{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:57:12Z","timestamp":1790402232773,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0008623","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T00:00:00Z","timestamp":1607558400000}}],"reference-count":77,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T00:00:00Z","timestamp":1606694400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100005527","name":"Carter Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005527","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["098051"],"award-info":[{"award-number":["098051"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["206194"],"award-info":[{"award-number":["206194"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/M003949\/1"],"award-info":[{"award-number":["BB\/M003949\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Guinea worm\u2013\n                      <jats:italic>Dracunculus medinensis\u2013<\/jats:italic>\n                      was historically one of the major parasites of humans and has been known since antiquity. Now, Guinea worm is on the brink of eradication, as efforts to interrupt transmission have reduced the annual burden of disease from millions of infections per year in the 1980s to only 54 human cases reported globally in 2019. Despite the enormous success of eradication efforts to date, one complication has arisen. Over the last few years, hundreds of dogs have been found infected with this previously apparently anthroponotic parasite, almost all in Chad. Moreover, the relative numbers of infections in humans and dogs suggests that dogs are currently the principal reservoir on infection and key to maintaining transmission in that country.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Principal findings<\/jats:title>\n                    <jats:p>\n                      In an effort to shed light on this peculiar epidemiology of Guinea worm in Chad, we have sequenced and compared the genomes of worms from dog, human and other animal infections. Confirming previous work with other molecular markers, we show that all of these worms are\n                      <jats:italic>D<\/jats:italic>\n                      .\n                      <jats:italic>medinensis<\/jats:italic>\n                      , and that the same population of worms are causing both infections, can confirm the suspected transmission between host species and detect signs of a population bottleneck due to the eradication efforts. The diversity of worms in Chad appears to exclude the possibility that there were no, or very few, worms present in the country during a 10-year absence of reported cases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This work reinforces the importance of adequate surveillance of both human and dog populations in the Guinea worm eradication campaign and suggests that control programs aiming to interrupt disease transmission should stay aware of the possible emergence of unusual epidemiology as pathogens approach elimination.<\/jats:p>\n                  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Muller","year":"1979","journal-title":"Bull World Health Organ"},{"issue":"1","key":"pntd.0008623.ref007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/014107688207500101","article-title":"Global eradication of guinea worm","volume":"75","author":"PG Bourne","year":"1982","journal-title":"J R Soc Med"},{"issue":"2","key":"pntd.0008623.ref008","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1128\/CMR.15.2.223-246.2002","article-title":"Dracunculiasis (Guinea worm disease) and the eradication initiative","volume":"15","author":"S Cairncross","year":"2002","journal-title":"Clin Microbiol Rev"},{"issue":"5","key":"pntd.0008623.ref009","first-page":"533","article-title":"Strategies for dracunculiasis eradication","volume":"69","author":"DR Hopkins","year":"1991","journal-title":"Bull World Health Organ"},{"key":"pntd.0008623.ref010","unstructured":"Centers for Disease Control and Prevention. Guinea worm wrap-up #110. 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Atlanta, GA. 2020."},{"issue":"suppl_1","key":"pntd.0008623.ref013","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1093\/cid\/ciy651","article-title":"Securing the Eradication of All Polioviruses","volume":"67","author":"NC Grassly","year":"2018","journal-title":"Clin Infect Dis"},{"issue":"11","key":"pntd.0008623.ref014","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/S1473-3099(16)30380-2","article-title":"Dogs and Guinea worm eradication","volume":"16","author":"ML Eberhard","year":"2016","journal-title":"Lancet Infect Dis"},{"issue":"1","key":"pntd.0008623.ref015","doi-asserted-by":"crossref","first-page":"61","DOI":"10.4269\/ajtmh.13-0554","article-title":"The peculiar epidemiology of dracunculiasis in Chad","volume":"90","author":"ML Eberhard","year":"2014","journal-title":"Am J Trop Med Hyg"},{"key":"pntd.0008623.ref016","unstructured":"World Health Organisation. Dracunculus eradication in Uzbekistan, report WHO\/CDS\/CEE\/DRA\/99.9. 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Tajima","year":"1989","journal-title":"Genetics"},{"issue":"9","key":"pntd.0008623.ref063","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.3201\/eid2309.161931","article-title":"Possible Role of Fish as Transport Hosts for Dracunculus spp. Larvae","volume":"23","author":"CA Cleveland","year":"2017","journal-title":"Emerg Infect Dis"},{"issue":"11","key":"pntd.0008623.ref064","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.3201\/eid2211.161332","article-title":"Guinea Worm (Dracunculus medinensis) Infection in a Wild-Caught Frog, Chad","volume":"22","author":"ML Eberhard","year":"2016","journal-title":"Emerg Infect Dis"},{"key":"pntd.0008623.ref065","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1146\/annurev-environ-102016-060653","article-title":"African Environmental Change from the Pleistocene to the Anthropocene","volume":"42","author":"C Hoag","year":"2017","journal-title":"Annu Rev Env Resour."},{"key":"pntd.0008623.ref066","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.quascirev.2014.07.003","article-title":"The demographic response to Holocene climate change in the Sahara","volume":"101","author":"K Manning","year":"2014","journal-title":"Quaternary Sci Rev"},{"issue":"8","key":"pntd.0008623.ref067","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.tig.2010.05.003","article-title":"Evolution of the mutation rate","volume":"26","author":"M. Lynch","year":"2010","journal-title":"Trends Genet"},{"issue":"3","key":"pntd.0008623.ref068","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.tree.2017.12.002","article-title":"Quantifying Temporal Genomic Erosion in Endangered Species","volume":"33","author":"D Diez-Del-Molino","year":"2018","journal-title":"Trends Ecol Evol"},{"issue":"4","key":"pntd.0008623.ref069","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1534\/genetics.108.094623","article-title":"Genetics of mating and sex determination in the parasitic nematode Haemonchus contortus","volume":"180","author":"E Redman","year":"2008","journal-title":"Genetics"},{"issue":"3","key":"pntd.0008623.ref070","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s00436-010-2116-3","article-title":"Molecular genetic evidence for polyandry in Ascaris suum","volume":"108","author":"C Zhou","year":"2011","journal-title":"Parasitol Res"},{"issue":"2","key":"pntd.0008623.ref071","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1093\/gbe\/evx269","article-title":"A Genome Resequencing-Based Genetic Map Reveals the Recombination Landscape of an Outbred Parasitic Nematode in the Presence of Polyploidy and Polyandry","volume":"10","author":"SR Doyle","year":"2018","journal-title":"Genome Biology and Evolution"},{"key":"pntd.0008623.ref072","unstructured":"Centers for Disease Control and Prevention. Guinea worm wrap-up #256. Atlanta, GA. 2018."},{"key":"pntd.0008623.ref073","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1186\/s13071-015-1004-1","article-title":"Not every worm wrapped around a stick is a guinea worm: a case of Onchocerca volvulus mimicking Dracunculus medinensis","volume":"8","author":"EN Mbong","year":"2015","journal-title":"Parasit Vectors"},{"key":"pntd.0008623.ref074","volume-title":"Accelerating work to overcome the global impact of neglected tropical diseases\u2014a roadmap for implementation","author":"World Health Organisation","year":"2012"},{"issue":"6398","key":"pntd.0008623.ref075","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1126\/science.aar6609","article-title":"Eradication genomics-lessons for parasite control","volume":"361","author":"JA Cotton","year":"2018","journal-title":"Science"},{"issue":"1623","key":"pntd.0008623.ref076","doi-asserted-by":"crossref","first-page":"20120137","DOI":"10.1098\/rstb.2012.0137","article-title":"Towards the endgame and beyond: complexities and challenges for the elimination of infectious diseases","volume":"368","author":"P Klepac","year":"2013","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"issue":"4","key":"pntd.0008623.ref077","doi-asserted-by":"crossref","first-page":"419","DOI":"10.7861\/clinmedicine.14-4-419","article-title":"Milroy Lecture: eradication of disease: hype, hope and reality","volume":"14","author":"CJ Whitty","year":"2014","journal-title":"Clin Med (Lond)"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0008623","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T00:00:00Z","timestamp":1607558400000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0008623","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,18]],"date-time":"2024-08-18T04:17:59Z","timestamp":1723954679000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0008623"}},"subtitle":[],"editor":[{"given":"Mar\u00eda-Gloria","family":"Bas\u00e1\u00f1ez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,11,30]]},"references-count":77,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,11,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0008623","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/808923","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,30]]}}}