{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T08:02:42Z","timestamp":1772179362630,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pntd.0008967","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T00:00:00Z","timestamp":1610064000000}}],"reference-count":74,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T00:00:00Z","timestamp":1609113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"USDA-HATCH","award":["2353077000"],"award-info":[{"award-number":["2353077000"]}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>\n                    Phlebotomine sand flies employ an elaborate system of pheromone communication wherein males produce pheromones that attract other males to leks (thus acting as an aggregation pheromone) and females to the lekking males (sex pheromone). In addition, the type of pheromone produced varies among populations. Despite the numerous studies on sand fly chemical communication, little is known of their chemosensory genome. Chemoreceptors interact with chemicals in an organism\u2019s environment to elicit essential behaviors such as the identification of suitable mates and food sources. Thus, they play important roles during adaptation and speciation. Major chemoreceptor gene families, odorant receptors (ORs), gustatory receptors (GRs) and ionotropic receptors (IRs) together detect and discriminate the chemical landscape. Here, we annotated the chemoreceptor repertoire in the genomes of\n                    <jats:italic>Lutzomyia longipalpis<\/jats:italic>\n                    and\n                    <jats:italic>Phlebotomus papatasi<\/jats:italic>\n                    , major phlebotomine vectors in the New World and Old World, respectively. Comparison with other sequenced Diptera revealed a large and unique expansion where over 80% of the ~140 ORs belong to a single, taxonomically restricted clade. We next conducted a comprehensive analysis of the chemoreceptors in 63\n                    <jats:italic>L<\/jats:italic>\n                    .\n                    <jats:italic>longipalpis<\/jats:italic>\n                    individuals from four different locations in Brazil representing allopatric and sympatric populations and three sex-aggregation pheromone types (chemotypes). Population structure based on single nucleotide polymorphisms (SNPs) and gene copy number in the chemoreceptors corresponded with their putative chemotypes, and corroborate previous studies that identified multiple populations. Our work provides genomic insights into the underlying behavioral evolution of sexual communication in the\n                    <jats:italic>L<\/jats:italic>\n                    .\n                    <jats:italic>longipalpis<\/jats:italic>\n                    species complex in Brazil, and highlights the importance of accounting for the ongoing speciation in central and South American\n                    <jats:italic>Lutzomyia<\/jats:italic>\n                    that could have important implications for vectorial capacity.\n                  <\/jats:p>","DOI":"10.1371\/journal.pntd.0008967","type":"journal-article","created":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T15:59:54Z","timestamp":1609171194000},"page":"e0008967","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Molecular signatures of sexual communication in the phlebotomine sand flies"],"prefix":"10.1371","volume":"14","author":[{"given":"Paul V.","family":"Hickner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9775-5877","authenticated-orcid":true,"given":"Nataliya","family":"Timoshevskaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2757-9986","authenticated-orcid":true,"given":"Ronald J.","family":"Nowling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4064-2361","authenticated-orcid":true,"given":"Fr\u00e9d\u00e9ric","family":"Labb\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew D.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4115-8464","authenticated-orcid":true,"given":"Mary Ann","family":"McDowell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3291-9903","authenticated-orcid":true,"given":"Carolina N.","family":"Spiegel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6235-7115","authenticated-orcid":true,"given":"Zainulabeuddin","family":"Syed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2020,12,28]]},"reference":[{"key":"pntd.0008967.ref001","unstructured":"WHO. Leishmaniasis: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/leishmanreviewiasis; 2020 [cited 2020]."},{"issue":"1","key":"pntd.0008967.ref002","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s13071-015-0712-x","article-title":"Recent advances in phlebotomine sand fly research related to leishmaniasis control","volume":"8","author":"PA Bates","year":"2015","journal-title":"Parasites & vectors"},{"key":"pntd.0008967.ref003","unstructured":"WHO. Leishmaniasis, The Vector: https:\/\/www.who.int\/leishmaniasis\/disease\/vector\/en\/; 2020."},{"issue":"3","key":"pntd.0008967.ref004","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1590\/0074-02760160463","article-title":"The current status of the Lutzomyia longipalpis (Diptera: Psychodidae: Phlebotominae) species complex","volume":"112","author":"NA Souza","year":"2017","journal-title":"Memorias do Instituto Oswaldo Cruz"},{"key":"pntd.0008967.ref005","first-page":"203","article-title":"The chemical ecology of sandflies","author":"DP Bray","year":"2010","journal-title":"Ecology and control of vector-borne diseases"},{"key":"pntd.0008967.ref006","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.cois.2017.09.004","article-title":"Evolutionary origin of insect pheromones","volume":"24","author":"J St\u00f6kl","year":"2017","journal-title":"Current opinion in insect science"},{"issue":"1","key":"pntd.0008967.ref007","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1186\/s13071-016-1866-x","article-title":"The Lutzomyia longipalpis complex: a brief natural history of aggregation-sex pheromone communication","volume":"9","author":"CN Spiegel","year":"2016","journal-title":"Parasites & vectors"},{"issue":"4","key":"pntd.0008967.ref008","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0169-4758(95)80137-5","article-title":"Genetic variability in phlebotomine sandflies: possible implications for leishmaniasis epidemiology","volume":"11","author":"GC Lanzaro","year":"1995","journal-title":"Parasitology today"},{"issue":"10","key":"pntd.0008967.ref009","doi-asserted-by":"crossref","first-page":"e2495","DOI":"10.1371\/journal.pntd.0002495","article-title":"Multilocus analysis of divergence and introgression in sympatric and allopatric sibling species of the Lutzomyia longipalpis complex in Brazil","volume":"7","author":"AS Araki","year":"2013","journal-title":"PLoS neglected tropical diseases"},{"issue":"4","key":"pntd.0008967.ref010","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/j.1365-2915.2005.00594.x","article-title":"Analysis of the sex pheromone extract of individual male Lutzomyia longipalpis sandflies from six regions in Brazil","volume":"19","author":"JG Hamilton","year":"2005","journal-title":"Med Vet Entomol"},{"issue":"20","key":"pntd.0008967.ref011","first-page":"1921","article-title":"Sobralene, a new sex-aggregation pheromone and likely shunt metabolite of the taxadiene synthase cascade, produced by a member of the sand fly","volume":"59","author":"MJ Palframan","year":"2018","journal-title":"Lutzomyia longipalpis species complex"},{"issue":"4","key":"pntd.0008967.ref012","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1093\/cz\/zoy052","article-title":"A perspective on sensory drive","volume":"64","author":"RC Fuller","year":"2018","journal-title":"Current zoology"},{"issue":"4","key":"pntd.0008967.ref013","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1093\/cz\/zoy048","article-title":"Evolutionary ecology of chemosensation and its role in sensory drive","volume":"64","author":"LR Yohe","year":"2018","journal-title":"Current zoology"},{"key":"pntd.0008967.ref014","author":"M Stevens","year":"2013"},{"key":"pntd.0008967.ref015","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.cois.2017.03.003","article-title":"Genetic analysis of mosquito detection of humans","volume":"20","author":"JI Raji","year":"2017","journal-title":"Current opinion in insect science"},{"issue":"1","key":"pntd.0008967.ref016","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.pt.2018.10.003","article-title":"Of genes and genomes: mosquito evolution and diversity","volume":"35","author":"L Ruzzante","year":"2019","journal-title":"Trends in parasitology"},{"key":"pntd.0008967.ref017","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.cois.2015.04.011","article-title":"Chemical ecology and olfaction in arthropod vectors of diseases","volume":"10","author":"Z Syed","year":"2015","journal-title":"Current Opinion in Insect Science"},{"key":"pntd.0008967.ref018","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.cois.2019.03.005","article-title":"Behavioural adaptations of mosquito vectors to insecticide control","volume":"34","author":"D Carrasco","year":"2019","journal-title":"Current opinion in insect science"},{"issue":"2","key":"pntd.0008967.ref019","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/evo.12281","article-title":"Human impacts have shaped historical and recent evolution in Aedes aegypti, the dengue and yellow fever mosquito","volume":"68","author":"JE Brown","year":"2014","journal-title":"Evolution"},{"issue":"11","key":"pntd.0008967.ref020","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1093\/biosci\/biy119","article-title":"Recent history of Aedes aegypti: Vector genomics and epidemiology records","volume":"68","author":"JR Powell","year":"2018","journal-title":"Bioscience"},{"issue":"3","key":"pntd.0008967.ref021","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1017\/S0007485300009494","article-title":"Genetics of house-entering behaviour in East African populations of Aedes aegypti (L.)(Diptera: Culicidae) and its relevance to speciation","volume":"68","author":"M Trpis","year":"1978","journal-title":"Bulletin of Entomological Research"},{"issue":"7526","key":"pntd.0008967.ref022","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature13964","article-title":"Evolution of mosquito preference for humans linked to an odorant receptor","volume":"515","author":"CS McBride","year":"2014","journal-title":"Nature"},{"key":"pntd.0008967.ref023","article-title":"Climate and Urbanization Drive Mosquito Preference for Humans","author":"NH Rose","year":"2020","journal-title":"Curr Biol"},{"issue":"1","key":"pntd.0008967.ref024","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-61867-6","article-title":"characterization of copulatory courtship song in the old World sand fly species Phlebotomus argentipes","volume":"10","author":"AS Araki","year":"2020","journal-title":"Scientific reports"},{"issue":"10","key":"pntd.0008967.ref025","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.tree.2015.07.009","article-title":"Multigene family evolution: perspectives from insect chemoreceptors","volume":"30","author":"R Benton","year":"2015","journal-title":"Trends in ecology & evolution"},{"key":"pntd.0008967.ref026","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1146\/annurev-ento-020117-043322","article-title":"Molecular evolution of the major arthropod chemoreceptor gene families","volume":"64","author":"HM Robertson","year":"2019","journal-title":"Annual review of entomology"},{"issue":"6","key":"pntd.0008967.ref027","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1111\/mec.15066","article-title":"Going beyond SNPs: the role of structural genomic variants in adaptive evolution and species diversification","volume":"28","author":"M Wellenreuther","year":"2019","journal-title":"Molecular ecology"},{"issue":"12","key":"pntd.0008967.ref028","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1038\/nrg2480","article-title":"The evolution of animal chemosensory receptor gene repertoires: roles of chance and necessity","volume":"9","author":"M Nei","year":"2008","journal-title":"Nature Reviews Genetics"},{"issue":"1","key":"pntd.0008967.ref029","first-page":"648","article-title":"The making of a pest: Insights from the evolution of chemosensory receptor families in a pestiferous and invasive fly","volume":"17","author":"PV Hickner","year":"2016","journal-title":"Drosophila suzukii"},{"key":"pntd.0008967.ref030","doi-asserted-by":"crossref","first-page":"D707","DOI":"10.1093\/nar\/gku1117","article-title":"VectorBase: an updated bioinformatics resource for invertebrate vectors and other organisms related with human diseases","volume":"43","author":"GI Giraldo-Calderon","year":"2015","journal-title":"Nucleic acids research"},{"issue":"1","key":"pntd.0008967.ref031","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s13059-015-0721-2","article-title":"OrthoFinder: solving fundamental biases in whole genome comparisons dramatically improves orthogroup inference accuracy","volume":"16","author":"DM Emms","year":"2015","journal-title":"Genome biology"},{"issue":"10","key":"pntd.0008967.ref032","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1093\/molbev\/msv150","article-title":"FastME 2.0: a comprehensive, accurate, and fast distance-based phylogeny inference program","volume":"32","author":"V Lefort","year":"2015","journal-title":"Molecular biology and evolution"},{"issue":"8","key":"pntd.0008967.ref033","doi-asserted-by":"crossref","first-page":"e1001064","DOI":"10.1371\/journal.pgen.1001064","article-title":"Ancient protostome origin of chemosensory ionotropic glutamate receptors and the evolution of insect taste and olfaction","volume":"6","author":"V Croset","year":"2010","journal-title":"PLoS genetics"},{"issue":"5591","key":"pntd.0008967.ref034","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1126\/science.1076196","article-title":"G protein-coupled receptors in Anopheles gambiae","volume":"298","author":"CA Hill","year":"2002","journal-title":"Science"},{"issue":"7732","key":"pntd.0008967.ref035","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/s41586-018-0692-z","article-title":"Improved reference genome of Aedes aegypti informs arbovirus vector control","volume":"563","author":"BJ Matthews","year":"2018","journal-title":"Nature"},{"issue":"suppl 2","key":"pntd.0008967.ref036","doi-asserted-by":"crossref","first-page":"14537","DOI":"10.1073\/pnas.2335847100","article-title":"Molecular evolution of the insect chemoreceptor gene superfamily in Drosophila melanogaster","volume":"100","author":"HM Robertson","year":"2003","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"5","key":"pntd.0008967.ref037","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.cub.2014.12.057","article-title":"A massive expansion of effector genes underlies gall-formation in the wheat pest Mayetiola destructor","volume":"25","author":"C Zhao","year":"2015","journal-title":"Current Biology"},{"issue":"5","key":"pntd.0008967.ref038","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1093\/nar\/gkh340","article-title":"MUSCLE: multiple sequence alignment with high accuracy and high throughput","volume":"32","author":"RC Edgar","year":"2004","journal-title":"Nucleic acids research"},{"issue":"15","key":"pntd.0008967.ref039","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1093\/bioinformatics\/btp348","article-title":"trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses","volume":"25","author":"S Capella-Guti\u00e9rrez","year":"2009","journal-title":"Bioinformatics"},{"issue":"9","key":"pntd.0008967.ref040","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1093\/bioinformatics\/btu033","article-title":"RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies","volume":"30","author":"A Stamatakis","year":"2014","journal-title":"Bioinformatics"},{"issue":"suppl_1","key":"pntd.0008967.ref041","first-page":"D19","article-title":"Collaboration INSD. The sequence read archive","volume":"39","author":"R Leinonen","year":"2010","journal-title":"Nucleic acids research"},{"issue":"6","key":"pntd.0008967.ref042","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","article-title":"BEDTools: a flexible suite of utilities for comparing genomic features","volume":"26","author":"AR Quinlan","year":"2010","journal-title":"Bioinformatics"},{"key":"pntd.0008967.ref043","article-title":"Aligning sequence reads, clone sequences and assembly contigs with BWA-MEM","author":"H Li","year":"2013","journal-title":"arXiv preprint arXiv:13033997"},{"issue":"16","key":"pntd.0008967.ref044","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The sequence alignment\/map format and SAMtools","volume":"25","author":"H Li","year":"2009","journal-title":"Bioinformatics"},{"issue":"19","key":"pntd.0008967.ref045","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1093\/bioinformatics\/btm308","article-title":"TASSEL: software for association mapping of complex traits in diverse samples","volume":"23","author":"PJ Bradbury","year":"2007","journal-title":"Bioinformatics"},{"issue":"1","key":"pntd.0008967.ref046","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/1755-0998.12592","article-title":"pcadapt: an R package to perform genome scans for selection based on principal component analysis","volume":"17","author":"K Luu","year":"2017","journal-title":"Molecular ecology resources"},{"issue":"9","key":"pntd.0008967.ref047","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1101\/gr.094052.109","article-title":"Fast model-based estimation of ancestry in unrelated individuals","volume":"19","author":"DH Alexander","year":"2009","journal-title":"Genome research"},{"issue":"5","key":"pntd.0008967.ref048","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1111\/1755-0998.12387","article-title":"Clumpak: a program for identifying clustering modes and packaging population structure inferences across K","volume":"15","author":"NM Kopelman","year":"2015","journal-title":"Molecular ecology resources"},{"issue":"4","key":"pntd.0008967.ref049","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/hdy.2008.130","article-title":"Genetic markers in the playground of multivariate analysis","volume":"102","author":"T Jombart","year":"2009","journal-title":"Heredity"},{"issue":"2","key":"pntd.0008967.ref050","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/bib\/bbs012","article-title":"Using Tablet for visual exploration of second-generation sequencing data","volume":"14","author":"I Milne","year":"2012","journal-title":"Briefings in bioinformatics"},{"key":"pntd.0008967.ref051","first-page":"201901093","article-title":"Polar bear evolution is marked by rapid changes in gene copy number in response to dietary shift","author":"DC Rinker","year":"2019","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"10","key":"pntd.0008967.ref052","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1093\/bioinformatics\/btv033","article-title":"MEGAHIT: an ultra-fast single-node solution for large and complex metagenomics assembly via succinct de Bruijn graph","volume":"31","author":"D Li","year":"2015","journal-title":"Bioinformatics"},{"issue":"7","key":"pntd.0008967.ref053","doi-asserted-by":"crossref","first-page":"e0006614","DOI":"10.1371\/journal.pntd.0006614","article-title":"Genetic diversity, phylogeography and molecular clock of the Lutzomyia longipalpis complex (Diptera: Psychodidae)","volume":"12","author":"A Pech-May","year":"2018","journal-title":"PLoS neglected tropical diseases"},{"key":"pntd.0008967.ref054","volume-title":"Evolution by gene duplication","author":"S Ohno","year":"2013"},{"issue":"1312","key":"pntd.0008967.ref055","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1098\/rstb.1994.0097","article-title":"Saliva of Lutzomyia longipalpis sibling species differs in its composition and capacity to enhance leishmaniasis","volume":"345","author":"A Warburg","year":"1994","journal-title":"Philosophical Transactions of the Royal Society of London Series B: Biological Sciences"},{"key":"pntd.0008967.ref056","article-title":"The population genetic structure of vectors and our understanding of disease epidemiology","author":"K McCoy","year":"2008","journal-title":"EDP Sciences"},{"issue":"1","key":"pntd.0008967.ref057","first-page":"131","volume":"8","author":"PA Bates","year":"2015","journal-title":"Recent advances in phlebotomine sand fly research related to leishmaniasis control"},{"key":"pntd.0008967.ref058","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/978-3-319-75544-1_3","volume-title":"Brazilian Sand Flies","author":"PD Ready","year":"2018"},{"issue":"6","key":"pntd.0008967.ref059","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s10038-006-0391-8","article-title":"Evolutionary dynamics of olfactory and other chemosensory receptor genes in vertebrates","volume":"51","author":"Y Niimura","year":"2006","journal-title":"Journal of human genetics"},{"issue":"3","key":"pntd.0008967.ref060","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/hdy.2009.55","article-title":"Molecular evolution of the major chemosensory gene families in insects","volume":"103","author":"A S\u00e1nchez-Gracia","year":"2009","journal-title":"Heredity"},{"issue":"1","key":"pntd.0008967.ref061","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/1471-2164-12-164","article-title":"Taxonomically restricted genes are associated with the evolution of sociality in the honey bee","volume":"12","author":"BR Johnson","year":"2011","journal-title":"BMC genomics"},{"issue":"1","key":"pntd.0008967.ref062","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1093\/molbev\/msu266","article-title":"Dynamics of copy number variation in host races of the pea aphid","volume":"32","author":"L Duvaux","year":"2014","journal-title":"Molecular biology and evolution"},{"issue":"2","key":"pntd.0008967.ref063","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nrg2689","article-title":"The evolution of gene duplications: classifying and distinguishing between models","volume":"11","author":"H Innan","year":"2010","journal-title":"Nature Reviews Genetics"},{"key":"pntd.0008967.ref064","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9781139030748","volume-title":"Pheromones and animal behavior: chemical signals and signatures","author":"TD Wyatt","year":"2014"},{"issue":"1","key":"pntd.0008967.ref065","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/hdy.2008.55","article-title":"On the scent of speciation: the chemosensory system and its role in premating isolation","volume":"102","author":"C Smadja","year":"2009","journal-title":"Heredity"},{"issue":"3","key":"pntd.0008967.ref066","doi-asserted-by":"crossref","first-page":"e0003620","DOI":"10.1371\/journal.pntd.0003620","article-title":"Distribution of Lutzomyia longipalpis chemotype populations in S\u00e3o Paulo state, Brazil","volume":"9","author":"C Casanova","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"issue":"7","key":"pntd.0008967.ref067","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.cub.2007.02.043","article-title":"Receptors and neurons for fly odors in Drosophila","volume":"17","author":"Carlson JR van Naters WvdG","year":"2007","journal-title":"Current biology"},{"key":"pntd.0008967.ref068","first-page":"212","article-title":"sex pheromone receptor in the Hessian fly Mayetiola destructor (Diptera, Cecidomyiidae)","volume":"10","author":"MN Andersson","year":"2016","journal-title":"AFrontiers in cellular neuroscience"},{"key":"pntd.0008967.ref069","volume-title":"Sandfly pheromones: their biology and potential for use in control programs","author":"J Hamilton","year":"2008"},{"issue":"1","key":"pntd.0008967.ref070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/imb.12347","article-title":"The multidimensional ionotropic receptors of Drosophila melanogaster","volume":"27","author":"S Rimal","year":"2018","journal-title":"Insect molecular biology"},{"issue":"1","key":"pntd.0008967.ref071","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41564-018-0214-7","article-title":"Vector biology meets disease control: using basic research to fight vector-borne diseases","volume":"4","author":"WR Shaw","year":"2019","journal-title":"Nature microbiology"},{"issue":"1","key":"pntd.0008967.ref072","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2915.2003.00420.x","article-title":"Control of phlebotomine sandflies","volume":"17","author":"B Alexander","year":"2003","journal-title":"Medical and veterinary entomology"},{"issue":"32","key":"pntd.0008967.ref073","doi-asserted-by":"crossref","first-page":"12987","DOI":"10.1073\/pnas.1103472108","article-title":"Insect olfaction from model systems to disease control","volume":"108","author":"AF Carey","year":"2011","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"10","key":"pntd.0008967.ref074","doi-asserted-by":"crossref","first-page":"e0007767","DOI":"10.1371\/journal.pntd.0007767","article-title":"Sand fly synthetic sex-aggregation pheromone co-located with insecticide reduces the incidence of infection in the canine reservoir of visceral leishmaniasis: A stratified cluster randomised trial","volume":"13","author":"O Courtenay","year":"2019","journal-title":"PLoS neglected tropical diseases"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0008967","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T00:00:00Z","timestamp":1610064000000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0008967","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T13:53:11Z","timestamp":1670593991000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0008967"}},"subtitle":[],"editor":[{"given":"Yara M.","family":"Traub-Csek\u00f6","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,12,28]]},"references-count":74,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020,12,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0008967","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.08.11.247155","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,28]]}}}