{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:50:33Z","timestamp":1789674633592,"version":"4.0.1"},"reference-count":44,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T00:00:00Z","timestamp":1600646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0008585","type":"journal-article","created":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T13:46:19Z","timestamp":1600695979000},"page":"e0008585","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Evaluation of ocular involvement in patients with Hansen\u2019s disease"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4930-8597","authenticated-orcid":true,"given":"Priscila Daiane","family":"Pavezzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Bueno","family":"do Prado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Plinio \u00c2ngelo","family":"Boin Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Airton dos Santos","family":"Gon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna","family":"Tuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5213-2337","authenticated-orcid":true,"given":"Marco Aurelio","family":"Fornazieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana de Mari","family":"Scalone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana Rigolin Mazoni","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Hirayama","family":"Montero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Marcelo Barbante","family":"Casella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,9,21]]},"reference":[{"key":"pntd.0008585.ref001","volume-title":"Secretaria de Pol\u00edticas de Sa\u00fade. Departamento de Aten\u00e7\u00e3o B\u00e1sica. Guia para o Controle da hansen\u00edase","author":"Brazil. Minist\u00e9rio da Sa\u00fade","year":"2002"},{"key":"pntd.0008585.ref002","first-page":"1221","volume-title":"Dermatology","author":"M Ramos-e-Silva","year":"2012","edition":"3"},{"key":"pntd.0008585.ref003","first-page":"405","article-title":"Global leprosy update, 2015","volume":"91","author":"World Health Organization","year":"2016","journal-title":"Weekly Epidemiologic Rec"},{"key":"pntd.0008585.ref004","first-page":"1269","volume-title":"Tratado de dermatologia.","author":"LC Margarido","year":"2014","edition":"2"},{"issue":"2","key":"pntd.0008585.ref005","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1136\/bjo.75.2.123","article-title":"The continuing challenge of ocular leprosy","volume":"75","author":"TJ Ffytche","year":"1991","journal-title":"Br J Ophthalmol"},{"issue":"3","key":"pntd.0008585.ref006","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/IIO.0b013e318074e3eb","article-title":"An overview of ocular leprosy after 2 decades of multidrug therapy","volume":"47","author":"S Lewallen","year":"2007","journal-title":"Int Ophthalmol Clin"},{"issue":"1","key":"pntd.0008585.ref007","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.clindermatol.2014.07.003","article-title":"Ocular leprosy","volume":"33","author":"A Grzybowski","year":"2015","journal-title":"Clin Dermatol"},{"issue":"10","key":"pntd.0008585.ref008","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1016\/j.ophtha.2007.02.011","article-title":"Initial Diagnosis of Leprosy in Patients Treated by an Ophthalmologist and Confirmation by Conventional Analysis and Polymerase Chain Reaction","volume":"114","author":"IA Chaudhry","year":"2007","journal-title":"Ophthalmology"},{"issue":"35\/36","key":"pntd.0008585.ref009","first-page":"389","article-title":"Global leprosy update, 2018: moving towards a leprosy free world","volume":"94","year":"2019","journal-title":"Weekly Epidemiological Record"},{"key":"pntd.0008585.ref010","unstructured":"Brazil. Minist\u00e9rio da Sa\u00fade. Hansen\u00edase\u2014indicadores operacionais e epidemiol\u00f3gicos [Internet]. DATASUS\u2014tecnologia da Informa\u00e7\u00e3o a Servi\u00e7o do SUS; 2018 [cited 20 May 2019]. http:\/\/tabnet.datasus.gov.br\/cgi\/tabcgi.exe?sinannet\/hanseniase\/cnv\/hanswuf.def"},{"issue":"2","key":"pntd.0008585.ref011","first-page":"205","article-title":"Hansen\u00edase: revis\u00e3o dos aspectos epidemiol\u00f3gicos, etiopatog\u00eanicos e cl\u00ednicos\u2013Parte I","volume":"89","author":"JC Lastoria","year":"2014","journal-title":"An Bras Dermatol"},{"key":"pntd.0008585.ref012","unstructured":"Brazil. Minist\u00e9rio da Sa\u00fade. Secretaria de Vigil\u00e2ncia em Sa\u00fade. Departamento de Vigil\u00e2ncia das Doen\u00e7as Transmiss\u00edveis. Guia pr\u00e1tico sobre a hansen\u00edase [Internet]. Bras\u00edlia: Minist\u00e9rio da Sa\u00fade, 2017. http:\/\/portalarquivos2.saude.gov.br\/images\/pdf\/2017\/novembro\/22\/Guia-Pratico-de-Hanseniase-WEB.pdf"},{"issue":"2","key":"pntd.0008585.ref013","first-page":"1","article-title":"Hansen\u00edase: aspectos cl\u00ednicos, imunol\u00f3gicos e terap\u00eauticos","volume":"74","author":"TN Foss","year":"1999","journal-title":"An Bras Dermatol"},{"issue":"6","key":"pntd.0008585.ref014","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/0002-9394(74)90393-6","article-title":"Ocular Findings in Leprosy","volume":"77","author":"JA Shields","year":"1974","journal-title":"Am J Ophthalmol"},{"issue":"11","key":"pntd.0008585.ref015","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1016\/j.ophtha.2009.04.021","article-title":"Ocular Manifestation in Treated Multibacillary Hansen\u2019s Disease","volume":"116","author":"R Parikh","year":"2009","journal-title":"Ophthalmology"},{"key":"pntd.0008585.ref016","unstructured":"Brazil. Minist\u00e9rio da Sa\u00fade. Secretaria de Vigil\u00e2ncia em Sa\u00fade. Departamento de Vigil\u00e2ncia Epidemiol\u00f3gica. Manual de condutas para altera\u00e7\u00f5es oculares em hansen\u00edase\u2013 2ed., rev. e ampl. Bras\u00edlia: Minist\u00e9rio da Sa\u00fade; 2008. http:\/\/bvsms.saude.gov.br\/bvs\/publicacoes\/manual_condutas_oculares_hanseniase.pdf"},{"issue":"6","key":"pntd.0008585.ref017","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/eye.2011.43","article-title":"The prevalence of ocular complications in leprosy patients seen in the United Kingdom over a period of 21 years","volume":"25","author":"AN Malik","year":"2011","journal-title":"Eye (Lond)"},{"issue":"3","key":"pntd.0008585.ref018","doi-asserted-by":"crossref","first-page":"225","DOI":"10.47276\/lr.73.3.225","article-title":"Eye disease in multibacillary leprosy patients at the time of their leprosy diagnosis: findings from the Longitudinal Study of Ocular Leprosy (LOSOL) in India, the Philippines and Ethiopia","volume":"73","author":"P Courtright","year":"2002","journal-title":"Lepr Rev"},{"issue":"12","key":"pntd.0008585.ref019","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1136\/bjo.73.12.939","article-title":"Importance of early diagnosis in ocular leprosy","volume":"73","author":"T Ffytche","year":"1989","journal-title":"Br J Ophthalmol"},{"key":"pntd.0008585.ref020","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1038\/sj.eye.6701984","article-title":"Prevention of blindness in leprosy and the role of the Vision 2020 Proramme","volume":"19","author":"M Hogeweg","year":"2005","journal-title":"Eye (Lond)"},{"key":"pntd.0008585.ref021","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1136\/bjo.79.3.250","article-title":"Is leprosy blindness avoidable? The effect of disease type, duration, and treatment on eye damage from leprosy in Uganda","volume":"79","author":"KM Waddell","year":"1995","journal-title":"Br J Ophthalmol"},{"issue":"4","key":"pntd.0008585.ref022","doi-asserted-by":"crossref","first-page":"366","DOI":"10.47276\/lr.74.4.366","volume":"74","author":"JW Brandsma","year":"2003","journal-title":"Lepr Rev"},{"key":"pntd.0008585.ref023","volume-title":"Global Leprosy Strategy 2016\u20132020 Accelerating towards a leprosy-free world","author":"World Health Organization","year":"2016"},{"key":"pntd.0008585.ref024","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1590\/S0004-27492003000700005","article-title":"Altera\u00e7\u00f5es oculares na hansen\u00edase, observadas em pacientes ambulatoriais do servi\u00e7o de refer\u00eancia da cidade de Rio Branco, Acre\u2013Brasil","volume":"66","author":"RD Moreno","year":"2003","journal-title":"Arq Bras Oftalmol"},{"issue":"45","key":"pntd.0008585.ref025","doi-asserted-by":"crossref","first-page":"8183","DOI":"10.18410\/jebmh\/2015\/1101","article-title":"Incidence of ocular manifestations in type of leprosy: a clinical study","volume":"2","author":"S Rao","year":"2015","journal-title":"JEBMH"},{"issue":"2","key":"pntd.0008585.ref026","first-page":"106","article-title":"Epidemiological surveillance of the ocular impairments in hansen's disease","volume":"29","author":"NH Medina","year":"2004","journal-title":"Hansen Int"},{"issue":"8","key":"pntd.0008585.ref027","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1136\/bjo.2006.094870","article-title":"Incidence of ocular complications in patients with multibacillary leprosy after completion of a 2 year course of multidrug therapy","volume":"90","author":"E Daniel","year":"2006","journal-title":"Br J Ophtalmol"},{"issue":"3","key":"pntd.0008585.ref028","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jtos.2017.05.003","article-title":"TFOS DEWS II Epidemiology Report","volume":"15","author":"F Stapleton","year":"2017","journal-title":"Ocul Surf"},{"issue":"1","key":"pntd.0008585.ref029","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1038\/s41598-018-20273-9","article-title":"Prevalence and Risk Factors of self-reported dry eye in Brazil using a short symptom questionnaire","volume":"8","author":"JS Castro","year":"2018","journal-title":"Sci Rep"},{"issue":"4","key":"pntd.0008585.ref030","first-page":"457","article-title":"Prevalence of dry eye in Hansen's disease patients from a colony hospital in Goi\u00e2nia, Brazil","volume":"68","author":"KC Fraz\u00e3o","year":"2005","journal-title":"Arq Bras Oftalmol"},{"issue":"4","key":"pntd.0008585.ref031","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1167\/iovs.10-6997a","article-title":"The International Workshop on Meibomian Gland Dysfunction: Executive Summary.","volume":"52","author":"KK Nichols","year":"2011","journal-title":"Invest Ophthalmol Vis Sci."},{"issue":"3","key":"pntd.0008585.ref032","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0161-6420(93)31643-X","article-title":"Ocular evaporation in Meibomian gland dysfunction and dry eye","volume":"100","author":"WD Mathers","year":"1993","journal-title":"Ophthalmology"},{"issue":"4","key":"pntd.0008585.ref033","first-page":"428","article-title":"Pterygium in lepromatous leprosy","volume":"64","author":"E Daniel","year":"1996","journal-title":"Int J Lepr Other Mycobact Dis"},{"key":"pntd.0008585.ref034","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1136\/bjo.81.6.490","article-title":"Pathology of iris in leprosy","volume":"81","author":"E Daniel","year":"1997","journal-title":"Br J Ophthalmol"},{"key":"pntd.0008585.ref035","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1136\/bjo.65.4.231","article-title":"Role of iris changes as a cause of blindness in lepromatous leprosy","volume":"65","author":"TJ Ffytche","year":"1981","journal-title":"Br J Ophthalmol"},{"issue":"2","key":"pntd.0008585.ref036","first-page":"142","article-title":"Pupillary reactions in lepromatous leprosy","volume":"40","author":"TR Swift","year":"1972","journal-title":"Int J Lepr Other Mycobact Dis"},{"key":"pntd.0008585.ref037","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/ana.410060107","article-title":"Pupillary dysfunction in myasthenia gravis","volume":"6","author":"FE Lepore","year":"1979","journal-title":"Ann Neurol"},{"key":"pntd.0008585.ref038","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1136\/bjo.62.7.495","article-title":"Edge-light pupil cycle time","volume":"62","author":"SD Miller","year":"1978","journal-title":"Br J Ophthalmol"},{"key":"pntd.0008585.ref039","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1136\/bjo.75.1.45","article-title":"Pupil cycle time and early autonomic involvement in ocular leprosy","volume":"75","author":"MA Kara\u00e7orlu","year":"1991","journal-title":"Br J Ophthalmol"},{"key":"pntd.0008585.ref040","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1136\/bjo.73.12.946","article-title":"Ocular autonomic dysfunction and intraocular pressure in leprosy","volume":"73","author":"S Lewallen","year":"1989","journal-title":"Br J Ophthalmol"},{"key":"pntd.0008585.ref041","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1136\/bjo.75.2.120","article-title":"Influence of untreated chronic plastic iridocyclitis on intraocular pressure in leprosy patients.","volume":"75","author":"MA Kara\u00e7orlu","year":"1991","journal-title":"Br J Ophthalmol"},{"key":"pntd.0008585.ref042","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1136\/bjo.75.5.270","article-title":"Glaucoma in Hansen's disease","volume":"75","author":"RC Walton","year":"1991","journal-title":"Br J Ophthalmol"},{"issue":"4","key":"pntd.0008585.ref043","doi-asserted-by":"crossref","first-page":"316","DOI":"10.47276\/lr.84.4.316","article-title":"Optic nerve involvement in a borderline lepromatous leprosy patient on multidrug therapy","volume":"84","author":"N Prabha","year":"2013","journal-title":"Leprosy Review"},{"issue":"1","key":"pntd.0008585.ref044","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1869-5760-3-36","article-title":"Anterior segment optical coherence tomography findings of iris granulomas in Hansen's disease: a case report","volume":"3","author":"P Mahendradas","year":"2013","journal-title":"J Ophthalmic Inflamm Infect"}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0008585","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T15:32:14Z","timestamp":1617377534000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0008585"}},"subtitle":[],"editor":[{"given":"Angamuthu","family":"Selvapandiyan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,9,21]]},"references-count":44,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,9,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0008585","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,21]]}}}