{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T20:38:23Z","timestamp":1767731903782,"version":"build-2238731810"},"update-to":[{"DOI":"10.1371\/journal.pntd.0009451","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T00:00:00Z","timestamp":1624406400000}}],"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T00:00:00Z","timestamp":1623369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["13122"],"award-info":[{"award-number":["13122"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Recent research suggests that schistosomiasis targets for morbidity control and elimination as a public health problem could benefit from a reanalysis. These analyses would define evidence-based targets that control programs could use to confidently assert that they had controlled or eliminated schistosomiasis as a public health problem. We estimated how low\n                      <jats:italic>Schistosoma haematobium<\/jats:italic>\n                      infection levels diagnosed by urine filtration in school-age children should be decreased so that microhematuria prevalence was at, or below, a \u201cbackground\u201d level of morbidity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>Data obtained from school-age children in Burkina Faso, Mali, Niger, Tanzania, and Zambia who participated in schistosomiasis monitoring and evaluation cohorts were reanalyzed before and after initiation of preventive chemotherapy. Bayesian models estimated the infection level prevalence probabilities associated with microhematuria thresholds \u226410%, 13%, or 15%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Principal findings<\/jats:title>\n                    <jats:p>An infection prevalence of 5% could be a sensible target for urogenital schistosomiasis morbidity control in children as microhematuria prevalence was highly likely to be below 10% in all surveys. Targets of 8% and 11% infection prevalence were highly likely to result in microhematuria levels less than 13% and 15%, respectively. By contrast, measuring heavy-intensity infections only achieves these thresholds at impractically low prevalence levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions\/significance<\/jats:title>\n                    <jats:p>A target of 5%, 8%, or 11% urogenital schistosomiasis infection prevalence in school-age children could be used to determine whether a geographic area has controlled or eliminated schistosomiasis as a public health problem depending on the local background threshold of microhematuria.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pntd.0009451","type":"journal-article","created":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T13:40:09Z","timestamp":1623418809000},"page":"e0009451","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Urogenital schistosomiasis infection prevalence targets to determine elimination as a public health problem based on microhematuria prevalence in school-age children"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9486-1850","authenticated-orcid":true,"given":"Ryan E.","family":"Wiegand","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3866-2232","authenticated-orcid":true,"given":"Fiona M.","family":"Fleming","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Straily","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan P.","family":"Montgomery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1830-5668","authenticated-orcid":true,"given":"Sake J.","family":"de Vlas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrg","family":"Utzinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Penelope","family":"Vounatsou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0584-5961","authenticated-orcid":true,"given":"W. 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Fenwick","year":"2009","journal-title":"Parasitology"},{"key":"pntd.0009451.ref017","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1086\/520515","article-title":"Schistosoma haematobium infection and morbidity before and after large-scale administration of praziquantel in Burkina Faso","volume":"196","author":"A Koukounari","year":"2007","journal-title":"J Infect Dis"},{"key":"pntd.0009451.ref018","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1017\/S0031182009990369","article-title":"Present and future schistosomiasis control activities with support from the Schistosomiasis Control Initiative in West Africa","volume":"136","author":"A Garba","year":"2009","journal-title":"Parasitology"},{"key":"pntd.0009451.ref019","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.pt.2006.05.001","article-title":"The control of schistosomiasis and soil-transmitted helminths in East Africa","volume":"22","author":"NB 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Durbin","year":"1954","journal-title":"Rev Inst Int Stat"},{"key":"pntd.0009451.ref022","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/biomet\/71.1.19","article-title":"On errors-in-variables for binary regression models","volume":"71","author":"RJ Carroll","year":"1984","journal-title":"Biometrika"},{"key":"pntd.0009451.ref023","doi-asserted-by":"crossref","first-page":"98","DOI":"10.4269\/ajtmh.2004.71.98","article-title":"Diagnosis of urinary schistosomiasis: a novel approach to compare bladder pathology measured by ultrasound and three methods for hematuria detection","volume":"71","author":"MJ van der Werf","year":"2004","journal-title":"Am J Trop Med Hyg"},{"key":"pntd.0009451.ref024","article-title":"rjags: Bayesian graphical models using MCMC","author":"M. Plummer","year":"2019","journal-title":"R package version 4\u201310 ed"},{"key":"pntd.0009451.ref025","first-page":"620","article-title":"Discussion of the paper by Spiegelhalter et al","volume":"64","author":"M. Plummer","year":"2002","journal-title":"J Roy Stat Soc B Met"},{"key":"pntd.0009451.ref026","volume-title":"Validation of elimination of trachoma as a public health problem","author":"WHO","year":"2016"},{"key":"pntd.0009451.ref027","volume-title":"Validation of elimination of lymphatic filariasis as a public health problem","author":"WHO","year":"2017"},{"key":"pntd.0009451.ref028","doi-asserted-by":"crossref","first-page":"476","DOI":"10.4269\/ajtmh.1999.61.476","article-title":"Long-term suppression of adult bladder morbidity and severe hydronephrosis following selective population chemotherapy for Schistosoma haematobium","volume":"61","author":"AK Subramanian","year":"1999","journal-title":"Am J Trop Med Hyg"},{"key":"pntd.0009451.ref029","unstructured":"Neglected Tropical Diseases Support Center. MORBID: Morbidity Operational Research for Bilharziasis Implementation Decisions (Pilot) 2019 [updated August 27, 2019; cited 2020 May 20]. 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