{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T01:22:10Z","timestamp":1789780930226,"version":"4.0.1"},"update-to":[{"DOI":"10.1371\/journal.pntd.0009400","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T00:00:00Z","timestamp":1621814400000}}],"reference-count":65,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T00:00:00Z","timestamp":1620777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["NRF-2017M3A9E4061992"],"award-info":[{"award-number":["NRF-2017M3A9E4061992"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005073","name":"Agency for Defense Development","doi-asserted-by":"crossref","award":["UE202026GD"],"award-info":[{"award-number":["UE202026GD"]}],"id":[{"id":"10.13039\/501100005073","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\"><jats:title>Background<\/jats:title><jats:p>Orthohantaviruses, causing hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome, pose a significant public health threat worldwide. Despite the significant mortality and morbidity, effective antiviral therapeutics for orthohantavirus infections are currently unavailable. This study aimed to investigate the prevalence of HFRS-associated orthohantaviruses and identify the etiological agent of orthohantavirus outbreaks in southern Republic of Korea (ROK).<\/jats:p><\/jats:sec><jats:sec id=\"sec002\"><jats:title>Methodology\/Principal findings<\/jats:title><jats:p>We collected small mammals on Jeju Island during 2018\u20132020. We detected the Hantaan virus (HTNV)-specific antibodies and RNA using an indirect immunofluorescence assay test and reverse transcription-polymerase chain reaction on<jats:italic>Apodemus agrarius chejuensis<\/jats:italic>(<jats:italic>A<\/jats:italic>.<jats:italic>chejuensis<\/jats:italic>). The prevalence of anti-HTNV antibodies among rodents was 14.1%. A total of six seropositive mouse harbored HTNV RNA. The amplicon-based next-generation sequencing provided nearly full-length tripartite genomic sequences of six HTNV harbored by<jats:italic>A<\/jats:italic>.<jats:italic>chejuensis<\/jats:italic>. Phylogenetic and tanglegram analyses were conducted for inferring evolutionary relationships between orthohantaviruses with their reservoir hosts. Phylogenetic analysis showed a novel distinct HTNV genotype. The detected HTNV genomic sequences were phylogenetically related to a viral sequence derived from HFRS patient in southern ROK. Tanglegram analysis demonstrated the segregation of HTNV genotypes corresponding to<jats:italic>Apodemus spp<\/jats:italic>. divergence.<\/jats:p><\/jats:sec><jats:sec id=\"sec003\"><jats:title>Conclusions\/Significance<\/jats:title><jats:p>Our results suggest that<jats:italic>A<\/jats:italic>.<jats:italic>chejuensis<\/jats:italic>-borne HTNV may be a potential etiological agent of HFRS in southern ROK. Ancestral HTNV may infect<jats:italic>A<\/jats:italic>.<jats:italic>chejuensis<\/jats:italic>prior to geological isolation between the Korean peninsula and Jeju Island, supporting the co-evolution of orthohantaviruses and rodents. This study arises awareness among physicians for HFRS outbreaks in southern ROK.<\/jats:p><\/jats:sec>","DOI":"10.1371\/journal.pntd.0009400","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T17:56:13Z","timestamp":1620842173000},"page":"e0009400","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["A novel genotype of Hantaan orthohantavirus harbored by Apodemus agrarius chejuensis as a potential etiologic agent of hemorrhagic fever with renal syndrome in Republic of Korea"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2132-0674","authenticated-orcid":true,"given":"Kyungmin","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won-Keun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7840-422X","authenticated-orcid":true,"given":"Seung-Ho","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jongwoo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyeong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seungchan","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geum-Young","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4400-7872","authenticated-orcid":true,"given":"Jin Sun","family":"No","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9600-461X","authenticated-orcid":true,"given":"Keun Hwa","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3178-8569","authenticated-orcid":true,"given":"Jin-Won","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,5,12]]},"reference":[{"issue":"7","key":"pntd.0009400.ref001","doi-asserted-by":"crossref","first-page":"5586","DOI":"10.1128\/JVI.73.7.5586-5592.1999","article-title":"Isolation and characterization of a hantavirus from Lemmus sibiricus: evidence for host switch during hantavirus evolution","volume":"73","author":"O Vapalahti","year":"1999","journal-title":"J Virol"},{"key":"pntd.0009400.ref002","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1146\/annurev.med.50.1.531","article-title":"Spectrum of hantavirus infection: hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome","volume":"50","author":"CJ Peters","year":"1999","journal-title":"Annu Rev Med"},{"key":"pntd.0009400.ref003","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.virusres.2013.12.038","article-title":"Hantaviruses: rediscovery and new beginnings","volume":"187","author":"R Yanagihara","year":"2014","journal-title":"Virus research"},{"issue":"2","key":"pntd.0009400.ref004","doi-asserted-by":"crossref","first-page":"e1003159","DOI":"10.1371\/journal.ppat.1003159","article-title":"Phylogeny and origins of hantaviruses harbored by bats, insectivores, and rodents","volume":"9","author":"WP Guo","year":"2013","journal-title":"PLoS Pathog"},{"issue":"8","key":"pntd.0009400.ref005","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.tim.2014.04.008","article-title":"Reconstructing the evolutionary origins and phylogeography of hantaviruses","volume":"22","author":"SN Bennett","year":"2014","journal-title":"Trends Microbiol"},{"issue":"9","key":"pntd.0009400.ref006","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens9090775","article-title":"Orthohantaviruses, Emerging Zoonotic Pathogens","volume":"9","author":"E Kabwe","year":"2020","journal-title":"Pathogens"},{"key":"pntd.0009400.ref007","unstructured":"Korea Disease Control and Prevention Agency (KDCA). Infectious disease portal. Available at: http:\/\/www.cdc.go.kr\/npt\/biz\/npp\/ist\/bass\/bassDissStatsMain.do. Accessed 10 September 2020."},{"issue":"3","key":"pntd.0009400.ref008","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1093\/infdis\/137.3.298","article-title":"Isolation of the etiologic agent of Korean hemorrhagic fever","volume":"137","author":"HW Lee","year":"1978","journal-title":"Journal of infectious diseases"},{"issue":"5","key":"pntd.0009400.ref009","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1093\/infdis\/146.5.638","article-title":"Isolation of Hantaan virus, the etiologic agent of Korean hemorrhagic fever, from wild urban rats","volume":"146","author":"HW Lee","year":"1982","journal-title":"Journal of Infectious Diseases"},{"issue":"2","key":"pntd.0009400.ref010","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/jmv.20538","article-title":"Soochong virus: an antigenically and genetically distinct hantavirus isolated from Apodemus peninsulae in Korea","volume":"78","author":"LJ Baek","year":"2006","journal-title":"Journal of medical virology"},{"issue":"Pt 11","key":"pntd.0009400.ref011","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1099\/vir.0.83139-0","article-title":"Muju virus, a novel hantavirus harboured by the arvicolid rodent Myodes regulus in Korea","volume":"88","author":"K-J Song","year":"2007","journal-title":"The Journal of general virology"},{"issue":"12","key":"pntd.0009400.ref012","doi-asserted-by":"crossref","first-page":"6184","DOI":"10.1128\/JVI.00371-09","article-title":"Characterization of Imjin virus, a newly isolated hantavirus from the Ussuri white-toothed shrew (Crocidura lasiura)","volume":"83","author":"JW Song","year":"2009","journal-title":"J Virol"},{"issue":"2","key":"pntd.0009400.ref013","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.virol.2011.11.013","article-title":"Divergent ancestral lineages of newfound hantaviruses harbored by phylogenetically related crocidurine shrew species in Korea","volume":"424","author":"S Arai","year":"2012","journal-title":"Virology"},{"issue":"3","key":"pntd.0009400.ref014","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1093\/cid\/ciz234","article-title":"Active Targeted Surveillance to Identify Sites of Emergence of Hantavirus","volume":"70","author":"WK Kim","year":"2020","journal-title":"Clin Infect Dis"},{"issue":"8","key":"pntd.0009400.ref015","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1089\/vbz.2011.0618","article-title":"Hantaan virus surveillance in small mammals at firing points 10 and 60, Yeoncheon, Gyeonggi Province, Republic of Korea","volume":"12","author":"TA Klein","year":"2012","journal-title":"Vector-borne and Zoonotic Diseases"},{"issue":"4","key":"pntd.0009400.ref016","doi-asserted-by":"crossref","first-page":"e0118483","DOI":"10.1371\/journal.pone.0118483","article-title":"Hantaan virus surveillance targeting small mammals at nightmare range, a high elevation military training area, Gyeonggi Province, Republic of Korea","volume":"10","author":"TA Klein","year":"2015","journal-title":"PLoS One"},{"issue":"6","key":"pntd.0009400.ref017","doi-asserted-by":"crossref","first-page":"e0004650","DOI":"10.1371\/journal.pntd.0004650","article-title":"Genetic Diversity and Reassortment of Hantaan Virus Tripartite RNA Genomes in Nature, the Republic of Korea","volume":"10","author":"JA Kim","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"issue":"10","key":"pntd.0009400.ref018","doi-asserted-by":"crossref","first-page":"e0008714","DOI":"10.1371\/journal.pntd.0008714","article-title":"Phylogeographic diversity and hybrid zone of Hantaan orthohantavirus collected in Gangwon Province, Republic of Korea","volume":"14","author":"G-Y Lee","year":"2020","journal-title":"PLOS Neglected Tropical Diseases"},{"issue":"2","key":"pntd.0009400.ref019","doi-asserted-by":"crossref","first-page":"427","DOI":"10.7589\/0090-3558-47.2.427","article-title":"Prevalence of hantavirus infection in wild rodents from five provinces in Korea, 2007","volume":"47","author":"J Ryou","year":"2011","journal-title":"J Wildl Dis"},{"issue":"1","key":"pntd.0009400.ref020","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1948-7134.2012.00205.x","article-title":"Seroprevalence of hantaviruses in small wild mammals trapped in South Korea from 2005 to 2010","volume":"37","author":"MY Lim","year":"2012","journal-title":"J Vector Ecol"},{"issue":"1","key":"pntd.0009400.ref021","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1186\/s12879-017-2506-6","article-title":"The influence of climatic factors on the development of hemorrhagic fever with renal syndrome and leptospirosis during the peak season in Korea: an ecologic study","volume":"17","author":"YP Joshi","year":"2017","journal-title":"BMC Infect Dis"},{"issue":"6","key":"pntd.0009400.ref022","article-title":"Case of Hemorrhagic Fever with Renal Syndrome in Jeju Island","volume":"44","author":"CM Lim","year":"2012","journal-title":"Infection & Chemotherapy"},{"issue":"3","key":"pntd.0009400.ref023","doi-asserted-by":"crossref","first-page":"205","DOI":"10.4167\/jbv.2006.36.3.205","article-title":"Epidemiological Survey of Hantaan Virus Infection of Wild Rodents Trapped in Jeollanam-do, 2003~ 2004","volume":"36","author":"H-J Song","year":"2006","journal-title":"Journal of Bacteriology and Virology"},{"issue":"7","key":"pntd.0009400.ref024","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1007\/s00705-019-04253-6","article-title":"Taxonomy of the order Bunyavirales: update 2019","volume":"164","author":"A Abudurexiti","year":"2019","journal-title":"Arch Virol"},{"key":"pntd.0009400.ref025","volume-title":"Family Muridae. 1189\u20131531. Mammal species of the world: a taxonomic and geographic reference","author":"G Musser","year":"2005","edition":"3"},{"issue":"1\u20132","key":"pntd.0009400.ref026","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1023\/A:1001828203201","article-title":"A phylogenetic view on species radiation in Apodemus inferred from variation of nuclear and mitochondrial genes","volume":"38","author":"K Serizawa","year":"2000","journal-title":"Biochem Genet"},{"issue":"24","key":"pntd.0009400.ref027","doi-asserted-by":"crossref","first-page":"13816","DOI":"10.1128\/JVI.02586-12","article-title":"Complete genome sequence of an amur virus isolated from Apodemus peninsulae in Northeastern China","volume":"86","author":"LS Yao","year":"2012","journal-title":"J Virol"},{"issue":"3","key":"pntd.0009400.ref028","doi-asserted-by":"crossref","first-page":"545","DOI":"10.4269\/ajtmh.2012.11-0297","article-title":"Isolation and characterization of hantaviruses in Far East Russia and etiology of hemorrhagic fever with renal syndrome in the region","volume":"86","author":"H Kariwa","year":"2012","journal-title":"Am J Trop Med Hyg"},{"key":"pntd.0009400.ref029","first-page":"111","article-title":"The mammals of Korea","author":"M Yoon","year":"2004","journal-title":"Dongbangmedia, Seoul."},{"issue":"1","key":"pntd.0009400.ref030","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1046\/j.1365-2540.2000.00723.x","article-title":"The genetic relationships of two subspecies of striped field mice, Apodemus agrarius coreae and Apodemus agrarius chejuensis","volume":"85","author":"HS Koh","year":"2000","journal-title":"Heredity"},{"issue":"1","key":"pntd.0009400.ref031","first-page":"25","article-title":"Paleomagnetism and radiometric age of trachytes in Jeju Island, Korea","volume":"19","author":"JK Won","year":"1986","journal-title":"Economic and Environmental Geology"},{"key":"pntd.0009400.ref032","article-title":"Quaternary Geology in the Southern Part of Jeju Island. Report of the Korea Institute of Energy and Resourcev","author":"S Yun","year":"1987","journal-title":"KE-86-2-(B)-2** in Korean or Japanese with English abstract"},{"key":"pntd.0009400.ref033","first-page":"233","article-title":"Quaternary geology of the Jeju Island","volume":"87","author":"D. Lee","year":"1988","journal-title":"Korea Institute of Energy and Resources Report"},{"key":"pntd.0009400.ref034","first-page":"321","article-title":"Geology of coasts and mountains in Cheju-Do","volume":"2","author":"D. Park","year":"1985","journal-title":"Cheju-Do Study"},{"issue":"2","key":"pntd.0009400.ref035","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3109\/19401736.2012.726619","article-title":"Migration route estimation of the Jeju striped field mouse Apodemus agrarius chejuensis (Rodentia, Muridae)","volume":"24","author":"D-J Oh","year":"2013","journal-title":"Mitochondrial Dna"},{"issue":"2","key":"pntd.0009400.ref036","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3106\/mammalstudy.21.125","article-title":"Variation of the mitochondrial DNA and the nuclear ribosomal DNA in the striped field mouse Apodemus agrarius on the mainland and offshore islands of South Korea","volume":"21","author":"SH Han","year":"1996","journal-title":"Mammal Study"},{"key":"pntd.0009400.ref037","author":"H-S Oh","year":"1998","journal-title":"Taxonomic re-examination of the striped field mouse, Apodemus agrarius coreae and A. a. chejuensis: Evidence from crossbreeding experiments (Mammalia: Rodentia)"},{"issue":"1","key":"pntd.0009400.ref038","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3390\/su10010073","article-title":"International Tourists\u2019 Perceived Sustainability of Jeju Island, South Korea","volume":"10","author":"M-S Kim","year":"2018","journal-title":"Sustainability"},{"issue":"9","key":"pntd.0009400.ref039","doi-asserted-by":"crossref","first-page":"3008","DOI":"10.1128\/JCM.02573-06","article-title":"Hantavirus disease outbreak in Germany: limitations of routine serological diagnostics and clustering of virus sequences of human and rodent origin","volume":"45","author":"S Schilling","year":"2007","journal-title":"J Clin Microbiol"},{"issue":"11","key":"pntd.0009400.ref040","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.3201\/eid1511.090076","article-title":"Hemorrhagic fever with renal syndrome in 4 US soldiers, South Korea, 2005","volume":"15","author":"JW Song","year":"2009","journal-title":"Emerg Infect Dis"},{"issue":"3","key":"pntd.0009400.ref041","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1007\/s13365-018-0624-6","article-title":"Hemorrhagic fever with renal syndrome accompanied by panhypopituitarism and central diabetes insipidus: a case report","volume":"24","author":"HJ Ahn","year":"2018","journal-title":"J Neurovirol"},{"issue":"3","key":"pntd.0009400.ref042","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s00705-012-1514-5","article-title":"Complex evolution and epidemiology of Dobrava-Belgrade hantavirus: definition of genotypes and their characteristics","volume":"158","author":"B Klempa","year":"2013","journal-title":"Archives of Virology"},{"issue":"1","key":"pntd.0009400.ref043","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/rmv.1722","article-title":"Hantavirus infections in Europe and their impact on public health","volume":"23","author":"A Vaheri","year":"2013","journal-title":"Reviews in medical virology"},{"issue":"4","key":"pntd.0009400.ref044","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1086\/515185","article-title":"Hemorrhagic fever with renal syndrome in the Dolenjska region of Slovenia\u2014a 10-year survey","volume":"28","author":"T Av\u0161i\u010d-\u017dupanc","year":"1999","journal-title":"Clinical infectious diseases"},{"issue":"2","key":"pntd.0009400.ref045","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1023\/A:1017987104363","article-title":"Hantavirus infections in Greece\u2013an update","volume":"17","author":"A Papa","year":"2001","journal-title":"European journal of epidemiology"},{"issue":"4","key":"pntd.0009400.ref046","doi-asserted-by":"crossref","first-page":"617","DOI":"10.3201\/eid1404.071310","article-title":"Hemorrhagic fever with renal syndrome caused by 2 lineages of Dobrava hantavirus, Russia","volume":"14","author":"B Klempa","year":"2008","journal-title":"Emerg Infect Dis"},{"issue":"11","key":"pntd.0009400.ref047","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.3201\/eid1311.070221","article-title":"Characterization of hemorrhagic fever with renal syndrome caused by hantaviruses, Estonia","volume":"13","author":"I Golovljova","year":"2007","journal-title":"Emerging infectious diseases"},{"issue":"12","key":"pntd.0009400.ref048","doi-asserted-by":"crossref","first-page":"4029","DOI":"10.1128\/JCM.01225-09","article-title":"Molecular diagnostics of hemorrhagic fever with renal syndrome during a Dobrava virus infection outbreak in the European part of Russia","volume":"47","author":"TK Dzagurova","year":"2009","journal-title":"Journal of clinical microbiology"},{"issue":"7","key":"pntd.0009400.ref049","doi-asserted-by":"crossref","first-page":"e1004902","DOI":"10.1371\/journal.ppat.1004902","article-title":"RNA Virus Reassortment: An Evolutionary Mechanism for Host Jumps and Immune Evasion","volume":"11","author":"D Vijaykrishna","year":"2015","journal-title":"PLoS Pathog"},{"issue":"8","key":"pntd.0009400.ref050","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1099\/vir.0.2008\/000497-0","article-title":"Molecular diversity and phylogeny of Hantaan virus in Guizhou, China: evidence for Guizhou as a radiation center of the present Hantaan virus","volume":"89","author":"Y Zou","year":"2008","journal-title":"Journal of general virology"},{"issue":"4","key":"pntd.0009400.ref051","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.yhbeh.2007.07.001","article-title":"Elevated testosterone and reduced 5-HIAA concentrations are associated with wounding and hantavirus infection in male Norway rats","volume":"52","author":"JD Easterbrook","year":"2007","journal-title":"Horm Behav"},{"issue":"2","key":"pntd.0009400.ref052","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1017\/S0950268800054418","article-title":"Association of intraspecific wounding with hantaviral infection in wild rats (Rattus norvegicus)","volume":"101","author":"GE Glass","year":"1988","journal-title":"Epidemiol Infect"},{"issue":"1","key":"pntd.0009400.ref053","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/j.1365-3156.2007.01968.x","article-title":"Prevalence of hantavirus infection in wild Rattus norvegicus and R. rattus populations of Buenos Aires City, Argentina","volume":"13","author":"GR Cueto","year":"2008","journal-title":"Trop Med Int Health"},{"issue":"1","key":"pntd.0009400.ref054","doi-asserted-by":"crossref","first-page":"33","DOI":"10.4269\/ajtmh.2001.65.33","article-title":"Longitudinal studies of Sin Nombre virus in deer mouse-dominated ecosystems of Montana","volume":"65","author":"RJ Douglass","year":"2001","journal-title":"Am J Trop Med Hyg"},{"issue":"1","key":"pntd.0009400.ref055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7589\/0090-3558-41.1.1","article-title":"Epizootiology of Sin Nombre and El Moro Canyon hantaviruses, southeastern Colorado, 1995\u20132000","volume":"41","author":"CH Calisher","year":"2005","journal-title":"J Wildl Dis"},{"issue":"9","key":"pntd.0009400.ref056","doi-asserted-by":"crossref","first-page":"930","DOI":"10.3201\/eid0809.010537","article-title":"Behavioral, physiologic, and habitat influences on the dynamics of Puumala virus infection in bank voles (Clethrionomys glareolus)","volume":"8","author":"S Escutenaire","year":"2002","journal-title":"Emerg Infect Dis"},{"issue":"6","key":"pntd.0009400.ref057","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.4269\/ajtmh.2005.73.1043","article-title":"A longitudinal study of Bayou virus, hosts, and habitat","volume":"73","author":"NE McIntyre","year":"2005","journal-title":"Am J Trop Med Hyg"},{"issue":"3","key":"pntd.0009400.ref058","doi-asserted-by":"crossref","first-page":"310","DOI":"10.4269\/ajtmh.2004.70.310","article-title":"Wounding: the primary mode of Seoul virus transmission among male Norway rats","volume":"70","author":"ER Hinson","year":"2004","journal-title":"The American journal of tropical medicine and hygiene"},{"issue":"2","key":"pntd.0009400.ref059","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1007\/BF02515385","article-title":"Evolution of the cytochrome b gene of mammals","volume":"32","author":"DM Irwin","year":"1991","journal-title":"J Mol Evol"},{"issue":"1","key":"pntd.0009400.ref060","first-page":"1","article-title":"Phylogeographic analysis of hemorrhagic fever with renal syndrome patients using multiplex PCR-based next generation sequencing","volume":"6","author":"W-K Kim","year":"2016","journal-title":"Scientific reports"},{"issue":"22","key":"pntd.0009400.ref061","doi-asserted-by":"crossref","first-page":"3718","DOI":"10.1093\/bioinformatics\/btv428","article-title":"dendextend: an R package for visualizing, adjusting and comparing trees of hierarchical clustering","volume":"31","author":"T. Galili","year":"2015","journal-title":"Bioinformatics"},{"issue":"1","key":"pntd.0009400.ref062","doi-asserted-by":"crossref","first-page":"vev003","DOI":"10.1093\/ve\/vev003","article-title":"RDP4: Detection and analysis of recombination patterns in virus genomes","volume":"1","author":"DP Martin","year":"2015","journal-title":"Virus evolution"},{"issue":"6","key":"pntd.0009400.ref063","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.1093\/nar\/gkq1232","article-title":"GiRaF: robust, computational identification of influenza reassortments via graph mining","volume":"39","author":"N Nagarajan","year":"2011","journal-title":"Nucleic acids research"},{"issue":"8","key":"pntd.0009400.ref064","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1093\/bioinformatics\/17.8.754","article-title":"MRBAYES: Bayesian inference of phylogenetic trees","volume":"17","author":"JP Huelsenbeck","year":"2001","journal-title":"Bioinformatics"},{"issue":"5","key":"pntd.0009400.ref065","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/protein\/3.5.433","article-title":"Sequence differences between glycosylated and non-glycosylated Asn-X-Thr\/Ser acceptor sites: implications for protein engineering","volume":"3","author":"Y Gavel","year":"1990","journal-title":"Protein Engineering, Design and Selection"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0009400","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T00:00:00Z","timestamp":1621814400000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0009400","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T19:24:33Z","timestamp":1725045873000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0009400"}},"subtitle":[],"editor":[{"given":"Brett M.","family":"Forshey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,5,12]]},"references-count":65,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,5,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0009400","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pntd.0009400","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,12]]}}}