{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T20:36:53Z","timestamp":1791059813700,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0009052","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000}}],"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T00:00:00Z","timestamp":1611100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["388288"],"award-info":[{"award-number":["388288"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008997","name":"University of Victoria","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008997","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Canadian Foundation for Innovation","award":["36419"],"award-info":[{"award-number":["36419"]}]},{"DOI":"10.13039\/501100007711","name":"British Columbia Knowledge Development Fund","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007711","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>Intestinal helminth infection can impair host resistance to co-infection with enteric bacterial pathogens. However, it is not known whether helminth drug-clearance can restore host resistance to bacterial infection. Using a mouse helminth-<jats:italic>Salmonella<\/jats:italic>co-infection system, we show that anthelmintic treatment prior to<jats:italic>Salmonella<\/jats:italic>challenge is sufficient to restore host resistance to<jats:italic>Salmonella<\/jats:italic>. The presence of the small intestine-dwelling helminth<jats:italic>Heligmosomoides polygyrus<\/jats:italic>at the point of<jats:italic>Salmonella<\/jats:italic>infection supports the initial establishment of<jats:italic>Salmonella<\/jats:italic>in the small intestinal lumen. Interestingly, if helminth drug-clearance is delayed until<jats:italic>Salmonella<\/jats:italic>has already established in the small intestinal lumen, anthelmintic treatment does not result in complete clearance of<jats:italic>Salmonella<\/jats:italic>. This suggests that while the presence of helminths supports initial<jats:italic>Salmonella<\/jats:italic>colonization, helminths are dispensable for<jats:italic>Salmonella<\/jats:italic>persistence in the host small intestine. These data contribute to the mechanistic understanding of how an ongoing or prior helminth infection can affect pathogenic bacterial colonization and persistence in the mammalian intestine.<\/jats:p>","DOI":"10.1371\/journal.pntd.0009052","type":"journal-article","created":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T19:41:13Z","timestamp":1611171673000},"page":"e0009052","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Impaired host resistance to Salmonella during helminth co-infection is restored by anthelmintic treatment prior to bacterial challenge"],"prefix":"10.1371","volume":"15","author":[{"given":"Tara P.","family":"Brosschot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine M.","family":"Lawrence","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8152-293X","authenticated-orcid":true,"given":"Brandon E.","family":"Moeller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8708-4486","authenticated-orcid":true,"given":"Mia H. 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