{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:16:52Z","timestamp":1790630212764,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0008277","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T00:00:00Z","timestamp":1594684800000}}],"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T00:00:00Z","timestamp":1592784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0008277","type":"journal-article","created":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T17:42:04Z","timestamp":1592847724000},"page":"e0008277","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Efficacy and safety of single-dose 40 mg\/kg oral praziquantel in the treatment of schistosomiasis in preschool-age versus school-age children: An individual participant data meta-analysis"],"prefix":"10.1371","volume":"14","author":[{"given":"Piero L.","family":"Olliaro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean T.","family":"Coulibaly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amadou","family":"Garba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Halleux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Keiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles H.","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"Mutapi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eli\u00e9zer K.","family":"N\u2019Goran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Raso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra U.","family":"Scherrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Carlos","family":"Sousa-Figueiredo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Stete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrg","family":"Utzinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4714-8128","authenticated-orcid":true,"given":"Michel T.","family":"Vaillant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,6,22]]},"reference":[{"key":"pntd.0008277.ref001","volume-title":"Preventive chemotherapy in human helminthiasis: coordinated use of anthelminthic drugs in control interventions: a manual for health professionals and programme managers","author":"WHO","year":"2006"},{"issue":"2","key":"pntd.0008277.ref002","doi-asserted-by":"crossref","first-page":"e0006144","DOI":"10.1371\/journal.pntd.0006144","article-title":"Paediatric schistosomiasis: What we know and what we need to know","volume":"12","author":"DNM Osakunor","year":"2018","journal-title":"PLoS Negl Trop Dis"},{"issue":"4","key":"pntd.0008277.ref003","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.pt.2013.02.001","article-title":"Schistosomiasis in African infants and preschool children: let them now be treated!","volume":"29","author":"JR Stothard","year":"2013","journal-title":"Trends Parasitol"},{"issue":"12","key":"pntd.0008277.ref004","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1017\/S0031182011001235","article-title":"Closing the praziquantel treatment gap: new steps in epidemiological monitoring and control of schistosomiasis in African infants and preschool-aged children","volume":"138","author":"JR Stothard","year":"2011","journal-title":"Parasitology"},{"key":"pntd.0008277.ref005","volume-title":"Report of a meeting to review the results of studies on the treatment of Schistosomiasis in preschool-age chidren, WHO report","author":"WHO","year":"2010"},{"issue":"1","key":"pntd.0008277.ref006","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/cts.12601","article-title":"Relative Bioavailability of Orally Dispersible Tablet Formulations of Levo- and Racemic Praziquantel: Two Phase I Studies","volume":"12","author":"WM Bagchus","year":"2019","journal-title":"Clin Transl Sci"},{"issue":"1","key":"pntd.0008277.ref007","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s40249-017-0336-9","article-title":"Developing a comprehensive response for treatment of children under 6 years of age with schistosomiasis: research and development of a pediatric formulation of praziquantel","volume":"6","author":"J Reinhard-Rupp","year":"2017","journal-title":"Infect Dis Poverty"},{"issue":"9","key":"pntd.0008277.ref008","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1111\/tmi.12152","article-title":"Practical dosing of praziquantel for schistosomiasis in preschool-aged children","volume":"18","author":"PL Olliaro","year":"2013","journal-title":"Tropical medicine & international health: TM & IH"},{"issue":"9","key":"pntd.0008277.ref009","doi-asserted-by":"crossref","first-page":"e1260","DOI":"10.1371\/journal.pntd.0001260","article-title":"Resolution of praziquantel","volume":"5","author":"M Woelfle","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"issue":"4","key":"pntd.0008277.ref010","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00227-16","article-title":"Population Pharmacokinetics and Pharmacodynamics of Praziquantel in Ugandan Children with Intestinal Schistosomiasis: Higher Dosages Are Required for Maximal Efficacy","volume":"7","author":"AL Bustinduy","year":"2016","journal-title":"MBio"},{"issue":"1","key":"pntd.0008277.ref011","first-page":"24","article-title":"[Continued ultrasonic follow-up of children infected with Schistosoma haematobium after treatment with praziquantel]","volume":"6","author":"G Campagne","year":"2008","journal-title":"Tropical medicine & international health: TM & IH"},{"key":"pntd.0008277.ref012","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/1756-3305-5-135","article-title":"Intestinal parasitic infections in schoolchildren in different settings of C\u00f4te d'Ivoire: effect of diagnostic approach and implications for control","volume":"5","author":"JT Coulibaly","year":"2012","journal-title":"Parasit Vectors"},{"issue":"7","key":"pntd.0008277.ref013","doi-asserted-by":"crossref","first-page":"e688","DOI":"10.1016\/S2214-109X(17)30187-0","article-title":"Efficacy and safety of praziquantel in preschool-aged and school-aged children infected with Schistosoma mansoni: a randomised controlled, parallel-group, dose-ranging, phase 2 trial","volume":"5","author":"JT Coulibaly","year":"2017","journal-title":"Lancet Glob Health"},{"issue":"1","key":"pntd.0008277.ref014","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s12916-018-1066-y","article-title":"Efficacy and safety of ascending doses of praziquantel against Schistosoma haematobium infection in preschool-aged and school-aged children: a single-blind randomised controlled trial","volume":"16","author":"JT Coulibaly","year":"2018","journal-title":"BMC Med"},{"key":"pntd.0008277.ref015","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.actatropica.2012.08.008","article-title":"Efficacy and safety of two closely spaced doses of praziquantel against Schistosoma haematobium and S. mansoni and re-infection patterns in school-aged children in Niger","volume":"128","author":"A Garba","year":"2013","journal-title":"Acta Trop"},{"issue":"2","key":"pntd.0008277.ref016","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.actatropica.2012.12.003","article-title":"Safety and efficacy of praziquantel syrup (Epiquantel(R)) against Schistosoma haematobium and Schistosoma mansoni in preschool-aged children in Niger","volume":"128","author":"A Garba","year":"2013","journal-title":"Acta Trop"},{"issue":"1\u20132","key":"pntd.0008277.ref017","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.actatropica.2010.02.007","article-title":"Risk factors for Schistosoma haematobium infection and morbidity in two villages with different transmission patterns in Niger","volume":"115","author":"A Garba","year":"2010","journal-title":"Acta Trop"},{"issue":"7","key":"pntd.0008277.ref018","doi-asserted-by":"crossref","first-page":"e1774","DOI":"10.1371\/journal.pntd.0001774","article-title":"Significantly reduced intensity of infection but persistent prevalence of schistosomiasis in a highly endemic region in Mali after repeated treatment","volume":"6","author":"A Landour\u00e9","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"issue":"5","key":"pntd.0008277.ref019","doi-asserted-by":"crossref","first-page":"e1143","DOI":"10.1371\/journal.pntd.0001143","article-title":"Schistosoma haematobium treatment in 1\u20135 year old children: safety and efficacy of the antihelminthic drug praziquantel","volume":"5","author":"F Mutapi","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"issue":"1","key":"pntd.0008277.ref020","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1179\/000349803125002553","article-title":"Efficacy and side-effects of two praziquantel treatments against Schistosoma haematobium infection, among schoolchildren from C\u00f4te d'Ivoire","volume":"97","author":"EK N'Goran","year":"2003","journal-title":"Annals of tropical medicine and parasitology"},{"issue":"4","key":"pntd.0008277.ref021","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1086\/314686","article-title":"Double-blind placebo-controlled study of concurrent administration of albendazole and praziquantel in schoolchildren with schistosomiasis and geohelminths","volume":"179","author":"GR Olds","year":"1999","journal-title":"J Infect Dis"},{"issue":"6","key":"pntd.0008277.ref022","doi-asserted-by":"crossref","first-page":"e1165","DOI":"10.1371\/journal.pntd.0001165","article-title":"A multicentre randomized controlled trial of the efficacy and safety of single-dose praziquantel at 40 mg\/kg vs. 60 mg\/kg for treating intestinal schistosomiasis in the Philippines, Mauritania, Tanzania and Brazil","volume":"5","author":"PL Olliaro","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"issue":"1","key":"pntd.0008277.ref023","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0035-9203(03)00003-8","article-title":"Efficacy and side effects of praziquantel against Schistosoma mansoni in a community of western C\u00f4te d'Ivoire","volume":"98","author":"G Raso","year":"2004","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"3","key":"pntd.0008277.ref024","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.actatropica.2008.11.015","article-title":"Sequential analysis of helminth egg output in human stool samples following albendazole and praziquantel administration","volume":"109","author":"AU Scherrer","year":"2009","journal-title":"Acta Trop"},{"issue":"10","key":"pntd.0008277.ref025","doi-asserted-by":"crossref","first-page":"e1864","DOI":"10.1371\/journal.pntd.0001864","article-title":"Performance and safety of praziquantel for treatment of intestinal schistosomiasis in infants and preschool children","volume":"6","author":"JC Sousa-Figueiredo","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"pntd.0008277.ref026","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1186\/1756-3305-5-298","article-title":"Dynamics of Schistosoma haematobium egg output and associated infection parameters following treatment with praziquantel in school-aged children","volume":"5","author":"K Stete","year":"2012","journal-title":"Parasit Vectors"},{"issue":"9","key":"pntd.0008277.ref027","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1046\/j.1365-3156.1998.00292.x","article-title":"Schistosoma mansoni, intestinal parasites and perceived morbidity indicators in schoolchildren in a rural endemic area of western C\u00f4te d'Ivoire","volume":"3","author":"J Utzinger","year":"1998","journal-title":"Tropical medicine & international health: TM & IH"},{"issue":"11","key":"pntd.0008277.ref028","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1046\/j.1365-3156.2000.00646.x","article-title":"Efficacy of praziquantel against Schistosoma mansoni with particular consideration for intensity of infection","volume":"5","author":"J Utzinger","year":"2000","journal-title":"Tropical medicine & international health: TM & IH"},{"issue":"14","key":"pntd.0008277.ref029","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1017\/S0031182014000213","article-title":"Comparing parasitological vs serological determination of Schistosoma haematobium infection prevalence in preschool and primary school-aged children: implications for control programmes","volume":"141","author":"WM Wami","year":"2014","journal-title":"Parasitology"},{"issue":"8","key":"pntd.0008277.ref030","first-page":"718","article-title":"Efficacy and adverse effects of film coated praziquantel for treatment of schistosomiasis japonica","volume":"43","author":"J Xu","year":"2009","journal-title":"Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]"},{"issue":"6","key":"pntd.0008277.ref031","doi-asserted-by":"crossref","first-page":"e0004784","DOI":"10.1371\/journal.pntd.0004784","article-title":"The Schistosomiasis Clinical Trials Landscape: A Systematic Review of Antischistosomal Treatment Efficacy Studies and a Case for Sharing Individual Participant-Level Data (IPD)","volume":"10","author":"AM Jule","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"pntd.0008277.ref032","doi-asserted-by":"crossref","DOI":"10.1002\/9780470712184","volume-title":"Cochrane Handbook of Systematic Reviews of Interventions Version 500 [updated February 2008]","author":"JPT Higgins","year":"2008"},{"issue":"6","key":"pntd.0008277.ref033","first-page":"397","article-title":"A simple device for quantitative stool thick-smear technique in Schistosomiasis mansoni","volume":"14","author":"N Katz","year":"1972","journal-title":"Revista do Instituto de Medicina Tropical de Sao Paulo"},{"issue":"i-vi","key":"pntd.0008277.ref034","first-page":"1","article-title":"Prevention and control of schistosomiasis and soil-transmitted helminthiasis","volume":"912","author":"WHO","year":"2002","journal-title":"World Health Organization technical report series"},{"issue":"6","key":"pntd.0008277.ref035","doi-asserted-by":"crossref","first-page":"e0003821","DOI":"10.1371\/journal.pntd.0003821","article-title":"Toward Measuring Schistosoma Response to Praziquantel Treatment with Appropriate Descriptors of Egg Excretion","volume":"9","author":"PL Olliaro","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"pntd.0008277.ref036","volume-title":"Assessing the efficacy of anthelmintic drug against schistosomiasis and soil-transmitted helminthiases","author":"WHO","year":"2013"},{"key":"pntd.0008277.ref037","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1002\/sim.5584","article-title":"Combining individual patient data and aggregate data in mixed treatment comparison meta-analysis: individual patient data may be beneficial if only for a subset of trials","volume":"32","author":"S Donegan","year":"2013","journal-title":"Statistics in Medicine"},{"key":"pntd.0008277.ref038","first-page":"1","article-title":"Individual patient data network meta-analysis of mortality effects of implantable cardiac devices","volume":"0","author":"B Woods","year":"2015","journal-title":"Heart"},{"issue":"5","key":"pntd.0008277.ref039","doi-asserted-by":"crossref","first-page":"e241","DOI":"10.1371\/journal.pntd.0000241","article-title":"Controlling schistosomiasis: significant decrease of anaemia prevalence one year after a single dose of praziquantel in Nigerian schoolchildren","volume":"2","author":"ZB Tohon","year":"2008","journal-title":"PLoS Negl Trop Dis"},{"issue":"2","key":"pntd.0008277.ref040","doi-asserted-by":"crossref","first-page":"e64","DOI":"10.1016\/S1473-3099(16)30535-7","article-title":"A call to strengthen the global strategy against schistosomiasis and soil-transmitted helminthiasis: the time is now","volume":"17","author":"NC Lo","year":"2017","journal-title":"Lancet Infect Dis"},{"issue":"1","key":"pntd.0008277.ref041","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s13071-016-1958-7","article-title":"Efficacy and safety of praziquantel 40 mg\/kg in preschool-aged and school-aged children: a meta-analysis","volume":"10","author":"J Zwang","year":"2017","journal-title":"Parasit Vectors"},{"issue":"7","key":"pntd.0008277.ref042","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1124\/dmd.115.068593","article-title":"Hepatic Cytochrome P450 Activity, Abundance, and Expression Throughout Human Development","volume":"44","author":"NC Sadler","year":"2016","journal-title":"Drug Metab Dispos"},{"issue":"11","key":"pntd.0008277.ref043","doi-asserted-by":"crossref","first-page":"e3286","DOI":"10.1371\/journal.pntd.0003286","article-title":"Clinical efficacy and tolerability of praziquantel for intestinal and urinary schistosomiasis-a meta-analysis of comparative and non-comparative clinical trials","volume":"8","author":"J Zwang","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"pntd.0008277.ref044","first-page":"Cd000528","article-title":"Drugs for treating Schistosoma mansoni infection","volume":"2","author":"A Danso-Appiah","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"issue":"8","key":"pntd.0008277.ref045","first-page":"CD000053","article-title":"Drugs for treating urinary schistosomiasis","author":"CV Kramer","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"pntd.0008277.ref046","doi-asserted-by":"crossref","first-page":"e938","DOI":"10.1371\/journal.pntd.0000938","article-title":"Schistosoma mansoni Infections in young children: when are schistosome antigens in urine, eggs in stool and antibodies to eggs first detectable?","volume":"5","author":"JR Stothard","year":"2011","journal-title":"PLoS Negl Trop Dis"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0008277","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T00:00:00Z","timestamp":1594684800000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0008277","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,21]],"date-time":"2021-03-21T08:43:08Z","timestamp":1616316188000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0008277"}},"subtitle":[],"editor":[{"given":"Antonio","family":"Montresor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,6,22]]},"references-count":46,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,6,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0008277","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pntd.0008277","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,22]]}}}