{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:10:25Z","timestamp":1787069425439,"version":"build-2736575974"},"update-to":[{"DOI":"10.1371\/journal.pntd.0009207","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T00:00:00Z","timestamp":1614729600000}}],"reference-count":62,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T00:00:00Z","timestamp":1613692800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","award":["55008749"],"award-info":[{"award-number":["55008749"]}],"id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"name":"FONDECYT","award":["1201805"],"award-info":[{"award-number":["1201805"]}]},{"name":"FONDECYT","award":["REDI170269"],"award-info":[{"award-number":["REDI170269"]}]},{"DOI":"10.13039\/501100002941","name":"DICYT","doi-asserted-by":"crossref","award":["022001BZ"],"award-info":[{"award-number":["022001BZ"]}],"id":[{"id":"10.13039\/501100002941","id-type":"DOI","asserted-by":"crossref"}]},{"name":"FONDECYT","award":["1191074"],"award-info":[{"award-number":["1191074"]}]},{"name":"MCMi Challenge Grants Program","award":["2018-646"],"award-info":[{"award-number":["2018-646"]}]},{"name":"FDA Foods Program Intramural Funds"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>\n                    <jats:italic>Campylobacter jejuni<\/jats:italic>\n                    and\n                    <jats:italic>Campylobacter coli<\/jats:italic>\n                    are the leading cause of human gastroenteritis in the industrialized world and an emerging threat in developing countries. The incidence of campylobacteriosis in South America is greatly underestimated, mostly due to the lack of adequate diagnostic methods. Accordingly, there is limited genomic and epidemiological data from this region. In the present study, we performed a genome-wide analysis of the genetic diversity, virulence, and antimicrobial resistance of the largest collection of clinical\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>jejuni<\/jats:italic>\n                    and\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>coli<\/jats:italic>\n                    strains from Chile available to date (n = 81), collected in 2017\u20132019 in Santiago, Chile. This culture collection accounts for more than one third of the available genome sequences from South American clinical strains. cgMLST analysis identified high genetic diversity as well as 13 novel STs and alleles in both\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>jejuni<\/jats:italic>\n                    and\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>coli<\/jats:italic>\n                    . Pangenome and virulome analyses showed a differential distribution of virulence factors, including both plasmid and chromosomally encoded T6SSs and T4SSs. Resistome analysis predicted widespread resistance to fluoroquinolones, but low rates of erythromycin resistance. This study provides valuable genomic and epidemiological data and highlights the need for further genomic epidemiology studies in Chile and other South American countries to better understand molecular epidemiology and antimicrobial resistance of this emerging intestinal pathogen.\n                  <\/jats:p>","DOI":"10.1371\/journal.pntd.0009207","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T00:00:41Z","timestamp":1613779241000},"page":"e0009207","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":45,"title":["Genomic analysis of the diversity, antimicrobial resistance and virulence potential of clinical Campylobacter jejuni and Campylobacter coli strains from Chile"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6743-6851","authenticated-orcid":true,"given":"Veronica","family":"Bravo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5481-7399","authenticated-orcid":true,"given":"Assaf","family":"Katz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1175-5946","authenticated-orcid":true,"given":"Lorena","family":"Porte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Weitzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Varela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4568-0022","authenticated-orcid":true,"given":"Narjol","family":"Gonzalez-Escalona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7099-6347","authenticated-orcid":true,"given":"Carlos J.","family":"Blondel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,2,19]]},"reference":[{"key":"pntd.0009207.ref001","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1128\/CMR.00006-15","article-title":"Global Epidemiology of Campylobacter Infection","volume":"28","author":"NO Kaakoush","year":"2015","journal-title":"Clin Microbiol Rev"},{"key":"pntd.0009207.ref002","volume-title":"The global view of campylobacteriosis: report of an expert consultation, Utrecht, Netherlands, 9\u201311 July 2012","author":"World Health Organization","year":"2013"},{"key":"pntd.0009207.ref003","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1086\/319760","article-title":"Campylobacter jejuni Infections: Update on Emerging Issues and Trends","volume":"32","author":"D Acheson","year":"2001","journal-title":"Clinical Infectious Diseases"},{"key":"pntd.0009207.ref004","first-page":"7","article-title":"Global priority list of antibiotic-resistant bacteria to guide research, discovery","author":"E. 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