{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T01:27:27Z","timestamp":1772760447232,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pntd.0007980","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T00:00:00Z","timestamp":1591574400000}}],"reference-count":141,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T00:00:00Z","timestamp":1589932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32 GM007752"],"award-info":[{"award-number":["T32 GM007752"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["T32 AR064194"],"award-info":[{"award-number":["T32 AR064194"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002836","name":"Ray Thomas Edwards Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002836","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007911","name":"University of California, San Diego","doi-asserted-by":"publisher","award":["UC President's Office"],"award-info":[{"award-number":["UC President's Office"]}],"id":[{"id":"10.13039\/100007911","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007911","name":"University of California, San Diego","doi-asserted-by":"publisher","award":["RQ276R"],"award-info":[{"award-number":["RQ276R"]}],"id":[{"id":"10.13039\/100007911","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0007980","type":"journal-article","created":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T18:11:44Z","timestamp":1589998304000},"page":"e0007980","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Molecular dissection of Chagas induced cardiomyopathy reveals central disease associated and druggable signaling pathways"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2453-0861","authenticated-orcid":true,"given":"Jacob M.","family":"Wozniak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana Ara\u00fajo","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9574-8174","authenticated-orcid":true,"given":"Jair L.","family":"Siqueira-Neto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James H.","family":"McKerrow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1275-1226","authenticated-orcid":true,"given":"Claudia M.","family":"Calvet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2020,5,20]]},"reference":[{"key":"pntd.0007980.ref001","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1186\/1756-3305-7-317","article-title":"The history of Chagas disease.","volume":"7","author":"D. Steverding","year":"2014","journal-title":"Parasit Vectors."},{"issue":"37","key":"pntd.0007980.ref002","doi-asserted-by":"crossref","DOI":"10.2807\/ese.16.37.19968-en","article-title":"Chagas disease in European countries: the challenge of a surveillance system.","volume":"16","author":"L Basile","year":"2011","journal-title":"Euro Surveill."},{"issue":"11","key":"pntd.0007980.ref003","doi-asserted-by":"crossref","first-page":"e0005033","DOI":"10.1371\/journal.pntd.0005033","article-title":"Estimating the Burden of Chagas Disease in the United States.","volume":"10","author":"J Manne-Goehler","year":"2016","journal-title":"PLoS Negl Trop Dis."},{"issue":"5","key":"pntd.0007980.ref004","doi-asserted-by":"crossref","first-page":"e52","DOI":"10.1086\/605091","article-title":"An estimate of the burden of Chagas disease in the United States","volume":"49","author":"C Bern","year":"2009","journal-title":"Clin Infect Dis"},{"key":"pntd.0007980.ref005","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1146\/annurev-pathol-020117-043711","article-title":"Pathology and Pathogenesis of Chagas Heart Disease.","volume":"14","author":"KM Bonney","year":"2019","journal-title":"Annu Rev Pathol"},{"key":"pntd.0007980.ref006","unstructured":"WHO. Neglected tropical diseases 2019 [cited 2019 August 5]. Available from: https:\/\/www.who.int\/neglected_diseases\/diseases\/en\/."},{"issue":"4","key":"pntd.0007980.ref007","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/S1473-3099(13)70002-1","article-title":"Global economic burden of Chagas disease: a computational simulation model","volume":"13","author":"BY Lee","year":"2013","journal-title":"Lancet Infect Dis"},{"issue":"10115","key":"pntd.0007980.ref008","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0140-6736(17)31612-4","article-title":"Chagas disease.","volume":"391","author":"JA Perez-Molina","year":"2018","journal-title":"Lancet"},{"issue":"1","key":"pntd.0007980.ref009","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ccl.2016.08.013","article-title":"Chagas Cardiomyopathy: Clinical Presentation and Management in the Americas.","volume":"35","author":"CP Benziger","year":"2017","journal-title":"Cardiol Clin."},{"issue":"1","key":"pntd.0007980.ref010","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0020-7519(01)00311-3","article-title":"Pathogenesis of chronic Chagas heart disease: parasite persistence and autoimmune responses versus cardiac remodelling and neurohormonal activation","volume":"32","author":"DF Davila","year":"2002","journal-title":"Int J Parasitol"},{"issue":"6","key":"pntd.0007980.ref011","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1016\/j.ajpath.2014.12.023","article-title":"Autoimmune pathogenesis of Chagas heart disease: looking back, looking ahead","volume":"185","author":"KM Bonney","year":"2015","journal-title":"Am J Pathol"},{"key":"pntd.0007980.ref012","article-title":"Spontaneous dormancy protects Trypanosoma cruzi during extended drug exposure.","volume":"7","author":"FJ Sanchez-Valdez","year":"2018","journal-title":"Elife"},{"issue":"3","key":"pntd.0007980.ref013","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1097\/QCO.0000000000000157","article-title":"Molecular mechanisms of myocarditis caused by Trypanosoma cruzi.","volume":"28","author":"L Esper","year":"2015","journal-title":"Curr Opin Infect Dis"},{"issue":"4","key":"pntd.0007980.ref014","first-page":"925","article-title":"Temporal expression of pro-inflammatory cytokines and inducible nitric oxide synthase in experimental acute chagasic cardiomyopathy","volume":"152","author":"B Chandrasekar","year":"1998","journal-title":"Am J Pathol"},{"issue":"1","key":"pntd.0007980.ref015","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1128\/IAI.64.1.128-134.1996","article-title":"Regulation of Trypanosoma cruzi infection in mice by gamma interferon and interleukin 10: role of NK cells","volume":"64","author":"F Cardillo","year":"1996","journal-title":"Infect Immun"},{"issue":"5\u20136","key":"pntd.0007980.ref016","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.cytogfr.2008.08.002","article-title":"Pivotal role for TGF-beta in infectious heart disease: The case of Trypanosoma cruzi infection and consequent chagasic myocardiopathy","volume":"19","author":"TC Araujo-Jorge","year":"2008","journal-title":"Cytokine Growth Factor Rev"},{"issue":"6","key":"pntd.0007980.ref017","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1023\/A:1020546615229","article-title":"TNF-induced signaling in apoptosis","volume":"19","author":"PC Rath","year":"1999","journal-title":"J Clin Immunol"},{"issue":"4","key":"pntd.0007980.ref018","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.ijmm.2008.08.005","article-title":"Regulation of extracellular matrix expression and distribution in Trypanosoma cruzi-infected cardiomyocytes","volume":"299","author":"CM Calvet","year":"2009","journal-title":"Int J Med Microbiol"},{"issue":"1","key":"pntd.0007980.ref019","doi-asserted-by":"crossref","first-page":"e0003747","DOI":"10.1371\/journal.pntd.0003747","article-title":"Early Regulation of Profibrotic Genes in Primary Human Cardiac Myocytes by Trypanosoma cruzi.","volume":"10","author":"AN Udoko","year":"2016","journal-title":"PLoS Negl Trop Dis."},{"issue":"9","key":"pntd.0007980.ref020","doi-asserted-by":"crossref","first-page":"e0006792","DOI":"10.1371\/journal.pntd.0006792","article-title":"Phospho-proteomic analysis of primary human colon epithelial cells during the early Trypanosoma cruzi infection phase.","volume":"12","author":"S Suman","year":"2018","journal-title":"PLoS Negl Trop Dis"},{"key":"pntd.0007980.ref021","first-page":"2019050171","article-title":"Differential Role of TGF-\u03b2 in Extracellular Matrix Regulation during Trypanosoma cruzi\u2014Host Cell Interaction","author":"L.F.D.C. Silva TAF","year":"2019","journal-title":"Preprints"},{"issue":"24","key":"pntd.0007980.ref022","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.2174\/092986707782023325","article-title":"Phytochemical genistein in the regulation of vascular function: new insights","volume":"14","author":"H Si","year":"2007","journal-title":"Curr Med Chem"},{"issue":"23","key":"pntd.0007980.ref023","doi-asserted-by":"crossref","first-page":"5559","DOI":"10.1111\/bph.13002","article-title":"Genistein alleviates pressure overload-induced cardiac dysfunction and interstitial fibrosis in mice","volume":"172","author":"W Qin","year":"2015","journal-title":"Br J Pharmacol"},{"issue":"24","key":"pntd.0007980.ref024","doi-asserted-by":"crossref","first-page":"13681","DOI":"10.1073\/pnas.251194298","article-title":"SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase","volume":"98","author":"BL Bennett","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7\u20138","key":"pntd.0007980.ref025","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.bbadis.2010.04.001","article-title":"Pharmacological inhibition of c-Jun N-terminal kinase signaling prevents cardiomyopathy caused by mutation in LMNA gene","volume":"1802","author":"W Wu","year":"2010","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"pntd.0007980.ref026","doi-asserted-by":"crossref","first-page":"e0004490","DOI":"10.1371\/journal.pntd.0004490","article-title":"Changes in Proteome Profile of Peripheral Blood Mononuclear Cells in Chronic Chagas Disease.","volume":"10","author":"NJ Garg","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"issue":"3","key":"pntd.0007980.ref027","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.cell.2017.04.001","article-title":"AKT\/PKB Signaling: Navigating the Network.","volume":"169","author":"BD Manning","year":"2017","journal-title":"Cell"},{"issue":"1","key":"pntd.0007980.ref028","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1128\/MMBR.00031-10","article-title":"Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases","volume":"75","author":"M Cargnello","year":"2011","journal-title":"Microbiol Mol Biol Rev"},{"issue":"Pt 8","key":"pntd.0007980.ref029","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1242\/jcs.00963","article-title":"The JAK\/STAT signaling pathway","volume":"117","author":"JS Rawlings","year":"2004","journal-title":"J Cell Sci"},{"issue":"3","key":"pntd.0007980.ref030","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nbt0303-255","article-title":"Proteomic analysis of post-translational modifications","volume":"21","author":"M Mann","year":"2003","journal-title":"Nat Biotechnol"},{"issue":"13","key":"pntd.0007980.ref031","doi-asserted-by":"crossref","first-page":"3957","DOI":"10.1016\/j.celrep.2017.11.111","article-title":"Protein Expression Landscape of Mouse Embryos during Pre-implantation Development","volume":"21","author":"Y Gao","year":"2017","journal-title":"Cell Rep"},{"key":"pntd.0007980.ref032","article-title":"Quantitative Temporal Viromics of an Inducible HIV-1 Model Yields Insight to Global Host Targets and Phospho-Dynamics Associated with Vpr","author":"JD Lapek","year":"2017","journal-title":"Mol Cell Proteomics"},{"issue":"3","key":"pntd.0007980.ref033","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.yexmp.2015.03.034","article-title":"Mitochondrial dysfunction in skeletal muscle during experimental Chagas disease","volume":"98","author":"AL Baez","year":"2015","journal-title":"Exp Mol Pathol"},{"issue":"1","key":"pntd.0007980.ref034","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s40588-018-0081-2","article-title":"Pathogenesis of Chronic Chagas Disease: Macrophages, Mitochondria, and Oxidative Stress.","volume":"5","author":"M Lopez","year":"2018","journal-title":"Curr Clin Microbiol Rep."},{"issue":"5","key":"pntd.0007980.ref035","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1590\/0037-8682-0184-2018","article-title":"Electrocardiogram in Chagas disease.","volume":"51","author":"BOF Brito","year":"2018","journal-title":"Rev Soc Bras Med Trop"},{"issue":"7","key":"pntd.0007980.ref036","doi-asserted-by":"crossref","first-page":"e0007602","DOI":"10.1371\/journal.pntd.0007602","article-title":"TGF-beta inhibitor therapy decreases fibrosis and stimulates cardiac improvement in a pre-clinical study of chronic Chagas' heart disease","volume":"13","author":"RR Ferreira","year":"2019","journal-title":"PLoS Negl Trop Dis"},{"issue":"3","key":"pntd.0007980.ref037","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0167-5273(91)90012-E","article-title":"The pattern of myocardial fibrosis in chronic Chagas' heart disease","volume":"30","author":"MA Rossi","year":"1991","journal-title":"Int J Cardiol"},{"issue":"7","key":"pntd.0007980.ref038","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/j.cell.2010.12.001","article-title":"A tissue-specific atlas of mouse protein phosphorylation and expression","volume":"143","author":"EL Huttlin","year":"2010","journal-title":"Cell"},{"issue":"44","key":"pntd.0007980.ref039","doi-asserted-by":"crossref","first-page":"12592","DOI":"10.1073\/pnas.1606444113","article-title":"Global phosphoproteomic profiling reveals perturbed signaling in a mouse model of dilated cardiomyopathy","volume":"113","author":"U Kuzmanov","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"pntd.0007980.ref040","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1093\/bioinformatics\/btr671","article-title":"A novel significance score for gene selection and ranking","volume":"30","author":"Y Xiao","year":"2014","journal-title":"Bioinformatics"},{"issue":"D1","key":"pntd.0007980.ref041","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"D Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"pntd.0007980.ref042","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"W Huang da","year":"2009","journal-title":"Nat Protoc"},{"issue":"1","key":"pntd.0007980.ref043","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkn923","article-title":"Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists","volume":"37","author":"W Huang da","year":"2009","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"pntd.0007980.ref044","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S0952-7915(99)80014-4","article-title":"Antigen presentation by MHC class I and its regulation by interferon gamma","volume":"11","author":"K Fruh","year":"1999","journal-title":"Curr Opin Immunol"},{"issue":"1","key":"pntd.0007980.ref045","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.bbapap.2011.07.006","article-title":"The endosome-lysosome pathway and information generation in the immune system","volume":"1824","author":"C. Watts","year":"2012","journal-title":"Biochim Biophys Acta"},{"issue":"5","key":"pntd.0007980.ref046","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1189\/jlb.0309187","article-title":"CCL2\/MCP-1 controls parasite burden, cell infiltration, and mononuclear activation during acute Trypanosoma cruzi infection","volume":"86","author":"CN Paiva","year":"2009","journal-title":"J Leukoc Biol"},{"issue":"4","key":"pntd.0007980.ref047","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1086\/427515","article-title":"CCR5 plays a critical role in the development of myocarditis and host protection in mice infected with Trypanosoma cruzi","volume":"191","author":"FS Machado","year":"2005","journal-title":"J Infect Dis"},{"issue":"10","key":"pntd.0007980.ref048","doi-asserted-by":"crossref","first-page":"5434","DOI":"10.1128\/IAI.67.10.5434-5440.1999","article-title":"Infection of endothelial cells with Trypanosoma cruzi activates NF-kappaB and induces vascular adhesion molecule expression","volume":"67","author":"H Huang","year":"1999","journal-title":"Infect Immun"},{"issue":"2","key":"pntd.0007980.ref049","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/imm.12438","article-title":"Signal transducer and activator of transcription 1 (STAT-1) plays a critical role in control of Trypanosoma cruzi infection.","volume":"145","author":"MM Kulkarni","year":"2015","journal-title":"Immunology"},{"issue":"10","key":"pntd.0007980.ref050","doi-asserted-by":"crossref","first-page":"e2469","DOI":"10.1371\/journal.pntd.0002469","article-title":"NLRP3 controls Trypanosoma cruzi infection through a caspase-1-dependent IL-1R-independent NO production.","volume":"7","author":"VM Goncalves","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"issue":"2","key":"pntd.0007980.ref051","doi-asserted-by":"crossref","first-page":"192","DOI":"10.4269\/ajtmh.1993.49.192","article-title":"Expression of major histocompatibility complex antigens and adhesion molecules in hearts of patients with chronic Chagas' disease","volume":"49","author":"DD Reis","year":"1993","journal-title":"Am J Trop Med Hyg"},{"issue":"11","key":"pntd.0007980.ref052","doi-asserted-by":"crossref","first-page":"e79629","DOI":"10.1371\/journal.pone.0079629","article-title":"Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.","volume":"8","author":"X Deng","year":"2013","journal-title":"PLoS One."},{"issue":"1","key":"pntd.0007980.ref053","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1186\/s13071-018-2988-0","article-title":"Host-parasite interaction: changes in human placental gene expression induced by Trypanosoma cruzi","volume":"11","author":"C Castillo","year":"2018","journal-title":"Parasit Vectors"},{"issue":"3","key":"pntd.0007980.ref054","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1086\/653481","article-title":"Gene expression changes associated with myocarditis and fibrosis in hearts of mice with chronic chagasic cardiomyopathy","volume":"202","author":"MB Soares","year":"2010","journal-title":"J Infect Dis"},{"issue":"6","key":"pntd.0007980.ref055","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.86898","article-title":"Molecular profiling of dilated cardiomyopathy that progresses to heart failure","volume":"1","author":"MA Burke","year":"2016","journal-title":"JCI Insight"},{"issue":"6","key":"pntd.0007980.ref056","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/0092-8674(94)90278-X","article-title":"Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27","volume":"78","author":"NW Freshney","year":"1994","journal-title":"Cell"},{"issue":"2","key":"pntd.0007980.ref057","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.bbrc.2007.08.195","article-title":"SOCS1 induced by NDRG2 expression negatively regulates STAT3 activation in breast cancer cells","volume":"363","author":"Y Park","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"pntd.0007980.ref058","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.gene.2012.04.044","article-title":"Microarray profiling of HepG2 cells ectopically expressing NDRG2","volume":"503","author":"X Liu","year":"2012","journal-title":"Gene"},{"issue":"3","key":"pntd.0007980.ref059","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1093\/protein\/gzq094","article-title":"GPS 2.1: enhanced prediction of kinase-specific phosphorylation sites with an algorithm of motif length selection","volume":"24","author":"Y Xue","year":"2011","journal-title":"Protein Eng Des Sel"},{"key":"pntd.0007980.ref060","doi-asserted-by":"crossref","first-page":"e7046","DOI":"10.7717\/peerj.7046","article-title":"PTMphinder: an R package for PTM site localization and motif extraction from proteomic datasets.","volume":"7","author":"JM Wozniak","year":"2019","journal-title":"PeerJ"},{"key":"pntd.0007980.ref061","first-page":"5","article-title":"Biological sequence motif discovery using motif-x","author":"MF Chou","year":"2011","journal-title":"Curr Protoc Bioinformatics"},{"issue":"1","key":"pntd.0007980.ref062","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1074\/mcp.M115.052357","article-title":"Uncovering Phosphorylation-Based Specificities through Functional Interaction Networks","volume":"15","author":"O Wagih","year":"2016","journal-title":"Mol Cell Proteomics"},{"key":"pntd.0007980.ref063","doi-asserted-by":"crossref","first-page":"D668","DOI":"10.1093\/nar\/gkj067","article-title":"DrugBank: a comprehensive resource for in silico drug discovery and exploration","volume":"34","author":"DS Wishart","year":"2006","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"pntd.0007980.ref064","doi-asserted-by":"crossref","first-page":"D1074","DOI":"10.1093\/nar\/gkx1037","article-title":"DrugBank 5.0: a major update to the DrugBank database for 2018","volume":"46","author":"DS Wishart","year":"2018","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"pntd.0007980.ref065","doi-asserted-by":"crossref","first-page":"e16959","DOI":"10.1371\/journal.pone.0016959","article-title":"Aspirin treatment of mice infected with Trypanosoma cruzi and implications for the pathogenesis of Chagas disease.","volume":"6","author":"S Mukherjee","year":"2011","journal-title":"PLoS One."},{"key":"pntd.0007980.ref066","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.exppara.2017.09.019","article-title":"Trypanosoma cruzi: Inhibition of infection of human monocytes by aspirin","volume":"182","author":"R Carvalho de Freitas","year":"2017","journal-title":"Exp Parasitol"},{"issue":"4","key":"pntd.0007980.ref067","first-page":"M111","article-title":"Proteome expression and carbonylation changes during Trypanosoma cruzi infection and Chagas disease in rats","volume":"11","author":"JJ Wen","year":"2012","journal-title":"Mol Cell Proteomics"},{"issue":"8","key":"pntd.0007980.ref068","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1074\/mcp.M112.017640","article-title":"Serum proteomic signature of human chagasic patients for the identification of novel potential protein biomarkers of disease","volume":"11","author":"JJ Wen","year":"2012","journal-title":"Mol Cell Proteomics"},{"key":"pntd.0007980.ref069","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.3389\/fmicb.2018.03320","article-title":"Potential Utility of Protein Targets of Cysteine-S-Nitrosylation in Identifying Clinical Disease Status in Human Chagas Disease.","volume":"9","author":"MP Zago","year":"2018","journal-title":"Front Microbiol."},{"issue":"5","key":"pntd.0007980.ref070","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1007\/s12192-019-01018-7","article-title":"Quantitative phosphoproteome and proteome analyses emphasize the influence of phosphorylation events during the nutritional stress of Trypanosoma cruzi: the initial moments of in vitro metacyclogenesis","volume":"24","author":"ACR Lucena","year":"2019","journal-title":"Cell Stress Chaperones"},{"issue":"12","key":"pntd.0007980.ref071","doi-asserted-by":"crossref","first-page":"3457","DOI":"10.1074\/mcp.M114.040329","article-title":"Quantitative proteomic and phosphoproteomic analysis of Trypanosoma cruzi amastigogenesis","volume":"13","author":"RM Queiroz","year":"2014","journal-title":"Mol Cell Proteomics"},{"issue":"17","key":"pntd.0007980.ref072","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1002\/pmic.201200078","article-title":"Quantitative proteomics of Trypanosoma cruzi during metacyclogenesis","volume":"12","author":"LM de Godoy","year":"2012","journal-title":"Proteomics"},{"issue":"26","key":"pntd.0007980.ref073","doi-asserted-by":"crossref","first-page":"17662","DOI":"10.1016\/S0021-9258(19)47422-X","article-title":"Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro.","volume":"266","author":"A Astrom","year":"1991","journal-title":"J Biol Chem"},{"issue":"5\u20136","key":"pntd.0007980.ref074","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/S0891-5849(98)00266-4","article-title":"Antioxidant potentials of vitamin A and carotenoids and their relevance to heart disease","volume":"26","author":"VP Palace","year":"1999","journal-title":"Free Radic Biol Med"},{"issue":"9","key":"pntd.0007980.ref075","doi-asserted-by":"crossref","DOI":"10.3390\/jcm7090258","article-title":"Role of Vitamin A in the Immune System.","volume":"7","author":"Z Huang","year":"2018","journal-title":"J Clin Med."},{"issue":"1\u20132","key":"pntd.0007980.ref076","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0378-4347(97)00303-4","article-title":"Determination of endogenous levels of 13-cis-retinoic acid (isotretinoin), all-trans-retinoic acid (tretinoin) and their 4-oxo metabolites in human and animal plasma by high-performance liquid chromatography with automated column switching and ultraviolet detection.","volume":"700","author":"R Wyss","year":"1997","journal-title":"J Chromatogr B Biomed Sci Appl"},{"issue":"3","key":"pntd.0007980.ref077","doi-asserted-by":"crossref","first-page":"e0005472","DOI":"10.1371\/journal.pntd.0005472","article-title":"Trypanocidal Effect of Isotretinoin through the Inhibition of Polyamine and Amino Acid Transporters in Trypanosoma cruzi.","volume":"11","author":"C Reigada","year":"2017","journal-title":"PLoS Negl Trop Dis."},{"issue":"9","key":"pntd.0007980.ref078","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00514-18","article-title":"Benefits of Ascorbic Acid in Association with Low-Dose Benznidazole in Treatment of Chagas Disease","volume":"62","author":"MV Providello","year":"2018","journal-title":"Antimicrob Agents Chemother"},{"issue":"12","key":"pntd.0007980.ref079","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1517\/14728222.2013.837886","article-title":"Targeting CCL5 in inflammation","volume":"17","author":"RE Marques","year":"2013","journal-title":"Expert Opin Ther Targets"},{"issue":"1","key":"pntd.0007980.ref080","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s12865-017-0237-5","article-title":"Functional expression of CCL8 and its interaction with chemokine receptor CCR3","volume":"18","author":"B Ge","year":"2017","journal-title":"BMC Immunol"},{"issue":"1","key":"pntd.0007980.ref081","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1089\/jir.2010.0102","article-title":"The guanylate-binding proteins: emerging insights into the biochemical properties and functions of this family of large interferon-induced guanosine triphosphatase","volume":"31","author":"DJ Vestal","year":"2011","journal-title":"J Interferon Cytokine Res"},{"issue":"5","key":"pntd.0007980.ref082","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/ni.3440","article-title":"Interferon-induced guanylate-binding proteins in inflammasome activation and host defense","volume":"17","author":"BH Kim","year":"2016","journal-title":"Nat Immunol"},{"issue":"9","key":"pntd.0007980.ref083","doi-asserted-by":"crossref","first-page":"e24434","DOI":"10.1371\/journal.pone.0024434","article-title":"Determinants of GBP recruitment to Toxoplasma gondii vacuoles and the parasitic factors that control it.","volume":"6","author":"S Virreira Winter","year":"2011","journal-title":"PLoS One."},{"issue":"1","key":"pntd.0007980.ref084","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1073\/pnas.1205635110","article-title":"Murine guanylate binding protein 2 (mGBP2) controls Toxoplasma gondii replication.","volume":"110","author":"D Degrandi","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"pntd.0007980.ref085","doi-asserted-by":"crossref","DOI":"10.1111\/cmi.12807","article-title":"Targeting host mitochondria: A role for the Trypanosoma cruzi amastigote flagellum","volume":"20","author":"G Lentini","year":"2018","journal-title":"Cell Microbiol"},{"issue":"1","key":"pntd.0007980.ref086","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1089\/ars.2008.2418","article-title":"Mitochondrial complex III defects contribute to inefficient respiration and ATP synthesis in the myocardium of Trypanosoma cruzi-infected mice","volume":"12","author":"JJ Wen","year":"2010","journal-title":"Antioxid Redox Signal"},{"issue":"2","key":"pntd.0007980.ref087","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.freeradbiomed.2006.04.009","article-title":"Increased oxidative stress is correlated with mitochondrial dysfunction in chagasic patients","volume":"41","author":"JJ Wen","year":"2006","journal-title":"Free Radic Biol Med"},{"issue":"12","key":"pntd.0007980.ref088","doi-asserted-by":"crossref","first-page":"e1006800","DOI":"10.1371\/journal.ppat.1006800","article-title":"Host triacylglycerols shape the lipidome of intracellular trypanosomes and modulate their growth.","volume":"13","author":"F Gazos-Lopes","year":"2017","journal-title":"PLoS Pathog."},{"issue":"4","key":"pntd.0007980.ref089","first-page":"385","article-title":"Mitochondrial cardiomyopathy: pathophysiology, diagnosis, and management","volume":"40","author":"DE Meyers","year":"2013","journal-title":"Tex Heart Inst J"},{"issue":"2","key":"pntd.0007980.ref090","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1161\/CIRCULATIONAHA.108.827949","article-title":"Developing hearts need their SPEG","volume":"119","author":"MA Sussman","year":"2009","journal-title":"Circulation"},{"issue":"4","key":"pntd.0007980.ref091","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1165\/rcmb.2016-0104OC","article-title":"Tensin 1 Is Essential for Myofibroblast Differentiation and Extracellular Matrix Formation","volume":"56","author":"K Bernau","year":"2017","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"4","key":"pntd.0007980.ref092","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s10741-015-9487-6","article-title":"BAG3: a new player in the heart failure paradigm","volume":"20","author":"T Knezevic","year":"2015","journal-title":"Heart Fail Rev"},{"issue":"1","key":"pntd.0007980.ref093","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1247\/csf.27.1","article-title":"Vinexin, CAP\/ponsin, ArgBP2: a novel adaptor protein family regulating cytoskeletal organization and signal transduction","volume":"27","author":"N Kioka","year":"2002","journal-title":"Cell Struct Funct"},{"issue":"20","key":"pntd.0007980.ref094","doi-asserted-by":"crossref","first-page":"4007","DOI":"10.1093\/hmg\/ddq315","article-title":"Alpha-cardiac myosin heavy chain (MYH6) mutations affecting myofibril formation are associated with congenital heart defects.","volume":"19","author":"JT Granados-Riveron","year":"2010","journal-title":"Hum Mol Genet"},{"issue":"2","key":"pntd.0007980.ref095","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.gene.2015.09.008","article-title":"Cardiac myosin-binding protein C (MYBPC3) in cardiac pathophysiology.","volume":"573","author":"L Carrier","year":"2015","journal-title":"Gene"},{"issue":"18","key":"pntd.0007980.ref096","doi-asserted-by":"crossref","first-page":"7202","DOI":"10.1074\/jbc.RA118.004560","article-title":"A novel isoform of myosin 18A (Myo18Agamma) is an essential sarcomeric protein in mouse heart.","volume":"294","author":"M Horsthemke","year":"2019","journal-title":"J Biol Chem"},{"issue":"1","key":"pntd.0007980.ref097","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.gene.2015.06.027","article-title":"Functions of myosin light chain-2 (MYL2) in cardiac muscle and disease.","volume":"569","author":"F Sheikh","year":"2015","journal-title":"Gene"},{"issue":"3","key":"pntd.0007980.ref098","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.bbrc.2011.01.056","article-title":"A myomesin mutation associated with hypertrophic cardiomyopathy deteriorates dimerisation properties","volume":"405","author":"R Siegert","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"issue":"6","key":"pntd.0007980.ref099","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1161\/01.RES.0000263008.66799.aa","article-title":"Myozenin 2 is a novel gene for human hypertrophic cardiomyopathy","volume":"100","author":"A Osio","year":"2007","journal-title":"Circ Res"},{"issue":"5","key":"pntd.0007980.ref100","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.imbio.2016.01.009","article-title":"Proteins involved on TGF-beta pathway are up-regulated during the acute phase of experimental Chagas disease","volume":"221","author":"RR Ferreira","year":"2016","journal-title":"Immunobiology"},{"issue":"28","key":"pntd.0007980.ref101","doi-asserted-by":"crossref","first-page":"26161","DOI":"10.18632\/oncotarget.4544","article-title":"Tumor suppressor NDRG2 inhibits glycolysis and glutaminolysis in colorectal cancer cells by repressing c-Myc expression","volume":"6","author":"X Xu","year":"2015","journal-title":"Oncotarget"},{"issue":"1","key":"pntd.0007980.ref102","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/ijc.23945","article-title":"NDRG2 suppresses cell proliferation through down-regulation of AP-1 activity in human colon carcinoma cells","volume":"124","author":"YJ Kim","year":"2009","journal-title":"Int J Cancer"},{"issue":"4","key":"pntd.0007980.ref103","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1093\/carcin\/bgp047","article-title":"NDRG2 expression decreases with tumor stages and regulates TCF\/beta-catenin signaling in human colon carcinoma","volume":"30","author":"YJ Kim","year":"2009","journal-title":"Carcinogenesis"},{"issue":"1","key":"pntd.0007980.ref104","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1161\/CIRCRESAHA.116.303613","article-title":"The GSK-3 family as therapeutic target for myocardial diseases","volume":"116","author":"H Lal","year":"2015","journal-title":"Circ Res"},{"issue":"12","key":"pntd.0007980.ref105","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1016\/j.yexcr.2010.02.028","article-title":"HIF-1 and NDRG2 contribute to hypoxia-induced radioresistance of cervical cancer Hela cells","volume":"316","author":"J Liu","year":"2010","journal-title":"Exp Cell Res"},{"issue":"18","key":"pntd.0007980.ref106","doi-asserted-by":"crossref","first-page":"8478","DOI":"10.18632\/oncotarget.2328","article-title":"The iron chelator Dp44mT inhibits hepatocellular carcinoma metastasis via N-Myc downstream-regulated gene 2 (NDRG2)\/gp130\/STAT3 pathway.","volume":"5","author":"J Wang","year":"2014","journal-title":"Oncotarget"},{"issue":"11","key":"pntd.0007980.ref107","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/nrc3818","article-title":"Revisiting STAT3 signalling in cancer: new and unexpected biological functions","volume":"14","author":"H Yu","year":"2014","journal-title":"Nat Rev Cancer"},{"issue":"3","key":"pntd.0007980.ref108","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s00395-013-0341-5","article-title":"NDRG2: a newly identified mediator of insulin cardioprotection against myocardial ischemia-reperfusion injury.","volume":"108","author":"Z Sun","year":"2013","journal-title":"Basic Res Cardiol"},{"issue":"10","key":"pntd.0007980.ref109","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1016\/j.cellsig.2016.07.004","article-title":"The MNK-1\/eIF4E pathway as a new therapeutic pathway to target inflammation and remodelling in asthma","volume":"28","author":"P Seidel","year":"2016","journal-title":"Cell Signal"},{"issue":"3","key":"pntd.0007980.ref110","doi-asserted-by":"crossref","first-page":"a000158","DOI":"10.1101\/cshperspect.a000158","article-title":"The IKK complex, a central regulator of NF-kappaB activation","volume":"2","author":"A. Israel","year":"2010","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"1","key":"pntd.0007980.ref111","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1006\/smim.2000.0210","article-title":"The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling.","volume":"12","author":"M Karin","year":"2000","journal-title":"Semin Immunol."},{"issue":"8","key":"pntd.0007980.ref112","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1093\/emboj\/16.8.1909","article-title":"Mitogen-activated protein kinases activate the serine\/threonine kinases Mnk1 and Mnk2","volume":"16","author":"AJ Waskiewicz","year":"1997","journal-title":"EMBO J"},{"issue":"3","key":"pntd.0007980.ref113","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1128\/MCB.19.3.1871","article-title":"Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo","volume":"19","author":"AJ Waskiewicz","year":"1999","journal-title":"Mol Cell Biol"},{"issue":"6","key":"pntd.0007980.ref114","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1080\/15384101.2015.1007751","article-title":"Engagement of DYRK2 in proper control for cell division","volume":"14","author":"NT Nihira","year":"2015","journal-title":"Cell Cycle"},{"issue":"5","key":"pntd.0007980.ref115","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.molcel.2007.02.007","article-title":"DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage","volume":"25","author":"N Taira","year":"2007","journal-title":"Mol Cell"},{"issue":"7","key":"pntd.0007980.ref116","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1002\/cm.21021","article-title":"Dyrk kinases regulate phosphorylation of doublecortin, cytoskeletal organization, and neuronal morphology.","volume":"69","author":"TI Slepak","year":"2012","journal-title":"Cytoskeleton (Hoboken)."},{"issue":"2","key":"pntd.0007980.ref117","doi-asserted-by":"crossref","first-page":"e1660","DOI":"10.1371\/journal.pone.0001660","article-title":"Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein.","volume":"3","author":"S Blanco","year":"2008","journal-title":"PLoS One."},{"issue":"20","key":"pntd.0007980.ref118","doi-asserted-by":"crossref","first-page":"7273","DOI":"10.1128\/MCB.00025-07","article-title":"Vaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1","volume":"27","author":"S Blanco","year":"2007","journal-title":"Mol Cell Biol"},{"issue":"5","key":"pntd.0007980.ref119","doi-asserted-by":"crossref","first-page":"e0177834","DOI":"10.1371\/journal.pone.0177834","article-title":"Site-specific phosphorylation of casein kinase 1 delta (CK1delta) regulates its activity towards the circadian regulator PER2.","volume":"12","author":"GWL Eng","year":"2017","journal-title":"PLoS One."},{"issue":"5","key":"pntd.0007980.ref120","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/0092-8674(92)90311-Y","article-title":"Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity","volume":"70","author":"A Lin","year":"1992","journal-title":"Cell"},{"issue":"8","key":"pntd.0007980.ref121","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/s00109-008-0352-0","article-title":"Protein kinase CK2, an important regulator of the inflammatory response?","volume":"86","author":"NN Singh","year":"2008","journal-title":"J Mol Med (Berl)."},{"issue":"6","key":"pntd.0007980.ref122","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1134\/S0006297918060123","article-title":"The Role of p38 and CK2 Protein Kinases in the Response of RAW 264.7 Macrophages to Lipopolysaccharide.","volume":"83","author":"OV Glushkova","year":"2018","journal-title":"Biochemistry (Mosc)."},{"issue":"7","key":"pntd.0007980.ref123","first-page":"1265","article-title":"Redox regulation of casein kinase II autophosphorylation and its effect on Jun-DNA binding","volume":"46","author":"M Moussazadeh","year":"2000","journal-title":"Cell Mol Biol (Noisy-le-grand)."},{"issue":"7","key":"pntd.0007980.ref124","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1002\/ajh.25125","article-title":"Fostamatinib for the treatment of adult persistent and chronic immune thrombocytopenia: Results of two phase 3, randomized, placebo-controlled trials","volume":"93","author":"J Bussel","year":"2018","journal-title":"Am J Hematol"},{"issue":"11","key":"pntd.0007980.ref125","doi-asserted-by":"crossref","first-page":"e112682","DOI":"10.1371\/journal.pone.0112682","article-title":"Zinc supplementation inhibits complement activation in age-related macular degeneration","volume":"9","author":"D Smailhodzic","year":"2014","journal-title":"PLoS One"},{"issue":"7","key":"pntd.0007980.ref126","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1093\/ndt\/11.7.1243","article-title":"Bacterial infections during immunosuppression\u2014immunosuppressive agents interfere not only with immune response, but also with polymorphonuclear cell function","volume":"11","author":"S Schmaldienst","year":"1996","journal-title":"Nephrol Dial Transplant"},{"issue":"10","key":"pntd.0007980.ref127","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18102222","article-title":"Zinc Signals and Immunity.","volume":"18","author":"M Maywald","year":"2017","journal-title":"Int J Mol Sci"},{"issue":"12","key":"pntd.0007980.ref128","doi-asserted-by":"crossref","first-page":"e0006132","DOI":"10.1371\/journal.pntd.0006132","article-title":"4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection.","volume":"11","author":"CM Calvet","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"issue":"7","key":"pntd.0007980.ref129","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis.","volume":"9","author":"J Schindelin","year":"2012","journal-title":"Nat Methods."},{"issue":"7","key":"pntd.0007980.ref130","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1074\/mcp.M500339-MCP200","article-title":"Optimization and use of peptide mass measurement accuracy in shotgun proteomics","volume":"5","author":"W Haas","year":"2006","journal-title":"Mol Cell Proteomics"},{"issue":"1","key":"pntd.0007980.ref131","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0003-2697(84)90782-6","article-title":"A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids","volume":"138","author":"D Wessel","year":"1984","journal-title":"Anal Biochem"},{"issue":"89","key":"pntd.0007980.ref132","doi-asserted-by":"crossref","DOI":"10.3791\/51416","article-title":"Quantitative proteomics using reductive dimethylation for stable isotope labeling","author":"AC Tolonen","year":"2014","journal-title":"J Vis Exp"},{"issue":"8","key":"pntd.0007980.ref133","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1021\/ac0262560","article-title":"Tandem mass tags: a novel quantification strategy for comparative analysis of complex protein mixtures by MS\/MS","volume":"75","author":"A Thompson","year":"2003","journal-title":"Anal Chem"},{"issue":"17","key":"pntd.0007980.ref134","doi-asserted-by":"crossref","first-page":"7469","DOI":"10.1021\/ac301572t","article-title":"Increasing the multiplexing capacity of TMTs using reporter ion isotopologues with isobaric masses","volume":"84","author":"GC McAlister","year":"2012","journal-title":"Anal Chem"},{"issue":"14","key":"pntd.0007980.ref135","doi-asserted-by":"crossref","first-page":"7150","DOI":"10.1021\/ac502040v","article-title":"MultiNotch MS3 enables accurate, sensitive, and multiplexed detection of differential expression across cancer cell line proteomes","volume":"86","author":"GC McAlister","year":"2014","journal-title":"Anal Chem"},{"issue":"11","key":"pntd.0007980.ref136","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/1044-0305(94)80016-2","article-title":"An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database","volume":"5","author":"JK Eng","year":"1994","journal-title":"J Am Soc Mass Spectrom"},{"issue":"9","key":"pntd.0007980.ref137","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/nmeth785","article-title":"Comparative evaluation of mass spectrometry platforms used in large-scale proteomics investigations","volume":"2","author":"JE Elias","year":"2005","journal-title":"Nat Methods"},{"issue":"3","key":"pntd.0007980.ref138","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nmeth1019","article-title":"Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry.","volume":"4","author":"JE Elias","year":"2007","journal-title":"Nat Methods"},{"issue":"11","key":"pntd.0007980.ref139","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/nmeth.1714","article-title":"MS3 eliminates ratio distortion in isobaric multiplexed quantitative proteomics","volume":"8","author":"L Ting","year":"2011","journal-title":"Nat Methods"},{"key":"pntd.0007980.ref140","article-title":"Detection of dysregulated protein-association networks by high-throughput proteomics predicts cancer vulnerabilities","author":"JD Lapek","year":"2017","journal-title":"Nat Biotechnol"},{"issue":"Suppl 1","key":"pntd.0007980.ref141","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.1186\/1471-2105-12-S1-S22","article-title":"Motif-All: discovering all phosphorylation motifs.","volume":"12","author":"Z He","year":"2011","journal-title":"BMC Bioinformatics"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0007980","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T00:00:00Z","timestamp":1591574400000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0007980","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T01:24:26Z","timestamp":1615857866000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0007980"}},"subtitle":[],"editor":[{"given":"Carlos A.","family":"Buscaglia","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,5,20]]},"references-count":141,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,5,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0007980","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pntd.0007980","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,20]]}}}