new class of antifungals targeting the synthesis of fungal sphingolipids","volume":"6","author":"V Mor","year":"2015","journal-title":"MBio"},{"issue":"18","key":"ref27","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.1093\/bioinformatics\/btw230","article-title":"Combenefit: an interactive platform for the analysis and visualization of drug combinations","volume":"32","author":"GY Di Veroli","year":"2016","journal-title":"Bioinformatics"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.2217\/fmb-2017-0065","article-title":"A new small-molecule KRE2 inhibitor against invasive <italic>Candida parapsilosis<\/italic> infection","volume":"12","author":"TP Salci","year":"2017","journal-title":"Future Microbiol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.bioorg.2018.11.019","article-title":"Repurposing approach identifies new treatment options for invasive fungal disease","volume":"84","author":"IRG Capoci","year":"2018","journal-title":"Bioorg Chem"},{"issue":"12","key":"ref30","doi-asserted-by":"crossref","first-page":"8035","DOI":"10.4049\/jimmunol.179.12.8035","article-title":"A novel role of IL-2 in organ-specific autoimmune inflammation beyond regulatory T cell checkpoint: both IL-2 knockout and Fas mutation prolong lifespan of Scurfy mice but by different mechanisms","volume":"179","author":"L Zheng","year":"2007","journal-title":"J Immunol"},{"issue":"2","key":"ref31","first-page":"95","article-title":"Establishment of reference values for hematological and biochemical parameters of mice strains produced in the animal facility at Centro de Pesquisas Ren\u00e9 Rachou\/Fiocruz\u2014Minas Gerais","volume":"3","author":"FTM Ara\u00fajo","year":"2015","journal-title":"R Soc Bras Ci Anim Lab"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1086\/504810","article-title":"Time to initiation of fluconazole therapy impacts mortality in patients with candidemia: a multi-institutional study","volume":"43","author":"KW Garey","year":"2006","journal-title":"Clin Infect Dis"},{"issue":"Suppl. 19","key":"ref33","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1590\/S0036-46652015000700007","article-title":"Paracoccidioidomycosis treatment","volume":"57","author":"MA Shikanai-Yasuda","year":"2015","journal-title":"Rev Inst Med Trop"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.2217\/fmb-2018-0175","article-title":"Computer-aided identification of novel anti-paracoccidioidomycosis compounds","volume":"13","author":"LC Silva","year":"2018","journal-title":"Future Microbiol"},{"issue":"9","key":"ref35","doi-asserted-by":"crossref","first-page":"4015","DOI":"10.1007\/s00253-015-7223-8","article-title":"Structural and functional characterization of the recombinant thioredoxin reductase from <italic>Candida albicans<\/italic> as a potential target for vaccine and drug design","volume":"100","author":"JS Godoy","year":"2016","journal-title":"Appl Microbiol Biotechnol"},{"issue":"20","key":"ref36","doi-asserted-by":"crossref","first-page":"6110","DOI":"10.1046\/j.1432-1327.2000.01702.x","article-title":"Thioredoxin reductase: two modes of catalysis have evolved","volume":"267","author":"CH Williams","year":"2000","journal-title":"Eur J Biochem"},{"issue":"9","key":"ref37","doi-asserted-by":"crossref","first-page":"5581","DOI":"10.1128\/AAC.04711-14","article-title":"Alkaloids as inhibitors of malate synthase from <italic>Paracoccidioides<\/italic> spp.: receptor-ligand interaction-based virtual screening and molecular docking studies, antifungal activity, and the adhesion process","volume":"59","author":"FG Costa","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"issue":"14","key":"ref38","doi-asserted-by":"crossref","first-page":"235","DOI":"10.2217\/fmb-2018-0276","article-title":"New 4-methoxy-naphthalene derivatives as promisor antifungal agents for paracoccidioidomycosis treatment.","author":"MC, F Bagatin","year":"2019","journal-title":"Future Microbiol."},{"issue":"3","key":"ref39","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1093\/mmy\/myy045","article-title":"Thiosemicarbazone of lapachol acts on cell membrane in <italic>Paracoccidioides brasiliensis<\/italic>","volume":"57","author":"NP de S\u00e1","year":"2019","journal-title":"Med Mycol"},{"issue":"6","key":"ref40","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1517\/14656566.9.6.927","article-title":"Fungicidal versus fungistatic: what\u2019s in a word?","volume":"9","author":"JS Lewis","year":"2008","journal-title":"Expert Opin Pharmacother"},{"issue":"5","key":"ref41","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1093\/jac\/dkh434","article-title":"Combinations of antifungal agents in therapy\u2014what value are they?","volume":"54","author":"M Cuenca-Estrella","year":"2004","journal-title":"J Antimicrob Chemother"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"e93960","DOI":"10.1371\/journal.pone.0093960","article-title":"Synergistic and antagonistic drug combinations depend on network topology","volume":"9","author":"N Yin","year":"2014","journal-title":"PLoS One"},{"issue":"11","key":"ref43","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1517\/14656566.4.11.2099","article-title":"Amphotericin B lipid complex for the treatment of invasive fungal infections","volume":"4","author":"PK Linden","year":"2003","journal-title":"Expert Opin Pharmacother"},{"issue":"5","key":"ref44","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1093\/mmy\/myx080","article-title":"Evaluation of the hepatobiliary system in patients with paracoccidioidomycosis treated with cotrimoxazole or itraconazole","volume":"56","author":"AD Levorato","year":"2018","journal-title":"Med Mycol"},{"issue":"3","key":"ref45","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/jac\/dku427","article-title":"Antifungal activity of 6-quinolinyl N-oxide chalcones against <italic>Paracoccidioides<\/italic>","volume":"70","author":"NP de S\u00e1","year":"2015","journal-title":"J Antimicrob Chemother"},{"issue":"12","key":"ref46","doi-asserted-by":"crossref","first-page":"7214","DOI":"10.1128\/AAC.00512-15","article-title":"Cyclopalladated compound 7a induces apoptosis- and autophagy-like mechanisms in <italic>Paracoccidioides<\/italic> and is a candidate for paracoccidioidomycosis treatment","volume":"59","author":"DC Arruda","year":"2015","journal-title":"Antimicrob Agents Chemother"}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0007441","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T02:40:31Z","timestamp":1608172831000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0007441"}},"subtitle":[],"editor":[{"given":"Pamela L. C.","family":"Small","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,6,4]]},"references-count":46,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,6,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0007441","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,4]]}}}