{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T10:27:07Z","timestamp":1789900027129,"version":"4.0.1"},"reference-count":94,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T00:00:00Z","timestamp":1601856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011102","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["602051"],"award-info":[{"award-number":["602051"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0008586","type":"journal-article","created":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T17:23:25Z","timestamp":1601918605000},"page":"e0008586","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":37,"title":["Proteomic analysis of plasma exosomes from Cystic Echinococcosis patients provides in vivo support for distinct immune response profiles in active vs inactive infection and suggests potential biomarkers"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0807-930X","authenticated-orcid":true,"given":"Federica","family":"Fratini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Tamarozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Macchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4278-2376","authenticated-orcid":true,"given":"L.","family":"Bertuccini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4154-930X","authenticated-orcid":true,"given":"M.","family":"Mariconti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Birago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5862-0152","authenticated-orcid":true,"given":"A.","family":"Iriarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Brunetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CM.","family":"Cretu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Akhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Siles-Lucas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5375-6766","authenticated-orcid":true,"given":"A.","family":"D\u00edaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano","family":"Casulli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,10,5]]},"reference":[{"issue":"2","key":"pntd.0008586.ref001","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3201\/eid1202.050499","article-title":"Global socioeconomic impact of cystic echinococcosis","volume":"12","author":"CM Budke","year":"2006","journal-title":"Emerg Infect Dis"},{"key":"pntd.0008586.ref002","volume-title":"Ending the neglect to attain the Sustainable Development Goals: a road map for neglected tropical diseases 2021\u20132030","year":"2020"},{"key":"pntd.0008586.ref003","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/bs.apar.2016.11.001","article-title":"Global distribution of alveolar and cystic echinococcosis","volume":"95","author":"P Deplazes","year":"2017","journal-title":"Adv Parasitol"},{"key":"pntd.0008586.ref004","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/bs.apar.2016.09.006","article-title":"The echinococcoses: diagnosis, clinical management and burden of disease","volume":"96","author":"P Kern","year":"2017","journal-title":"Adv Parasitol"},{"issue":"1","key":"pntd.0008586.ref005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actatropica.2009.11.001","article-title":"Writing Panel for the WHO-IWGE. Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans","volume":"114","author":"E Brunetti","year":"2010","journal-title":"Acta Trop"},{"issue":"7","key":"pntd.0008586.ref006","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1002\/nbm.1252","article-title":"Metabolic viability assessment of cystic echinococcosis using high-field 1H MRS of cyst contents","volume":"21","author":"W Hosch","year":"2008","journal-title":"NMR Biomed"},{"key":"pntd.0008586.ref007","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/bs.apar.2016.09.003","article-title":"Laboratory diagnosis of Echinococcus spp. in human patients and infected animals.","volume":"96","author":"M Siles-Lucas","year":"2017","journal-title":"Adv Parasitol"},{"issue":"1","key":"pntd.0008586.ref008","first-page":"133","article-title":"Multiplex cytokine and antibody profile in cystic echinococcosis patients during a three-year follow-up in reference to the cyst stages","volume":"13","author":"ZD Li","journal-title":"Parasit Vectors. 2020"},{"issue":"5","key":"pntd.0008586.ref009","first-page":"164","article-title":"Management of cystic echinococcosis: Thirty year experience in a single referral center in Northern Italy","volume":"89","author":"F Cattaneo","year":"2013","journal-title":"Am J Trop Med Hyg"},{"issue":"2","key":"pntd.0008586.ref010","doi-asserted-by":"crossref","first-page":"405","DOI":"10.4269\/ajtmh.16-0187","article-title":"Costs associated with surgically treated cases of abdominal cystic echinococcosis: A single center's experience from 2008 to 2014, Pavia, Italy","volume":"95","author":"R Narra","year":"2016","journal-title":"Am J Trop Med Hyg"},{"issue":"25","key":"pntd.0008586.ref011","doi-asserted-by":"crossref","first-page":"41717","DOI":"10.18632\/oncotarget.16684","article-title":"Exosome: emerging biomarker in breast cancer","volume":"8","author":"Y Jia","year":"2017","journal-title":"Oncotarget"},{"key":"pntd.0008586.ref012","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3389\/fcell.2018.00018","article-title":"Exosome-based cell-cell communication in the tumor microenvironment","volume":"6","author":"J Maia","year":"2018","journal-title":"Front Cell Dev Biol"},{"issue":"1","key":"pntd.0008586.ref013","doi-asserted-by":"crossref","first-page":"24","DOI":"10.15252\/embr.201439363","article-title":"Exosomes and other extracellular vesicles in host-pathogen interactions","volume":"16","author":"JS Schorey","year":"2015","journal-title":"EMBO Rep"},{"issue":"1","key":"pntd.0008586.ref014","doi-asserted-by":"crossref","first-page":"1440131","DOI":"10.1080\/20013078.2018.1440131","article-title":"Extracellular vesicles as a platform for membrane-associated therapeutic protein delivery","volume":"7","author":"Y Yang","year":"2018","journal-title":"J Extracell Vesicles"},{"key":"pntd.0008586.ref015","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3389\/fimmu.2018.00090","article-title":"Exosomes in Pathogen Infections: A Bridge to Deliver Molecules and Link Functions","volume":"9","author":"WC Zhang","year":"2018","journal-title":"Front Immunol"},{"issue":"1","key":"pntd.0008586.ref016","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.molbiopara.2016.06.003","article-title":"Host parasite communications-Messages from helminths for the immune system: Parasite communication and cell-cell interactions","volume":"208","author":"G Coakley","year":"2016","journal-title":"Mol Biochem Parasitol"},{"key":"pntd.0008586.ref017","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.3389\/fimmu.2018.02349","article-title":"Immunomodulation by helminths: intracellular pathways and extracellular vesicles","volume":"9","author":"A Zakeri","year":"2018","journal-title":"Front Immunol"},{"key":"pntd.0008586.ref018","doi-asserted-by":"crossref","first-page":"25040","DOI":"10.3402\/jev.v3.25040","article-title":"Extracellular vesicles in parasitic diseases","volume":"3","author":"A Marcilla","year":"2014","journal-title":"J Extracell Vesicles"},{"issue":"10","key":"pntd.0008586.ref019","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1016\/j.jprot.2010.06.006","article-title":"Exosomes: extracellular organelles important in intercellular communication","volume":"73","author":"S Mathivanan","year":"2010","journal-title":"J Proteomics"},{"issue":"10","key":"pntd.0008586.ref020","doi-asserted-by":"crossref","first-page":"531","DOI":"10.5483\/BMBRep.2014.47.10.164","article-title":"Extracellular vesicles as emerging intercellular communicasomes","volume":"47","author":"YJ Yoon","year":"2014","journal-title":"BMB Rep"},{"issue":"1","key":"pntd.0008586.ref021","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/cdd.2014.130","article-title":"Exosomes as divine messengers: are they the Hermes of modern molecular oncology?","volume":"22","author":"C Braicu","year":"2015","journal-title":"Cell Death Differ"},{"issue":"11","key":"pntd.0008586.ref022","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1016\/j.bbapap.2013.04.005","article-title":"Blood\/plasma secretome and microvesicles","volume":"1834","author":"JM Inal","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"pntd.0008586.ref023","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1146\/annurev.biochem.76.061705.130002","article-title":"Unsolved mysteries in membrane traffic","volume":"76","author":"SR Pfeffer","year":"2007","journal-title":"Annu Rev Biochem"},{"key":"pntd.0008586.ref024","doi-asserted-by":"crossref","first-page":"27066","DOI":"10.3402\/jev.v4.27066","article-title":"Biological properties of extracellular vesicles and their physiological functions","volume":"4","author":"M Yanez-Mo","year":"2015","journal-title":"J Extracell Vesicles"},{"issue":"5","key":"pntd.0008586.ref025","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.immuni.2018.10.016","article-title":"Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules","volume":"49","author":"RM Maizels","year":"2018","journal-title":"Immunity"},{"issue":"10","key":"pntd.0008586.ref026","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1515\/hsz-2013-0141","article-title":"Current methods for the isolation of extracellular vesicles","volume":"394","author":"F Momen-Heravi","year":"2013","journal-title":"Biol Chem"},{"issue":"16","key":"pntd.0008586.ref027","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1007\/s00018-011-0689-3","article-title":"Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles","volume":"68","author":"B Gyorgy","year":"2011","journal-title":"Cell Mol Life Sci"},{"issue":"1","key":"pntd.0008586.ref028","doi-asserted-by":"crossref","first-page":"1535750","DOI":"10.1080\/20013078.2018.1535750","article-title":"Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines","volume":"7","author":"C Thery","year":"2018","journal-title":"J Extracell Vesicles"},{"issue":"7","key":"pntd.0008586.ref029","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S1473-3099(18)30221-4","article-title":"Prevalence of abdominal cystic echinococcosis in rural Bulgaria, Romania, and Turkey: a cross-sectional, ultrasound-based, population study from the HERACLES project","volume":"18","author":"F Tamarozzi","year":"2018","journal-title":"Lancet Infect Dis"},{"key":"pntd.0008586.ref030","unstructured":"HERACLES (Human cystic Echinococcosis ReseArch in CentraL and Eastern Societies). http:\/\/www.heracles-fp7.eu. Accessed September 2019."},{"key":"pntd.0008586.ref031","doi-asserted-by":"crossref","DOI":"10.3402\/jev.v3.23111","article-title":"The influence of rotor type and centrifugation time on the yield and purity of extracellular vesicles","volume":"3","author":"A Cvjetkovic","year":"2014","journal-title":"J Extracell Vesicles"},{"issue":"22","key":"pntd.0008586.ref032","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.1002\/pmic.201300282","article-title":"Comparative proteomics evaluation of plasma exosome isolation techniques and assessment of the stability of exosomes in normal human blood plasma","volume":"13","author":"H Kalra","year":"2013","journal-title":"Proteomics"},{"issue":"10","key":"pntd.0008586.ref033","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1074\/mcp.M117.067041","article-title":"An integrated approach to explore composition and dynamics of cholesterol-rich membrane microdomains in sexual stages of malaria parasite","volume":"16","author":"F Fratini","year":"2017","journal-title":"Mol Cell Proteomics"},{"issue":"1","key":"pntd.0008586.ref034","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pt.2019.10.009","article-title":"Achievements of the HERACLES project on cystic echinococcosis","volume":"36","author":"A Casulli","year":"2020","journal-title":"Trends Parasitol"},{"key":"pntd.0008586.ref035","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1186\/s13071-016-1532-3","article-title":"The first meeting of the European Register of Cystic Echinococcosis (ERCE)","volume":"9","author":"P Rossi","year":"2016","journal-title":"Parasit Vectors"},{"issue":"1","key":"pntd.0008586.ref036","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1186\/s13071-020-04101-6","article-title":"The European Register of Cystic Echinococcosis, ERCE: state-of-the-art five years after its launch","volume":"13","author":"P Rossi","year":"2020","journal-title":"Parasit Vectors"},{"issue":"2","key":"pntd.0008586.ref037","doi-asserted-by":"crossref","first-page":"375","DOI":"10.4269\/ajtmh.18-0164","article-title":"Watch and Wait approach for inactive echinococcal cysts of the liver: An update","volume":"99","author":"R Lissandrin","year":"2018","journal-title":"Am J Trop Med Hyg"},{"issue":"8","key":"pntd.0008586.ref038","doi-asserted-by":"crossref","first-page":"e3057","DOI":"10.1371\/journal.pntd.0003057","article-title":"Long-term sonographic and serological follow-up of inactive echinococcal cysts of the liver: hints for a \"watch-and-wait\" approach","volume":"8","author":"L Piccoli","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"issue":"12","key":"pntd.0008586.ref039","doi-asserted-by":"crossref","first-page":"e0005243","DOI":"10.1371\/journal.pntd.0005243","article-title":"Watch and Wait management of inactive cystic echinococcosis\u2014Does the path to inactivity matter\u2014Analysis of a prospective patient cohort","volume":"10","author":"M Stojkovic","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"issue":"1","key":"pntd.0008586.ref040","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipides from animal tissues","volume":"226","author":"J Folch","year":"1957","journal-title":"J Biol Chem"},{"issue":"12","key":"pntd.0008586.ref041","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1074\/mcp.M900240-MCP200","article-title":"Unbiased quantitation of Escherichia coli membrane proteome using phase transfer surfactants","volume":"8","author":"T Masuda","year":"2009","journal-title":"Mol Cell Proteomics"},{"issue":"1","key":"pntd.0008586.ref042","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1074\/mcp.M500230-MCP200","article-title":"Absolute quantification of proteins by LCMSE: a virtue of parallel MS acquisition","volume":"5","author":"JC Silva","year":"2006","journal-title":"Mol Cell Proteomics"},{"key":"pntd.0008586.ref043","volume-title":"R: A language and environment for statistical computing","author":"R Core Team","year":"2013"},{"issue":"2","key":"pntd.0008586.ref044","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1021\/acs.jproteome.8b00702","article-title":"Cytoscape StringApp: Network analysis and visualization of proteomics data","volume":"18","author":"NT Doncheva","year":"2019","journal-title":"J Proteome Res"},{"issue":"1","key":"pntd.0008586.ref045","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1038\/s41598-020-57497-7","article-title":"A comparison of methods for the isolation and separation of extracellular vesicles from protein and lipid particles in human serum","volume":"10","author":"K Brennan","year":"2020","journal-title":"Sci Rep"},{"issue":"12","key":"pntd.0008586.ref046","doi-asserted-by":"crossref","first-page":"3574","DOI":"10.1016\/j.jprot.2012.03.054","article-title":"Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability","volume":"75","author":"P Bastos-Amador","year":"2012","journal-title":"J Proteomics"},{"issue":"3","key":"pntd.0008586.ref047","doi-asserted-by":"crossref","first-page":"5338","DOI":"10.3390\/ijms14035338","article-title":"Exosomes as intercellular signaling organelles involved in health and disease: basic science and clinical applications","volume":"14","author":"C Corrado","year":"2013","journal-title":"Int J Mol Sci"},{"issue":"9","key":"pntd.0008586.ref048","doi-asserted-by":"crossref","first-page":"e0006741","DOI":"10.1371\/journal.pntd.0006741","article-title":"Evaluation of the recombinant antigens B2t and 2B2t, compared with hydatid fluid, in IgG-ELISA and immunostrips for the diagnosis and follow up of CE patients","volume":"12","author":"A Hernandez-Gonzalez","year":"2018","journal-title":"PLoS Negl Trop Dis"},{"key":"pntd.0008586.ref049","unstructured":"ExoCarta. http:\/\/www.exocarta.org. Accessed September 2019."},{"key":"pntd.0008586.ref050","unstructured":"UniProt. http:\/\/www.uniprot.org. Accessed September 2019."},{"key":"pntd.0008586.ref051","unstructured":"WormBase ParaSite. http:\/\/www.parasite.wormbase.org. Accessed September 2019."},{"issue":"1\u20132","key":"pntd.0008586.ref052","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1080\/21541248.2016.1264352","article-title":"New insights into the function of Rab GTPases in the context of exosomal secretion","volume":"9","author":"L Blanc","year":"2018","journal-title":"Small GTPases"},{"issue":"11","key":"pntd.0008586.ref053","doi-asserted-by":"crossref","first-page":"a022616","DOI":"10.1101\/cshperspect.a022616","article-title":"Rab proteins and the compartmentalization of the endosomal system","volume":"6","author":"A Wandinger-Ness","year":"2014","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"13\u201314","key":"pntd.0008586.ref054","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.ijpara.2019.08.003","article-title":"Extracellular vesicles derived from Echinococcus granulosus hydatid cyst fluid from patients: isolation, characterization and evaluation of immunomodulatory functions on T cells","volume":"49","author":"X Zhou","year":"2019","journal-title":"Int J Parasitol"},{"issue":"11","key":"pntd.0008586.ref055","doi-asserted-by":"crossref","first-page":"e0004209","DOI":"10.1371\/journal.pntd.0004209","article-title":"Polyfunctional specific response to Echinococcus granulosus associates to the biological activity of the cysts","volume":"9","author":"L Petrone","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"issue":"1","key":"pntd.0008586.ref056","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.0141-9838.2004.00682.x","article-title":"Echinococcus granulosus-specific T-cell lines derived from patients at various clinical stages of cystic echinococcosis","volume":"26","author":"R Rigano","year":"2004","journal-title":"Parasite Immunol"},{"issue":"3","key":"pntd.0008586.ref057","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/pim.12301","article-title":"The intermediate host immune response in cystic echinococcosis","volume":"38","author":"F Tamarozzi","year":"2016","journal-title":"Parasite Immunol"},{"issue":"3","key":"pntd.0008586.ref058","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.jinf.2014.10.009","article-title":"IL-4 specific-response in whole blood associates with human cystic echinococcosis and cyst activity","volume":"70","author":"L Petrone","year":"2015","journal-title":"J Infect"},{"key":"pntd.0008586.ref059","doi-asserted-by":"crossref","first-page":"639362","DOI":"10.1155\/2012\/639362","article-title":"Host-parasite relationship in cystic echinococcosis: an evolving story","volume":"2012","author":"A Siracusano","year":"2012","journal-title":"Clin Dev Immunol"},{"key":"pntd.0008586.ref060","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1186\/s12879-015-1156-9","article-title":"CCR7(lo)PD-1(hi) CXCR5(+) CD4(+) T cells are positively correlated with levels of IL-21 in active and transitional cystic echinococcosis patients","volume":"15","author":"F Zhang","year":"2015","journal-title":"BMC Infect Dis"},{"issue":"9","key":"pntd.0008586.ref061","doi-asserted-by":"crossref","first-page":"e45974","DOI":"10.1371\/journal.pone.0045974","article-title":"Extracellular vesicles from parasitic helminths contain specific excretory\/secretory proteins and are internalized in intestinal host cells","volume":"7","author":"A Marcilla","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"pntd.0008586.ref062","doi-asserted-by":"crossref","first-page":"e0007032","DOI":"10.1371\/journal.pntd.0007032","article-title":"Extracellular vesicles from Echinococcus granulosus larval stage: Isolation, characterization and uptake by dendritic cells","volume":"13","author":"MC Nicolao","year":"2019","journal-title":"PLoS Negl Trop Dis"},{"issue":"6","key":"pntd.0008586.ref063","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.pt.2011.01.008","article-title":"Understanding the laminated layer of larval Echinococcus II: immunology","volume":"27","author":"A Diaz","year":"2011","journal-title":"Trends Parasitol"},{"issue":"5","key":"pntd.0008586.ref064","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.pt.2010.12.012","article-title":"Understanding the laminated layer of larval Echinococcus I: structure","volume":"27","author":"A Diaz","year":"2011","journal-title":"Trends Parasitol"},{"key":"pntd.0008586.ref065","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.vetpar.2017.01.022","article-title":"Isolation and characterization of exosomes derived from fertile sheep hydatid cysts","volume":"236","author":"M Siles-Lucas","year":"2017","journal-title":"Vet Parasitol"},{"issue":"5","key":"pntd.0008586.ref066","doi-asserted-by":"crossref","first-page":"e12523","DOI":"10.1111\/pim.12523","article-title":"Granulomatous responses in larval taeniid infections","volume":"40","author":"A Diaz","year":"2018","journal-title":"Parasite Immunol"},{"key":"pntd.0008586.ref067","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.cellimm.2015.10.006","article-title":"TGF-beta in tolerance, development and regulation of immunity","volume":"299","author":"CJ Johnston","year":"2016","journal-title":"Cell Immunol"},{"key":"pntd.0008586.ref068","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1146\/annurev-immunol-032713-120257","article-title":"TGF-beta activation and function in immunity","volume":"32","author":"MA Travis","year":"2014","journal-title":"Annu Rev Immunol"},{"issue":"4","key":"pntd.0008586.ref069","doi-asserted-by":"crossref","first-page":"519","DOI":"10.3347\/kjp.2016.54.4.519","article-title":"Increased Expression of TGF-beta1 in correlation with liver fibrosis during Echinococcus granulosus infection in mice","volume":"54","author":"Y Liu","year":"2016","journal-title":"Korean J Parasitol"},{"issue":"4","key":"pntd.0008586.ref070","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1051\/parasite\/2002094351","article-title":"Echinococcus granulosus down regulates the hepatic expression of inflammatory cytokines IL-6 and TNF alpha in BALB\/c mice","volume":"9","author":"C Mondragon-de-la-Pena","year":"2002","journal-title":"Parasite"},{"issue":"4","key":"pntd.0008586.ref071","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.jinf.2018.01.005","article-title":"TGF-beta\/Smad signaling pathway positively up-regulates the differentiation of Interleukin-9-producing CD4(+) T cells in human Echinococcus granulosus infection","volume":"76","author":"N Pang","year":"2018","journal-title":"J Infect"},{"issue":"3","key":"pntd.0008586.ref072","article-title":"The effect of Echinococcus granulosus on spleen cells and TGF-beta expression in the peripheral blood of BALB\/c mice","volume":"39","author":"S Yin","year":"2017","journal-title":"Parasite Immunol"},{"issue":"7578","key":"pntd.0008586.ref073","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nature15756","article-title":"Tumour exosome integrins determine organotropic metastasis","volume":"527","author":"A Hoshino","year":"2015","journal-title":"Nature"},{"issue":"1","key":"pntd.0008586.ref074","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/pim.12152","article-title":"Co-existence of Echinococcus granulosus infection and cancer metastasis in the liver correlates with reduced Th1 immune responses","volume":"37","author":"N Turhan","year":"2015","journal-title":"Parasite Immunol"},{"issue":"1","key":"pntd.0008586.ref075","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.cellimm.2013.04.008","article-title":"CD147 in regulatory T cells","volume":"282","author":"J Landskron","year":"2013","journal-title":"Cell Immunol"},{"issue":"19","key":"pntd.0008586.ref076","doi-asserted-by":"crossref","first-page":"5141","DOI":"10.1182\/blood-2011-02-339242","article-title":"CD147 (Basigin\/Emmprin) identifies FoxP3+CD45RO+CTLA4+-activated human regulatory T cells","volume":"118","author":"T Solstad","year":"2011","journal-title":"Blood"},{"issue":"19","key":"pntd.0008586.ref077","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1002\/adhm.201600308","article-title":"Exosomes from cardiomyocyte progenitor cells and mesenchymal stem cells stimulate angiogenesis via EMMPRIN","volume":"5","author":"KR Vrijsen","year":"2016","journal-title":"Adv Healthc Mater"},{"issue":"12","key":"pntd.0008586.ref078","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/nri2199","article-title":"Protective immune mechanisms in helminth infection","volume":"7","author":"RM Anthony","year":"2007","journal-title":"Nat Rev Immunol"},{"issue":"4","key":"pntd.0008586.ref079","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1128\/MCB.23.4.1316-1333.2003","article-title":"Rho family GTPases are required for activation of Jak\/STAT signaling by G protein-coupled receptors","volume":"23","author":"S Pelletier","year":"2003","journal-title":"Mol Cell Biol"},{"issue":"12","key":"pntd.0008586.ref080","doi-asserted-by":"crossref","first-page":"8057","DOI":"10.4049\/jimmunol.180.12.8057","article-title":"IFN-gamma and STAT1 arrest monocyte migration and modulate RAC\/CDC42 pathways","volume":"180","author":"Y Hu","year":"2008","journal-title":"J Immunol"},{"issue":"11","key":"pntd.0008586.ref081","doi-asserted-by":"crossref","first-page":"5507","DOI":"10.4049\/jimmunol.158.11.5507","article-title":"Accelerated collagen-induced arthritis in IFN-gamma receptor-deficient mice","volume":"158","author":"K Vermeire","year":"1997","journal-title":"J Immunol"},{"issue":"4","key":"pntd.0008586.ref082","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1053\/joca.1999.0304","article-title":"Activation of annexin II and V expression, terminal differentiation, mineralization and apoptosis in human osteoarthritic cartilage","volume":"8","author":"T Kirsch","year":"2000","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"pntd.0008586.ref083","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1158\/1541-7786.MCR-16-0163","article-title":"Exosomal Annexin II promotes angiogenesis and breast cancer metastasis","volume":"15","author":"S Maji","year":"2017","journal-title":"Mol Cancer Res"},{"issue":"1","key":"pntd.0008586.ref084","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0166-6851(00)00256-5","article-title":"Host-derived annexin II at the host-parasite interface of the Echinococcus granulosus hydatid cyst","volume":"110","author":"A Diaz","year":"2000","journal-title":"Mol Biochem Parasitol"},{"issue":"6\u20137","key":"pntd.0008586.ref085","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.molimm.2004.04.010","article-title":"Src-family kinases: rheostats of immune cell signaling","volume":"41","author":"CA Lowell","year":"2004","journal-title":"Mol Immunol"},{"issue":"1","key":"pntd.0008586.ref086","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/s41467-017-00294-0","article-title":"Lyn and Fyn function as molecular switches that control immunoreceptors to direct homeostasis or inflammation","volume":"8","author":"SB Mkaddem","year":"2017","journal-title":"Nat Commun"},{"issue":"1","key":"pntd.0008586.ref087","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S1074-7613(00)80511-7","article-title":"Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation","volume":"7","author":"VW Chan","year":"1997","journal-title":"Immunity"},{"issue":"4","key":"pntd.0008586.ref088","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1006\/smim.1998.0122","article-title":"Positive and negative roles of the tyrosine kinase Lyn in B cell function","volume":"10","author":"AL DeFranco","year":"1998","journal-title":"Semin Immunol"},{"issue":"12","key":"pntd.0008586.ref089","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1084\/jem.20020515","article-title":"Sustained activation of Lyn tyrosine kinase in vivo leads to autoimmunity","volume":"196","author":"ML Hibbs","year":"2002","journal-title":"J Exp Med"},{"issue":"2","key":"pntd.0008586.ref090","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0092-8674(95)90171-X","article-title":"Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease","volume":"83","author":"ML Hibbs","year":"1995","journal-title":"Cell"},{"issue":"5","key":"pntd.0008586.ref091","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/1074-7613(95)90126-4","article-title":"Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice","volume":"3","author":"H Nishizumi","year":"1995","journal-title":"Immunity"},{"issue":"1","key":"pntd.0008586.ref092","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cellsig.2004.05.014","article-title":"Subversion of immunological signalling by a filarial nematode phosphorylcholine-containing secreted product","volume":"17","author":"HS Goodridge","year":"2005","journal-title":"Cell Signal"},{"issue":"3","key":"pntd.0008586.ref093","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/j.1365-2567.2005.02167.x","article-title":"Signalling mechanisms underlying subversion of the immune response by the filarial nematode secreted product ES-62","volume":"115","author":"HS Goodridge","year":"2005","journal-title":"Immunology"},{"key":"pntd.0008586.ref094","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1186\/1471-2334-14-492","article-title":"Medical treatment versus \"Watch and Wait\" in the clinical management of CE3b echinococcal cysts of the liver","volume":"14","author":"F Rinaldi","year":"2014","journal-title":"BMC Infect Dis"}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0008586","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T02:16:15Z","timestamp":1696817775000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0008586"}},"subtitle":[],"editor":[{"given":"Hector H.","family":"Garcia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,10,5]]},"references-count":94,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2020,10,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0008586","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,5]]}}}