{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T13:15:44Z","timestamp":1761311744664,"version":"3.40.5"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>In Burkina Faso, onchocerciasis was no longer a public health problem when the WHO Onchocerciasis Control Programme in West Africa closed at the end in 2002. However, epidemiological surveillance carried out from November 2010 to February of 2011, showed a recrudescence of infection in the Cascades Region. This finding was made at a time when ivermectin, a drug recommended for the treatment of both onchocerciasis and lymphatic filariasis, had been distributed in this area since 2004 for the elimination of lymphatic filariasis. It was surprising that ivermectin distributed for treating lymphatic filariasis had not prevented the recrudescence of onchocerciasis. Faced with this situation, the aim of our study was to evaluate the effectiveness of ivermectin on the onchocerciasis parasite. The percentage reduction in microfilarial load after treatment with ivermectin was used as a proxy measure for assessing possible resistance. A cohort study was carried out with 130 individuals who had tested positive for microfilariae of <jats:italic>Onchocerca volvulus<\/jats:italic> in 2010 using microscopic examination of skin-snip biopsies from five endemic villages. Subjects were followed from July 2011 to June 2012. The microfilarial load of each individual was enumerated by skin-snip biopsy in 2010, prior to the first ivermectin treatment against onchocerciasis under community guidelines. All individuals received two ivermectin treatments six months apart. In 2012, the microfilarial loads were determined again, six months after the second round of ivermectin and the reductions in parasite loads were calculated to measure the impact of the drug. The percentage reduction of the microfilarial loads ranged from 87% to 98% in the villages. In all villages, there was a statistically significant difference between the average microfilarial loads in 2010 and 2012. The level of reduction of microfilarial loads suggests that ivermectin is effective against the recrudescent population of <jats:italic>O<\/jats:italic>. <jats:italic>volvulus<\/jats:italic> in Cascades Region of Burkina Faso. Further investigations would be necessary to determine the causes of the recrudescence of onchocerciasis. 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Niki\u00e8ma","key":"pntd.0009117.ref023"},{"key":"pntd.0009117.ref024","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1016\/S0140-6736(07)60942-8","article-title":"Prevalence and intensity off Onchocerca volvulus infection and efficacy of ivermectin in endemic communities in Ghana: a two-phase epidemiological study","volume":"369","author":"M Osei-Atweneboana","year":"2007","journal-title":"Lancet"},{"volume-title":"\u00c9tude du Potentiel infestant des Onchocerquiens en fonction de leurs Charges Microfilariennes. Zones de grandes rivi\u00e8res de for\u00eat de C\u00f4te d\u2019Ivoire","year":"1989","author":"G. Brika","key":"pntd.0009117.ref025"},{"key":"pntd.0009117.ref026","first-page":"251","article-title":"Transmission de l\u2019onchocercose humaine en zone de savane d\u2019Afrique Occidentale. Passage des microfilaires d\u2019Onchocerca volvulus Leuck. dans l\u2019h\u00e9moc\u00e8le de la femelle Simulium damnosum Th\u00e9obald. Cahiers O.R.S.T.O.M. S\u00e9rie entomologie m\u00e9dicale et parasitologie","volume":"10","author":"B Philippon","year":"1972"},{"key":"pntd.0009117.ref027","first-page":"1","article-title":"Optimization of the Esperanza window trap for the collection of the African onchocerciasis vector Simulium damnosum s.l","volume":"39","author":"L To\u00e9","year":"2014","journal-title":"Acta Trop"},{"year":"1979","author":"D. Quill\u00e9v\u00e9r\u00e9","key":"pntd.0009117.ref028"},{"key":"pntd.0009117.ref029","first-page":"367","article-title":"A community trial of ivermectin in the onchocerciasis focus of Asubende, Ghana. Effect on the microfilarial reservoir and the transmission of Onchocerca volvulus","volume":"40","author":"J Remme","year":"1989","journal-title":"Trop Med Parasitol"},{"key":"pntd.0009117.ref030","first-page":"20","article-title":"Contribution du MECTIZAN au contr\u00f4le de l\u2019onchocercose: Impact sur la transmission apr\u00e8s huit ann\u00e9es de traitement","volume":"8","author":"M. 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