{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:26:17Z","timestamp":1790270777088,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0007458","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T00:00:00Z","timestamp":1559692800000}}],"reference-count":26,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T00:00:00Z","timestamp":1558569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["214185\/Z\/18\/Z"],"award-info":[{"award-number":["214185\/Z\/18\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0007458","type":"journal-article","created":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T18:30:53Z","timestamp":1558636253000},"page":"e0007458","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":27,"title":["Leptospirosis as a risk factor for chronic kidney disease: A systematic review of observational studies"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2090-1856","authenticated-orcid":true,"given":"Rodrigo M.","family":"Carrillo-Larco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Altez-Fernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Gonzalo","family":"Acevedo-Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karol","family":"Ortiz-Acha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar","family":"Ugarte-Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,5,23]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.kint.2018.04.011","article-title":"Analysis of the Global Burden of Disease study highlights the global, regional, and national trends of chronic kidney disease epidemiology from 1990 to 2016","volume":"94","author":"Y Xie","year":"2018","journal-title":"Kidney international"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1590\/1516-3180.2015.005","article-title":"Attributable causes of chronic kidney disease in adults: a five-year retrospective study in a tertiary-care hospital in the northeast of the Malaysian Peninsula","volume":"133","author":"M Salman","year":"2015","journal-title":"Sao Paulo medical journal = Revista paulista de medicina"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1093\/ckj\/sfx136","article-title":"What do epidemiological studies tell us about chronic kidney disease of undetermined cause in Meso-America? A systematic review and meta-analysis","volume":"11","author":"M Gonzalez-Quiroz","year":"2018","journal-title":"Clinical kidney journal"},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1053\/j.ajkd.2013.10.062","article-title":"CKD of unknown origin in Central America: the case for a Mesoamerican nephropathy","volume":"63","author":"R Correa-Rotter","year":"2014","journal-title":"American journal of kidney diseases: the official journal of the National Kidney Foundation"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.mehy.2016.04.009","article-title":"Chronic kidney disease of uncertain etiology in Sri Lanka: Are leptospirosis and Hantaviral infection likely causes?","volume":"91","author":"CD Gamage","year":"2016","journal-title":"Medical hypotheses"},{"issue":"2016","key":"ref6","doi-asserted-by":"crossref","first-page":"303","DOI":"10.5414\/CN108865","article-title":"Acute kidney injury in leptospirosis: the Kidney Disease Improving Global Outcomes (KDIGO) criteria and mortality","volume":"86","author":"F Teles","year":"2016","journal-title":"Clinical nephrology"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1159\/000480691","article-title":"Leptospirosis Renal Disease: Emerging Culprit of Chronic Kidney Disease Unknown Etiology","volume":"138","author":"CW Yang","year":"2018","journal-title":"Nephron"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"379","DOI":"10.2215\/CJN.07500715","article-title":"CKD of Uncertain Etiology: A Systematic Review","volume":"11","author":"J Lunyera","year":"2016","journal-title":"Clinical journal of the American Society of Nephrology: CJASN"},{"issue":"4","key":"ref9","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1097\/MNH.0000000000000331","article-title":"Pathophysiologic insight into MesoAmerican nephropathy","volume":"26","author":"M Madero","year":"2017","journal-title":"Current opinion in nephrology and hypertension"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.ekir.2016.11.003","article-title":"Endemic Nephropathy Around the World","volume":"2","author":"FJ Gifford","year":"2017","journal-title":"Kidney international reports"},{"issue":"7","key":"ref11","doi-asserted-by":"crossref","first-page":"e1000100","DOI":"10.1371\/journal.pmed.1000100","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration","volume":"6","author":"A Liberati","year":"2009","journal-title":"PLoS medicine"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/kisup.2012.64","article-title":"Chapter 1: Definition and classification of CKD","volume":"3","year":"2013","journal-title":"Kidney international supplements"},{"key":"ref13","unstructured":"Ouzzani MA-O, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan-a web and mobile app for systematic reviews. (2046\u20134053 (Electronic))."},{"key":"ref14","unstructured":"GA Wells, B Shea, D O&apos;Connell, J Peterson, V Welch, M Losos, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. URL: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp\" xlink:type=\"simple\">http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp<\/ext-link>."},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10773525.2016.1275462","article-title":"Leptospira seropositivity as a risk factor for Mesoamerican Nephropathy","volume":"23","author":"A Riefkohl","year":"2017","journal-title":"International journal of occupational and environmental health"},{"issue":"10","key":"ref16","doi-asserted-by":"crossref","first-page":"e0004105","DOI":"10.1371\/journal.pntd.0004105","article-title":"Overlooked Risk for Chronic Kidney Disease after Leptospiral Infection: A Population-Based Survey and Epidemiological Cohort Evidence","volume":"9","author":"HY Yang","year":"2015","journal-title":"PLoS neglected tropical diseases"},{"issue":"12","key":"ref17","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.5588\/ijtld.17.0211","article-title":"Diabetes and poor tuberculosis treatment outcomes: issues and implications in data interpretation and analysis","volume":"21","author":"P Huangfu","year":"2017","journal-title":"The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease"},{"issue":"5","key":"ref18","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1053\/j.ajkd.2015.10.019","article-title":"Acute Kidney Injury Recovery Pattern and Subsequent Risk of CKD: An Analysis of Veterans Health Administration Data","volume":"67","author":"M Heung","year":"2016","journal-title":"American journal of kidney diseases: the official journal of the National Kidney Foundation"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s12882-018-0876-7","article-title":"The prognostic importance of duration of AKI: a systematic review and meta-analysis","volume":"19","author":"S Mehta","year":"2018","journal-title":"BMC nephrology"},{"issue":"Suppl 1","key":"ref20","first-page":"82","article-title":"Histopathological kidney alterations in rats naturally infected with Leptospira","volume":"33","author":"P Agudelo-Florez","year":"2013","journal-title":"Biomedica: revista del Instituto Nacional de Salud"},{"issue":"9","key":"ref21","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1093\/infdis\/jiy339","article-title":"Murine Renal Transcriptome Profiles Upon Leptospiral Infection: Implications for Chronic Kidney Diseases","volume":"218","author":"LF Chou","year":"2018","journal-title":"The Journal of infectious diseases"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"e2664","DOI":"10.1371\/journal.pntd.0002664","article-title":"Leptospira Interrogans induces fibrosis in the mouse kidney through Inos-dependent, TLR- and NLR-independent signaling pathways","volume":"8","author":"M Fanton d'Andon","year":"2014","journal-title":"PLoS neglected tropical diseases"},{"issue":"10","key":"ref23","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1681\/ASN.2006020159","article-title":"Leptospiral outer membrane protein induces extracellular matrix accumulation through a TGF-beta1\/Smad-dependent pathway","volume":"17","author":"YC Tian","year":"2006","journal-title":"Journal of the American Society of Nephrology: JASN"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"e612","DOI":"10.1371\/journal.pntd.0000612","article-title":"Asymptomatic renal colonization of humans in the peruvian Amazon by Leptospira","volume":"4","author":"CA Ganoza","year":"2010","journal-title":"PLoS neglected tropical diseases"},{"issue":"9","key":"ref25","doi-asserted-by":"crossref","first-page":"e0003898","DOI":"10.1371\/journal.pntd.0003898","article-title":"Global Morbidity and Mortality of Leptospirosis: A Systematic Review","volume":"9","author":"F Costa","year":"2015","journal-title":"PLoS neglected tropical diseases"},{"issue":"10","key":"ref26","doi-asserted-by":"crossref","first-page":"e0004122","DOI":"10.1371\/journal.pntd.0004122","article-title":"Global Burden of Leptospirosis: Estimated in Terms of Disability Adjusted Life Years","volume":"9","author":"PR Torgerson","year":"2015","journal-title":"PLoS neglected tropical diseases"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0007458","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T00:00:00Z","timestamp":1559692800000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0007458","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T12:37:05Z","timestamp":1589027825000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0007458"}},"subtitle":[],"editor":[{"given":"Tao","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,5,23]]},"references-count":26,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2019,5,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0007458","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pntd.0007458","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,23]]}}}