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Gasteiger","year":"2005"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1093\/nar\/gkn072","article-title":"PROMALS3D: A tool for multiple protein sequence and structure alignments","volume":"36","author":"J Pei","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nprot.2015.053","article-title":"The Phyre2 web portal for protein modeling, prediction and analysis","volume":"10","author":"LA Kelley","year":"2015","journal-title":"Nat Protoc"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.ab.2008.10.044","article-title":"A set of baculovirus transfer vectors for screening of affinity tags and parallel expression strategies","volume":"385","author":"W Abdulrahman","year":"2009","journal-title":"Anal Biochem"},{"key":"ref52","first-page":"181","article-title":"Insect cells-baculovirus system for the production of difficult to express proteins","author":"J Osz-Papai","year":"2014","journal-title":"Insoluble Proteins: Methods and Protocols"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1194\/jlr.M061036","article-title":"Membrane lipids regulate ganglioside GM2 catabolism and GM2 activator protein activity","volume":"56","author":"S Anheuser","year":"2015","journal-title":"J Lipid Res"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0014-5793(96)01331-2","article-title":"Purification of acid sphingomyelinase from human placenta: Characterization and N-terminal sequence","volume":"399","author":"S Lansmann","year":"1996","journal-title":"FEBS Lett"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0076-6879(87)38028-0","article-title":"Lysogangliosides: Synthesis and Use in Preparing Labeled Gangliosides","volume":"138","author":"G Schwarzmann","year":"1987","journal-title":"Methods Enzymol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0005-2736(91)90295-J","article-title":"Hu L rong. Small-volume extrusion apparatus for preparation of large, unilamellar vesicles","volume":"1061","author":"RC MacDonald","year":"1991","journal-title":"BBA\u2014Biomembr"},{"key":"ref57","article-title":"The enzyme-binding region of human GM2-activator protein","author":"M Wendeler","year":"2006","journal-title":"FEBS J"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2307\/2531595","article-title":"Comparing the Areas under Two or More Correlated Receiver Operating Characteristic Curves: A Nonparametric Approach","volume":"44","author":"ER DeLong","year":"1988","journal-title":"Biometrics"},{"key":"ref59","first-page":"1","article-title":"Measures of diagnostic accuracy: Basic definitions","author":"A-M \u0160imundi\u0107","year":"2008","journal-title":"Med Biol Sci"},{"key":"ref60","first-page":"285","article-title":"Titanji, V.P.K, Molecular cloning of OVL3.C1, Marker of Putatively Immunity in Onchocerciasis..pdf","volume":"2","author":"V.P.K. Titanji","year":"2002","journal-title":"J Cameroon Acad Sci"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S1046-5928(02)00599-5","article-title":"Expression of recombinant human GM2-activator protein in insect cells: Purification and characterization by mass spectrometry","volume":"27","author":"M Wendeler","year":"2003","journal-title":"Protein Expr Purif"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1074\/mcp.M600392-MCP200","article-title":"Proteomics reveals N-linked glycoprotein diversity in <italic>Caenorhabditis elegans<\/italic> and suggests an atypical translocation mechanism for integral membrane proteins","volume":"12","author":"H Kaji","year":"2007","journal-title":"Mol Cell Proteomics"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1111\/j.1742-4658.2006.05126.x","article-title":"The enzyme-binding region of human GM2-activator protein","volume":"273","author":"M Wendeler","year":"2006","journal-title":"FEBS J"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1515\/bchm2.1979.360.2.1837","article-title":"Purification and characterization of an activator protein for the degradation of glycolipids GM2 and GA2 by hexosaminidase A","volume":"360","author":"E Conzelmann","year":"1979","journal-title":"Hoppe Seylers Z Physiol Chem"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.molbiopara.2006.02.014","article-title":"Functional characterisation of a nematode secreted GM2-activator protein","volume":"147","author":"AF Bruce","year":"2006","journal-title":"Mol Biochem Parasitol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"15057","DOI":"10.1038\/mtm.2015.57","article-title":"Construction of a hybrid \u03b2-hexosaminidase subunit capable of forming stable homodimers that hydrolyze GM2 ganglioside in vivo","volume":"3","author":"MB Tropak","year":"2016","journal-title":"Mol Ther\u2014Methods Clin Dev. Cell Press"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1139\/o03-079","article-title":"Phospholipase D","volume":"82","author":"M McDermott","year":"2004","journal-title":"Biochem Cell Biol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1600-0854.2006.00389.x","article-title":"Dynamics and Function of Phospholipase D and Phosphatidic Acid During Phagocytosis","volume":"7","author":"M Corrotte","year":"2006","journal-title":"Traffic"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1210\/me.2004-0530","article-title":"Role of Phosphoinositide Signaling in the Control of Insulin Exocytosis","volume":"19","author":"L Waselle","year":"2005","journal-title":"Mol Endocrinol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1038\/ncb1774","article-title":"A role for phosphatidic acid in COPI vesicle fission yields insights into Golgi maintenance","volume":"10","author":"J-S Yang","year":"2008","journal-title":"Nat Cell Biol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1126\/science.1170179","article-title":"Sequential Regulation of DOCK2 Dynamics by Two Phospholipids During Neutrophil Chemotaxis","volume":"324","author":"A Nishikimi","year":"2009","journal-title":"Science"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1124\/mol.108.053298","article-title":"5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a Phospholipase D Pharmacological Inhibitor That Alters Cell Spreading and Inhibits Chemotaxis","volume":"75","author":"W Su","year":"2009","journal-title":"Mol Pharmacol"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.1016\/j.molimm.2007.01.033","article-title":"Stable adhesion and migration of human neutrophils requires phospholipase D-mediated activation of the integrin CD11b\/CD18","volume":"44","author":"DJ Powner","year":"2007","journal-title":"Mol Immunol"},{"issue":"Pt 2","key":"ref74","first-page":"571","article-title":"Over-expression of a functionally active human GM2-activator protein in <italic>Escherichia coli<\/italic>","volume":"292","author":"H Klima","year":"1993","journal-title":"Biochem J. Portland Press Ltd"},{"key":"ref75","first-page":"8325","article-title":"Two Mechanisms for the Recapture of Extracellular GM2 Activator Protein: Evidence for a Major Secretory Form of the Protein\u2020","volume":"36","author":"Brigitte Rigat","year":"1997","journal-title":"Biochemistry. American Chemical Society"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.bpj.2009.03.065","article-title":"Ligand extraction properties of the GM2 activator protein and its interactions with lipid vesicles","volume":"97","author":"Y Ran","year":"2009","journal-title":"Biophys J"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s40249-018-0410-y","article-title":"Impact of five annual rounds of mass drug administration with ivermectin on onchocerciasis in Sierra Leone","volume":"7","author":"JB Koroma","year":"2018","journal-title":"Infect Dis Poverty"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/nri1183","article-title":"Immune regulation by helminth parasites: cellular and molecular mechanisms","volume":"3","author":"RM Maizels","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"ref79","first-page":"12","article-title":"Immunomodulation by Filarial Parasites","volume":"1","author":"Anuradha Rajamanickam","year":"2013","journal-title":"Int Trends Immun"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1179\/136485910X12786389891407","article-title":"Induction of immunoglobulin G4 in human filariasis: an indicator of immunoregulation","volume":"104","author":"T Adjobimey","year":"2010","journal-title":"Ann Trop Med Parasitol"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s00281-012-0346-4","article-title":"Immunopathogenesis of lymphatic filarial disease","author":"S Babu","year":"2012","journal-title":"Seminars in Immunopathology"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0007591","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0007591","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T18:14:16Z","timestamp":1610561656000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0007591"}},"subtitle":[],"editor":[{"given":"Abdallah M.","family":"Samy","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,7,22]]},"references-count":81,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2019,7,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0007591","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,22]]}}}