{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T23:37:16Z","timestamp":1784590636304,"version":"3.55.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0008155","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T00:00:00Z","timestamp":1589414400000}}],"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T00:00:00Z","timestamp":1588550400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100011272","name":"FP7 Health","doi-asserted-by":"publisher","award":["201588"],"award-info":[{"award-number":["201588"]}],"id":[{"id":"10.13039\/100011272","id-type":"DOI","asserted-by":"publisher"}]},{"name":"MiP Consortium & Gates Foundation","award":["46099"],"award-info":[{"award-number":["46099"]}]},{"DOI":"10.13039\/501100003329","name":"ministerio de economia y competitividad","doi-asserted-by":"crossref","award":["RYC-2008-02631"],"award-info":[{"award-number":["RYC-2008-02631"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de economia y competitividad","doi-asserted-by":"crossref","award":["EUS2009-03560"],"award-info":[{"award-number":["EUS2009-03560"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0008155","type":"journal-article","created":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T17:39:59Z","timestamp":1588613999000},"page":"e0008155","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Cytokine signatures of\u00a0Plasmodium vivax infection during pregnancy and delivery outcomes"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6751-4060","authenticated-orcid":true,"given":"Carlota","family":"Doba\u00f1o","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azucena","family":"Bardaj\u00ed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Ar\u00e9valo-Herrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flor E.","family":"Mart\u00ednez-Espinosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"B\u00f4tto-Menezes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma","family":"Padilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Menegon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Kochar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay Kumar","family":"Kochar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Unger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Ome-Kaius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Rosanas-Urgell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Malheiros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Eugenia","family":"Castellanos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhiraj","family":"Hans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghna","family":"Desai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aina","family":"Casellas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chetan E.","family":"Chitnis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Severini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Rogerson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Men\u00e9ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2298-4085","authenticated-orcid":true,"given":"Pilar","family":"Requena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,5,4]]},"reference":[{"key":"pntd.0008155.ref001","unstructured":"World Health Organization. World Malaria Report 2018 [Internet]. Geneva; 2018. Available: https:\/\/www.who.int\/malaria\/publications\/world-malaria-report-2018\/en\/"},{"key":"pntd.0008155.ref002","doi-asserted-by":"crossref","first-page":"e107","DOI":"10.1016\/S1473-3099(18)30066-5","article-title":"Burden, pathology, and costs of malaria in pregnancy: new developments for an old problem","volume":"18","author":"SJ Rogerson","year":"2018","journal-title":"Lancet Infect Dis"},{"key":"pntd.0008155.ref003","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0005606","article-title":"Burden and impact of Plasmodium vivax in pregnancy: A multi-centre prospective observational study","volume":"11","author":"A Bardaj\u00ed","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"key":"pntd.0008155.ref004","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2017.00163","article-title":"Naturally acquired binding-inhibitory antibodies to Plasmodium vivax duffy binding protein in pregnant women are associated with higher birth weight in a multicenter study","volume":"8","author":"P Requena","year":"2017","journal-title":"Front Immunol"},{"key":"pntd.0008155.ref005","doi-asserted-by":"crossref","first-page":"e0005009","DOI":"10.1371\/journal.pntd.0005009","article-title":"Plasmodium vivax VIR Proteins Are Targets of Naturally-Acquired Antibody and T Cell Immune Responses to Malaria in Pregnant Women","volume":"10","author":"P Requena","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"pntd.0008155.ref006","doi-asserted-by":"crossref","first-page":"3275","DOI":"10.4049\/jimmunol.1401038","article-title":"Proinflammatory responses and higher IL-10 production by T cells correlate with protection against malaria during pregnancy and delivery outcomes","volume":"194","author":"P Requena","year":"2015","journal-title":"J Immunol"},{"key":"pntd.0008155.ref007","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.4049\/jimmunol.1401037","article-title":"Pregnancy and malaria exposure are associated with changes in the B cell pool and in plasma eotaxin levels","volume":"193","author":"P Requena","year":"2014","journal-title":"J Immunol"},{"key":"pntd.0008155.ref008","doi-asserted-by":"crossref","first-page":"154818","DOI":"10.1016\/j.cyto.2019.154818","article-title":"Blood cytokine, chemokine and growth factor profiling in a cohort of pregnant women from tropical countries","volume":"125","author":"C Doba\u00f1o","year":"2020","journal-title":"Cytokine"},{"key":"pntd.0008155.ref009","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1475-2875-9-13","article-title":"Severe Plasmodium vivax malaria exhibits marked inflammatory imbalance","volume":"9","author":"BB Andrade","year":"2010","journal-title":"Malar J"},{"key":"pntd.0008155.ref010","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.molimm.2018.03.019","article-title":"Role of IL-1\u03b2, IL-6 and TNF-\u03b1 cytokines and TNF-\u03b1 promoter variability in Plasmodium vivax infection during pregnancy in endemic population of Jharkhand, India","volume":"97","author":"KP Singh","year":"2018","journal-title":"Mol Immunol"},{"key":"pntd.0008155.ref011","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1186\/1475-2875-9-361","article-title":"Comparison of diagnostic methods for the detection and quantification of the four sympatric Plasmodium species in field samples from Papua New Guinea","volume":"9","author":"A Rosanas-Urgell","year":"2010","journal-title":"Malar J"},{"key":"pntd.0008155.ref012","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/BF02291575","article-title":"An index of factorial simplicity","volume":"39","author":"HF Kaiser","year":"1974","journal-title":"Psychometrika"},{"key":"pntd.0008155.ref013","doi-asserted-by":"crossref","first-page":"532","DOI":"10.4269\/ajtmh.1995.53.532","article-title":"Prediction of accelerated cure in Plasmodium falciparum malaria by the elevated capacity of tumor necrosis factor production","volume":"53","author":"PG Kremsner","year":"1995","journal-title":"Am J Trop Med Hyg"},{"key":"pntd.0008155.ref014","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1600-065X.1989.tb00552.x","article-title":"Tumor-necrosis factor and other cytokines in cerebral malaria: experimental and clinical data","volume":"112","author":"GE Grau","year":"1989","journal-title":"Immunol Rev"},{"key":"pntd.0008155.ref015","doi-asserted-by":"crossref","first-page":"e73360","DOI":"10.1371\/journal.pone.0073360","article-title":"Cytokine profiling in immigrants with clinical malaria after extended periods of interrupted exposure to Plasmodium falciparum","volume":"8","author":"G Moncunill","year":"2013","journal-title":"PLoS One"},{"key":"pntd.0008155.ref016","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s12639-013-0237-1","article-title":"Serum IL-4, IL-12 and TNF-alpha in malaria: a comparative study associating cytokine responses with severity of disease from the Coastal Districts of Odisha","volume":"38","author":"A Sarangi","year":"2014","journal-title":"J Parasit Dis"},{"key":"pntd.0008155.ref017","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s12936-017-1683-5","article-title":"On the cytokine\/chemokine network during Plasmodium vivax malaria: new insights to understand the disease","volume":"16","author":"NS Hojo-Souza","year":"2017","journal-title":"Malar J"},{"key":"pntd.0008155.ref018","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1590\/0074-0276140275","article-title":"Alterations in cytokines and haematological parameters during the acute and convalescent phases of Plasmodium falciparum and Plasmodium vivax infections","volume":"109","author":"RN Rodrigues-da-Silva","year":"2014","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"pntd.0008155.ref019","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1086\/378500","article-title":"Changes in the levels of chemokines and cytokines in the placentas of women with Plasmodium falciparum malaria","volume":"188","author":"AL Suguitan","year":"2003","journal-title":"J Infect Dis"},{"key":"pntd.0008155.ref020","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.4049\/jimmunol.170.5.2759","article-title":"Host response to malaria during pregnancy: placental monocyte recruitment is associated with elevated beta chemokine expression","volume":"170","author":"ET Abrams","year":"2003","journal-title":"J Immunol"},{"key":"pntd.0008155.ref021","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.4049\/jimmunol.160.5.2523","article-title":"Malaria elicits type 1 cytokines in the human placenta: IFN-gamma and TNF-alpha associated with pregnancy outcomes","volume":"160","author":"M Fried","year":"1998","journal-title":"J Immunol"},{"key":"pntd.0008155.ref022","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1086\/315135","article-title":"Malaria and Pregnancy: Placental Cytokine Expression and Its Relationship to Intrauterine Growth Retardation","volume":"180","author":"AM Moormann","year":"1999","journal-title":"J Infect Dis"},{"key":"pntd.0008155.ref023","doi-asserted-by":"crossref","first-page":"223.e1","DOI":"10.1016\/j.ajog.2011.01.002","article-title":"Maternal inflammation in spontaneous term labor","author":"ER Unal","year":"2011","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"pntd.0008155.ref024","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.placenta.2018.07.006","article-title":"Fetal-placental crosstalk occurs through fetal cytokine synthesis and placental clearance","volume":"69","author":"IN Mir","year":"2018","journal-title":"Placenta"},{"key":"pntd.0008155.ref025","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1093\/infdis\/jis614","article-title":"Placental infection with Plasmodium vivax: a histopathological and molecular study","volume":"206","author":"A Mayor","year":"2012","journal-title":"J Infect Dis"},{"key":"pntd.0008155.ref026","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.1002\/eji.200838186","article-title":"Plasmodium vivax parasites alter the balance of myeloid and plasmacytoid dendritic cells and the induction of regulatory T cells","volume":"38","author":"K Jangpatarapongsa","year":"2008","journal-title":"Eur J Immunol"},{"key":"pntd.0008155.ref027","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/S0167-5699(99)01522-4","article-title":"Eotaxin: from an eosinophilic chemokine to a major regulator of allergic reactions","volume":"20","author":"JC Gutierrez-Ramos","year":"1999","journal-title":"Immunol Today"},{"key":"pntd.0008155.ref028","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.pt.2011.01.007","article-title":"Malaria in pregnancy: small babies, big problem","volume":"27","author":"AJ Umbers","year":"2011","journal-title":"Trends Parasitol"},{"key":"pntd.0008155.ref029","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1128\/IAI.01420-07","article-title":"Elevated gamma interferon-producing NK cells, CD45RO memory-like T cells, and CD4 T cells are associated with protection against malaria infection in pregnancy","volume":"76","author":"C Othoro","year":"2008","journal-title":"Infect Immun"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0008155","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T00:00:00Z","timestamp":1589414400000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0008155","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T17:27:17Z","timestamp":1696094837000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0008155"}},"subtitle":[],"editor":[{"given":"Rhoel Ramos","family":"Dinglasan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,5,4]]},"references-count":29,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,5,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0008155","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pntd.0008155","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,4]]}}}