{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:59:35Z","timestamp":1791910775240,"version":"4.3.4"},"update-to":[{"DOI":"10.1371\/journal.pntd.0007813","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000}}],"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T00:00:00Z","timestamp":1584662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HI15C2891"],"award-info":[{"award-number":["HI15C2891"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["2017M3A9E4061998"],"award-info":[{"award-number":["2017M3A9E4061998"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0007813","type":"journal-article","created":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T13:50:37Z","timestamp":1584712237000},"page":"e0007813","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":50,"title":["Vaccination with single plasmid DNA encoding IL-12 and antigens of severe fever with thrombocytopenia syndrome virus elicits complete protection in IFNAR knockout mice"],"prefix":"10.1371","volume":"14","author":[{"given":"Jun-Gu","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyeongseok","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hooncheol","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Il","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo-Jin","family":"Ro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Bok","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jua","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junho","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Kyung","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang Soo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9600-461X","authenticated-orcid":true,"given":"Keun Hwa","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3673-6397","authenticated-orcid":true,"given":"Nam-Hyuk","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,3,20]]},"reference":[{"issue":"4","key":"pntd.0007813.ref001","doi-asserted-by":"crossref","first-page":"992","DOI":"10.4269\/ajtmh.16-0967","article-title":"The Emergence of Severe Fever with Thrombocytopenia Syndrome Virus","volume":"97","author":"JA Silvas","year":"2017","journal-title":"Am J Trop Med Hyg"},{"issue":"7","key":"pntd.0007813.ref002","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1007\/s00705-019-04253-6","article-title":"Taxonomy of the order Bunyavirales: update 2019","volume":"164","author":"A Abudurexiti","year":"2019","journal-title":"Arch Virol"},{"issue":"10","key":"pntd.0007813.ref003","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/S1473-3099(18)30293-7","article-title":"Epidemiological and clinical features of laboratory-diagnosed severe fever with thrombocytopenia syndrome in China, 2011\u201317: a prospective observational study","volume":"18","author":"H Li","year":"2018","journal-title":"Lancet Infect Dis"},{"issue":"1","key":"pntd.0007813.ref004","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s12879-019-3773-1","article-title":"Severe fever with thrombocytopenia syndrome: comparison with scrub typhus and clinical diagnostic prediction","volume":"19","author":"SW Park","year":"2019","journal-title":"BMC infectious diseases"},{"issue":"6","key":"pntd.0007813.ref005","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.jiac.2019.01.013","article-title":"Viral load and inflammatory cytokine dynamics associated with the prognosis of severe fever with thrombocytopenia syndrome virus infection: An autopsy case","volume":"25","author":"S Nakamura","year":"2019","journal-title":"J Infect Chemother"},{"issue":"5","key":"pntd.0007813.ref006","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.3201\/eid2505.181463","article-title":"Endemic Severe Fever with Thrombocytopenia Syndrome, Vietnam","volume":"25","author":"XC Tran","year":"2019","journal-title":"Emerg Infect Dis"},{"issue":"5","key":"pntd.0007813.ref007","doi-asserted-by":"crossref","first-page":"633 e1","DOI":"10.1016\/j.cmi.2019.01.006","article-title":"Nosocomial person-to-person transmission of severe fever with thrombocytopenia syndrome","volume":"25","author":"IY Jung","year":"2019","journal-title":"Clin Microbiol Infect"},{"key":"pntd.0007813.ref008","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.coviro.2018.03.005","article-title":"Current status of Severe Fever with Thrombocytopenia Syndrome vaccine development","volume":"29","author":"LM Reece","year":"2018","journal-title":"Current opinion in virology"},{"issue":"2","key":"pntd.0007813.ref009","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1089\/vim.2014.0100","article-title":"Immunization with recombinant SFTSV\/NSs protein does not promote virus clearance in SFTSV-infected C57BL\/6J mice","volume":"28","author":"R Liu","year":"2015","journal-title":"Viral Immunol"},{"key":"pntd.0007813.ref010","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.colsurfb.2017.07.059","article-title":"Nano-patterning of a stainless steel microneedle surface to improve the dip-coating efficiency of a DNA vaccine and its immune response","volume":"159","author":"D Jung","year":"2017","journal-title":"Colloids Surf B Biointerfaces"},{"key":"pntd.0007813.ref011","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41541-018-0096-y","article-title":"Single dose of a rVSV-based vaccine elicits complete protection against severe fever with thrombocytopenia syndrome virus","volume":"4","author":"F Dong","year":"2019","journal-title":"NPJ Vaccines"},{"issue":"25","key":"pntd.0007813.ref012","doi-asserted-by":"crossref","first-page":"10053","DOI":"10.1073\/pnas.1120246109","article-title":"Pathogenesis of emerging severe fever with thrombocytopenia syndrome virus in C57\/BL6 mouse model","volume":"109","author":"C Jin","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"pntd.0007813.ref013","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1128\/JVI.02277-13","article-title":"The pathogenesis of severe fever with thrombocytopenia syndrome virus infection in alpha\/beta interferon knockout mice: insights into the pathologic mechanisms of a new viral hemorrhagic fever","volume":"88","author":"Y Liu","year":"2014","journal-title":"J Virol"},{"key":"pntd.0007813.ref014","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3389\/fmicb.2017.00104","article-title":"Animal Models of Emerging Tick-Borne Phleboviruses: Determining Target Cells in a Lethal Model of SFTSV Infection","volume":"8","author":"K Matsuno","year":"2017","journal-title":"Front Microbiol"},{"key":"pntd.0007813.ref015","doi-asserted-by":"crossref","first-page":"5317","DOI":"10.1038\/ncomms6317","article-title":"Clearance of persistent HPV infection and cervical lesion by therapeutic DNA vaccine in CIN3 patients","volume":"5","author":"TJ Kim","year":"2014","journal-title":"Nat Commun"},{"issue":"5","key":"pntd.0007813.ref016","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.4049\/jimmunol.170.5.2496","article-title":"Long-term maintenance of gp120-specific immune responses by genetic vaccination with the HIV-1 envelope genes linked to the gene encoding Flt-3 ligand","volume":"170","author":"G Sailaja","year":"2003","journal-title":"J Immunol"},{"issue":"4","key":"pntd.0007813.ref017","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nbt0402-381","article-title":"Engineering N-glycosylation mutations in IL-12 enhances sustained cytotoxic T lymphocyte responses for DNA immunization","volume":"20","author":"SJ Ha","year":"2002","journal-title":"Nat Biotechnol"},{"key":"pntd.0007813.ref018","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/B978-0-12-418687-3.00018-5","article-title":"Transient mammalian cell transfection with polyethylenimine (PEI)","volume":"529","author":"PA Longo","year":"2013","journal-title":"Methods Enzymol"},{"issue":"2","key":"pntd.0007813.ref019","doi-asserted-by":"crossref","first-page":"e1007375","DOI":"10.1371\/journal.ppat.1007375","article-title":"An anti-Gn glycoprotein antibody from a convalescent patient potently inhibits the infection of severe fever with thrombocytopenia syndrome virus","volume":"15","author":"KH Kim","year":"2019","journal-title":"PLoS Pathog"},{"issue":"3","key":"pntd.0007813.ref020","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1128\/JCM.16.3.542-544.1982","article-title":"Methylcellulose media for plaque assay of murine leukemia virus","volume":"16","author":"T Watanabe","year":"1982","journal-title":"J Clin Microbiol"},{"issue":"6","key":"pntd.0007813.ref021","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.3201\/eid2506.181722","article-title":"Sequential Emergence and Wide Spread of Neutralization Escape Middle East Respiratory Syndrome Coronavirus Mutants, South Korea, 2015","volume":"25","author":"YS Kim","year":"2019","journal-title":"Emerg Infect Dis"},{"key":"pntd.0007813.ref022","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.3389\/fimmu.2018.02022","article-title":"A Type I Interferon and IL-10 Induced by Orientia tsutsugamushi Infection Suppresses Antigen-Specific T Cells and Their Memory Responses","volume":"9","author":"CK Min","year":"2018","journal-title":"Frontiers in immunology"},{"issue":"3","key":"pntd.0007813.ref023","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01942-16","article-title":"Modeling Severe Fever with Thrombocytopenia Syndrome Virus Infection in Golden Syrian Hamsters: Importance of STAT2 in Preventing Disease and Effective Treatment with Favipiravir","volume":"91","author":"BB Gowen","year":"2017","journal-title":"J Virol"},{"key":"pntd.0007813.ref024","doi-asserted-by":"crossref","first-page":"129","DOI":"10.21775\/cimb.022.129","article-title":"DNA Vaccine Delivery and Improved Immunogenicity","volume":"22","author":"KR Porter","year":"2017","journal-title":"Current Issues in Molecular Biology"},{"issue":"2\u20133","key":"pntd.0007813.ref025","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.jbiotec.2012.08.012","article-title":"The future of human DNA vaccines","volume":"162","author":"L Li","year":"2012","journal-title":"Journal of Biotechnology"},{"issue":"1","key":"pntd.0007813.ref026","doi-asserted-by":"crossref","first-page":"3836","DOI":"10.1038\/s41467-019-11815-4","article-title":"Development of a SFTSV DNA vaccine that confers complete protection against lethal infection in ferrets","volume":"10","author":"JE Kwak","year":"2019","journal-title":"Nat Commun"},{"issue":"3","key":"pntd.0007813.ref027","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0165-2478(02)00039-1","article-title":"Intramuscular co-injection of naked DNA encoding HBV core antigen and Flt3 ligand suppresses anti-HBc antibody response","volume":"81","author":"TK Kwon","year":"2002","journal-title":"Immunol Lett"},{"issue":"22","key":"pntd.0007813.ref028","doi-asserted-by":"crossref","first-page":"3841","DOI":"10.1016\/j.vaccine.2010.03.010","article-title":"Co-expression of Flt-3 ligand gene ablates tumor immunity elicited by HER-2\/neu DNA vaccine in transgenic mice","volume":"28","author":"FM Venanzi","year":"2010","journal-title":"Vaccine"},{"issue":"3","key":"pntd.0007813.ref029","first-page":"1080","article-title":"Enhancement of DNA vaccine potency by linkage of antigen gene to a gene encoding the extracellular domain of Fms-like tyrosine kinase 3-ligand","volume":"61","author":"CF Hung","year":"2001","journal-title":"Cancer research"},{"issue":"1\u20132","key":"pntd.0007813.ref030","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S1386-6532(99)00008-6","article-title":"Enhanced protection against viral infection by co-administration of plasmid DNA coding for viral antigen and cytokines in mice","volume":"13","author":"E Operschall","year":"1999","journal-title":"J Clin Virol"},{"issue":"7","key":"pntd.0007813.ref031","doi-asserted-by":"crossref","DOI":"10.3390\/v8070202","article-title":"The Role of Phlebovirus Glycoproteins in Viral Entry, Assembly and Release","volume":"8","author":"M Spiegel","year":"2016","journal-title":"Viruses-Basel"},{"issue":"26","key":"pntd.0007813.ref032","doi-asserted-by":"crossref","first-page":"7154","DOI":"10.1073\/pnas.1603827113","article-title":"Structure of a phleboviral envelope glycoprotein reveals a consolidated model of membrane fusion","volume":"113","author":"S Halldorsson","year":"2016","journal-title":"P Natl Acad Sci USA"},{"issue":"36","key":"pntd.0007813.ref033","doi-asserted-by":"crossref","first-page":"E7564","DOI":"10.1073\/pnas.1705176114","article-title":"Structures of phlebovirus glycoprotein Gn and identification of a neutralizing antibody epitope","volume":"114","author":"Y Wu","year":"2017","journal-title":"P Natl Acad Sci USA"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0007813","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0007813","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T13:39:52Z","timestamp":1585748392000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0007813"}},"subtitle":[],"editor":[{"given":"Aaron C.","family":"Brault","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,3,20]]},"references-count":33,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,3,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0007813","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/787879","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,20]]}}}