{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:58:37Z","timestamp":1790751517867,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0008941","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T00:00:00Z","timestamp":1607990400000}}],"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T00:00:00Z","timestamp":1606953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Like many countries from the Americas, Cuba is threatened by <jats:italic>Aedes aegypti<\/jats:italic>-associated arboviruses such as dengue (DENV), Zika (ZIKV), and chikungunya (CHIKV) viruses. Curiously, when CHIKV was actively circulating in the region in 2013\u20132014, no autochthonous transmission of this virus was detected in Havana, Cuba, despite the importation of chikungunya cases into this city. To investigate if the transmission ability of local mosquito populations could explain this epidemiological scenario, we evaluated for the first time the vector competence of two <jats:italic>Ae<\/jats:italic>. <jats:italic>aegypti<\/jats:italic> populations (Pasteur and P\u00e1rraga) collected from Havana for dengue virus type 1 (DENV-1), CHIKV, and ZIKV.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methodology\/Principal findings<\/jats:title>\n<jats:p>Mosquito populations were fed separately using blood containing ZIKV, DENV-1, or CHIKV. Infection, dissemination, and transmission rates, were estimated at 3 (exclusively for CHIKV), 7, and 14 days post exposure (dpe) for each <jats:italic>Ae<\/jats:italic>. <jats:italic>aegypti<\/jats:italic> population-virus combination. Both mosquito populations were susceptible to DENV-1 and ZIKV, with viral infection and dissemination rates ranging from 24\u201397% and 6\u201367% respectively. In addition, CHIKV disseminated in both populations and was subsequently transmitted. Transmission rates were low (&lt;30%) regardless of the mosquito population\/virus combination and no ZIKV was detected in saliva of females from the Pasteur population at any dpe.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Conclusions\/Significance<\/jats:title>\n<jats:p>Our study demonstrated the ability of <jats:italic>Ae<\/jats:italic>. <jats:italic>aegypti<\/jats:italic> from Cuba to transmit DENV, ZIKV, and CHIKV. These results, along with the widespread distribution and high abundance of this species in the urban settings throughout the island, highlight the importance of <jats:italic>Ae<\/jats:italic>. <jats:italic>aegypti<\/jats:italic> control and arbovirus surveillance to prevent future outbreaks.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pntd.0008941","type":"journal-article","created":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T19:33:10Z","timestamp":1607023990000},"page":"e0008941","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":32,"title":["Vector competence of Aedes aegypti from Havana, Cuba, for dengue virus type 1, chikungunya, and Zika viruses"],"prefix":"10.1371","volume":"14","author":[{"given":"Gladys","family":"Guti\u00e9rrez-Bugallo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8309-5065","authenticated-orcid":true,"given":"Antoine","family":"Boullis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanet","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyza","family":"Hery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan A.","family":"Bisset","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1670-5350","authenticated-orcid":true,"given":"Anubis","family":"Vega-R\u00faa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,12,3]]},"reference":[{"key":"pntd.0008941.ref001","unstructured":"Pan American Health Organization (PAHO). 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