{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:26:46Z","timestamp":1790270806057,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0007950","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T00:00:00Z","timestamp":1579132800000}}],"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T00:00:00Z","timestamp":1578268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007197","name":"U.S. Public Health Service","doi-asserted-by":"publisher","award":["R44 AI096551"],"award-info":[{"award-number":["R44 AI096551"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007197","name":"U.S. Public Health Service","doi-asserted-by":"publisher","award":["R43 AI136551"],"award-info":[{"award-number":["R43 AI136551"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007197","name":"U.S. Public Health Service","doi-asserted-by":"publisher","award":["R21 AI142129"],"award-info":[{"award-number":["R21 AI142129"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0007950","type":"journal-article","created":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T18:34:11Z","timestamp":1578335651000},"page":"e0007950","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":31,"title":["The route of infection with Leptospira interrogans serovar Copenhageni affects the kinetics of bacterial dissemination and kidney colonization"],"prefix":"10.1371","volume":"14","author":[{"given":"Nisha","family":"Nair","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5549-0620","authenticated-orcid":true,"given":"Mariana Soares","family":"Guedes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Werts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3715-4543","authenticated-orcid":true,"given":"Maria","family":"Gomes-Solecki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,1,6]]},"reference":[{"issue":"12","key":"pntd.0007950.ref001","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S1473-3099(03)00830-2","article-title":"Leptospirosis: a zoonotic disease of global importance","volume":"3","author":"AR Bharti","year":"2003","journal-title":"Lancet Infect Dis"},{"key":"pntd.0007950.ref002","first-page":"65","article-title":"Leptospirosis in humans","volume":"387","author":"DA Haake","year":"2015","journal-title":"Curr Top Microbiol Immunol"},{"issue":"3","key":"pntd.0007950.ref003","doi-asserted-by":"crossref","first-page":"e0004569","DOI":"10.1371\/journal.pntd.0004569","article-title":"Comparison of Mucosal, Subcutaneous and Intraperitoneal Routes of Rat Leptospira Infection","volume":"10","author":"AL Zilber","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"issue":"10","key":"pntd.0007950.ref004","doi-asserted-by":"crossref","first-page":"7014","DOI":"10.1128\/IAI.73.10.7014-7017.2005","article-title":"Lethal infection of C3H\/HeJ and C3H\/SCID mice with an isolate of Leptospira interrogans serovar copenhageni","volume":"73","author":"JE Nally","year":"2005","journal-title":"Infect Immun"},{"issue":"Pt 9","key":"pntd.0007950.ref005","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1099\/jmm.0.021089-0","article-title":"Different outcomes of experimental leptospiral infection in mouse strains with distinct genotypes","volume":"59","author":"CS Santos","year":"2010","journal-title":"J Med Microbiol"},{"issue":"7","key":"pntd.0007950.ref006","doi-asserted-by":"crossref","first-page":"2936","DOI":"10.1128\/IAI.05099-11","article-title":"Attenuated nephritis in inducible nitric oxide synthase knockout C57BL\/6 mice and pulmonary hemorrhage in CB17 SCID and recombination activating gene 1 knockout C57BL\/6 mice infected with Leptospira interrogans","volume":"79","author":"M Bandeira","year":"2011","journal-title":"Infect Immun"},{"issue":"1","key":"pntd.0007950.ref007","doi-asserted-by":"crossref","first-page":"e2664","DOI":"10.1371\/journal.pntd.0002664","article-title":"Leptospira Interrogans induces fibrosis in the mouse kidney through Inos-dependent, TLR- and NLR-independent signaling pathways","volume":"8","author":"M Fanton d'Andon","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"issue":"12","key":"pntd.0007950.ref008","doi-asserted-by":"crossref","first-page":"e3359","DOI":"10.1371\/journal.pntd.0003359","article-title":"Live imaging of bioluminescent leptospira interrogans in mice reveals renal colonization as a stealth escape from the blood defenses and antibiotics","volume":"8","author":"G Ratet","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"issue":"12","key":"pntd.0007950.ref009","doi-asserted-by":"crossref","first-page":"4693","DOI":"10.1128\/IAI.01115-15","article-title":"Mouse model for sublethal Leptospira interrogans infection","volume":"83","author":"L Richer","year":"2015","journal-title":"Infect Immun"},{"key":"pntd.0007950.ref010","article-title":"Eye-Drop Inoculation Leads to Sublethal Leptospirosis in Mice","author":"JP Sullivan","year":"2017","journal-title":"Infect Immun"},{"issue":"12E 2","key":"pntd.0007950.ref011","article-title":"Hamster model of leptospirosis","volume":"12","author":"DA Haake","year":"2006","journal-title":"Curr Protoc Microbiol"},{"issue":"11","key":"pntd.0007950.ref012","doi-asserted-by":"crossref","first-page":"e3307","DOI":"10.1371\/journal.pntd.0003307","article-title":"Kinetics of Leptospira interrogans infection in hamsters after intradermal and subcutaneous challenge","volume":"8","author":"ML Coutinho","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"issue":"12","key":"pntd.0007950.ref013","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1086\/340615","article-title":"Outbreak of leptospirosis among triathlon participants and community residents in Springfield, Illinois, 1998","volume":"34","author":"J Morgan","year":"2002","journal-title":"Clin Infect Dis"},{"issue":"8","key":"pntd.0007950.ref014","doi-asserted-by":"crossref","first-page":"e0005870","DOI":"10.1371\/journal.pntd.0005870","article-title":"Pre-treatment with Lactobacillus plantarum prevents severe pathogenesis in mice infected with Leptospira interrogans and may be associated with recruitment of myeloid cells","volume":"11","author":"HH Potula","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"issue":"3","key":"pntd.0007950.ref015","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0940-2993(98)80083-3","article-title":"Morphological characterization of lung and kidney lesions in C3H\/HeJ mice infected with Leptospira interrogans serovar icterohaemorrhagiae: defect of CD4+ and CD8+ T-cells are prognosticators of the disease progression","volume":"50","author":"MM Pereira","year":"1998","journal-title":"Exp Toxicol Pathol"},{"issue":"2","key":"pntd.0007950.ref016","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1128\/IAI.74.2.887-895.2006","article-title":"Toll-like receptor 4 protects against lethal Leptospira interrogans serovar icterohaemorrhagiae infection and contributes to in vivo control of leptospiral burden","volume":"74","author":"S Viriyakosol","year":"2006","journal-title":"Infect Immun"},{"issue":"9\u201310","key":"pntd.0007950.ref017","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1191\/0960327102ht287oa","article-title":"Critical windows in development of the rodent immune system","volume":"21","author":"KS Landreth","year":"2002","journal-title":"Hum Exp Toxicol"},{"issue":"9","key":"pntd.0007950.ref018","doi-asserted-by":"crossref","first-page":"6022","DOI":"10.4049\/jimmunol.175.9.6022","article-title":"Differential TLR recognition of leptospiral lipid A and lipopolysaccharide in murine and human cells","volume":"175","author":"MA Nahori","year":"2005","journal-title":"J Immunol"},{"issue":"24","key":"pntd.0007950.ref019","doi-asserted-by":"crossref","first-page":"25420","DOI":"10.1074\/jbc.M400598200","article-title":"A methylated phosphate group and four amide-linked acyl chains in leptospira interrogans lipid A. The membrane anchor of an unusual lipopolysaccharide that activates TLR2","volume":"279","author":"NL Que-Gewirth","year":"2004","journal-title":"J Biol Chem"},{"key":"pntd.0007950.ref020","article-title":"Animal models of leptospirosis: of mice and hamsters","author":"M Gomes-Solecki","year":"2017","journal-title":"Frontiers in Immunology"},{"issue":"4","key":"pntd.0007950.ref021","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1084\/jem.189.4.615","article-title":"Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)","volume":"189","author":"ST Qureshi","year":"1999","journal-title":"J Exp Med"},{"issue":"4","key":"pntd.0007950.ref022","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.4049\/jimmunol.0900506","article-title":"TLR4- and TLR2-mediated B cell responses control the clearance of the bacterial pathogen, Leptospira interrogans","volume":"183","author":"C Chassin","year":"2009","journal-title":"J Immunol"},{"issue":"1","key":"pntd.0007950.ref023","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1128\/CDLI.12.1.60-67.2005","article-title":"Acute inflammatory response to endotoxin in mice and humans","volume":"12","author":"S Copeland","year":"2005","journal-title":"Clin Diagn Lab Immunol"},{"issue":"10","key":"pntd.0007950.ref024","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/nrmicro2208","article-title":"Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen","volume":"7","author":"AI Ko","year":"2009","journal-title":"Nat Rev Microbiol"},{"issue":"6","key":"pntd.0007950.ref025","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1139\/cjm-2014-0016","article-title":"Natural defense by saliva and mucosa against oral infection by Leptospira","volume":"60","author":"T Asoh","year":"2014","journal-title":"Can J Microbiol"},{"issue":"748","key":"pntd.0007950.ref026","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1136\/pgmj.64.748.163","article-title":"Leptospirosis\u2014can it be a sexually transmitted disease?","volume":"64","author":"NA Harrison","year":"1988","journal-title":"Postgrad Med J"},{"issue":"1","key":"pntd.0007950.ref027","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1093\/infdis\/158.1.246","article-title":"Human-to-human transmission of Leptospira interrogans by milk","volume":"158","author":"CA Bolin","year":"1988","journal-title":"J Infect Dis"},{"issue":"6","key":"pntd.0007950.ref028","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.4049\/jimmunol.1101987","article-title":"Downregulation of the Na\/K-ATPase pump by leptospiral glycolipoprotein activates the NLRP3 inflammasome","volume":"188","author":"S Lacroix-Lamande","year":"2012","journal-title":"J Immunol"},{"issue":"1","key":"pntd.0007950.ref029","doi-asserted-by":"crossref","first-page":"20","DOI":"10.4049\/jimmunol.160.1.20","article-title":"Identification of the mouse IgG3 receptor: implications for antibody effector function at the interface between innate and adaptive immunity","volume":"160","author":"AL Gavin","year":"1998","journal-title":"J Immunol"},{"issue":"3","key":"pntd.0007950.ref030","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.it.2019.01.005","article-title":"Role of IgG3 in Infectious Diseases","volume":"40","author":"T Damelang","year":"2019","journal-title":"Trends Immunol"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0007950","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T00:00:00Z","timestamp":1579132800000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0007950","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T19:49:35Z","timestamp":1695584975000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0007950"}},"subtitle":[],"editor":[{"given":"Melissa J.","family":"Caimano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,1,6]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,1,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0007950","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pntd.0007950","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,6]]}}}