{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:09:51Z","timestamp":1790186991012,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0008220","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T00:00:00Z","timestamp":1586390400000}}],"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2020,3,30]],"date-time":"2020-03-30T00:00:00Z","timestamp":1585526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0008220","type":"journal-article","created":{"date-parts":[[2020,3,30]],"date-time":"2020-03-30T17:29:42Z","timestamp":1585589382000},"page":"e0008220","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Dopaminergic antagonists inhibit bile chemotaxis of adult Clonorchis sinensis and its egg production"],"prefix":"10.1371","volume":"14","author":[{"given":"Fuhong","family":"Dai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Ho","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6375-1213","authenticated-orcid":true,"given":"Yeon Pyo","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelian","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woon-Mok","family":"Sohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8677-4714","authenticated-orcid":true,"given":"Sung-Jong","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,3,30]]},"reference":[{"issue":"1","key":"pntd.0008220.ref001","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1473-3099(04)01252-6","article-title":"Clonorchiasis: a key foodborne zoonosis in China","volume":"5","author":"ZR Lun","year":"2005","journal-title":"Lancet Infect Dis"},{"issue":"1","key":"pntd.0008220.ref002","doi-asserted-by":"crossref","first-page":"93","DOI":"10.4269\/ajtmh.2006.75.93","article-title":"Clonorchis sinensis infection and increasing risk of cholangiocarcinoma in the Republic of Korea","volume":"75","author":"MK Lim","year":"2006","journal-title":"Am J Trop Med Hyg"},{"issue":"2","key":"pntd.0008220.ref003","first-page":"118","article-title":"Epidemiology of liver cancer: an overview","volume":"5","author":"P Srivatanakul","year":"2004","journal-title":"Asian Pac J Cancer Prev"},{"issue":"4","key":"pntd.0008220.ref004","doi-asserted-by":"crossref","first-page":"379","DOI":"10.3347\/kjp.2019.57.4.379","article-title":"Cytokine production in cholangiocarcinoma cells in response to Clonorchis sinensis excretory-secretory products and their putative protein components","volume":"57","author":"JH Pak","year":"2019","journal-title":"Korean J Parasitol"},{"issue":"6","key":"pntd.0008220.ref005","doi-asserted-by":"crossref","first-page":"671","DOI":"10.3347\/kjp.2019.57.6.671","article-title":"Partial characterization of two cathepsin D family aspartic peptidases of Clonorchis sinensis","volume":"57","author":"JM Kang","year":"2019","journal-title":"Korean J Parasitol"},{"issue":"8","key":"pntd.0008220.ref006","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.ijpara.2004.04.012","article-title":"Navigation within host tissues: Schistosoma mansoni and Trichobilharzia ocellata schistosomula respond to chemical gradients","volume":"34","author":"K Grabe","year":"2004","journal-title":"Int J Parasitol"},{"issue":"9","key":"pntd.0008220.ref007","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/S0020-7519(02)00089-9","article-title":"Diplostomum spathaceum cercariae respond to a unique profile of cues during recognition of their fish host","volume":"32","author":"W Haas","year":"2002","journal-title":"Int J Parasitol"},{"issue":"4","key":"pntd.0008220.ref008","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.neures.2003.12.008","article-title":"Effect of simultaneous presentation of multiple attractants on chemotactic response of the nematode Caenorhabditis elegans","volume":"48","author":"T Matsuura","year":"2004","journal-title":"Neurosci Res"},{"issue":"6","key":"pntd.0008220.ref009","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1007\/s00436-008-1144-8","article-title":"Bile-induced genes in Clonorchis sinensis metacercariae","volume":"103","author":"TI Kim","year":"2008","journal-title":"Parasitol Res"},{"issue":"5","key":"pntd.0008220.ref010","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1007\/s00436-008-1084-3","article-title":"Bile components and amino acids affect survival of the newly excysted juvenile Clonorchis sinensis in maintaining media","volume":"103","author":"S Li","year":"2008","journal-title":"Parasitol Res"},{"issue":"12","key":"pntd.0008220.ref011","doi-asserted-by":"crossref","first-page":"e1414","DOI":"10.1371\/journal.pntd.0001414","article-title":"Tracing of the bile-chemotactic migration of juvenile Clonorchis sinensis in rabbits by PET-CT","volume":"5","author":"TI Kim","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"issue":"10","key":"pntd.0008220.ref012","doi-asserted-by":"crossref","first-page":"e0006818","DOI":"10.1371\/journal.pntd.0006818","article-title":"Bile acids drive chemotaxis of Clonorchis sinensis juveniles to the bile duct","volume":"12","author":"S Li","year":"2018","journal-title":"PLoS Negl Trop Dis"},{"issue":"8","key":"pntd.0008220.ref013","doi-asserted-by":"crossref","first-page":"e0007573","DOI":"10.1371\/journal.pntd.0007573","article-title":"Chemotactic migration of newly excysted juvenile Clonorchis sinensis is suppressed by neuro-antagonists","volume":"13","author":"S Li","year":"2019","journal-title":"PLoS Negl Trop Dis"},{"issue":"2","key":"pntd.0008220.ref014","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0166-6851(00)00220-6","article-title":"Molecular cloning and immunological characterization of phosphoglycerate kinase from Clonorchis sinensis","volume":"108","author":"SJ Hong","year":"2000","journal-title":"Mol Biochem Parasitol"},{"issue":"1","key":"pntd.0008220.ref015","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0732-8893(03)00113-5","article-title":"The Kato-Katz method is reliable for diagnosis of Clonorchis sinensis infection","volume":"47","author":"ST Hong","year":"2003","journal-title":"Diagn Microbiol Infect Dis"},{"issue":"8","key":"pntd.0008220.ref016","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0024-3205(96)00656-X","article-title":"Two pyridinium metabolites of haloperidol are present in the brain of patients at post-mortem","volume":"60","author":"DW Eyles","year":"1997","journal-title":"Life Sci"},{"issue":"3","key":"pntd.0008220.ref017","first-page":"1463","article-title":"The metabolic formation of reactive intermediates from clozapine, a drug associated with agranulocytosis in man","volume":"275","author":"JL Maggs","year":"1995","journal-title":"J Pharmacol Exp Ther"},{"key":"pntd.0008220.ref018","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1002\/jps.2600531018","article-title":"Hepatic secretion and urinary excretion of three S35-labeled phenothiazines in the dog","volume":"53","author":"EJ Vanloon","year":"1964","journal-title":"J Pharm Sci"},{"issue":"3","key":"pntd.0008220.ref019","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S1383-5769(00)00039-8","article-title":"Chemokinetic behavior of the infective third-stage larvae of Strongyloides ratti on a sodium chloride gradient","volume":"49","author":"H Tobata-Kudo","year":"2000","journal-title":"Parasitol Int"},{"issue":"6","key":"pntd.0008220.ref020","doi-asserted-by":"crossref","first-page":"e1208","DOI":"10.1371\/journal.pntd.0001208","article-title":"Developmental transcriptomic features of the carcinogenic liver fluke, Clonorchis sinensis","volume":"5","author":"WG Yoo","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"issue":"2","key":"pntd.0008220.ref021","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/med.2610030204","article-title":"Praziquantel","volume":"3","author":"P Andrews","year":"1983","journal-title":"Med Res Rev"},{"issue":"12","key":"pntd.0008220.ref022","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1046\/j.1365-3156.1999.00499.x","article-title":"Little effect of praziquantel or artemisinin on clonorchiasis in Northern Vietnam. A pilot study","volume":"4","author":"N Tinga","year":"1999","journal-title":"Trop Med Int Health"},{"issue":"5","key":"pntd.0008220.ref023","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1007\/s00436-012-3151-z","article-title":"Susceptibility or resistance of praziquantel in human schistosomiasis: a review","volume":"111","author":"W Wang","year":"2012","journal-title":"Parasitol Res"},{"issue":"10","key":"pntd.0008220.ref024","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1016\/j.drudis.2016.06.021","article-title":"Drug repositioning approaches to parasitic diseases: a medicinal chemistry perspective","volume":"21","author":"LG Ferreira","year":"2016","journal-title":"Drug Discov Today"},{"issue":"1","key":"pntd.0008220.ref025","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s00436-009-1641-4","article-title":"Efficacy of artesunate and artemether against Clonorchis sinensis in rabbits","volume":"106","author":"TI Kim","year":"2009","journal-title":"Parasitol Res"},{"key":"pntd.0008220.ref026","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/1756-3305-4-201","article-title":"Efficacy of praziquantel and artemisinin derivatives for the treatment and prevention of human schistosomiasis: a systematic review and meta-analysis","volume":"4","author":"R Liu","year":"2011","journal-title":"Parasit Vectors"},{"issue":"9","key":"pntd.0008220.ref027","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1086\/651682","article-title":"Efficacy and safety of mefloquine, artesunate, mefloquine-artesunate, and praziquantel against Schistosoma haematobium: randomized, exploratory open-label trial","volume":"50","author":"J Keiser","year":"2010","journal-title":"Clin Infect Dis"},{"issue":"7","key":"pntd.0008220.ref028","doi-asserted-by":"crossref","first-page":"e76","DOI":"10.1093\/cid\/cis1011","article-title":"Efficacy and safety of tribendimidine against Clonorchis sinensis","volume":"56","author":"MB Qian","year":"2013","journal-title":"Clin Infect Dis"},{"issue":"10","key":"pntd.0008220.ref029","doi-asserted-by":"crossref","first-page":"e1339","DOI":"10.1371\/journal.pntd.0001339","article-title":"Correlation between discharged worms and fecal egg counts in human clonorchiasis","volume":"5","author":"JH Kim","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"issue":"11","key":"pntd.0008220.ref030","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.3390\/cells8111336","article-title":"Second-generation antipsychotics and dysregulation of glucose metabolism: beyond weight gain","volume":"8","author":"D Grajales","year":"2019","journal-title":"Cells"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0008220","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T00:00:00Z","timestamp":1586390400000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0008220","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T17:57:30Z","timestamp":1586455050000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0008220"}},"subtitle":[],"editor":[{"given":"jong-Yil","family":"Chai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,3,30]]},"references-count":30,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,3,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0008220","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pntd.0008220","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,30]]}}}