{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:53:25Z","timestamp":1787496805968,"version":"build-2736575974"},"update-to":[{"DOI":"10.1371\/journal.pntd.0009168","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T00:00:00Z","timestamp":1614816000000}}],"reference-count":20,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T00:00:00Z","timestamp":1613952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["NRF-2017M3A9E4061995"],"award-info":[{"award-number":["NRF-2017M3A9E4061995"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>Of various rodent-borne hantaviruses, Seoul orthohantavirus (SEOV) causes haemorrhagic fever with renal syndrome (HFRS), as does Hantaan orthohantavirus (HTNV). Given global-scale of cases of human infection with SEOV, it is of great clinical importance to distinguish SEOV from other HFRS-causing hantaviruses. In May 2019, a middle-aged patient who had lived in a suburban area of Chungcheong Province, Republic of Korea and enjoyed outdoor activities was transferred to Asan Medical Center in Seoul, Republic of Korea with HFRS; his symptoms included high fever and generalized myalgia. The rapid diagnostic test performed immediately after his transfer detected HTNV-specific antibodies, and the patient was treated accordingly. However, two consecutive IFAs performed at ten-day intervals showed no HTNV-specific immunoglobulin (Ig) G. During continuous supportive care, next-generation sequencing successfully identified viral genomic sequences in the patient\u2019s serum, which were SEOV and not HTNV. Phylogenetic analysis grouped the L, M, and S genes of this SEOV strain together with those of rat- or human-isolated Korean strains reported previously. Given global outbreaks and public health threats of zoonotic hantaviruses, a causative pathogen of hantavirus HFRS should be identified correctly at the time of diagnosis and by point-of-care testing.<\/jats:p>","DOI":"10.1371\/journal.pntd.0009168","type":"journal-article","created":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T13:37:11Z","timestamp":1614001031000},"page":"e0009168","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Human infection with Seoul orthohantavirus in Korea, 2019"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0698-9529","authenticated-orcid":true,"given":"Changmin","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8833-2138","authenticated-orcid":true,"given":"Jin Il","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7952-2877","authenticated-orcid":true,"given":"Jungmin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6375-3657","authenticated-orcid":true,"given":"Seongman","family":"Bae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5489-8608","authenticated-orcid":true,"given":"Min Jae","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7935-3719","authenticated-orcid":true,"given":"Ki-Joon","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Won","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6596-8253","authenticated-orcid":true,"given":"Sung-Han","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7427-486X","authenticated-orcid":true,"given":"Man-Seong","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,2,22]]},"reference":[{"issue":"3","key":"pntd.0009168.ref001","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1093\/infdis\/137.3.298","article-title":"Isolation of the etiologic agent of Korean Hemorrhagic fever","volume":"137","author":"HW Lee","year":"1978","journal-title":"J Infect Dis"},{"key":"pntd.0009168.ref002","unstructured":"ICTV. International COmmittee on Taxonomy of Viruses. Virus Taxonomy: 2018b Release (as of Feb 19, 2020; accessed through: https:\/\/talk.ictvonline.org\/taxonomy\/) 2020."},{"issue":"1","key":"pntd.0009168.ref003","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s10393-017-1305-2","article-title":"Global Diversity and Distribution of Hantaviruses and Their Hosts","volume":"15","author":"MT Milholland","year":"2018","journal-title":"Ecohealth"},{"key":"pntd.0009168.ref004","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.virusres.2013.12.036","article-title":"Hemorrhagic Fever with Renal Syndrome in the New, and Hantavirus Pulmonary Syndrome in the Old World: paradi(se)gm lost or regained?","volume":"187","author":"J Clement","year":"2014","journal-title":"Virus Res"},{"issue":"7","key":"pntd.0009168.ref005","doi-asserted-by":"crossref","DOI":"10.3390\/v11070652","article-title":"Wild Rats, Laboratory Rats, Pet Rats: Global Seoul Hantavirus Disease Revisited","volume":"11","author":"J Clement","year":"2019","journal-title":"Viruses"},{"issue":"4","key":"pntd.0009168.ref006","doi-asserted-by":"crossref","first-page":"131","DOI":"10.15585\/mmwr.mm6704a5","article-title":"Outbreak of Seoul Virus Among Rats and Rat Owners\u2014United States and Canada, 2017","volume":"67","author":"JL Kerins","year":"2018","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"6","key":"pntd.0009168.ref007","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.3201\/eid2406.172044","article-title":"Importation of Human Seoul Virus Infection to Germany from Indonesia","volume":"24","author":"J Hofmann","year":"2018","journal-title":"Emerging infectious diseases"},{"issue":"1","key":"pntd.0009168.ref008","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s12250-016-3899-x","article-title":"Hantavirus infection: a global zoonotic challenge","volume":"32","author":"H Jiang","year":"2017","journal-title":"Virol Sin"},{"issue":"10","key":"pntd.0009168.ref009","doi-asserted-by":"crossref","DOI":"10.1093\/ofid\/ofz404","article-title":"Domestically Acquired Seoul Virus Causing Hemophagocytic Lymphohistiocytosis-Washington, DC, 2018","volume":"6","author":"B Shastri","year":"2019","journal-title":"Open Forum Infect Dis"},{"issue":"4","key":"pntd.0009168.ref010","first-page":"155","article-title":"Seoul hantavirus in brown rats in the Netherlands: implications for physicians\u2014Epidemiology, clinical aspects, treatment and diagnostics","volume":"73","author":"M Goeijenbier","year":"2015","journal-title":"Neth J Med"},{"issue":"9","key":"pntd.0009168.ref011","doi-asserted-by":"crossref","first-page":"e0007757","DOI":"10.1371\/journal.pntd.0007757","article-title":"Intrinsic and extrinsic drivers of transmission dynamics of hemorrhagic fever with renal syndrome caused by Seoul hantavirus","volume":"13","author":"Y Li","year":"2019","journal-title":"PLoS Negl Trop Dis"},{"issue":"2","key":"pntd.0009168.ref012","doi-asserted-by":"crossref","first-page":"e0006901","DOI":"10.1371\/journal.pntd.0006901","article-title":"The ecological dynamics of hantavirus diseases: From environmental variability to disease prevention largely based on data from China","volume":"13","author":"H Tian","year":"2019","journal-title":"PLoS Negl Trop Dis"},{"issue":"5","key":"pntd.0009168.ref013","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1093\/infdis\/146.5.638","article-title":"Isolation of Hantaan virus, the etiologic agent of Korean hemorrhagic fever, from wild urban rats","volume":"146","author":"HW Lee","year":"1982","journal-title":"J Infect Dis"},{"issue":"4","key":"pntd.0009168.ref014","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1159\/000188762","article-title":"Hemorrhagic fever with renal syndrome caused by the Seoul virus","volume":"71","author":"YS Kim","year":"1995","journal-title":"Nephron"},{"issue":"2","key":"pntd.0009168.ref015","doi-asserted-by":"crossref","first-page":"470","DOI":"10.4269\/ajtmh.17-0459","article-title":"Urban Rodent Surveillance, Climatic Association, and Genomic Characterization of Seoul Virus Collected at U.S. Army Garrison, Seoul, Republic of Korea, 2006\u20132010","volume":"99","author":"HC Kim","year":"2018","journal-title":"Am J Trop Med Hyg"},{"issue":"4","key":"pntd.0009168.ref016","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1093\/molbev\/mst010","article-title":"MAFFT multiple sequence alignment software version 7: improvements in performance and usability","volume":"30","author":"K Katoh","year":"2013","journal-title":"Molecular biology and evolution"},{"issue":"6","key":"pntd.0009168.ref017","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1093\/molbev\/msy096","article-title":"MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms","volume":"35","author":"S Kumar","year":"2018","journal-title":"Molecular biology and evolution"},{"issue":"2","key":"pntd.0009168.ref018","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3201\/eid2402.171216","article-title":"Multiplex PCR-Based Next-Generation Sequencing and Global Diversity of Seoul Virus in Humans and Rats","volume":"24","author":"WK Kim","year":"2018","journal-title":"Emerging infectious diseases"},{"issue":"3","key":"pntd.0009168.ref019","doi-asserted-by":"crossref","DOI":"10.1128\/genomeA.00480-16","article-title":"Complete Genome Sequence of Seoul Virus Strain Tchoupitoulas","volume":"4","author":"RW Miles","year":"2016","journal-title":"Genome Announc"},{"issue":"6","key":"pntd.0009168.ref020","doi-asserted-by":"crossref","first-page":"973","DOI":"10.3201\/eid2306.160927","article-title":"Seoul Virus Infection in Humans, France, 2014\u20132016","volume":"23","author":"JM Reynes","year":"2017","journal-title":"Emerging infectious diseases"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0009168","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T00:00:00Z","timestamp":1614816000000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0009168","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T14:12:34Z","timestamp":1614867154000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0009168"}},"subtitle":[],"editor":[{"given":"Suzy J.","family":"Campbell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,2,22]]},"references-count":20,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,2,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0009168","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,22]]}}}