{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T10:43:04Z","timestamp":1788000184158,"version":"build-2784847793"},"update-to":[{"DOI":"10.1371\/journal.pntd.0008079","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T00:00:00Z","timestamp":1583193600000}}],"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T00:00:00Z","timestamp":1582156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-03490-13"],"award-info":[{"award-number":["APQ-03490-13"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0008079","type":"journal-article","created":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T13:30:27Z","timestamp":1582205427000},"page":"e0008079","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":22,"title":["Dogs with divergent serology for visceral leishmaniasis as sources of Leishmania infection for Lutzomyia longipalpis phlebotomine sand flies \u2013 an observational study in an endemic area in Brazil"],"prefix":"10.1371","volume":"14","author":[{"given":"Mar\u00edlia Fonseca","family":"Rocha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9rika Monteiro","family":"Michalsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana","family":"de Oliveira Lara-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josiane Lopes","family":"Valad\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Carlos","family":"Fran\u00e7a-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Let\u00edcia Cavalari","family":"Pinheiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel Fontes","family":"de Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronaldo Cardoso","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Dias","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Consuelo Latorre","family":"Fortes-Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2370-5113","authenticated-orcid":true,"given":"Edelberto Santos","family":"Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,2,20]]},"reference":[{"key":"pntd.0008079.ref001","unstructured":"Brazilian Ministry of Health, 2019. Available at http:\/\/tabnet.datasus.gov.br\/cgi\/tabcgi.exe?sinannet\/cnv\/leishvmg.def (accessed 01\/05\/2019)."},{"key":"pntd.0008079.ref002","first-page":"1","volume-title":"The Leishmaniasis in Biology and Medicine","author":"R Lainson","year":"1987"},{"issue":"1","key":"pntd.0008079.ref003","doi-asserted-by":"crossref","first-page":"e584","DOI":"10.1371\/journal.pntd.0000584","article-title":"Control of visceral leishmaniasis in Latin America-a systematic review","volume":"4","author":"GA Romero","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"pntd.0008079.ref004","volume-title":"Memoirs of the American Entomological Institute no. 54","author":"DG Young","year":"1994"},{"issue":"1","key":"pntd.0008079.ref005","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1186\/1756-3305-2-S1-S1","article-title":"Canine leishmaniosis in South America","volume":"2","author":"F. Dantas-Torres","year":"2009","journal-title":"Parasit Vectors"},{"key":"pntd.0008079.ref006","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.vetpar.2016.07.011","article-title":"Current status on prevention and treatment of canine leishmaniasis","volume":"227","author":"RM Reguera","year":"2016","journal-title":"Vet Parasitol"},{"issue":"9","key":"pntd.0008079.ref007","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1086\/344312","article-title":"Infectiousness in a cohort of Brazilian dogs: why culling fails to control visceral leishmaniasis in areas of high transmission","volume":"186","author":"O Courtenay","year":"2002","journal-title":"J Infect Dis"},{"issue":"9","key":"pntd.0008079.ref008","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S1471-4922(02)02347-4","article-title":"Canine leishmaniasis: epidemiological risk and the experimental model","volume":"18","author":"J Moreno","year":"2002","journal-title":"Trends Parasitol"},{"issue":"2\u20133","key":"pntd.0008079.ref009","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jcpa.2006.06.005","article-title":"Relationship between canine visceral leishmaniosis and the Leishmania (Leishmania) chagasi burden in dermal inflammatory foci","volume":"135","author":"RC Giunchetti","year":"2006","journal-title":"J Comp Pathol"},{"key":"pntd.0008079.ref010","first-page":"120","volume-title":"Secretaria de Vigil\u00e2ncia em Sa\u00fade. Departamento de Vigil\u00e2ncia Epidemiol\u00f3gica. Manual de vigil\u00e2ncia e controle da leishmaniose visceral","author":"Brazilian Ministry of Health","year":"2006"},{"issue":"1","key":"pntd.0008079.ref011","doi-asserted-by":"crossref","first-page":"53","DOI":"10.4269\/ajtmh.1998.59.53","article-title":"Studies on control of visceral leishmaniasis: impact of dog control on canine and human visceral leishmaniasis in Jacobina, Bahia, Brazil","volume":"59","author":"DA Ashford","year":"1998","journal-title":"Am J Trop Med Hyg"},{"issue":"5","key":"pntd.0008079.ref012","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1086\/516096","article-title":"Effect of eliminating seropositive canines on the transmission of visceral leishmaniasis in Brazil","volume":"25","author":"R Dietze","year":"1997","journal-title":"Clin Infect Dis"},{"issue":"5","key":"pntd.0008079.ref013","doi-asserted-by":"crossref","first-page":"510","DOI":"10.4269\/ajtmh.2001.65.510","article-title":"Impact of canine control on the epidemiology of canine and human visceral leishmaniasis in Brazil","volume":"65","author":"CB Palatnik-de-Sousa","year":"2001","journal-title":"Am J Trop Med Hyg"},{"key":"pntd.0008079.ref014","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.vetpar.2016.10.004","article-title":"Parasite load in the blood and skin of dogs naturally infected by Leishmania infantum is correlated with their capacity to infect sand fly vectors","volume":"229","author":"LS Borja","year":"2016","journal-title":"Vet Parasitol"},{"issue":"1","key":"pntd.0008079.ref015","doi-asserted-by":"crossref","first-page":"e0006082","DOI":"10.1371\/journal.pntd.0006082","article-title":"Canine visceral leishmaniasis: Diagnosis and management of the reservoir living among us","volume":"12","author":"BL Travi","year":"2018","journal-title":"PLoS Negl Trop Dis"},{"key":"pntd.0008079.ref016","unstructured":"Brazilian Institute of Geography and Statistics (IBGE). Available at: http:\/\/www.ibge.gov.br (accessed 01\/05\/2019)."},{"key":"pntd.0008079.ref017","unstructured":"Brazilian Ministry of Health, 2011. Esclarecimento sobre substitui\u00e7\u00e3o do protocolo diagn\u00f3stico da leishmaniose visceral canina. Nota t\u00e9cnica conjunta no. 01\/2011-CGDT-CGLAB\/DEVIT\/SVS\/MS. Minist\u00e9rio da Sa\u00fade, Bras\u00edlia, Brasil."},{"issue":"2","key":"pntd.0008079.ref018","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1046\/j.1365-2583.2002.00315.x","article-title":"Molecular evolution of the cacophony IVS6 region in sandflies","volume":"11","author":"RM Lins","year":"2002","journal-title":"Insect Mol Biol"},{"issue":"1","key":"pntd.0008079.ref019","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0166-6851(92)90208-2","article-title":"Sequence analysis of small subunit ribosomal RNA genes and its use for detection and identification of Leishmania parasites","volume":"51","author":"GJ van Eys","year":"1992","journal-title":"Mol Biochem Parasitol"},{"issue":"1","key":"pntd.0008079.ref020","doi-asserted-by":"crossref","first-page":"S185","DOI":"10.1016\/S0035-9203(02)90074-X","article-title":"Nested polymerase chain reaction (Ln-PCR) for diagnosing and monitoring Leishmania infantum infection in patients co-infected with human immunodeficiency virus","volume":"96","author":"I Cruz","year":"2002","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"12","key":"pntd.0008079.ref021","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1590\/S0102-311X2008001200023","article-title":"Forum: geographic spread and urbanization of visceral leishmaniasis in Brazil. Introduction","volume":"24","author":"GL Werneck","year":"2008","journal-title":"Cad Saude Publica"},{"issue":"9","key":"pntd.0008079.ref022","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.pt.2011.04.001","article-title":"Urban parasitology: visceral leishmaniasis in Brazil","volume":"27","author":"MO Harhay","year":"2011","journal-title":"Trends Parasitol"},{"key":"pntd.0008079.ref023","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.actatropica.2015.04.002","article-title":"Epidemiological aspects of vector, parasite, and domestic reservoir in areas of recent transmission and no reported human cases of visceral leishmaniasis in Brazil","volume":"148","author":"O Lara-Silva Fde","year":"2015","journal-title":"Acta Trop"},{"issue":"1","key":"pntd.0008079.ref024","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1186\/s13071-018-3084-1","article-title":"Dispersion of Lutzomyia longipalpis and expansion of visceral leishmaniasis in S\u00e3o Paulo State, Brazil: identification of associated factors through survival analysis","volume":"11","author":"AM Oliveira","year":"2018","journal-title":"Parasit Vectors"},{"issue":"5","key":"pntd.0008079.ref025","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1590\/0037-8682-0243-2017","article-title":"Changes in the epidemiology of visceral leishmaniasis in Brazil from 2001 to 2014","volume":"50","author":"LLD Reis","year":"2017","journal-title":"Rev Soc Bras Med Trop"},{"issue":"7","key":"pntd.0008079.ref026","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1093\/trstmh\/try058","article-title":"Visceral leishmaniasis and vulnerability conditions in an endemic urban area of Northeastern Brazil","volume":"112","author":"AT de Freitas Rocha","year":"2018","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"pntd.0008079.ref027","first-page":"198","article-title":"Visceral leishmaniasis in Brazil. Geographic distribution and transmission","volume":"4","author":"LM Deane","year":"1962","journal-title":"Rev Inst Med Trop Sao Paulo"},{"issue":"5","key":"pntd.0008079.ref028","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1590\/S0102-311X2001000500023","article-title":"Spatial distribution of human and canine visceral leishmaniasis in Belo Horizonte, Minas Gerais State, Brasil, 1994\u20131997","volume":"17","author":"CD Oliveira","year":"2001","journal-title":"Cad Saude Publica"},{"issue":"2\u20133","key":"pntd.0008079.ref029","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0304-4017(02)00351-5","article-title":"Epidemiology of canine visceral leishmaniosis in the endemic area of Montes Claros Municipality, Minas Gerais State","volume":"111","author":"JC Fran\u00e7a-Silva","year":"2003","journal-title":"Brazil. Vet Parasitol"},{"issue":"2","key":"pntd.0008079.ref030","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1590\/S0037-86822005000200004","article-title":"Leishmaniose visceral: estudo de flebotom\u00edneos e infec\u00e7\u00e3o canina em Montes Claros, Minas Gerais [Visceral leishmaniasis: a study on phlebotomine sand flies and canine infection in Montes Claros, State of Minas Gerais","volume":"38","author":"EM Monteiro","year":"2005","journal-title":"Rev Soc Bras Med Trop"},{"issue":"3","key":"pntd.0008079.ref031","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1590\/S0036-46652006000300007","article-title":"isceral leishmaniasis in Brazil: revisiting paradigms of epidemiology and control","volume":"48","author":"F Dantas-Torres","year":"2006","journal-title":"Rev Inst Med Trop Sao Paulo"},{"issue":"12","key":"pntd.0008079.ref032","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.1590\/S0102-311X2008001200026","article-title":"Visceral leishmaniasis in large Brazilian cities: challenges for control","volume":"24","author":"CD Oliveira","year":"2008","journal-title":"Cad Saude Publica"},{"issue":"6","key":"pntd.0008079.ref033","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1590\/S0034-89102009005000063","article-title":"TG-ROC analysis of immunofluorescence assays in canine visceral leishmaniasis diagnosis","volume":"43","author":"RM Silva","year":"2009","journal-title":"Rev Saude Publica"},{"key":"pntd.0008079.ref034","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1186\/1756-3305-4-197","article-title":"One Health: the global challenge of epidemic and endemic leishmaniasis","volume":"4","author":"CB Palatnik-de-Sousa","year":"2011","journal-title":"Parasit Vectors"},{"issue":"4","key":"pntd.0008079.ref035","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.vetpar.2004.05.019","article-title":"Assessment of an optimized dog-culling program in the dynamics of canine Leishmania transmission","volume":"122","author":"ED Moreira","year":"2004","journal-title":"Vet Parasitol"},{"key":"pntd.0008079.ref036","first-page":"405083","article-title":"Epidemiology of visceral leishmaniasis in a reemerging focus of intense transmission in Minas Gerais State","volume":"2013","author":"RA Barata","year":"2013","journal-title":"Brazil. Biomed Res Int"},{"issue":"2","key":"pntd.0008079.ref037","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1590\/S0037-86822011005000014","article-title":"How effective is dog culling in controlling zoonotic visceral leishmaniasis? A critical evaluation of the science, politics and ethics behind this public health policy","volume":"44","author":"CH Costa","year":"2011","journal-title":"Rev Soc Bras Med Trop"},{"issue":"3","key":"pntd.0008079.ref038","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/tmi.12429","article-title":"Serological diagnosis of canine visceral leishmaniasis in Brazil: systematic review and meta-analysis","volume":"20","author":"HM Peixoto","year":"2015","journal-title":"Trop Med Int Health"},{"issue":"7","key":"pntd.0008079.ref039","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.pt.2013.05.003","article-title":"The prevention of canine leishmaniasis and its impact on public health","volume":"29","author":"D Otranto","year":"2013","journal-title":"Trends Parasitol"},{"key":"pntd.0008079.ref040","doi-asserted-by":"crossref","first-page":"106","DOI":"10.5897\/AJMR2016.8300","article-title":"Dual-Path Platform (DPP) and enzyme-linked immunosorbent assay (ELISA): change the sequence of the tests does not change the number of positive dogs for canine visceral leishmaniasis","volume":"11","author":"SS Almeida","year":"2017","journal-title":"Afr J Microbiol Res"},{"issue":"1","key":"pntd.0008079.ref041","doi-asserted-by":"crossref","first-page":"e0004333","DOI":"10.1371\/journal.pntd.0004333","article-title":"The Rapid Test Based on Leishmania infantum Chimeric rK28 Protein Improves the Diagnosis of Canine Visceral Leishmaniasis by Reducing the Detection of False-Positive Dogs","volume":"10","author":"DB Fraga","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"issue":"2","key":"pntd.0008079.ref042","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.vaccine.2011.11.005","article-title":"The development and clinical evaluation of second-generation leishmaniasis vaccines","volume":"30","author":"MS Duthie","year":"2012","journal-title":"Vaccine"},{"issue":"1\u20132","key":"pntd.0008079.ref043","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0304-4017(96)00946-6","article-title":"Evaluation of dot enzyme-linked immunosorbent assay (dot-ELISA) for the serodiagnosis of canine leishmaniosis as compared with indirect immunofluorescence assay","volume":"65","author":"F Mancianti","year":"1996","journal-title":"Vet Parasitol"},{"issue":"Suppl.1","key":"pntd.0008079.ref044","first-page":"238","article-title":"Rea\u00e7\u00e3o cruzada no diagn\u00f3stico sorol\u00f3gico de leishmaniose canina [Cross-reaction in serological diagnosis of canine leishmaniasis","volume":"23","author":"RLR Gomes APS Cordeiro","year":"2004","journal-title":"Rev Bras Parasitol Vet"},{"issue":"1","key":"pntd.0008079.ref045","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1590\/0037-8682-0291-2014","article-title":"Leishmania, Babesia and Ehrlichia in urban pet dogs: co-infection or cross-reaction in serological methods?","volume":"48","author":"S Krawczak Fda","year":"2015","journal-title":"Rev Soc Bras Med Trop"},{"issue":"1","key":"pntd.0008079.ref046","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1590\/0037-8682-1723-2013","article-title":"Serological cross-reactivity of Trypanosoma cruzi, Ehrlichia canis, Toxoplasma gondii, Neospora caninum and Babesia canis to Leishmania infantum chagasi tests in dogs","volume":"47","author":"MF Zanette","year":"2014","journal-title":"Rev Soc Bras Med Trop"},{"issue":"1","key":"pntd.0008079.ref047","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0001-706X(97)00116-2","article-title":"Cohort study on canine emigration and Leishmania infection in an endemic area for American visceral leishmaniasis. Implications for the disease control","volume":"69","author":"M Paranhos-Silva","year":"1998","journal-title":"Acta Trop"},{"issue":"1\u20132","key":"pntd.0008079.ref048","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.vetpar.2008.01.005","article-title":"Dog culling and replacement in an area endemic for visceral leishmaniasis in Brazil","volume":"153","author":"CM Nunes","year":"2008","journal-title":"Vet Parasitol"},{"issue":"2","key":"pntd.0008079.ref049","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.tvjl.2012.06.010","article-title":"Assessment of serological tests for the diagnosis of canine visceral leishmaniasis","volume":"195","author":"DA da Silva","year":"2013","journal-title":"Vet J"},{"issue":"6","key":"pntd.0008079.ref050","doi-asserted-by":"crossref","DOI":"10.1590\/0102-311X00087415","article-title":"Dificuldades na execu\u00e7\u00e3o das diretrizes do Programa de Vigil\u00e2ncia e Controle da Leishmaniose Visceral em grandes munic\u00edpios brasileiros [Difficulties in implementing the guidelines of the Brazilian Visceral Leishmaniasis Control Program in large cities","volume":"32","author":"AP Zuben","year":"2016","journal-title":"Cad Saude Publica"},{"issue":"2","key":"pntd.0008079.ref051","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.pt.2018.11.005","article-title":"Culling Dogs for Zoonotic Visceral Leishmaniasis Control: The Wind of Change","volume":"35","author":"F Dantas-Torres","year":"2019","journal-title":"Trends Parasitol"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0008079","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T00:00:00Z","timestamp":1583193600000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0008079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T14:12:05Z","timestamp":1583244725000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0008079"}},"subtitle":[],"editor":[{"given":"Fabiano","family":"Oliveira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,2,20]]},"references-count":51,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,2,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0008079","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pntd.0008079","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,20]]}}}