{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T12:45:43Z","timestamp":1784033143456,"version":"3.55.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0009365","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T00:00:00Z","timestamp":1621814400000}}],"reference-count":99,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T00:00:00Z","timestamp":1620777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>In patients with hepatic cystic echinococcosis (CE), treatment effectiveness, outcomes, complications, and recurrence rate are controversial. Endocystectomy is a conservative surgical approach that adequately removes cyst contents without loss of parenchyma. This conservative procedure has been modified in several ways to prevent complications and to improve surgical outcomes. This systematic review aimed to evaluate the intraoperative and postoperative complications of endocysectomy for hepatic CE as well as the hepatic CE recurrence rate following endocystectomy.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>A systematic search was made for all studies reporting endocystectomy to manage hepatic CE in PubMed, Web of Science, and Cochrane CENTRAL databases. Study quality was assessed using the methodological index for non-randomized studies (MINORS) criteria and the Cochrane revised tool to assess risk of bias in randomized trials (RoB2). The random-effects model was used for meta-analysis and the arscine-transformed proportions were used to determine complication-, mortality-, and recurrence rates. This study is registered with PROSPERO (number CRD42020181732).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Of 3,930 retrieved articles, 54 studies reporting on 4,058 patients were included. Among studies reporting preoperative anthelmintic treatment (31 studies), albendazole was administered in all of them. Complications were reported in 19.4% (95% CI: 15.9\u201323.2; I<jats:sup>2<\/jats:sup> = 84%; p-value &lt;0.001) of the patients; biliary leakage (10.1%; 95% CI: 7.5\u201313.1; I<jats:sup>2<\/jats:sup> = 81%; p-value &lt;0.001) and wound infection (6.6%; 95% CI: 4.6\u20139; I<jats:sup>2<\/jats:sup> = 27%; p-value = 0.17) were the most common complications. The post-endocystectomy mortality rate was 1.2% (95% CI: 0.8\u20131.8; I<jats:sup>2<\/jats:sup> = 21%; p-value = 0.15) and the recurrence rate was 4.8% (95% CI: 3.1\u20136.8; I<jats:sup>2<\/jats:sup> = 87%; p-value &lt;0.001). Thirty-nine studies (88.7%) had a mean follow-up of more than one year after endocystectomy, and only 14 studies (31.8%) had a follow-up of more than five years.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Endocystectomy is a conservative and feasible surgical approach. Despite previous disencouraging experiences, our results suggest that endocystectomy is associated with low mortality and recurrence.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pntd.0009365","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T17:54:25Z","timestamp":1620842065000},"page":"e0009365","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":34,"title":["Endocystectomy as a conservative surgical treatment for hepatic cystic echinococcosis: A systematic review with single-arm meta-analysis"],"prefix":"10.1371","volume":"15","author":[{"given":"Mohammad","family":"Al-Saeedi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7431-4836","authenticated-orcid":true,"given":"Ali","family":"Ramouz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8599-0522","authenticated-orcid":true,"given":"Elias","family":"Khajeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"El Rafidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7424-1323","authenticated-orcid":true,"given":"Omid","family":"Ghamarnejad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Shafiei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadeq","family":"Ali-Hasan-Al-Saegh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0895-4015","authenticated-orcid":true,"given":"Pascal","family":"Probst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marija","family":"Stojkovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5911-123X","authenticated-orcid":true,"given":"Tim Frederik","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6163-1525","authenticated-orcid":true,"given":"Arianeb","family":"Mehrabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,5,12]]},"reference":[{"issue":"4","key":"pntd.0009365.ref001","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/s00423-003-0397-z","article-title":"Echinococcus granulosus infection: the challenge of surgical treatment","volume":"388","author":"K Buttenschoen","year":"2003","journal-title":"Langenbeck\u2019s archives of surgery"},{"issue":"4","key":"pntd.0009365.ref002","doi-asserted-by":"crossref","first-page":"e0005477","DOI":"10.1371\/journal.pntd.0005477","article-title":"Cystic and alveolar echinococcosis: Successes and continuing challenges","volume":"11","author":"CM Budke","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"issue":"3","key":"pntd.0009365.ref003","doi-asserted-by":"crossref","first-page":"301","DOI":"10.4269\/ajtmh.2008.79.301","article-title":"Clinical management of cystic echinococcosis: state of the art, problems, and perspectives","volume":"79","author":"T Junghanss","year":"2008","journal-title":"The American journal of tropical medicine and hygiene"},{"issue":"13","key":"pntd.0009365.ref004","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.3748\/wjg.v18.i13.1448","article-title":"Hepatic echinococcosis: clinical and therapeutic aspects.","volume":"18","author":"G Nunnari","year":"2012","journal-title":"World journal of gastroenterology: WJG"},{"issue":"6","key":"pntd.0009365.ref005","doi-asserted-by":"crossref","first-page":"e0007516","DOI":"10.1371\/journal.pntd.0007516","article-title":"Standardized endocystectomy technique for surgical treatment of uncomplicated hepatic cystic echinococcosis","volume":"13","author":"M Al-Saeedi","year":"2019","journal-title":"PLoS Negl Trop Dis"},{"issue":"1","key":"pntd.0009365.ref006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actatropica.2009.11.001","article-title":"Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans","volume":"114","author":"E Brunetti","year":"2010","journal-title":"Acta Trop"},{"issue":"1","key":"pntd.0009365.ref007","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1478-3231.2009.02116.x","article-title":"Surgical management of liver hydatidosis: a multicentre series of 1412 patients","volume":"30","author":"MA Secchi","year":"2010","journal-title":"Liver International"},{"issue":"5","key":"pntd.0009365.ref008","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/s00534-004-0915-6","article-title":"Primary hydatid disease of the gallbladder: a rare clinical entity","volume":"11","author":"M Safioleas","year":"2004","journal-title":"J Hepatobiliary Pancreat Sci"},{"issue":"6","key":"pntd.0009365.ref009","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.gassur.2004.10.016","article-title":"Changing concepts in the management of liver hydatid disease","volume":"9","author":"C Dervenis","year":"2005","journal-title":"J Gastrointest Surg"},{"key":"pntd.0009365.ref010","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijsu.2010.02.007","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","author":"D Moher","year":"2010"},{"issue":"1","key":"pntd.0009365.ref011","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s00423-017-1646-x","article-title":"Optimal literature search for systematic reviews in surgery","volume":"403","author":"K Goossen","year":"2018","journal-title":"Langenbeck\u2019s archives of surgery"},{"issue":"9","key":"pntd.0009365.ref012","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1046\/j.1445-2197.2003.02762.x","article-title":"Methodological index for non-randomized studies","volume":"73","author":"O. Dent","year":"2003","journal-title":"ANZ J Surg"},{"key":"pntd.0009365.ref013","doi-asserted-by":"crossref","first-page":"l4898","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"JAC Sterne","year":"2019","journal-title":"BMJ"},{"issue":"2","key":"pntd.0009365.ref014","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1148\/radiology.139.2.7220891","article-title":"Ultrasound examination of the hydatic liver","volume":"139","author":"HA Gharbi","year":"1981","journal-title":"Radiology"},{"issue":"2","key":"pntd.0009365.ref015","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/SLA.0b013e3181b13ca2","article-title":"The Clavien-Dindo classification of surgical complications: five-year experience","volume":"250","author":"PA Clavien","year":"2009","journal-title":"Ann Surg"},{"key":"pntd.0009365.ref016","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0065-308X(05)61011-1","article-title":"Control of cystic echinococcosis\/hydatidosis: 1863\u20132002","volume":"61","author":"PS Craig","year":"2006","journal-title":"Adv Parasitol"},{"issue":"7","key":"pntd.0009365.ref017","doi-asserted-by":"crossref","first-page":"e0005771","DOI":"10.1371\/journal.pntd.0005771","article-title":"The disease burden of human cystic echinococcosis based on HDRs from 2001 to 2014 in Italy","volume":"11","author":"T Piseddu","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"issue":"6","key":"pntd.0009365.ref018","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S1473-3099(07)70134-2","article-title":"Prevention and control of cystic echinococcosis","volume":"7","author":"PS Craig","year":"2007","journal-title":"Lancet Infect Dis"},{"issue":"3","key":"pntd.0009365.ref019","doi-asserted-by":"crossref","first-page":"e91342","DOI":"10.1371\/journal.pone.0091342","article-title":"Study of Hydatidosis-Attributed Mortality in Endemic Area","volume":"9","author":"M Belhassen-Garc\u00eda","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"pntd.0009365.ref020","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3201\/eid1202.050499","article-title":"Global socioeconomic impact of cystic echinococcosis","volume":"12","author":"CM Budke","year":"2006","journal-title":"Emerg Infect Dis"},{"issue":"2","key":"pntd.0009365.ref021","article-title":"Echinococcosis: Advances in the 21st Century","volume":"32","author":"H Wen","year":"2019","journal-title":"Clin Microbiol Rev"},{"issue":"2","key":"pntd.0009365.ref022","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ijid.2004.08.001","article-title":"Treatment options for hepatic cystic echinococcosis","volume":"9","author":"RA Smego","year":"2005","journal-title":"Int J Infect Dis"},{"issue":"13","key":"pntd.0009365.ref023","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.3748\/wjg.v18.i13.1438","article-title":"Multidisciplinary imaging of liver hydatidosis","volume":"18","author":"G Marrone","year":"2012","journal-title":"World J Gastroenterol"},{"issue":"10","key":"pntd.0009365.ref024","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001880","article-title":"Diagnosing and staging of cystic echinococcosis: how do CT and MRI perform in comparison to ultrasound?","volume":"6","author":"M Stojkovic","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"issue":"3","key":"pntd.0009365.ref025","doi-asserted-by":"crossref","first-page":"E70","DOI":"10.1055\/a-0650-3807","article-title":"Ultrasound and Cystic Echinococcosis","volume":"4","author":"E Brunetti","year":"2018","journal-title":"Ultrasound Int Open"},{"issue":"2","key":"pntd.0009365.ref026","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1097\/RCT.0000000000000687","article-title":"Performance of magnetic resonance susceptibility-weighted imaging for detection of calcifications in patients with hepatic echinococcosis","volume":"42","author":"J Mueller","year":"2018","journal-title":"J Comput Assist Tomogr"},{"issue":"2","key":"pntd.0009365.ref027","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.ejrad.2007.08.002","article-title":"MR imaging for diagnosing cysto-biliary fistulas in cystic echinococcosis","volume":"66","author":"W Hosch","year":"2008","journal-title":"Eur J Radiol"},{"issue":"5","key":"pntd.0009365.ref028","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1097\/QCO.0000000000000093","article-title":"Acceptance of standardized ultrasound classification, use of albendazole, and long-term follow-up in clinical management of cystic echinococcosis: a systematic review","volume":"27","author":"F Tamarozzi","year":"2014","journal-title":"Curr Opin Infect Dis"},{"issue":"5","key":"pntd.0009365.ref029","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/QCO.0000000000000485","article-title":"Clinical management of cystic echinococcosis: state of the art and perspectives","volume":"31","author":"M Stojkovic","year":"2018","journal-title":"Curr Opin Infect Dis"},{"issue":"12","key":"pntd.0009365.ref030","doi-asserted-by":"crossref","first-page":"e0005243","DOI":"10.1371\/journal.pntd.0005243","article-title":"Watch and wait management of inactive cystic echinococcosis\u2013does the path to inactivity matter\u2013analysis of a prospective patient cohort","volume":"10","author":"M Stojkovic","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"issue":"10","key":"pntd.0009365.ref031","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/j.hpb.2020.03.003","article-title":"Surgical management of hepatic hydatid cysts\u2014conservative versus radical surgery","volume":"22","author":"KB Deo","year":"2020","journal-title":"HPB (Oxford)"},{"issue":"4","key":"pntd.0009365.ref032","first-page":"1363","article-title":"Surgical treatment of liver echinococcosis\u2014open or laparoscopic surgery?","volume":"36","author":"Z Busi\u0107","year":"2012","journal-title":"Coll Antropol"},{"issue":"6","key":"pntd.0009365.ref033","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1007\/s11605-014-2494-4","article-title":"Conventional versus laparoscopic surgery for hepatic hydatidosis: a 6-year single-center experience","volume":"18","author":"T Tuxun","year":"2014","journal-title":"J Gastrointest Surg"},{"issue":"10","key":"pntd.0009365.ref034","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1007\/s11605-011-1649-9","article-title":"Hepatic hydatid: PAIR, drain or resect?","volume":"15","author":"N Gupta","year":"2011","journal-title":"J Gastrointest Surg"},{"issue":"3","key":"pntd.0009365.ref035","first-page":"199","article-title":"Surgical treatment of hepatic Echinococcus granulosus.","volume":"12","author":"W Patkowski","year":"2017","journal-title":"Prz Gastroenterol"},{"issue":"5","key":"pntd.0009365.ref036","first-page":"7039","article-title":"Efficacy of radical and conservative surgery for hepatic cystic echinococcosis: a meta-analysis","volume":"8","author":"Y-B He","year":"2015","journal-title":"J International journal of clinical experimental medicine"},{"key":"pntd.0009365.ref037","article-title":"International consensus on terminology to be used in the field of echinococcoses","volume":"27","author":"DA Vuitton","year":"2020","journal-title":"J Parasite"},{"issue":"2","key":"pntd.0009365.ref038","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1093\/trstmh\/try112","article-title":"Epidemiology, diagnosis, treatment and follow-up of cystic echinococcosis in asymptomatic carriers","volume":"113","author":"E Larrieu","year":"2018","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"6","key":"pntd.0009365.ref039","first-page":"e1154","article-title":"Justified concern or exaggerated fear: the risk of anaphylaxis in percutaneous treatment of cystic echinococcosis\u2014a systematic literature review","volume":"5","author":"A Neumayr","year":"2011"},{"issue":"1","key":"pntd.0009365.ref040","article-title":"Percutaneous needle aspiration, injection, and re-aspiration with or without benzimidazole coverage for uncomplicated hepatic hydatid cysts","author":"S Nasseri-Moghaddam","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"issue":"6","key":"pntd.0009365.ref041","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1007\/s00464-012-2719-0","article-title":"Open or laparoscopic treatment for hydatid disease of the liver? A 10-year single-institution experience.","volume":"27","author":"F Zaharie","year":"2013","journal-title":"J Surgical endoscopy."},{"issue":"11","key":"pntd.0009365.ref042","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1177\/014107680309601107","article-title":"Does laparoscopic surgery spell the end of the open surgeon?","volume":"96","author":"R Agha","year":"2003","journal-title":"Journal of the Royal Society of Medicine"},{"issue":"3","key":"pntd.0009365.ref043","doi-asserted-by":"crossref","first-page":"230","DOI":"10.4103\/jmas.JMAS_81_17","article-title":"Liver hydatid cyst with cystobiliary communication: Laparoscopic surgery remains an effective option","volume":"14","author":"N Chopra","year":"2018","journal-title":"J Minim Access Surg"},{"issue":"Suppl 3","key":"pntd.0009365.ref044","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1007\/s12262-014-1064-z","article-title":"Laparoscopic Management of Hydatid Cyst of Liver with Palanivelu Hydatid System over a Period of 3 Years: A Case Series of 32 Patients","volume":"77","author":"DS Samala","year":"2015","journal-title":"Indian J Surg"},{"issue":"4","key":"pntd.0009365.ref045","first-page":"878","article-title":"Comparison of long-term results of percutaneous treatment techniques for hepatic cystic echinococcosis types 2 and 3b","volume":"208","author":"O Akhan","year":"2017"},{"issue":"358","key":"pntd.0009365.ref046","first-page":"64","article-title":"PAIR vs Ormeci technique for the treatment of hydatid cyst","volume":"25","author":"N. Ormeci","year":"2014","journal-title":"Turk J Gastroenterol"},{"issue":"2","key":"pntd.0009365.ref047","doi-asserted-by":"crossref","first-page":"284","DOI":"10.5114\/aoms.2018.73344","article-title":"A systematic review and meta-analysis on the treatment of liver hydatid cyst using meta-MUMS tool: comparing PAIR and laparoscopic procedures","volume":"15","author":"M Sokouti","year":"2019","journal-title":"Arch Med Sci"},{"issue":"8","key":"pntd.0009365.ref048","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1086\/378275","article-title":"Percutaneous aspiration-injection-reaspiration drainage plus albendazole or mebendazole for hepatic cystic echinococcosis: a meta-analysis","volume":"37","author":"RA Smego","year":"2003","journal-title":"Clin Infect Dis"},{"issue":"28","key":"pntd.0009365.ref049","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.4254\/wjh.v8.i28.1169","article-title":"Current status of diagnosis and treatment of hepatic echinococcosis","volume":"8","author":"M Mihmanli","year":"2016","journal-title":"World J Hepatol"},{"issue":"1","key":"pntd.0009365.ref050","doi-asserted-by":"crossref","DOI":"10.4293\/JSLS.2016.00002","article-title":"Minimally Invasive Treatment of Liver Hydatidosis","volume":"20","author":"C Duta","year":"2016","journal-title":"JSLS"},{"issue":"1","key":"pntd.0009365.ref051","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s12893-019-0553-1","article-title":"Current approaches in the surgical treatment of liver hydatid disease: single center experience","volume":"19","author":"M Bayrak","year":"2019","journal-title":"BMC Surg"},{"key":"pntd.0009365.ref052","article-title":"Not just minor resections: robotic approach for cystic echinococcosis of the liver","author":"P Magistri","year":"2019","journal-title":"Infection"},{"issue":"6","key":"pntd.0009365.ref053","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.asjsur.2018.09.013","article-title":"Operative treatment of hepatic hydatid cysts: A single center experience","volume":"42","author":"G Marom","year":"2019","journal-title":"Asian J Surg"},{"key":"pntd.0009365.ref054","article-title":"Pattern of Relapse in Hepatic Hydatidosis: Analysis of 238 Cases in a Single Hospital","author":"I Jaen-Torrejimeno","year":"2019","journal-title":"J Gastrointest Surg."},{"issue":"2","key":"pntd.0009365.ref055","doi-asserted-by":"crossref","first-page":"130","DOI":"10.4103\/jmas.JMAS_42_17","article-title":"Single-incision trocar-less endoscopic management of giant liver hydatid cyst in children","volume":"14","author":"H Acharya","year":"2018","journal-title":"J Minim Access Surg"},{"issue":"8","key":"pntd.0009365.ref056","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1089\/lap.2017.0674","article-title":"The Role of Prophylactic Endoscopic Sphincterotomy for Prevention of Postoperative Bile Leak in Hydatid Liver Disease: A Randomized Controlled Study","volume":"28","author":"AM El-Gendi","year":"2018","journal-title":"J Laparoendosc Adv Surg Tech A"},{"issue":"12","key":"pntd.0009365.ref057","doi-asserted-by":"crossref","first-page":"3218","DOI":"10.1007\/s00268-017-4129-x","article-title":"Laparoscopic Treatment in Children with Hydatid Cyst of the Liver","volume":"41","author":"SV Minaev","year":"2017","journal-title":"World J Surg"},{"issue":"5","key":"pntd.0009365.ref058","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1590\/0037-8682-0223-2015","article-title":"Clinical and serological outcomes with different surgical approaches for human hepatic hydatidosis","volume":"48","author":"A Abdelraouf","year":"2015","journal-title":"Rev Soc Bras Med Trop"},{"key":"pntd.0009365.ref059","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.ijsu.2015.06.058","article-title":"Surgical management of hydatid liver disease","volume":"20","author":"GK Georgiou","year":"2015","journal-title":"Int J Surg"},{"issue":"5","key":"pntd.0009365.ref060","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1097\/SLE.0000000000000199","article-title":"Evaluation and Comparison of the Early Outcomes of Open and Laparoscopic Surgery of Liver Hydatid Cyst","volume":"25","author":"A Jabbari Nooghabi","year":"2015","journal-title":"Surg Laparosc Endosc Percutan Tech"},{"key":"pntd.0009365.ref061","first-page":"437","article-title":"Surgical treatment of hepatic hydatid cysts A retrospective analysis of 425 patients","volume":"86","author":"Y Yucel","year":"2015","journal-title":"Ann Ital Chir"},{"issue":"1","key":"pntd.0009365.ref062","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1177\/000313481708300119","article-title":"Risk Factors for Development of Biliary Complications after Surgery for Solitary Liver Hydatid Cyst","volume":"83","author":"A Surmelioglu","year":"2017","journal-title":"Am Surg"},{"issue":"5","key":"pntd.0009365.ref063","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1093\/trstmh\/tru003","article-title":"Abdominal echinococcosis: outcomes of conservative surgery","volume":"108","author":"A Pandey","year":"2014","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"4","key":"pntd.0009365.ref064","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.asjsur.2014.01.012","article-title":"Study of treatment results and early complications of tube drainage versus capitonnage after the unroofing and aspiration of hydatid cysts","volume":"37","author":"M Mehrabi Bahar","year":"2014","journal-title":"Asian J Surg"},{"issue":"3\u20134","key":"pntd.0009365.ref065","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ajg.2014.05.004","article-title":"Predictive factors of morbidity after surgical treatment of hydatid cyst of the liver","volume":"15","author":"O Baraket","year":"2014","journal-title":"Arab J Gastroenterol"},{"issue":"6","key":"pntd.0009365.ref066","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1002\/bjs.9408","article-title":"Radical versus conservative surgical treatment of liver hydatid cysts","volume":"101","author":"HO El Malki","year":"2014","journal-title":"Br J Surg"},{"issue":"3","key":"pntd.0009365.ref067","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3748\/wjg.v19.i3.355","article-title":"Biliary fistula after treatment for hydatid disease of the liver: when to intervene","volume":"19","author":"N Zeybek","year":"2013","journal-title":"World J Gastroenterol"},{"key":"pntd.0009365.ref068","doi-asserted-by":"crossref","first-page":"276807","DOI":"10.1155\/2013\/276807","article-title":"Operative treatment of hepatic hydatid cysts: a single center experience in Israel, a nonendemic country","volume":"2013","author":"D Maoz","year":"2013","journal-title":"ISRN Surg"},{"issue":"8","key":"pntd.0009365.ref069","first-page":"468","article-title":"Laparoscopic treatment of hepatic hydatid cyst","volume":"21","author":"M Rooh ul","year":"2011","journal-title":"J Coll Physicians Surg Pak"},{"issue":"6","key":"pntd.0009365.ref070","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1007\/s12262-010-0163-8","article-title":"Study of the Radical vs. Conservative Surgical Treatment of the Hepatic Hydatid Cyst: A 10-Year Experience","volume":"72","author":"MR Motie","year":"2010","journal-title":"Indian J Surg"},{"issue":"26","key":"pntd.0009365.ref071","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.3748\/wjg.v16.i26.3305","article-title":"Experience with the surgical treatment of hepatic hydatidosis: case series with follow-up","volume":"16","author":"H Losada Morales","year":"2010","journal-title":"World J Gastroenterol"},{"issue":"7","key":"pntd.0009365.ref072","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1007\/s11605-010-1220-0","article-title":"Does primary surgical management of liver hydatid cyst influence recurrence?","volume":"14","author":"HO El Malki","year":"2010","journal-title":"J Gastrointest Surg."},{"issue":"6","key":"pntd.0009365.ref073","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1007\/s00268-009-9971-z","article-title":"Efficacy of chlorhexidine gluconate during surgery for hydatid cyst","volume":"33","author":"O Topcu","year":"2009","journal-title":"World J Surg"},{"issue":"4","key":"pntd.0009365.ref074","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ijsu.2009.06.012","article-title":"Asymptomatic occult cysto-biliary communication without bile into cavity of the liver hydatid cyst: a pitfall in conservative surgery","volume":"7","author":"HR Unalp","year":"2009","journal-title":"Int J Surg"},{"issue":"5","key":"pntd.0009365.ref075","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00595-006-3398-z","article-title":"Surgical techniques and treatment for hepatic hydatid cysts","volume":"37","author":"S Gourgiotis","year":"2007","journal-title":"Surg Today"},{"issue":"1","key":"pntd.0009365.ref076","first-page":"22","article-title":"Cystic echinococcosis in Central Saudi Arabia: a 5-year experience","volume":"18","author":"F Fahim","year":"2007","journal-title":"Turk J Gastroenterol"},{"issue":"3","key":"pntd.0009365.ref077","first-page":"112","article-title":"Intact germinal layer of liver hydatid cysts removed after administration of albendazole","volume":"65","author":"A Manouras","year":"2007","journal-title":"Neth J Med"},{"issue":"11","key":"pntd.0009365.ref078","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1001\/archsurg.141.11.1101","article-title":"Hydatid disease of the liver: a continuing surgical problem","volume":"141","author":"MC Safioleas","year":"2006","journal-title":"Arch Surg"},{"issue":"1","key":"pntd.0009365.ref079","first-page":"56","article-title":"Laparoscopic management of hepatic hydatid disease","volume":"10","author":"C Palanivelu","year":"2006","journal-title":"JSLS"},{"issue":"9","key":"pntd.0009365.ref080","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1007\/s00268-005-0726-1","article-title":"Falciform ligament in the management of the residual cavity for liver hydatidosis: new surgical technique","volume":"30","author":"MM Ozmen","year":"2006","journal-title":"World J Surg"},{"issue":"2","key":"pntd.0009365.ref081","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.amjsurg.2006.11.033","article-title":"Laparoscopic surgical techniques in patients with hepatic hydatid cyst","volume":"194","author":"W Chen","year":"2007","journal-title":"Am J Surg"},{"issue":"1","key":"pntd.0009365.ref082","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.actatropica.2006.01.009","article-title":"Post-survey follow-up for human cystic echinococcosis in northwest China","volume":"98","author":"Y Wang","year":"2006","journal-title":"Acta Trop"},{"issue":"3","key":"pntd.0009365.ref083","first-page":"993","article-title":"Modified endocystectomy versus pericystectomy in echinococcus granulosus liver cysts: a randomized controlled study, and the role of specific anti-hydatid IgG4 in detection of early recurrence","volume":"36","author":"S Elsebaie","year":"2006","journal-title":"J Egypt Soc Parasitol"},{"issue":"2","key":"pntd.0009365.ref084","first-page":"559","article-title":"Conservative versus radical surgery for treatment of uncomplicated hepatic hydatid cysts","volume":"36","author":"M Abbas","year":"2006","journal-title":"J Egypt Soc Parasitol"},{"issue":"4","key":"pntd.0009365.ref085","first-page":"273","article-title":"The results of surgical treatment for hepatic hydatid cysts in an endemic area","volume":"17","author":"N Bulbuller","year":"2006","journal-title":"Turk J Gastroenterol"},{"issue":"6","key":"pntd.0009365.ref086","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1080\/00015458.2006.11679981","article-title":"Long-term results of surgical treatment of hydatid disease","volume":"106","author":"CG Mirelis","year":"2006","journal-title":"Acta Chir Belg"},{"issue":"1","key":"pntd.0009365.ref087","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s00423-004-0513-8","article-title":"Myoplasty versus omentoplasty in the surgical treatment of hydatidosis of the liver dome","volume":"390","author":"G Kouraklis","year":"2005","journal-title":"Langenbecks Arch Surg"},{"issue":"65","key":"pntd.0009365.ref088","first-page":"1526","article-title":"Videolaparoscopic treatment of hepatic hydatid cyst","volume":"52","author":"A Dervisoglu","year":"2005","journal-title":"Hepatogastroenterology"},{"issue":"2","key":"pntd.0009365.ref089","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/s00268-002-6558-3","article-title":"Diaphragm myoplasty in the prevention of complications after surgery of hydatid disease of the liver","volume":"27","author":"T Dosios","year":"2003","journal-title":"World J Surg"},{"issue":"12","key":"pntd.0009365.ref090","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1002\/bjs.4313","article-title":"Surgical treatment of hydatid cysts of the liver","volume":"90","author":"N Agaoglu","year":"2003","journal-title":"Br J Surg"},{"issue":"4","key":"pntd.0009365.ref091","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1159\/000071186","article-title":"A retrospective study comparing the different surgical procedures for the treatment of hydatid disease of the liver","volume":"20","author":"L Mueller","year":"2003","journal-title":"Dig Surg"},{"issue":"5","key":"pntd.0009365.ref092","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S1091-255X(02)00434-1","article-title":"Spontaneous and traumatic intra-peritoneal perforations of hepatic hydatid cysts: a case series","volume":"7","author":"N Kurt","year":"2003","journal-title":"J Gastrointest Surg"},{"issue":"1","key":"pntd.0009365.ref093","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1177\/147323000203000110","article-title":"Hydatid disease of the liver in children: evaluation of surgical treatment","volume":"30","author":"F Celebi","year":"2002","journal-title":"J Int Med Res"},{"issue":"6","key":"pntd.0009365.ref094","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0899-7071(01)00331-X","article-title":"Echinococcal cysts of the liver: a retrospective analysis of clinico-radiological findings and different therapeutic modalities","volume":"25","author":"MC Haddad","year":"2001","journal-title":"Clin Imaging"},{"issue":"1","key":"pntd.0009365.ref095","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s002680020368","article-title":"Evolution of surgery for liver hydatidosis from 1950 to today: analysis of a personal experience","volume":"25","author":"A Cirenei","year":"2001","journal-title":"World J Surg"},{"issue":"4","key":"pntd.0009365.ref096","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1155\/1999\/20148","article-title":"Surgical management of calcified hydatid cysts of the liver","volume":"11","author":"J Prousalidis","year":"1999","journal-title":"HPB Surg"},{"issue":"4","key":"pntd.0009365.ref097","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1159\/000018648","article-title":"Laparoscopic approach to hepatic hydatid disease","volume":"15","author":"M Ertem","year":"1998","journal-title":"Dig Surg"},{"issue":"6","key":"pntd.0009365.ref098","first-page":"415","article-title":"Conservative surgery in the treatment of hepatic hydatidosis","volume":"161","author":"CE Vagianos","year":"1995","journal-title":"Eur J Surg"},{"issue":"6","key":"pntd.0009365.ref099","first-page":"181","article-title":"A comparative study of various surgical treatments of hepatic hydatidosis with special reference to capitonnage","volume":"96","author":"CP Joshi","year":"1998","journal-title":"J Indian Med Assoc"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0009365","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T00:00:00Z","timestamp":1621814400000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0009365","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T17:36:22Z","timestamp":1621877782000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0009365"}},"subtitle":[],"editor":[{"given":"Paul R.","family":"Torgerson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,5,12]]},"references-count":99,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,5,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0009365","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pntd.0009365","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,12]]}}}