{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:28:50Z","timestamp":1792625330124,"version":"4.5.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0008126","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T00:00:00Z","timestamp":1586217600000}}],"reference-count":66,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T00:00:00Z","timestamp":1584662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2017R1A2B4002072"],"award-info":[{"award-number":["NRF-2017R1A2B4002072"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0008126","type":"journal-article","created":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T13:52:38Z","timestamp":1584712358000},"page":"e0008126","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":77,"title":["IL-6 produced by prostate epithelial cells stimulated with Trichomonas vaginalis\u00a0promotes proliferation of prostate cancer cells by inducing M2 polarization of THP-1-derived macrophages"],"prefix":"10.1371","volume":"14","author":[{"given":"Ik-Hwan","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Ouk","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9145-7900","authenticated-orcid":true,"given":"Jae-Sook","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,3,20]]},"reference":[{"issue":"1","key":"pntd.0008126.ref001","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/00007435-198701000-00002","article-title":"Urethral trichomoniasis in men","volume":"14","author":"AS Latif","year":"1987","journal-title":"Sex Transm Dis"},{"issue":"5","key":"pntd.0008126.ref002","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1093\/infdis\/166.5.1205","article-title":"The incidence of Trichomonas vaginalis in chronic prostatitis patients determined by culture using a newly modified liquid medium","volume":"166","author":"M Ohkawa","year":"1992","journal-title":"J Infect Dis"},{"issue":"2","key":"pntd.0008126.ref003","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3347\/kjp.2012.50.2.157","article-title":"PCR for diagnosis of male Trichomonas vaginalis infection with chronic prostatitis and urethritis","volume":"50","author":"JJ Lee","year":"2012","journal-title":"Korean J Parasitol"},{"issue":"1","key":"pntd.0008126.ref004","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00430-011-0205-2","article-title":"High detection rate of Trichomonas vaginalis in benign hyperplastic prostatic tissue","volume":"201","author":"D Mitteregger","year":"2012","journal-title":"Med Microbiol Immunol"},{"issue":"8","key":"pntd.0008126.ref005","doi-asserted-by":"crossref","first-page":"e1002801","DOI":"10.1371\/journal.ppat.1002801","article-title":"Trichomonosis, a common curable STI, and prostate carcinogenesis-a proposed molecular mechanism","volume":"8","author":"S Sutcliffe","year":"2012","journal-title":"PLoS pathog"},{"issue":"22","key":"pntd.0008126.ref006","doi-asserted-by":"crossref","first-page":"8179","DOI":"10.1073\/pnas.1321884111","article-title":"Trichomonas vaginalis homolog of macrophage migration inhibitory factor induces prostate cell growth, invasiveness, and inflammatory responses","volume":"111","author":"O Twu","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"pntd.0008126.ref007","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3347\/kjp.2019.57.1.21","article-title":"Comparison of Seropositivity to Trichomonas vaginalis between Men with Prostatic Tumor and Normal Men","volume":"57","author":"JH Kim","year":"2019","journal-title":"Korean J Parasitol"},{"issue":"8","key":"pntd.0008126.ref008","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1007\/s10552-017-0919-6","article-title":"Trichomonas vaginalis infection and risk of prostate cancer: associations by disease aggressiveness and race\/ethnicity in the PLCO Trial","volume":"28","author":"M Marous","year":"2017","journal-title":"Cancer Causes Control"},{"issue":"7","key":"pntd.0008126.ref009","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1002\/pros.23153","article-title":"Trichomonas vaginalis infection and risk of advanced prostate cancer","volume":"76","author":"IM Shui","year":"2016","journal-title":"Prostate"},{"issue":"3","key":"pntd.0008126.ref010","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1002\/path.4472","article-title":"A human prostatic bacterial isolate alters the prostatic microenvironment and accelerates prostate cancer progression","volume":"235","author":"BW Simons","year":"2015","journal-title":"J Pathol"},{"issue":"5","key":"pntd.0008126.ref011","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1155\/2007\/196046","article-title":"Persistent urethritis and prostatitis due to Trichomonas vaginalis: A case report","volume":"18","author":"A Abdolrasouli","year":"2007","journal-title":"Can J Infect Dis Med Microbiol"},{"issue":"1","key":"pntd.0008126.ref012","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1186\/s12879-016-1843-1","article-title":"Detection of Trichomonas vaginalis in prostate tissue and serostatus in patients with asymptomatic benign prostatic hyperplasia","volume":"16","author":"J Iqbal","year":"2016","journal-title":"BMC Infect Dis"},{"issue":"6","key":"pntd.0008126.ref013","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.cell.2010.01.025","article-title":"Immunity, inflammation, and cancer","volume":"140","author":"SI Grivennikov","year":"2010","journal-title":"Cell"},{"issue":"1","key":"pntd.0008126.ref014","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1365-2559.2011.04033.x","article-title":"Prostate cancer and inflammation: the evidence","volume":"60","author":"KS Sfanos","year":"2012","journal-title":"Histopathology"},{"issue":"5","key":"pntd.0008126.ref015","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1158\/1055-9965.EPI-13-1126","article-title":"Chronic inflammation in benign prostate tissue is associated with high-grade prostate cancer in the placebo arm of the prostate cancer prevention trial","volume":"23","author":"B Gurel","year":"2014","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"1","key":"pntd.0008126.ref016","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.canlet.2015.12.022","article-title":"Regulation of prostate cancer progression by the tumor microenvironment","volume":"380","author":"SL Shiao","year":"2016","journal-title":"Cancer letters"},{"issue":"4","key":"pntd.0008126.ref017","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/pim.12308","article-title":"Inflammatory response of a prostate stromal cell line induced by Trichomonas vaginalis","volume":"38","author":"SJ Im","year":"2016","journal-title":"Parasite immunol"},{"issue":"4","key":"pntd.0008126.ref018","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/pros.22766","article-title":"Inflammatory response of prostate epithelial cells to stimulation by Trichomonas vaginalis","volume":"74","author":"MY Seo","year":"2014","journal-title":"Prostate"},{"issue":"15","key":"pntd.0008126.ref019","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1002\/pros.23227","article-title":"Proliferation of Prostate Stromal Cell Induced by Benign Prostatic Hyperplasia Epithelial Cell Stimulated With Trichomonas vaginalis via Crosstalk With Mast Cell","volume":"76","author":"JH Kim","year":"2016","journal-title":"Prostate"},{"issue":"3","key":"pntd.0008126.ref020","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/S0002-9440(10)64255-1","article-title":"Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis","volume":"161","author":"SF Schoppmann","year":"2002","journal-title":"Am J Pathol"},{"issue":"1","key":"pntd.0008126.ref021","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/eji.200636910","article-title":"New vistas on macrophage differentiation and activation","volume":"37","author":"A Mantovani","year":"2007","journal-title":"Eur J Immunol"},{"issue":"1","key":"pntd.0008126.ref022","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.critrevonc.2007.07.004","article-title":"The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages","volume":"66","author":"P Allavena","year":"2008","journal-title":"Crit Rev Oncol Hematol"},{"key":"pntd.0008126.ref023","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/B978-0-12-411619-1.00016-1","article-title":"Flow cytometry analyses of adipose tissue macrophages","volume":"537","author":"KW Cho","year":"2014","journal-title":"Methods Enzymol"},{"issue":"3","key":"pntd.0008126.ref024","first-page":"445","article-title":"Tumor associated macrophages in human prostate cancer: relation to clinicopathological variables and survival","volume":"17","author":"IF Lissbrant","year":"2000","journal-title":"Int J Oncol"},{"key":"pntd.0008126.ref025","doi-asserted-by":"crossref","first-page":"13","DOI":"10.12703\/P6-13","article-title":"The M1 and M2 paradigm of macrophage activation: time for reassessment","volume":"6","author":"FO Martinez","year":"2014","journal-title":"F1000prime reports"},{"issue":"5","key":"pntd.0008126.ref026","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/ni.2865","article-title":"Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin","volume":"15","author":"J Mauer","year":"2014","journal-title":"Nat Immunol"},{"issue":"7","key":"pntd.0008126.ref027","first-page":"2927","article-title":"IL-6 Regulates M2 Polarization and Local Proliferation of Adipose Tissue Macrophages in Obesity","volume":"198","author":"J Braune","year":"2017"},{"issue":"6035","key":"pntd.0008126.ref028","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1126\/science.1204351","article-title":"Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation","volume":"332","author":"SJ Jenkins","year":"2011","journal-title":"Science"},{"issue":"8","key":"pntd.0008126.ref029","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/j.1365-3024.2008.01037.x","article-title":"Trichomonas vaginalis-induced neutrophil apoptosis causes anti-inflammatory cytokine production by human monocyte-derived macrophages","volume":"30","author":"MH Ahn","year":"2008","journal-title":"Parasite Immunol"},{"issue":"4","key":"pntd.0008126.ref030","doi-asserted-by":"crossref","first-page":"488","DOI":"10.2307\/3274682","article-title":"The establishment of various trichomonads of animals and man in axenic cultures","volume":"43","author":"LS Diamond","year":"1957","journal-title":"J Parasitol"},{"issue":"10","key":"pntd.0008126.ref031","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1002\/pros.23826","article-title":"Inflammatory mediators of prostate epithelial cells stimulated with Trichomonas vaginalis promote proliferative and invasive properties of prostate cancer cells","volume":"79","author":"IH Han","year":"2019","journal-title":"Prostate"},{"issue":"5","key":"pntd.0008126.ref032","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1002\/ijc.11464","article-title":"Orthotopic treatment model of prostate cancer and metastasis in the immunocompetent mouse: efficacy of flt3 ligand immunotherapy","volume":"107","author":"KD Somers","year":"2003","journal-title":"Int J Cancer"},{"issue":"1","key":"pntd.0008126.ref033","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s12307-009-0021-z","article-title":"Regulated expression of CCL21 in the prostate tumor microenvironment inhibits tumor growth and metastasis in an orthotopic model of prostate cancer","volume":"2","author":"N Yousefieh","year":"2009","journal-title":"Cancer Microenviron"},{"issue":"2","key":"pntd.0008126.ref034","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.canlet.2008.03.028","article-title":"Cancer related inflammation: the macrophage connection","volume":"267","author":"A Sica","year":"2008","journal-title":"Cancer Lett"},{"issue":"3","key":"pntd.0008126.ref035","first-page":"153","article-title":"Role of tumour-associated macrophages in cancer-related inflammation","volume":"32","author":"A Sica","year":"2010","journal-title":"Exp Oncol"},{"issue":"2","key":"pntd.0008126.ref036","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1074\/jbc.M115.651497","article-title":"Trichomonas vaginalis Lipophosphoglycan Exploits Binding to Galectin-1 and -3 to Modulate Epithelial Immunity","volume":"291","author":"RN Fichorova","year":"2016","journal-title":"J Biol Chem"},{"issue":"11","key":"pntd.0008126.ref037","doi-asserted-by":"crossref","first-page":"e48418","DOI":"10.1371\/journal.pone.0048418","article-title":"Endobiont viruses sensed by the human host\u2014beyond conventional antiparasitic therapy","volume":"7","author":"RN Fichorova","year":"2012","journal-title":"PLoS One"},{"issue":"4593","key":"pntd.0008126.ref038","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1126\/science.6828888","article-title":"Regulation of the macrophage content of neoplasms by chemoattractants","volume":"220","author":"B Bottazzi","year":"1983","journal-title":"Science"},{"issue":"4","key":"pntd.0008126.ref039","doi-asserted-by":"crossref","first-page":"e94188","DOI":"10.1371\/journal.pone.0094188","article-title":"The pro-inflammatory cytokine, interleukin-6, enhances the polarization of alternatively activated macrophages","volume":"9","author":"MR Fernando","year":"2014","journal-title":"PLoS One"},{"issue":"19","key":"pntd.0008126.ref040","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1038\/onc.2013.191","article-title":"Cancer-associated fibroblasts and M2-polarized macrophages synergize during prostate carcinoma progression","volume":"33","author":"G Comito","year":"2014","journal-title":"Oncogene"},{"issue":"Pt 21","key":"pntd.0008126.ref041","doi-asserted-by":"crossref","first-page":"4561","DOI":"10.1242\/jcs.151068","article-title":"TRPM7 regulates proliferation and polarisation of macrophages","volume":"127","author":"T Schilling","year":"2014","journal-title":"J Cell Sci"},{"issue":"6","key":"pntd.0008126.ref042","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/ni938","article-title":"IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages","volume":"4","author":"H Yasukawa","year":"2003","journal-title":"Nat Immunol"},{"issue":"1","key":"pntd.0008126.ref043","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21332","article-title":"Cancer statistics, 2016","volume":"66","author":"RL Siegel","year":"2016","journal-title":"CA Cancer J Clin"},{"issue":"3","key":"pntd.0008126.ref044","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/pcan.2008.3","article-title":"Prostate cancer: genes, environment, immunity and the use of immunotherapy","volume":"11","author":"D Karan","year":"2008","journal-title":"Prostate Cancer Prostatic Dis"},{"issue":"1","key":"pntd.0008126.ref045","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1097\/00001648-200201000-00012","article-title":"Meta-analysis of measures of sexual activity and prostate cancer","volume":"13","author":"LK Dennis","year":"2002","journal-title":"Epidemiology"},{"issue":"1","key":"pntd.0008126.ref046","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1023\/A:1020110718701","article-title":"The diet, prostate inflammation, and the development of prostate cancer","volume":"21","author":"WG Nelson","year":"2002","journal-title":"Cancer Metastasis Rev"},{"issue":"2","key":"pntd.0008126.ref047","first-page":"217\u201326","article-title":"Chronic inflammation and cancer","volume":"16","author":"E Shacter","year":"2002","journal-title":"Oncology"},{"issue":"4","key":"pntd.0008126.ref048","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/pros.23744","article-title":"Experimental rat prostatitis caused by Trichomonas vaginalis infection","volume":"79","author":"KS Jang","year":"2019","journal-title":"Prostate"},{"issue":"5","key":"pntd.0008126.ref049","first-page":"430","article-title":"Trichomonas vaginalis in the prostate gland","volume":"110","author":"WA Gardner","year":"1986","journal-title":"Arch Pathol Lab Med"},{"key":"pntd.0008126.ref050","first-page":"317","article-title":"Inflammation-proliferation: possible relationships in the prostate","volume":"239","author":"CJ Smith","year":"1987","journal-title":"Prog Clin Biol Res"},{"issue":"5","key":"pntd.0008126.ref051","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1158\/1055-9965.EPI-05-0781","article-title":"Plasma antibodies against Trichomonas vaginalis and subsequent risk of prostate cancer","volume":"15","author":"S Sutcliffe","year":"2006","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"6","key":"pntd.0008126.ref052","doi-asserted-by":"crossref","first-page":"e12531","DOI":"10.1111\/pim.12531","article-title":"Proliferation of prostate epithelia induced by IL-6 from stroma reacted with Trichomonas vaginalis","volume":"40","author":"JH Kim","year":"2018","journal-title":"Parasite Immunol"},{"issue":"19","key":"pntd.0008126.ref053","doi-asserted-by":"crossref","first-page":"9417","DOI":"10.1158\/0008-5472.CAN-07-1286","article-title":"Targeting CCL2 with systemic delivery of neutralizing antibodies induces prostate cancer tumor regression in vivo","volume":"67","author":"RD Loberg","year":"2007","journal-title":"Cancer Res"},{"issue":"3","key":"pntd.0008126.ref054","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.semcancer.2003.10.009","article-title":"CCL2 (monocyte chemoattractant protein-1) and cancer","volume":"14","author":"I Conti","year":"2004","journal-title":"Semin Cancer Biol"},{"issue":"2","key":"pntd.0008126.ref055","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/j.1365-2141.2005.05443.x","article-title":"Bone marrow endothelial cells in multiple myeloma secrete CXC-chemokines that mediate interactions with plasma cells","volume":"129","author":"A Pellegrino","year":"2005","journal-title":"Br J Haematol"},{"issue":"1","key":"pntd.0008126.ref056","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1158\/0008-5472.CAN-05-1130","article-title":"Interleukin-17 receptor-like gene is a novel antiapoptotic gene highly expressed in androgen-independent prostate cancer","volume":"66","author":"Z You","year":"2006","journal-title":"Cancer Res"},{"issue":"1","key":"pntd.0008126.ref057","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/sj.cdd.4401319","article-title":"c-Myc-deficient B lymphocytes are resistant to spontaneous and induced cell death","volume":"11","author":"IM de Alboran","year":"2004","journal-title":"Cell Death Differ"},{"issue":"10","key":"pntd.0008126.ref058","doi-asserted-by":"crossref","first-page":"3992","DOI":"10.1182\/blood-2005-09-3851","article-title":"c-Myc acts downstream of IL-15 in the regulation of memory CD8 T-cell homeostasis","volume":"107","author":"T Bianchi","year":"2006","journal-title":"Blood"},{"issue":"12","key":"pntd.0008126.ref059","doi-asserted-by":"crossref","first-page":"e0145342","DOI":"10.1371\/journal.pone.0145342","article-title":"Novel Markers to Delineate Murine M1 and M2 Macrophages","volume":"10","author":"KA Jablonski","year":"2015","journal-title":"PloS One"},{"issue":"2","key":"pntd.0008126.ref060","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1182\/blood-2011-02-339911","article-title":"Role of c-MYC in alternative activation of human macrophages and tumor-associated macrophage biology","volume":"119","author":"OM Pello","year":"2012","journal-title":"Blood"},{"issue":"5","key":"pntd.0008126.ref061","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1091\/mbc.02-07-0102","article-title":"Cyclin D1 governs adhesion and motility of macrophages","volume":"14","author":"P Neumeister","year":"2003","journal-title":"Mol Biol Cell"},{"issue":"10","key":"pntd.0008126.ref062","doi-asserted-by":"crossref","first-page":"7303","DOI":"10.4049\/jimmunol.177.10.7303","article-title":"Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression","volume":"177","author":"FO Martinez","year":"2006","journal-title":"J Immunol"},{"key":"pntd.0008126.ref063","doi-asserted-by":"crossref","first-page":"456","DOI":"10.3389\/fimmu.2016.00456","article-title":"Leishmania donovani-Induced Increase in Macrophage Bcl-2 Favors Parasite Survival","volume":"7","author":"RK Pandey","year":"2016","journal-title":"Front Immunol"},{"issue":"49","key":"pntd.0008126.ref064","doi-asserted-by":"crossref","first-page":"34342","DOI":"10.1074\/jbc.M109.042671","article-title":"CCL2 and interleukin-6 promote survival of human CD11b+ peripheral blood mononuclear cells and induce M2-type macrophage polarization","volume":"284","author":"H Roca","year":"2009","journal-title":"J Biol Chem"},{"issue":"3","key":"pntd.0008126.ref065","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s10549-010-1154-y","article-title":"Proliferating macrophages associated with high grade, hormone receptor negative breast cancer and poor clinical outcome","volume":"128","author":"MJ Campbell","year":"2011","journal-title":"Breast Cancer Res Treat"},{"issue":"43","key":"pntd.0008126.ref066","doi-asserted-by":"crossref","first-page":"36529","DOI":"10.1074\/jbc.M503111200","article-title":"RNA interference-directed knockdown of urokinase plasminogen activator and urokinase plasminogen activator receptor inhibits prostate cancer cell invasion, survival, and tumorigenicity in vivo","volume":"280","author":"SM Pulukuri","year":"2005","journal-title":"J Biol Chem"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0008126","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T00:00:00Z","timestamp":1586217600000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0008126","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T13:30:15Z","timestamp":1586266215000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0008126"}},"subtitle":[],"editor":[{"given":"Michael H.","family":"Hsieh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,3,20]]},"references-count":66,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,3,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0008126","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.737595422.793582798","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,20]]}}}