{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T14:25:22Z","timestamp":1773411922025,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pntd.0008106","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T00:00:00Z","timestamp":1585180800000}}],"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T00:00:00Z","timestamp":1584316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPPGH5342"],"award-info":[{"award-number":["OPPGH5342"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0008106","type":"journal-article","created":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T17:32:12Z","timestamp":1584379932000},"page":"e0008106","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["The safety of combined triple drug therapy with ivermectin, diethylcarbamazine and albendazole in the neglected tropical diseases co-endemic setting of Fiji: A\u00a0cluster randomised trial"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3482-6348","authenticated-orcid":true,"given":"Myra","family":"Hardy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josaia","family":"Samuela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mike","family":"Kama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meciusela","family":"Tuicakau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9038-5300","authenticated-orcid":true,"given":"Lucia","family":"Romani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4509-4461","authenticated-orcid":true,"given":"Margot J.","family":"Whitfeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3873-7860","authenticated-orcid":true,"given":"Christopher L.","family":"King","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6336-3824","authenticated-orcid":true,"given":"Gary J.","family":"Weil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7809-7688","authenticated-orcid":true,"given":"Anneke C.","family":"Grobler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leanne J.","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Kaldor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7346-0196","authenticated-orcid":true,"given":"Andrew C.","family":"Steer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2020,3,16]]},"reference":[{"issue":"93","key":"pntd.0008106.ref001","first-page":"589","article-title":"Global programme to eliminate lymphatic filariasis: progress report, 2017","volume":"44","author":"World Health Organization","year":"2018","journal-title":"Wkly Epidemiol Rec"},{"key":"pntd.0008106.ref002","unstructured":"Crompton D, World Health Organization. Preventative chemotherapy in human helminthiasis: coordinated use of antihelminthic durgs in control interventions: a manual for health professionals and programme managers. 2006."},{"key":"pntd.0008106.ref003","volume-title":"Rovings in the Pacific, from 1837 to 1849; with a glance at California by a merchant long resident at Tahiti","author":"E. Lucatt","year":"1851"},{"key":"pntd.0008106.ref004","unstructured":"Nelson S, Cruikshank J. Filariasis in Fiji 1944\u20131955.1956. 50 p."},{"issue":"9","key":"pntd.0008106.ref005","first-page":"208","article-title":"Filariasis Research in Fiji 1957\u20131959. Part III. Experiments in Control of Adult Mosquitoes","author":"G. Burnett","year":"1960","journal-title":"Journal of Tropical Medicine and Hygiene"},{"issue":"8","key":"pntd.0008106.ref006","first-page":"184","article-title":"Filariasis research in Fiji 1957\u20131959. Part II. Experiments in larval control of mosquito vectors","volume":"63","author":"G. Burnett","year":"1960","journal-title":"Journal of Tropical Medicine and Hygiene"},{"key":"pntd.0008106.ref007","volume-title":"Regional Office for the Western Pacific, South Pacific Commission. Report on the fourth joint WHO\/SPC seminar on filariasis and vector control: Apia, Western Samoa: 1 to 10 July 1974","author":"World Health Organization","year":"1974"},{"issue":"19","key":"pntd.0008106.ref008","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1056\/NEJMoa1706854","article-title":"A Trial of a Triple-Drug Treatment for Lymphatic Filariasis","volume":"379","author":"C King","year":"2018","journal-title":"N Engl J Med"},{"issue":"3","key":"pntd.0008106.ref009","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1093\/cid\/civ882","article-title":"Efficacy, Safety, and Pharmacokinetics of Coadministered Diethylcarbamazine, Albendazole, and Ivermectin for Treatment of Bancroftian Filariasis","volume":"62","author":"E Thomsen","year":"2016","journal-title":"Clin Infect Dis"},{"issue":"5","key":"pntd.0008106.ref010","article-title":"Pharmacokinetics, safety, and efficacy of a single co-administered dose of diethylcarbamazine, albendazole and ivermectin in adults with and without Wuchereria bancrofti infection in Cote d\u2019Ivoire.","volume":"13","author":"C Edi","year":"2019","journal-title":"PLoS Negl Trop Dis."},{"issue":"5","key":"pntd.0008106.ref011","doi-asserted-by":"crossref","first-page":"e0006454","DOI":"10.1371\/journal.pntd.0006454","article-title":"Adverse events following single dose treatment of lymphatic filariasis: Observations from a review of the literature.","volume":"12","author":"P Budge","year":"2018","journal-title":"PLoS Negl Trop Dis"},{"issue":"2","key":"pntd.0008106.ref012","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1093\/infdis\/jix578","article-title":"Changes in Cytokine, Filarial Antigen, and DNA Levels Associated With Adverse Events Following Treatment of Lymphatic Filariasis","volume":"217","author":"B Andersen","year":"2018","journal-title":"J Infect Dis"},{"issue":"6","key":"pntd.0008106.ref013","doi-asserted-by":"crossref","first-page":"e1002839","DOI":"10.1371\/journal.pmed.1002839","article-title":"The safety of double- and triple-drug community mass drug administration for lymphatic filariasis: A multicenter, open-label, cluster-randomized study.","volume":"16","author":"G Weil","year":"2019","journal-title":"PLOS Medicine"},{"key":"pntd.0008106.ref014","unstructured":"World Health Organization. Guideline: Alternative mass drug administration regimens to eliminate lymphatic filariasis. 2017."},{"issue":"1","key":"pntd.0008106.ref015","first-page":"34","article-title":"Control of scabies, skin sores and haematuria in children in the Solomon Islands: another role for ivermectin","volume":"83","author":"G Lawrence","year":"2005","journal-title":"Bull World Health Organ"},{"issue":"24","key":"pntd.0008106.ref016","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1056\/NEJMoa1500987","article-title":"Mass Drug Administration for Scabies Control in a Population with Endemic Disease","volume":"373","author":"L Romani","year":"2015","journal-title":"N Engl J Med"},{"key":"pntd.0008106.ref017","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1186\/1756-3305-5-299","article-title":"Soil transmitted helminths and scabies in Zanzibar, Tanzania following mass drug administration for lymphatic filariasis\u2014a rapid assessment methodology to assess impact.","volume":"5","author":"K Mohammed","year":"2012","journal-title":"Parasit Vectors."},{"issue":"4","key":"pntd.0008106.ref018","doi-asserted-by":"crossref","first-page":"e0006458","DOI":"10.1371\/journal.pntd.0006458","article-title":"Efficacy and safety of co-administered ivermectin plus albendazole for treating soil-transmitted helminths: A systematic review, meta-analysis and individual patient data analysis.","volume":"12","author":"M Palmeirim","year":"2018","journal-title":"PLOS Neglected Tropical Diseases"},{"issue":"3","key":"pntd.0008106.ref019","doi-asserted-by":"crossref","first-page":"e0003452","DOI":"10.1371\/journal.pntd.0003452","article-title":"Scabies and impetigo prevalence and risk factors in Fiji: a national survey","volume":"9","author":"L Romani","year":"2015","journal-title":"PLoS Neglected Tropical Diseases [electronic resource]."},{"issue":"1216","key":"pntd.0008106.ref020","first-page":"U1492","article-title":"Soil-transmitted helminth infection, skin infection, anaemia, and growth retardation in schoolchildren of Taveuni Island, Fiji","volume":"118","author":"M Thomas","year":"2005","journal-title":"N Z Med J"},{"issue":"1","key":"pntd.0008106.ref021","first-page":"74","article-title":"Prevalence of intestinal helminth infection in Fiji","volume":"5","author":"E Mathai","year":"1998","journal-title":"Pacific Health Dialog: journal of community health and clinical medicine for the Pacific"},{"issue":"3","key":"pntd.0008106.ref022","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1080\/0960312042000218589","article-title":"Environmental influences on helminthiasis and nutritional status among Pacific schoolchildren.","volume":"14","author":"R Hughes","year":"2004","journal-title":"Int J Environ Health Res"},{"key":"pntd.0008106.ref023","unstructured":"Statistics FBo. 2017 Population and housing census: release 1: age, sex, geography and economic activity. Statistical News. 2018."},{"issue":"1","key":"pntd.0008106.ref024","first-page":"16","article-title":"Lymphatic filariasis in Fiji: Incidence and review of literature","volume":"1","author":"NHR Office","year":"2012","journal-title":"Fiji Journal of Public Health"},{"key":"pntd.0008106.ref025","volume-title":"Mid-term assessment towards elimination of lymphatic filariasis in Fiji, 2013.","author":"M Rinamalo","year":"2013"},{"key":"pntd.0008106.ref026","unstructured":"Medical Dictionary for Regulatory Activities. 2017;(Version 20.0)."},{"key":"pntd.0008106.ref027","unstructured":"Services USDoHaH. Common terminology criteria for adverse events (CTCAE). 2010;(Version4.03)."},{"issue":"1","key":"pntd.0008106.ref028","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4269\/ajtmh.13-0089","article-title":"Laboratory and Field Evaluation of a New Rapid Test for Detecting Wuchereria bancrofti Antigen in Human Blood","volume":"89","author":"G Weil","year":"2013","journal-title":"The American Journal of Tropical Medicine and Hygiene"},{"issue":"4","key":"pntd.0008106.ref029","first-page":"629","article-title":"Microfilaria survey methods and analysis of survey data in filariasis control programmes","volume":"37","author":"M. Sasa","year":"1967","journal-title":"Bull World Health Organ"},{"key":"pntd.0008106.ref030","unstructured":"World Health Organization. Monitoring and epidemiological assessment of mass drug administration in the global programme to eliminate lymphatic filariasis: a manual for national elimination programmes. 2011."},{"issue":"3","key":"pntd.0008106.ref031","doi-asserted-by":"crossref","first-page":"173","DOI":"10.2471\/BLT.08.052712","article-title":"Validation of an Integrated Management of Childhood Illness algorithm for managing common skin conditions in Fiji","volume":"87","author":"A Steer","year":"2009","journal-title":"Bull World Health Organ"},{"key":"pntd.0008106.ref032","unstructured":"World Health Organization. Bench aids for the diagnosis of intestinal parasites. 1994."},{"issue":"3","key":"pntd.0008106.ref033","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/1097-0258(20010215)20:3<489::AID-SIM806>3.0.CO;2-S","article-title":"Extending the CONSORT statement to cluster randomized trials: for discussion.","volume":"20","author":"D Elbourne","year":"2001","journal-title":"Stat Med."},{"key":"pntd.0008106.ref034","doi-asserted-by":"crossref","first-page":"e5661","DOI":"10.1136\/bmj.e5661","article-title":"Consort 2010 statement: extension to cluster randomised trials","volume":"345","author":"M Campbell","year":"2012","journal-title":"BMJ: British Medical Journal"},{"key":"pntd.0008106.ref035","unstructured":"World Health Organization. A practical handbook on the pharmacovigilance of medicines used in the treatment of tuberculosis: enhancing the safety of the TB patient. 2012."},{"key":"pntd.0008106.ref036","volume-title":"Strategy Development and Monitoring for Eradication and Elimination Team & Global Programme to Eliminate Lymphatic Filariasis. Global Programme to Eliminate Lymphatic Filariasis: annual report on lymphatic filariasis 2003","author":"World Health Organization","year":"2005"},{"key":"pntd.0008106.ref037","volume-title":"Control of lymphatic filariasis: a manual for health personnel","author":"World Health Organization","year":"1987"},{"issue":"4","key":"pntd.0008106.ref038","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S1473-3099(04)00973-9","article-title":"Mathematical modelling and the control of lymphatic filariasis","volume":"4","author":"E Michael","year":"2004","journal-title":"Lancet Infect Dis"},{"issue":"4","key":"pntd.0008106.ref039","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S1473-3099(16)30467-4","article-title":"Effectiveness of a triple-drug regimen for global elimination of lymphatic filariasis: a modelling study","volume":"17","author":"M Irvine","year":"2017","journal-title":"Lancet Infect Dis"},{"issue":"1","key":"pntd.0008106.ref040","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1186\/s12889-018-5157-7","article-title":"Community perspectives on persistent transmission of lymphatic filariasis in three hotspot districts in Ghana after 15 rounds of mass drug administration: a qualitative assessment.","volume":"18","author":"C Ahorlu","year":"2018","journal-title":"BMC Public Health"},{"issue":"11","key":"pntd.0008106.ref041","doi-asserted-by":"crossref","first-page":"e2447","DOI":"10.1371\/journal.pntd.0002447","article-title":"A review of factors that influence individual compliance with mass drug administration for elimination of lymphatic filariasis","volume":"7","author":"A Krentel","year":"2013","journal-title":"PLoS Neglected Tropical Diseases [electronic resource]"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0008106","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T00:00:00Z","timestamp":1585180800000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0008106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T17:45:31Z","timestamp":1585244731000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0008106"}},"subtitle":[],"editor":[{"given":"Sabine","family":"Specht","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,3,16]]},"references-count":41,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,3,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0008106","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pntd.0008106","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,16]]}}}