{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T03:48:34Z","timestamp":1793936914083,"version":"4.8.0"},"reference-count":86,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T00:00:00Z","timestamp":1614816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>Throughout the last decade, chikungunya virus (CHIKV) and Zika virus (ZIKV) infections have spread globally, causing a spectrum of disease that ranges from self-limited febrile illness to permanent severe disability, congenital anomalies, and early death. Nevertheless, estimates of their aggregate health impact are absent from the literature and are currently omitted from the Global Burden of Disease (GBD) reports. We systematically reviewed published literature and surveillance records to evaluate the global burden caused by CHIKV and ZIKV between 2010 and 2019, to calculate estimates of their disability-adjusted life year (DALY) impact. Extracted data on acute, chronic, and perinatal outcomes were used to create annualized DALY estimates, following techniques outlined in the GBD framework. This study is registered with PROSPERO (CRD42020192502). Of 7,877 studies identified, 916 were screened in detail, and 21 were selected for inclusion. Available data indicate that CHIKV and ZIKV caused the average yearly loss of over 106,000 and 44,000 DALYs, respectively, between 2010 and 2019. Both viruses caused substantially more burden in the Americas than in any other World Health Organization (WHO) region. This unequal distribution is likely due to a combination of limited active surveillance reporting in other regions and the lack of immunity that left the previously unexposed populations of the Americas susceptible to severe outbreaks during the last decade. Long-term rheumatic sequelae provided the largest DALY component for CHIKV, whereas congenital Zika syndrome (CZS) contributed most significantly for ZIKV. Acute symptoms and early mortality accounted for relatively less of the overall burden. Suboptimal reporting and inconsistent diagnostics limit precision when determining arbovirus incidence and frequency of complications. Despite these limitations, it is clear from our assessment that CHIKV and ZIKV represent a significant cause of morbidity that is not included in current disease burden reports. These results suggest that transmission-blocking strategies, including vector control and vaccine development, remain crucial priorities in reducing global disease burden through prevention of potentially devastating arboviral outbreaks.<\/jats:p>","DOI":"10.1371\/journal.pntd.0009055","type":"journal-article","created":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T13:26:09Z","timestamp":1614864369000},"page":"e0009055","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":218,"title":["Measuring the global burden of chikungunya and Zika viruses: A systematic review"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5121-2826","authenticated-orcid":true,"given":"Christopher J.","family":"Puntasecca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8349-9270","authenticated-orcid":true,"given":"Charles H.","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8364-6867","authenticated-orcid":true,"given":"Angelle Desiree","family":"LaBeaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,3,4]]},"reference":[{"key":"pntd.0009055.ref001","doi-asserted-by":"crossref","first-page":"e101","DOI":"10.1016\/S1473-3099(16)30518-7","article-title":"Epidemic arboviral diseases: priorities for research and public health","volume":"17","author":"A Wilder-Smith","year":"2017","journal-title":"Lancet Infect Dis"},{"key":"pntd.0009055.ref002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1478-7954-9-1","article-title":"Measuring the burden of arboviral diseases: the spectrum of morbidity and mortality from four prevalent infections","volume":"9","author":"A LaBeaud","year":"2011","journal-title":"Popul Health Metr"},{"key":"pntd.0009055.ref003","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.jinf.2016.02.011","article-title":"Zika fever and congenital Zika syndrome: An unexpected emerging arboviral disease","volume":"72","author":"JFW Chan","year":"2016","journal-title":"J Infect"},{"key":"pntd.0009055.ref004","first-page":"13","article-title":"Chikungunya virus infection in Aruba: Diagnosis, clinical features and predictors of post-chikungunya chronic polyarthralgia","volume":"e0196630","author":"R Huits","year":"2018","journal-title":"PLoS ONE"},{"key":"pntd.0009055.ref005","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/s41586-018-0446-y","article-title":"The emergence of Zika virus and its new clinical syndromes","volume":"560","author":"TC Pierson","year":"2018","journal-title":"Nature"},{"key":"pntd.0009055.ref006","doi-asserted-by":"crossref","first-page":"e235","DOI":"10.1016\/j.jfo.2018.05.002","article-title":"Ocular manifestations of emerging arboviruses: Dengue fever, Chikungunya, Zika virus, West Nile virus, and yellow fever","volume":"41","author":"H Merle","year":"2018","journal-title":"J Fr Ophtalmol"},{"key":"pntd.0009055.ref007","first-page":"8","article-title":"Epidemiology of Chikungunya Virus in Bahia, Brazil, 2014\u20132015","author":"NR Faria","year":"2016","journal-title":"PLoS Curr"},{"key":"pntd.0009055.ref008","unstructured":"Chikungunya virus | CDC. 19 Sep 2019 [cited 27 Jul 2020]. 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