{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T17:39:05Z","timestamp":1791740345269,"version":"4.3.4"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T00:00:00Z","timestamp":1624838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1104516"],"award-info":[{"award-number":["OPP1104516"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1154033"],"award-info":[{"award-number":["OPP1154033"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1154033"],"award-info":[{"award-number":["OPP1154033"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Gambian human African trypanosomiasis (gHAT) is a neglected tropical disease caused by <jats:italic>Trypanosoma brucei gambiense<\/jats:italic> transmitted by tsetse flies (<jats:italic>Glossina<\/jats:italic>). In C\u00f4te d\u2019Ivoire, Bonon is the most important focus of gHAT, with 325 cases diagnosed from 2000 to 2015 and efforts against gHAT have relied largely on mass screening and treatment of human cases. We assessed whether the addition of tsetse control by deploying Tiny Targets offers benefit to sole reliance on the screen-and-treat strategy.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methodology and principal findings<\/jats:title>\n<jats:p>In 2015, we performed a census of the human population of the Bonon focus, followed by an exhaustive entomological survey at 278 sites. After a public sensitization campaign, ~2000 Tiny Targets were deployed across an area of 130 km<jats:sup>2<\/jats:sup> in February of 2016, deployment was repeated annually in the same month of 2017 and 2018. The intervention\u2019s impact on tsetse was evaluated using a network of 30 traps which were operated for 48 hours at three-month intervals from March 2016 to December 2018. A second comprehensive entomological survey was performed in December 2018 with traps deployed at 274 of the sites used in 2015. Sub-samples of tsetse were dissected and examined microscopically for presence of trypanosomes. The census recorded 26,697 inhabitants residing in 331 settlements. Prior to the deployment of targets, the mean catch of tsetse from the 30 monitoring traps was 12.75 tsetse\/trap (5.047\u201332.203, 95%CI), i.e. 6.4 tsetse\/trap\/day. Following the deployment of Tiny Targets, mean catches ranged between 0.06 (0.016\u20130.260, 95%CI) and 0.55 (0.166\u20131.794, 95%CI) tsetse\/trap, i.e. 0.03\u20130.28 tsetse\/trap\/day. During the final extensive survey performed in December 2018, 52 tsetse were caught compared to 1,909 in 2015, with 11.6% (5\/43) and 23.1% (101\/437) infected with <jats:italic>Trypanosoma<\/jats:italic> respectively.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The annual deployment of Tiny Targets in the gHAT focus of Bonon reduced the density of <jats:italic>Glossina palpalis palpalis<\/jats:italic> by &gt;95%. Tiny Targets offer a powerful addition to current strategies towards eliminating gHAT from C\u00f4te d\u2019Ivoire.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pntd.0009404","type":"journal-article","created":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T17:23:54Z","timestamp":1624901034000},"page":"e0009404","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":38,"title":["Use of vector control to protect people from sleeping sickness in the focus of Bonon (C\u00f4te d\u2019Ivoire)"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7103-0440","authenticated-orcid":true,"given":"Dramane","family":"Kaba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9011-8103","authenticated-orcid":true,"given":"Vincent","family":"Djohan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3113-7432","authenticated-orcid":true,"given":"Djakaridja","family":"Bert\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bi Tra Dieudonn\u00e9","family":"TA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3034-8345","authenticated-orcid":true,"given":"Richard","family":"Selby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koffi Alain De Marie","family":"Kouadio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bamoro","family":"Coulibaly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabehonron","family":"Traor\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Baptiste","family":"Rayaisse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Fauret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8427-0769","authenticated-orcid":true,"given":"Vincent","family":"Jamonneau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouakou","family":"Lingue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4351-3506","authenticated-orcid":true,"given":"Phillipe","family":"Solano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9550-4030","authenticated-orcid":true,"given":"Steve J.","family":"Torr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4920-316X","authenticated-orcid":true,"given":"Fabrice","family":"Courtin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,6,28]]},"reference":[{"key":"pntd.0009404.ref001","unstructured":"WHO. 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s.l","volume":"20","author":"JP Gouteux","year":"1982","journal-title":"Cahiers ORSTOM, s\u00e9rie Entomologie m\u00e9dicale et parasitologie"},{"key":"pntd.0009404.ref037","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1756-3305-4-18","article-title":"Progress towards the eradication of tsetse from the Loos islands, Guinea","volume":"4","author":"M Kagbadouno","year":"2011","journal-title":"Parasit Vectors."},{"issue":"10","key":"pntd.0009404.ref038","doi-asserted-by":"crossref","first-page":"e3284","DOI":"10.1371\/journal.pntd.0003284","article-title":"Improvements on Restricted Insecticide Application Protocol for Control of Human and Animal African Trypanosomiasis in Eastern Uganda","volume":"8","author":"D Muhanguzi","year":"2014","journal-title":"PLOS Neglected Tropical Diseases."},{"issue":"2","key":"pntd.0009404.ref039","first-page":"159","article-title":"Preliminary observations of tsetse flies fed on a pig dipped in deltamethrin","volume":"68","author":"P Van 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