{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:57:01Z","timestamp":1787021821167,"version":"build-2736575974"},"update-to":[{"DOI":"10.1371\/journal.pntd.0009423","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T00:00:00Z","timestamp":1622592000000}}],"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T00:00:00Z","timestamp":1621468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Beni-Suef University, University Performance Development Center, Support and Project Finance Office"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Nanotechnology has been manufactured from medicinal plants to develop safe, and effective antischistosmal alternatives to replace today\u2019s therapies. The aim of the study is to evaluate the prophylactic effect of ginger-derived nanoparticles (GNPs), and the therapeutic effect of ginger aqueous extract, and GNPs on\n                      <jats:italic>Schistosoma mansoni<\/jats:italic>\n                      (\n                      <jats:italic>S<\/jats:italic>\n                      .\n                      <jats:italic>mansoni<\/jats:italic>\n                      ) infected mice compared to praziquantel (PZQ), and mefloquine (MFQ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methodology\/principal findings<\/jats:title>\n                    <jats:p>\n                      Eighty four mice, divided into nine different groups, were sacrificed at 6\n                      <jats:sup>th<\/jats:sup>\n                      , 8\n                      <jats:sup>th<\/jats:sup>\n                      , and 10\n                      <jats:sup>th<\/jats:sup>\n                      week post-infection (PI), with assessment of parasitological, histopathological, and oxidative stress parameters, and scanning the worms by electron microscope. As a prophylactic drug, GNPs showed slight reduction in worm burden, egg density, and granuloma size and number. As a therapeutic drug, GNPs significantly reduced worm burden (59.9%), tissue egg load (64.9%), granuloma size, and number at 10\n                      <jats:sup>th<\/jats:sup>\n                      week PI, and altered adult worm tegumental architecture, added to antioxidant effect. Interestingly, combination of GNPs with PZQ or MFQ gave almost similar or sometimes better curative effects as obtained with each drug separately. The highest therapeutic effect was obtained when \u00bd dose GNPs combined with \u00bd dose MFQ which achieved 100% reduction in both the total worm burden, and ova tissue density as early as the 6\n                      <jats:sup>th<\/jats:sup>\n                      week PI, with absence of detected eggs or tissue granuloma, and preservation of liver architecture.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Conclusions\/significance<\/jats:title>\n                    <jats:p>GNPs have a schistosomicidal, antioxidant, and hepatoprotective role. GNPs have a strong synergistic effect when combined with etiological treatments (PZQ or MFQ), and significantly reduced therapeutic doses by 50%, which may mitigate side effects and resistance to etiological drugs, a hypothesis requiring further research. We recommend extending this study to humans.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pntd.0009423","type":"journal-article","created":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T14:05:26Z","timestamp":1621519526000},"page":"e0009423","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":44,"title":["Ginger (Zingiber Officinale)-derived nanoparticles in Schistosoma mansoni infected mice: Hepatoprotective and enhancer of etiological treatment"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6269-603X","authenticated-orcid":true,"given":"Wegdan M.","family":"Abd El Wahab","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9673-2622","authenticated-orcid":true,"given":"Ayman A.","family":"El-Badry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soheir S.","family":"Mahmoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6874-440X","authenticated-orcid":true,"given":"Yaser A.","family":"El-Badry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4643-4990","authenticated-orcid":true,"given":"Mohamed A.","family":"El-Badry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6235-7174","authenticated-orcid":true,"given":"Doaa A.","family":"Hamdy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,5,20]]},"reference":[{"key":"pntd.0009423.ref001","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3389\/fgene.2014.00119","article-title":"Donnelly, S. 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