{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:25:16Z","timestamp":1790234716469,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0008398","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T00:00:00Z","timestamp":1594252800000}}],"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T00:00:00Z","timestamp":1592784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0008398","type":"journal-article","created":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T17:42:49Z","timestamp":1592847769000},"page":"e0008398","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":26,"title":["Access to Chagas disease treatment in the United States after the regulatory approval of benznidazole"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8463-4913","authenticated-orcid":true,"given":"Kota","family":"Yoshioka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Manne-Goehler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James H.","family":"Maguire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3338-0612","authenticated-orcid":true,"given":"Michael R.","family":"Reich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,6,22]]},"reference":[{"issue":"5","key":"pntd.0008398.ref001","doi-asserted-by":"crossref","first-page":"e52","DOI":"10.1086\/605091","article-title":"An estimate of the burden of Chagas disease in the United States","volume":"49","author":"C Bern","year":"2009","journal-title":"Clin Infect Dis"},{"issue":"11","key":"pntd.0008398.ref002","doi-asserted-by":"crossref","first-page":"e0005033","DOI":"10.1371\/journal.pntd.0005033","article-title":"Estimating the Burden of Chagas Disease in the United States","volume":"10","author":"J Manne-Goehler","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"issue":"9","key":"pntd.0008398.ref003","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1093\/cid\/cix064","article-title":"Prevalence of Chagas Disease in the Latin American\u2013born Population of Los Angeles","volume":"64","author":"S Meymandi","year":"2017","journal-title":"Clin Infect Dis"},{"issue":"4","key":"pntd.0008398.ref004","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/S1473-3099(13)70002-1","article-title":"Global economic burden of Chagas disease: a computational simulation model","volume":"13","author":"BY Lee","year":"2013","journal-title":"Lancet Infect Dis"},{"issue":"5","key":"pntd.0008398.ref005","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1056\/NEJMra1410150","article-title":"Chagas\u2019 Disease","volume":"373","author":"C Bern","year":"2015","journal-title":"N Engl J Med"},{"issue":"18","key":"pntd.0008398.ref006","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1001\/jama.298.18.2171","article-title":"Evaluation and treatment of Chagas disease in the United States: a systematic review","volume":"298","author":"C Bern","year":"2007","journal-title":"Jama"},{"issue":"9","key":"pntd.0008398.ref007","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1093\/infdis\/jix087","article-title":"Treatment of Infected Women of Childbearing Age Prevents Congenital Trypanosoma cruzi Infection by Eliminating the Parasitemia Detected by PCR","volume":"215","author":"L Murcia","year":"2017","journal-title":"J Infect Dis"},{"key":"pntd.0008398.ref008","first-page":"1","article-title":"Safety Profile of Benznidazole in the Treatment of Chronic Chagas Disease: Experience of a Referral Centre and Systematic Literature Review with Meta-Analysis","author":"C Crespillo-And\u00fajar","year":"2018","journal-title":"Drug Saf"},{"key":"pntd.0008398.ref009","doi-asserted-by":"crossref","DOI":"10.15585\/mmwr.mm6729a3","article-title":"Characteristics of Patients for Whom Benznidazole Was Released Through the CDC-Sponsored Investigational New Drug Program for Treatment of Chagas Disease\u2014United States, 2011\u20132018","volume":"67","author":"BL Herwaldt","year":"2018","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"1","key":"pntd.0008398.ref010","doi-asserted-by":"crossref","first-page":"108","DOI":"10.4269\/ajtmh.14-0826","article-title":"Access to Care for Chagas Disease in the United States: A Health Systems Analysis","volume":"93","author":"J Manne-Goehler","year":"2015","journal-title":"Am J Trop Med Hyg"},{"key":"pntd.0008398.ref011","unstructured":"U.S. Food and Drug Administration. Press Announcements\u2014FDA approves first U.S. treatment for Chagas disease [Internet]. 2017 [cited 2018 Aug 14]. Available from: https:\/\/www.fda.gov\/newsevents\/newsroom\/pressannouncements\/ucm573942.htm"},{"key":"pntd.0008398.ref012","unstructured":"Priority Review Voucher [Internet]. [cited 2019 May 1]. Available from: https:\/\/priorityreviewvoucher.org\/"},{"key":"pntd.0008398.ref013","unstructured":"DNDi. U.S. FDA approves Chemo Group\u2019s benznidazole to treat children with Chagas disease [Internet]. DNDi\u2013Best science for the most neglected. 2017 [cited 2019 Feb 23]. Available from: https:\/\/www.dndi.org\/2017\/media-centre\/press-releases\/fda-approves-benznidazole-chagas-children\/"},{"issue":"3","key":"pntd.0008398.ref014","doi-asserted-by":"crossref","first-page":"e000709","DOI":"10.1136\/bmjgh-2018-000709","article-title":"Why miltefosine\u2014a life-saving drug for leishmaniasis\u2014is unavailable to people who need it the most","volume":"3","author":"T Sunyoto","year":"2018","journal-title":"BMJ Glob Health"},{"key":"pntd.0008398.ref015","volume-title":"Access: how do good health technologies get to poor people in poor countries?","author":"LJ Frost","year":"2008"},{"issue":"5","key":"pntd.0008398.ref016","doi-asserted-by":"crossref","first-page":"e029141","DOI":"10.1136\/bmjopen-2019-029141","article-title":"Exploring global and country-level barriers to an effective supply of leishmaniasis medicines and diagnostics in eastern Africa: a qualitative study","volume":"9","author":"T Sunyoto","year":"2019","journal-title":"BMJ Open"},{"issue":"5","key":"pntd.0008398.ref017","doi-asserted-by":"crossref","first-page":"e0007372","DOI":"10.1371\/journal.pntd.0007372","article-title":"Formative research to inform development of a new diagnostic for soil-transmitted helminths: Going beyond the laboratory to ensure access to a needed product","volume":"13","author":"HL Storey","year":"2019","journal-title":"PLoS Negl Trop Dis"},{"key":"pntd.0008398.ref018","article-title":"Current Gaps and Needs for Increasing Access to Healthcare for People with Chagas Disease in the USA","author":"CJ Forsyth","year":"2019","journal-title":"Curr Trop Med Rep"},{"key":"pntd.0008398.ref019","unstructured":"CDC-Centers for Disease Control and Prevention. CDC\u2014Chagas Disease\u2014Antiparasitic Treatment [Internet]. 2018 [cited 2018 Aug 15]. Available from: https:\/\/www.cdc.gov\/parasites\/chagas\/health_professionals\/tx.html"},{"issue":"3","key":"pntd.0008398.ref020","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s40506-018-0170-z","article-title":"Treatment of Chagas Disease in the United States","volume":"10","author":"S Meymandi","year":"2018","journal-title":"Curr Treat Options Infect Dis"},{"key":"pntd.0008398.ref021","article-title":"Evaluation and Management of Congenital Chagas Disease in the United States","author":"MS Edwards","journal-title":"J Pediatr Infect Dis Soc"},{"issue":"8","key":"pntd.0008398.ref022","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1001\/jama.2018.9660","article-title":"Clinical Practice Guidelines: What\u2019s Next?","volume":"320","author":"PG Shekelle","year":"2018","journal-title":"JAMA"},{"issue":"5","key":"pntd.0008398.ref023","doi-asserted-by":"crossref","first-page":"871","DOI":"10.3201\/eid1605.091440","article-title":"Physician Awareness of Chagas Disease, USA","volume":"16","author":"KK Stimpert","year":"2010","journal-title":"Emerg Infect Dis"},{"issue":"4","key":"pntd.0008398.ref024","doi-asserted-by":"crossref","first-page":"891","DOI":"10.4269\/ajtmh.2010.09-0543","article-title":"Survey of Obstetrician-Gynecologists in the United States About Chagas Disease","volume":"83","author":"JR Verani","year":"2010","journal-title":"Am J Trop Med Hyg"},{"issue":"3","key":"pntd.0008398.ref025","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s40615-016-0254-8","article-title":"Physician Knowledge of Chagas Disease in Hispanic Immigrants Living in Appalachian Ohio","volume":"4","author":"S Amstutz-Szalay","year":"2017","journal-title":"J Racial Ethn Health Disparities"},{"issue":"1","key":"pntd.0008398.ref026","doi-asserted-by":"crossref","first-page":"e24","DOI":"10.1097\/INF.0000000000001733","article-title":"Survey of Pediatric Infectious Diseases Society Members About Congenital Chagas Disease","volume":"37","author":"MS Edwards","year":"2018","journal-title":"Pediatr Infect Dis J"},{"issue":"3","key":"pntd.0008398.ref027","doi-asserted-by":"crossref","first-page":"735","DOI":"10.4269\/ajtmh.17-0691","article-title":"\u201cIt\u2019s Like a Phantom Disease\u201d: Patient Perspectives on Access to Treatment for Chagas Disease in the United States","volume":"98","author":"CJ Forsyth","year":"2018","journal-title":"Am J Trop Med Hyg"},{"issue":"1","key":"pntd.0008398.ref028","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00520-018-4479-4","article-title":"Peer support opportunities across the cancer care continuum: a systematic scoping review of recent peer-reviewed literature","volume":"27","author":"SD Kowitt","year":"2019","journal-title":"Support Care Cancer"},{"issue":"9","key":"pntd.0008398.ref029","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0005794","article-title":"Access to benznidazole for Chagas disease in the United States\u2014Cautious optimism?","volume":"11","author":"JD Alpern","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"key":"pntd.0008398.ref030","unstructured":"DNDi. Study shows dramatically shorter treatment for Chagas disease could be just as effective, and significantly safer [Internet]. DNDi\u2013Drugs for Neglected Diseases initiative. 2019 [cited 2019 Mar 16]. Available from: https:\/\/www.dndi.org\/2019\/media-centre\/press-releases\/study-shows-dramatically-shorter-treatment-chagas-effective-and-safer\/"},{"key":"pntd.0008398.ref031","doi-asserted-by":"crossref","unstructured":"Bennett C. Chagas Disease Surveillance Activities\u2014Seven States, 2017. MMWR Morb Mortal Wkly Rep [Internet]. 2018 [cited 2018 Jul 6];67. Available from: https:\/\/www.cdc.gov\/mmwr\/volumes\/67\/wr\/mm6726a2.htm","DOI":"10.15585\/mmwr.mm6726a2"},{"key":"pntd.0008398.ref032","unstructured":"CDC\u2014National Health Initiatives, Strategies, and Action Plans\u2014STLT Gateway [Internet]. 2019 [cited 2019 Aug 30]. Available from: https:\/\/www.cdc.gov\/publichealthgateway\/strategy\/index.html"},{"key":"pntd.0008398.ref033","first-page":"JCM.01217","article-title":"Chagas disease serological test performance in United States blood donor specimens","author":"JD Whitman","year":"2019","journal-title":"J Clin Microbiol"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0008398","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T00:00:00Z","timestamp":1594252800000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0008398","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T17:55:25Z","timestamp":1594317325000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0008398"}},"subtitle":[],"editor":[{"given":"Helton da Costa","family":"Santiago","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,6,22]]},"references-count":33,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,6,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0008398","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pntd.0008398","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,22]]}}}