{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:39:21Z","timestamp":1790789961495,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0009475","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T00:00:00Z","timestamp":1623715200000}}],"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T00:00:00Z","timestamp":1622678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>Dengue is transmitted mainly by the adult female <jats:italic>Aedes aegypti<\/jats:italic> mosquito. However, little is known about the impact of adult <jats:italic>Aedes<\/jats:italic> abundance on the risk of dengue transmission. Here we analysed nationally representative dengue case and vector surveillance data collected from Singapore, to determine the effect of adult <jats:italic>Aedes<\/jats:italic> abundance on the risk of dengue transmission. A case was an area with active dengue transmission as indicated by the presence of dengue cluster. A control was an area where no dengue cluster was reported. Using multivariate logistic regression, we analysed 88 cases and 602 controls and estimated the odds of dengue cluster formation at various adult <jats:italic>Aedes<\/jats:italic> abundance levels, estimated by the mean number of adult female <jats:italic>Aedes<\/jats:italic> per Gravitrap per week and categorised into Low, Moderate, High and Very High abundance level. We found that the risk of dengue cluster formation was positively associated with adult <jats:italic>Ae<\/jats:italic>. <jats:italic>aegypti<\/jats:italic> abundance. We observed a three to four-fold increase in the odds of dengue clusters forming in areas with High (AOR: 3.40, 95% CI: 2.09, 5.52) and Very High (AOR: 3.99, 95% CI: 2.46, 6.46) adult <jats:italic>Aedes aegypti<\/jats:italic> abundance level compared to those with low <jats:italic>Ae<\/jats:italic>. <jats:italic>aegypti<\/jats:italic> abundance level. Our study strengthens the evidence for the use of adult <jats:italic>Aedes<\/jats:italic> indices for dengue risk assessment and early warning for dengue outbreaks. Entomological indicators of adult <jats:italic>Ae<\/jats:italic>. <jats:italic>aegypti<\/jats:italic> could be used to anticipate and prioritize areas for dengue control.<\/jats:p>","DOI":"10.1371\/journal.pntd.0009475","type":"journal-article","created":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T18:18:01Z","timestamp":1622744281000},"page":"e0009475","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":32,"title":["Short Report: Adult Aedes abundance and risk of dengue transmission"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8792-318X","authenticated-orcid":true,"given":"Janet","family":"Ong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2851-9424","authenticated-orcid":true,"given":"Joel","family":"Aik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2413-3863","authenticated-orcid":true,"given":"Lee Ching","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,6,3]]},"reference":[{"key":"pntd.0009475.ref001","unstructured":"World Health Organization. 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Population and Population Structure [cited 16 Nov 2020]. Available from: https:\/\/www.singstat.gov.sg\/find-data\/search-by-theme\/population\/population-and-population-structure\/latest-data."},{"key":"pntd.0009475.ref014","unstructured":"Meteorological Service Singapore. Climate of Singapore [cited 16 Nov 2020]. Available from: http:\/\/www.weather.gov.sg\/climate-climate-of-singapore\/."},{"issue":"1","key":"pntd.0009475.ref015","doi-asserted-by":"crossref","first-page":"204","DOI":"10.4269\/ajtmh.17-0819","article-title":"Dengue in Singapore from 2004 to 2016: Cyclical epidemic patterns dominated by serotypes 1 and 2","volume":"99","author":"J Rajarethinam","year":"2018","journal-title":"Am J Trop Med Hyg"},{"key":"pntd.0009475.ref016","article-title":"NEA Urges Continued Vigilance At Start of 2021 As Aedes Aegypti Mosquito Population Remains High and Many Residents Continue To Work From Home","author":"National Environment Agency, Singapore","year":"2021","journal-title":"NEA News"},{"key":"pntd.0009475.ref017","article-title":"NEA Urges Continued Vigilance As Aedes Aegypti Mosquito Population And Number Of Dengue Cases Remain High At The Start Of 2020","author":"National Environment Agency, Singapore","year":"2020","journal-title":"NEA News"},{"key":"pntd.0009475.ref018","author":"Singapore Department of Statistics","year":"2019","journal-title":"Population trends"},{"issue":"1","key":"pntd.0009475.ref019","doi-asserted-by":"crossref","first-page":"40","DOI":"10.4269\/ajtmh.14-0671","article-title":"Dengue seroprevalence of healthy adults in Singapore: serosurvey among blood donors, 2009","volume":"93","author":"S-L Low","year":"2015","journal-title":"Am J Trop Med Hyg"},{"key":"pntd.0009475.ref020","unstructured":"Singapore Department of Statistics [Internet]. Households [cited 16 Nov 2020]. Available from: https:\/\/www.singstat.gov.sg\/find-data\/search-by-theme\/households\/households\/latest-data."},{"key":"pntd.0009475.ref021","first-page":"1","article-title":"Illustrated keys to the mosquitoes of Thailand. VI","volume":"41","author":"R Rattanarithikul","year":"2010","journal-title":"Tribe Aedini. Southeast Asian J Trop Med Public Health"},{"issue":"8","key":"pntd.0009475.ref022","doi-asserted-by":"crossref","first-page":"e0008528","DOI":"10.1371\/journal.pntd.0008528","article-title":"Gravitrap deployment for adult Aedes aegypti surveillance and its impact on dengue cases","volume":"14","author":"J Ong","year":"2020","journal-title":"PLoS Negl Trop Dis"},{"key":"pntd.0009475.ref023","unstructured":"Epidemiological News Bulletin [Internet]. Review of the Dengue Situation in Singapore [cited 16 Nov 2020]. 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Available from: https:\/\/www.moh.gov.sg\/diseases-updates\/dengue."}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0009475","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T00:00:00Z","timestamp":1623715200000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0009475","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T17:40:38Z","timestamp":1623778838000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0009475"}},"subtitle":[],"editor":[{"given":"Pattamaporn","family":"Kittayapong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,6,3]]},"references-count":33,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,6,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0009475","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pntd.0009475","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,3]]}}}