{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:57:02Z","timestamp":1787021822901,"version":"build-2736575974"},"update-to":[{"DOI":"10.1371\/journal.pntd.0009390","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T00:00:00Z","timestamp":1620691200000}}],"reference-count":66,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T00:00:00Z","timestamp":1619654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2018\/20468-0; 2020\/06747-4"],"award-info":[{"award-number":["2018\/20468-0; 2020\/06747-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2017\/05782-8"],"award-info":[{"award-number":["2017\/05782-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["409216\/2018-6"],"award-info":[{"award-number":["409216\/2018-6"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical Research Council United Kingdom","award":["MR\/M01360X\/1; MR\/N010469\/1; MR\/R025576\/1; MR\/R020973\/1"],"award-info":[{"award-number":["MR\/M01360X\/1; MR\/N010469\/1; MR\/R025576\/1; MR\/R020973\/1"]}]},{"name":"Medical Research Council United Kingdom","award":["MR\/M01360X\/1; MR\/R025576\/1; MR\/R020973\/1"],"award-info":[{"award-number":["MR\/M01360X\/1; MR\/R025576\/1; MR\/R020973\/1"]}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2015\/26722-8; 2017\/03966-4"],"award-info":[{"award-number":["2015\/26722-8; 2017\/03966-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2017\/24267-7"],"award-info":[{"award-number":["2017\/24267-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2018\/18257-1; 2018\/15549-1; 2020\/04923-0"],"award-info":[{"award-number":["2018\/18257-1; 2018\/15549-1; 2020\/04923-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/12068-5"],"award-info":[{"award-number":["2019\/12068-5"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2017\/03939-7"],"award-info":[{"award-number":["2017\/03939-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PD\/BD\/138900\/2018"],"award-info":[{"award-number":["PD\/BD\/138900\/2018"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Malaria in Brazil represents one of the highest percentages of Latin America cases, where approximately 84% of infections are attributed to\n                      <jats:italic>Plasmodium<\/jats:italic>\n                      (\n                      <jats:italic>P<\/jats:italic>\n                      .\n                      <jats:italic>) vivax<\/jats:italic>\n                      . Despite the high incidence, many aspects of gestational malaria resulting from\n                      <jats:italic>P<\/jats:italic>\n                      .\n                      <jats:italic>vivax<\/jats:italic>\n                      infections remain poorly studied. As such, we aimed to evaluate the consequences of\n                      <jats:italic>P<\/jats:italic>\n                      .\n                      <jats:italic>vivax<\/jats:italic>\n                      infections during gestation on the health of mothers and their neonates in an endemic area of the Amazon.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods and findings<\/jats:title>\n                    <jats:p>\n                      We have conducted an observational cohort study in Brazilian Amazon between January 2013 and April 2015. 600 pregnant women were enrolled and followed until delivery. After applying exclusion criteria, 329 mother-child pairs were included in the analysis. Clinical data regarding maternal infection, newborn\u2019s anthropometric measures, placental histopathological characteristics, and angiogenic and inflammatory factors were evaluated. The presence of plasma IgG against the\n                      <jats:italic>P<\/jats:italic>\n                      .\n                      <jats:italic>vivax<\/jats:italic>\n                      (Pv) MSP1\n                      <jats:sub>19<\/jats:sub>\n                      protein was used as marker of exposure and possible associations with pregnancy outcomes were analyzed. Multivariate logistic regression analysis revealed that\n                      <jats:italic>P<\/jats:italic>\n                      .\n                      <jats:italic>vivax<\/jats:italic>\n                      infections during the first trimester of pregnancy are associated with adverse gestational outcomes such as premature birth (adjusted odds ratio [aOR] 8.12, 95% confidence interval [95%CI] 2.69\u201324.54,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.0001) and reduced head circumference (aOR 3.58, 95%CI 1.29\u20139.97,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.01). Histopathology analysis showed marked differences between placentas from\n                      <jats:italic>P<\/jats:italic>\n                      .\n                      <jats:italic>vivax<\/jats:italic>\n                      -infected and non-infected pregnant women, especially regarding placental monocytes infiltrate. Placental levels of vasomodulatory factors such as angiopoietin-2 (ANG-2) and complement proteins such as C5a were also altered at delivery. Plasma levels of anti-PvMSP1\n                      <jats:sub>19<\/jats:sub>\n                      IgG in infected pregnant women were shown to be a reliable exposure marker; yet, with no association with improved pregnancy outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study indicates that\n                      <jats:italic>P<\/jats:italic>\n                      .\n                      <jats:italic>vivax<\/jats:italic>\n                      malaria during the first trimester of pregnancy represents a higher likelihood of subsequent poor pregnancy outcomes associated with marked placental histologic modification and angiogenic\/inflammatory imbalance. Additionally, our findings support the idea that antibodies against PvMSP1\n                      <jats:sub>19<\/jats:sub>\n                      are not protective against poor pregnancy outcomes induced by\n                      <jats:italic>P<\/jats:italic>\n                      .\n                      <jats:italic>vivax<\/jats:italic>\n                      infections.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pntd.0009390","type":"journal-article","created":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T13:57:13Z","timestamp":1619704633000},"page":"e0009390","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":31,"title":["Adverse pregnancy outcomes are associated with Plasmodium vivax malaria in a prospective cohort of women from the Brazilian Amazon"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1863-1914","authenticated-orcid":true,"given":"Jamille Greg\u00f3rio","family":"Dombrowski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2280-6991","authenticated-orcid":true,"given":"Andr\u00e9","family":"Barateiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0886-6848","authenticated-orcid":true,"given":"Erika Paula Machado","family":"Peixoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6139-5013","authenticated-orcid":true,"given":"Andr\u00e9 Boler Cl\u00e1udio da Silva","family":"Barros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7775-6901","authenticated-orcid":true,"given":"Rodrigo Medeiros de","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8985-9265","authenticated-orcid":true,"given":"Taane Gregory","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1403-6138","authenticated-orcid":true,"given":"Susana","family":"Campino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5987-1749","authenticated-orcid":true,"given":"Carsten","family":"Wrenger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1724-0337","authenticated-orcid":true,"given":"Gerhard","family":"Wunderlich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Palmisano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Epiphanio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9804-6899","authenticated-orcid":true,"given":"L\u00edgia Antunes","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1227-3845","authenticated-orcid":true,"given":"Claudio Romero Farias","family":"Marinho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,4,29]]},"reference":[{"key":"pntd.0009390.ref001","unstructured":"World Health Organization W. World Malaria Report 2019. 2019."},{"key":"pntd.0009390.ref002","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.pt.2011.01.007","article-title":"Malaria in pregnancy: small babies, big problem","volume":"27","author":"AJ Umbers","year":"2011","journal-title":"Trends Parasitol"},{"key":"pntd.0009390.ref003","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1093\/infdis\/jiq049","article-title":"Impact of malaria at the end of pregnancy on infant mortality and morbidity","volume":"203","author":"A Bardaj\u00ed","year":"2011","journal-title":"J Infect Dis"},{"key":"pntd.0009390.ref004","article-title":"Impact of Malaria during Pregnancy on Low Birth Weight in Sub-Saharan Africa","volume":"17","author":"HL Guyatt","year":"2004","journal-title":"Society"},{"key":"pntd.0009390.ref005","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/1475-2875-11-71","article-title":"An analysis of timing and frequency of malaria infection during pregnancy in relation to the risk of low birth weight, anaemia and perinatal mortality in Burkina Faso","volume":"11","author":"I Valea","year":"2012","journal-title":"Malar J"},{"key":"pntd.0009390.ref006","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.trstmh.2009.07.004","article-title":"Placental malaria, anaemia and low birthweight in Yemen","volume":"104","author":"AH Albiti","year":"2010","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"pntd.0009390.ref007","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S1473-3099(07)70021-X","article-title":"Epidemiology and burden of malaria in pregnancy","volume":"7","author":"M Desai","year":"2007","journal-title":"Lancet Infect Dis"},{"key":"pntd.0009390.ref008","first-page":"1","article-title":"Impact of Malaria in Pregnancy as Latin America Approaches Elimination","volume":"xx","author":"SK Yanow","year":"2016","journal-title":"Trends Parasitol"},{"key":"pntd.0009390.ref009","doi-asserted-by":"crossref","first-page":"398","DOI":"10.4269\/ajtmh.2004.70.398","article-title":"The effects of Plasmodium falciparum and P. vivax infections on placental histopathology in an area of low malaria transmission","volume":"70","author":"R McGready","year":"2004","journal-title":"Am J Trop Med Hyg"},{"key":"pntd.0009390.ref010","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.4269\/ajtmh.12-0363","article-title":"Placental malaria in Colombia: Histopathologic findings in Plasmodium vivax and P. falciparum infections","volume":"88","author":"J Carmona-Fonseca","year":"2013","journal-title":"Am J Trop Med Hyg"},{"key":"pntd.0009390.ref011","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/annotation\/28901e80-13ad-4cae-99e8-8d54625743b6","article-title":"Placental Histopathological Changes Associated with Plasmodium vivax Infection during Pregnancy","volume":"7","author":"RM Souza","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"pntd.0009390.ref012","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1365-2559.1993.tb00110.x","article-title":"Placental Malaria.I. Pathological Classification","volume":"22","author":"JN Bulmer","year":"1993","journal-title":"Histopathology"},{"key":"pntd.0009390.ref013","doi-asserted-by":"crossref","first-page":"e193300","DOI":"10.1001\/jamanetworkopen.2019.3300","article-title":"Association of Malaria Infection During Pregnancy With Head Circumference of Newborns in the Brazilian Amazon","volume":"2","author":"JG Dombrowski","year":"2019","journal-title":"Jama Netw Open"},{"key":"pntd.0009390.ref014","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1086\/654815","article-title":"On the Cytoadhesion of Plasmodium vivax\u2013Infected Erythrocytes","volume":"202","author":"BO Carvalho","year":"2010","journal-title":"J Infect Dis"},{"key":"pntd.0009390.ref015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0034509","article-title":"Plasmodium vivax adherence to placental glycosaminoglycans.","volume":"7","author":"K Chotivanich","year":"2012","journal-title":"PLoS One"},{"key":"pntd.0009390.ref016","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/S0140-6736(98)09247-2","article-title":"Effects of Plasmodium vivax malaria in pregnancy","volume":"354","author":"F Nosten","year":"1999","journal-title":"Lancet"},{"key":"pntd.0009390.ref017","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1086\/586743","article-title":"Adverse Pregnancy Outcomes in an Area Where Multidrug-Resistant Plasmodium vivax and Plasmodium falciparum Infections Are Endemic","volume":"46","author":"JR Poespoprodjo","year":"2008","journal-title":"Clin Infect Dis"},{"key":"pntd.0009390.ref018","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pntd.0005606","article-title":"Burden and impact of Plasmodium vivax in pregnancy: A multi-centre prospective observational study","volume":"11","author":"A Bardaj\u00ed","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"key":"pntd.0009390.ref019","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1086\/653211","article-title":"Greater Endothelial Activation, Weibel-Palade Body Release and Host Inflammatory Response to Plasmodium vivax, Compared with Plasmodium falciparum : A Prospective Study in Papua, Indonesia","volume":"202","author":"TW Yeo","year":"2010","journal-title":"J Infect Dis"},{"key":"pntd.0009390.ref020","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1475-2875-9-13","article-title":"Severe Plasmodium vivax malaria exhibits marked inflammatory imbalance","volume":"9","author":"BBB Andrade","year":"2010","journal-title":"Malar J."},{"key":"pntd.0009390.ref021","doi-asserted-by":"crossref","first-page":"e0003824","DOI":"10.1371\/journal.pntd.0003824","article-title":"Malaria in Pregnancy Interacts with and Alters the Angiogenic Profiles of the Placenta","volume":"9","author":"R Ata\u00edde","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"pntd.0009390.ref022","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.pt.2013.12.007","article-title":"Malaria, primigravidae, and antibodies: Knowledge gained and future perspectives","volume":"30","author":"R Ata\u00edde","year":"2014","journal-title":"Trends Parasitol"},{"key":"pntd.0009390.ref023","doi-asserted-by":"crossref","first-page":"3309","DOI":"10.4049\/jimmunol.165.6.3309","article-title":"Plasma Antibodies from Malaria-Exposed Pregnant Women Recognize Variant Surface Antigens on Plasmodium falciparum -Infected Erythrocytes in a Parity-Dependent Manner and Block Parasite Adhesion to Chondroitin Sulfate A","volume":"165","author":"CH Ricke","year":"2000","journal-title":"J Immunol"},{"key":"pntd.0009390.ref024","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0140-6736(03)15386-X","article-title":"Variant surface antigen-specific IgG and protection against clinical consequences of pregnancy-associated Plasmodium falciparum malaria","volume":"363","author":"T Staalsoe","year":"2004","journal-title":"Lancet"},{"key":"pntd.0009390.ref025","doi-asserted-by":"crossref","first-page":"813","DOI":"10.3201\/eid2105.141626","article-title":"Protective antibodies against placental malaria and poor outcomes during pregnancy, Benin","volume":"21","author":"N Tuikue Ndam","year":"2015","journal-title":"Emerg Infect Dis"},{"key":"pntd.0009390.ref026","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1128\/IAI.01000-10","article-title":"Parity and placental infection affect antibody responses against Plasmodium falciparum during pregnancy","volume":"79","author":"A Mayor","year":"2011","journal-title":"Infect Immun"},{"key":"pntd.0009390.ref027","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12936-016-1335-1","article-title":"Challenges for malaria elimination in Brazil","volume":"15","author":"MU Ferreira","year":"2016","journal-title":"Malar J"},{"key":"pntd.0009390.ref028","doi-asserted-by":"crossref","DOI":"10.4081\/gh.2016.443","article-title":"Spatial and spatio-temporal analysis of malaria in the state of Acre, western Amazon, Brazil","volume":"11","author":"LA Kohara Melchior","year":"2016","journal-title":"Geospat Health."},{"key":"pntd.0009390.ref029","volume-title":"Malaria\u2019s treatment in Brazil practical guide. Brazilian Ministry of Health, Departamento de Vigil\u00e2ncia Epidemiol\u00f3gica\u2014Secretaria de Vigil\u00e2ncia em Sa\u00fade","author":"Brazil. Ministry of Health. Secretariat of Health Surveillance. Department of Epidemiological Surveillance","year":"2010"},{"key":"pntd.0009390.ref030","doi-asserted-by":"crossref","first-page":"e56677","DOI":"10.1371\/journal.pone.0056677","article-title":"Molecular Diagnosis of Malaria by Photo-Induced Electron Transfer Fluorogenic Primers: PET-PCR","volume":"8","author":"NW Lucchi","year":"2013","journal-title":"PLoS One"},{"key":"pntd.0009390.ref031","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0140-6736(14)60932-6","article-title":"International standards for newborn weight, length, and head circumference by gestational age and sex: the Newborn Cross-Sectional Study of the INTERGROWTH-21st Project","volume":"384","author":"J Villar","year":"2014","journal-title":"Lancet"},{"key":"pntd.0009390.ref032","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1128\/CVI.00243-07","article-title":"Antigenic Polymorphism and Naturally Acquired Antibodies to Plasmodium vivax Merozoite Surface Protein 1 in Rural Amazonians","volume":"14","author":"MS Bastos","year":"2007","journal-title":"Clin Vaccine Immunol"},{"key":"pntd.0009390.ref033","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1016\/S0264-410X(99)00176-0","article-title":"Antigenic properties of the merozoite surface protein 1 gene of Plasmodium vivax","volume":"17","author":"CI De Oliveira","year":"1999","journal-title":"Vaccine"},{"key":"pntd.0009390.ref034","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s12916-017-0877-6","article-title":"Influence of the number and timing of malaria episodes during pregnancy on prematurity and small-for-gestational-age in an area of low transmission","volume":"15","author":"KA Moore","year":"2017","journal-title":"BMC Med"},{"key":"pntd.0009390.ref035","doi-asserted-by":"crossref","first-page":"371","DOI":"10.4269\/ajtmh.13-0285","article-title":"Effects of Vivax Malaria Acquired Before 20 Weeks of Pregnancy on Subsequent Changes in Fetal Growth","volume":"90","author":"ACM Filho","year":"2014","journal-title":"Am J Trop Med Hyg"},{"key":"pntd.0009390.ref036","doi-asserted-by":"crossref","first-page":"73","DOI":"10.4269\/ajtmh.18-0135","article-title":"The Hidden Burden of Plasmodium vivax Malaria in Pregnancy in the Amazon: An Observational Study in Northwestern Brazil","volume":"99","author":"A Pincelli","year":"2018","journal-title":"Am J Trop Med Hyg"},{"key":"pntd.0009390.ref037","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.pt.2004.06.007","article-title":"Malaria in pregnancy and the endemicity spectrum: What can we learn?","volume":"20","author":"F Nosten","year":"2004","journal-title":"Trends Parasitol"},{"key":"pntd.0009390.ref038","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1590\/S0037-86822011005000030","article-title":"Retardo no crescimento intrauterino, baixo peso ao nascer e prematuridade em rec\u00e9m-nascidos de gr\u00e1vidas com mal\u00e1ria, na Col\u00f4mbia.","volume":"44","author":"A Tob\u00f3n-casta\u00f1o","year":"2011","journal-title":"Rev Soc Bras Med Trop"},{"key":"pntd.0009390.ref039","doi-asserted-by":"crossref","first-page":"755","DOI":"10.4269\/ajtmh.2006.74.755","article-title":"Short report: Pregnancy outcomes associated with Plasmodium vivax malaria in northeastern Venezuela","volume":"74","author":"AJ Rodriguez-Morales","year":"2006","journal-title":"Am J Trop Med Hyg"},{"key":"pntd.0009390.ref040","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.3201\/eid1910.130308","article-title":"Plasmodium vivax malaria during pregnancy, Bolivia","volume":"19","author":"L Brutus","year":"2013","journal-title":"Emerg Infect Dis"},{"key":"pntd.0009390.ref041","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.preghy.2018.04.008","article-title":"First trimester placental vascularization and angiogenetic factors are associated with adverse pregnancy outcome","volume":"13","author":"JEW Leijnse","year":"2018","journal-title":"Pregnancy Hypertens"},{"key":"pntd.0009390.ref042","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/s41574-020-0372-6","article-title":"Tracking placental development in health and disease","volume":"16","author":"JD Aplin","year":"2020","journal-title":"Nat Rev Endocrinol"},{"key":"pntd.0009390.ref043","unstructured":"Valle S da CN do. Mal\u00e1ria em gestantes no munic\u00edpio de Cruzeiro do Sul pertencente \u00e0 regi\u00e3o amaz\u00f4nica brazileira. Universidade de S\u00e3o Paulo. 2011."},{"key":"pntd.0009390.ref044","unstructured":"Organization UNCF and WH. Low Birthweight: Country, regional and global estimates. 1st ed. UNICEF, editor. New York; 2004."},{"key":"pntd.0009390.ref045","volume-title":"Guidelines for the treatment of malaria","author":"WHO","year":"2015","edition":"3"},{"key":"pntd.0009390.ref046","first-page":"1005","article-title":"An analysis of malaria in pregnancy in Africa","volume":"61","author":"BJ Brabin","year":"1983","journal-title":"Bull World Health Organ"},{"key":"pntd.0009390.ref047","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7243\/2054-0841-3-1","article-title":"Prevalence of malaria parasitaemia among asymptomatic women at booking visit in a tertiary hospital, Northcentral Nigeria","volume":"3","author":"GI Ogbu","year":"2015","journal-title":"J Reprod Biol Heal"},{"key":"pntd.0009390.ref048","first-page":"1","article-title":"Placental malaria and its effect on pregnancy outcomes in Sudanese women from Blue Nile State","volume":"16","author":"SA Omer","year":"2017","journal-title":"Malar J"},{"key":"pntd.0009390.ref049","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1086\/315449","article-title":"The Impact of Placental Malaria on Gestational Age and Birth Weight","volume":"181","author":"C Menendez","year":"2000","journal-title":"J Infect Dis"},{"key":"pntd.0009390.ref050","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1186\/s12936-017-2077-4","article-title":"Risk factors and pregnancy outcomes associated with placental malaria in a prospective cohort of Papua New Guinean women","volume":"16","author":"E Lufele","year":"2017","journal-title":"Malar J"},{"key":"pntd.0009390.ref051","doi-asserted-by":"crossref","first-page":"115","DOI":"10.4269\/ajtmh.2003.68.1.0680115","article-title":"Placental monocyte infiltrates in response to Plasmodium falciparum malaria infection and their association with adverse pregnancy outcomes","volume":"68","author":"SJ Rogerson","year":"2003","journal-title":"Am J Trop Med Hyg"},{"key":"pntd.0009390.ref052","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1093\/cid\/cix623","article-title":"Systemic Inflammatory Response to Malaria during Pregnancy Is Associated with Pregnancy Loss and Preterm Delivery","volume":"65","author":"M Fried","year":"2017","journal-title":"Clin Infect Dis"},{"key":"pntd.0009390.ref053","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.4049\/jimmunol.170.5.2759","article-title":"Host Response to Malaria During Pregnancy: Placental Monocyte Recruitment Is Associated with Elevated \u03b2 Chemokine Expression","volume":"170","author":"ET Abrams","year":"2003","journal-title":"J Immunol"},{"key":"pntd.0009390.ref054","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.4049\/jimmunol.160.5.2523","article-title":"Malaria elicits type 1 cytokines in the human placenta: IFN-gamma and TNF-alpha associated with pregnancy outcomes","volume":"160","author":"M Fried","year":"1998","journal-title":"J Immunol"},{"key":"pntd.0009390.ref055","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1093\/infdis\/jis614","article-title":"Placental infection with Plasmodium vivax: A histopathological and molecular study","volume":"206","author":"A Mayor","year":"2012","journal-title":"J Infect Dis"},{"key":"pntd.0009390.ref056","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0009481","article-title":"Dysregulation of angiopoietins is associated with placental malaria and low birth weight","volume":"5","author":"KL Silver","year":"2010","journal-title":"PLoS One."},{"key":"pntd.0009390.ref057","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0109246","article-title":"Angiopoietin-2 and angiopoietin-2\/angiopoietin-1 ratio as indicators of potential severity of plasmodium vivax malaria in patients with thrombocytopenia","volume":"9","author":"LT Gomes","year":"2014","journal-title":"PLoS One"},{"key":"pntd.0009390.ref058","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/1477-7827-7-79","article-title":"Vasodilator factors in the systemic and local adaptations to pregnancy","volume":"7","author":"G Valdes","year":"2009","journal-title":"Reprod Biol Endocrinol"},{"key":"pntd.0009390.ref059","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/35025215","article-title":"Vascular-specific growth factors and blood vessel formation","volume":"407","author":"GD Yancopoulos","year":"2000","journal-title":"Nature"},{"key":"pntd.0009390.ref060","doi-asserted-by":"crossref","first-page":"e0008155","DOI":"10.1371\/journal.pntd.0008155","article-title":"Cytokine signatures of Plasmodium vivax infection during pregnancy and delivery outcomes","volume":"14","author":"C Doba\u00f1o","year":"2020","journal-title":"PLoS Negl Trop Dis"},{"key":"pntd.0009390.ref061","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.pt.2011.02.005","article-title":"Complement activation: A critical mediator of adverse fetal outcomes in placental malaria","volume":"27","author":"AL Conroy","year":"2011","journal-title":"Trends Parasitol"},{"key":"pntd.0009390.ref062","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.chom.2013.01.010","article-title":"Complement activation and the resulting placental vascular insufficiency drives fetal growth restriction associated with placental malaria","volume":"13","author":"AL Conroy","year":"2013","journal-title":"Cell Host Microbe"},{"key":"pntd.0009390.ref063","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1128\/IAI.74.5.2726-2733.2006","article-title":"A Reduced Risk of Infection with Plasmodium vivax and Clinical Protection against Malaria Are Associated with Antibodies against the N Terminus but Not the C Terminus of Merozoite Surface Protein 1","volume":"74","author":"PA Nogueira","year":"2006","journal-title":"Infect Immun"},{"key":"pntd.0009390.ref064","doi-asserted-by":"crossref","first-page":"e0151900","DOI":"10.1371\/journal.pone.0151900","article-title":"Naturally Acquired Antibody Responses to Plasmodium vivax and Plasmodium falciparum Merozoite Surface Protein 1 (MSP1) C-Terminal 19 kDa Domains in an Area of Unstable Malaria Transmission in Southeast Asia","volume":"11","author":"Q Wang","year":"2016","journal-title":"PLoS One"},{"key":"pntd.0009390.ref065","doi-asserted-by":"crossref","first-page":"e0005009","DOI":"10.1371\/journal.pntd.0005009","article-title":"Plasmodium vivax VIR Proteins Are Targets of Naturally-Acquired Antibody and T Cell Immune Responses to Malaria in Pregnant Women.","volume":"10","author":"P Requena","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"pntd.0009390.ref066","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2017.00163","article-title":"Naturally acquired binding-inhibitory antibodies to Plasmodium vivax duffy binding protein in pregnant women are associated with higher birth weight in a multicenter study","volume":"8","author":"P Requena","year":"2017","journal-title":"Front Immunol"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0009390","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T00:00:00Z","timestamp":1620691200000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0009390","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T20:31:08Z","timestamp":1698957068000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0009390"}},"subtitle":[],"editor":[{"given":"Hans-Peter","family":"Fuehrer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,4,29]]},"references-count":66,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,4,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0009390","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,29]]}}}